Polypeptide dimer and its use
By designing the polypeptide dimer, the circulating rearranged IL-2 or IL-15 is linked to the Fc region of human IgG1, solving the problems of short half-life of cytokines and large side effects, achieving more lasting immune stimulation and higher safety.
CN113912735BActive Publication Date: 2025-03-28NANJING NORMAL UNIVERSITY
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Patent Information
- Application Number
- CN202010651373.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2020-07-08
- Publication Date
- 2025-03-28
- Estimated Expiration
- 2040-07-08
AI Technical Summary
Technical Problem
Existing cytokines such as IL-2 and IL-15 have short in vivo half-life and require continuous injection. Their bilateral nature causes only a small number of patients to be effective in treating cancer, and have great side effects.
Method used
A polypeptide dimer is designed that contains circulating rearranged IL-2 or IL-15 connected to the Fc region of human IgG1, and binds to the CD25 or CD215 binding domain through the Fc region, prolongs the half-life of the cytokine and improves its immune stimulation effect.
Benefits of technology
Achieve prolonging the half-life of cytokines, improving its effectiveness in treating cancer and activating immune cells, and reducing the risk of side effects.
✦ Generated by Eureka AI based on patent content.
Abstract
The present invention provides a polypeptide dimer, which comprises a first polypeptide and a second polypeptide, wherein the first polypeptide comprises a first dimerization domain and a polypeptide of interest, wherein the polypeptide of interest is located at the first end of the first dimerization domain, wherein the second polypeptide comprises a second dimerization domain and a binding domain, wherein the binding domain is located at the first end of the second dimerization domain, wherein the first polypeptide and the second polypeptide form a dimer through the first dimerization domain and the second dimerization domain, and the first end of the first dimerization domain is adjacent to the first end of the second dimerization domain, and the binding domain can bind to the site of interest on the polypeptide of interest. The present invention also provides nucleic acids and vectors encoding the polypeptide dimers of the present invention, host cells comprising the nucleic acids and vectors, and uses of the polypeptide dimers for treating diseases, such as cancer.
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