Application of daffodiline derivatives in the preparation of antibacterial drugs

By developing antibacterial drugs from daffodil derivatives, the problem of drug-resistant strains has been solved, providing effective inhibition against Gram-positive bacteria such as Escherichia coli, Pseudomonas aeruginosa, and Candida albicans, thus achieving an improvement over existing antibiotics.

CN113730414BActive Publication Date: 2026-06-30JIANGSU VOCATIONAL COLLEGE OF MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIANGSU VOCATIONAL COLLEGE OF MEDICINE
Filing Date
2021-09-26
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

The overuse of existing antibiotics has led to an increase in drug-resistant strains of both Gram-positive and Gram-negative bacteria, and there is a lack of effective antimicrobial drugs without cross-resistance, especially in the treatment of methicillin-resistant Staphylococcus aureus.

Method used

Develop dapoxetine derivatives, especially mixed antibacterial drug structures of isochorine and dapoxetine ketone, and prepare them into tablets, capsules, granules or emulsions by combining them with drug carriers or excipients for the purpose of inhibiting Gram-positive bacteria such as Escherichia coli, Pseudomonas aeruginosa and Candida albicans.

Benefits of technology

This drug exhibits a strong inhibitory effect on Gram-positive bacteria, and in vitro pharmacodynamic experiments show that it has significant antibacterial effects against Escherichia coli, Pseudomonas aeruginosa, and Candida albicans.

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Abstract

This invention belongs to the field of pharmaceutical technology. It provides a novel antibacterial drug represented by general formula 1. This compound has a caustic solanine antibacterial structural unit, where R1-R5 are independently selected from H, OH, OMe, t-Bu, and halogens. Experiments have shown that this type of drug has a strong inhibitory effect on Escherichia coli, Pseudomonas aeruginosa, and Candida albicans, and can be used to prepare effective antibacterial drugs.
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