analyzer device

Abstract

This invention provides an analyzer device, comprising: at least one analyzer; a cap removal mechanism for removing caps from covered sample containers before sample aspiration; a capping mechanism for capping uncapped sample containers; a sample loading device for dispatching at least a portion of the covered sample containers to the cap removal mechanism for cap removal and dispatching the capped sample containers to the aspiration area for sample aspiration; a sample unloading device for dispatching at least a portion of the uncapped sample containers to the capping mechanism for capping; and a control device communicatively connected to the analyzer, the cap removal mechanism, the capping mechanism, the sample loading device, and the sample unloading device, and at least for: controlling the sample loading device to dispatch at least a portion of the covered sample containers to the cap removal mechanism for cap removal and to dispatch the capped sample containers to the aspiration area, and controlling the sample unloading device to dispatch at least a portion of the uncapped sample containers to the capping mechanism for capping.

Description

Technical Field

[0001] This invention relates generally to the field of medical device technology, and more specifically to an analyzer device. Background Technology

[0002] In clinical departments of biochemistry and immunology in the laboratory, samples need to be decapped before testing. For analyzers not connected to the automated testing line, samples need to be decapped manually before being loaded onto the analyzer, or they need to be decapped in advance using a dedicated decapping machine. After decapping, the samples need to be manually transported and loaded onto the machine, which is quite cumbersome and cannot be completed in one go. Manual decapping can easily generate aerosols or even cause samples to be ejected, resulting in users coming into contact with the samples. Transporting samples without caps also carries the risk of sample sloshing and contact with users. When the test sample is pathogenic, it can easily lead to infection of users.

[0003] A sample connected to a pipeline can complete input, centrifugation, decapping, and sample analysis in one go. However, pipelines are suitable for large batches of samples. If a pipeline is set up with a small sample volume, the cost is too high and the space required may be too large for the department to accommodate, making it unsuitable. Currently, the decapping module is usually a separate module, which takes up a lot of space and is not conducive to the placement of instruments in departments with limited space.

[0004] Therefore, most common analyzers currently available either lack the function of removing caps, requiring manual removal of caps and manual transport of uncapped samples, which may lead to infection of users when these samples are highly pathogenic, or they have the function of removing caps but are integrated into the analyzer as a separate module, occupying a large space and hindering the saving and efficient use of departmental space.

[0005] In addition, for some samples that have been collected or tested, if the sample container does not have a lid when transporting the samples manually, there is a risk that the samples may be shaken and splashed out during the transportation process and come into contact with the user. If the test sample is pathogenic, it is very easy to cause the user to become infected.

[0006] Therefore, in view of the above-mentioned problems, this application proposes a new analyzer device to at least partially solve the above-mentioned technical problems. Summary of the Invention

[0007] The present invention is proposed to solve at least one of the above-mentioned problems. Specifically, one aspect of the present invention provides an analyzer apparatus, the analyzer apparatus comprising:

[0008] At least one analyzer is used to test the sample.

[0009] The cap removal mechanism is used to remove the caps from covered sample containers before sample aspiration.

[0010] A capping mechanism is used to cap an uncapped sample container, wherein the uncapped sample container contains a sample that has already been aspirated.

[0011] A sample loading device is used to dispatch at least partially covered sample containers to the cap removal mechanism for cap removal processing, and to dispatch the capped sample containers to the aspiration area for aspiration.

[0012] A sample unloading device is used to dispatch at least partially uncovered sample containers to the capping mechanism for capping, wherein the at least partially uncovered sample containers are sample containers that have already been aspirated.

[0013] A control device, communicatively connected to the analyzer, the capping mechanism, the capping mechanism, the sample loading device, and the sample unloading device, is used for at least:

[0014] The sample loading device is controlled to dispatch at least some of the capped sample containers to the cap removal mechanism for cap removal, and then dispatch the capped sample containers to the aspiration area for sample aspiration.

[0015] The sample unloading device is controlled to dispatch at least partially uncovered sample containers to the capping mechanism for capping.

[0016] In one example, the control device is further configured to: determine, based on the biohazard level of the sample contained in the uncovered sample container, whether to control the sample unloading device to dispatch the uncovered sample container to the capping mechanism for capping processing, wherein,

[0017] When the biological risk level of the sample is higher than the threshold risk level, the control device controls the sample unloading device to dispatch the uncovered sample container to the capping mechanism for capping.

[0018] When the biological risk level of the sample is lower than the threshold risk level, the control device controls the sample unloading device to transfer the sample to the user processing channel to wait for the user to process it.

[0019] In one example, the biological risk level of the sample is determined based on the risk level of the test item used to test the sample.

[0020] In one example, the biorisk level of the tested sample is determined based on the test results of the tested sample, wherein a first biorisk level is set for the tested sample with a positive test result, and a second biorisk level is set for the tested sample with a negative test result, wherein the first biorisk level is higher than a threshold risk level, and the second biorisk level is lower than a threshold risk level.

[0021] In one example, the biological risk level of the tested sample is determined based on the test results of the tested sample. When the test results are higher than a set concentration range, the corresponding tested sample is set to a first biological risk level. When the test results are lower than the set concentration range, the corresponding tested sample is set to a second biological risk level. The first biological risk level is higher than a threshold risk level, and the second biological risk level is lower than a threshold risk level.

[0022] In one example, the pipeline is used to test samples for at least one test item, and the control device is also used for:

[0023] Based on the test status of the sample, the sample unloading device is controlled to dispatch the uncapped sample container to the capping mechanism for capping.

[0024] In one example, when the sample's testing status indicates that all tests of the analyzer have been completed, the control device controls the sample unloading device to dispatch the uncovered sample container to the capping mechanism for capping; or...

[0025] When the test status of the sample is that an abnormal event occurred during the test, the control device is used to:

[0026] Obtain the user's input selection instruction regarding whether to cover the sample container where the abnormal event occurred;

[0027] When the selection instruction indicates that the sample container needs to be capped, the sample unloading device is controlled to dispatch the corresponding sample container to the capping mechanism for capping.

[0028] In one example, the abnormal event includes at least one of the following events: needle blockage during testing, barcode unreadable, and inability to obtain test information for the sample.

[0029] In one example, when the analyzer device is connected to the pipeline and the sample's testing status is such that the sample still has untested test items in the analyzer device, the control device controls the sample loading device to schedule the sample to the pipeline.

[0030] In one example, the analyzer device is configured to connect to a pipeline including a sample storage device and / or an output module. When the analyzer device is connected to the pipeline, the control device is further configured to:

[0031] The sample unloading device controls the sample container, after being capped by the capping mechanism, to be dispatched to the production line, so as to save the capped sample container to the sample storage device, or to output the capped sample container from the output module.

[0032] In one example, when the sample's testing status indicates that all test items of the analyzer device have been tested, the control device is used to:

[0033] Depending on the sample type, the sample unloading device can be controlled to dispatch the sample to the capping mechanism for capping, and then dispatch the capped sample to the production line; or, the sample unloading device can be controlled to dispatch the sample to the output area; and / or

[0034] Based on the test items tested on the sample, the sample unloading device is controlled to schedule the sample to the pipeline for storage, or the sample unloading device is controlled to schedule the sample to the output area.

[0035] In one example, the sample loading device further includes a front track section, a sample injection section, and at least one buffer, wherein,

[0036] The front track section connects the sample injection section and the analyzer. The sample injection section is used to move the sample rack placed in the sample injection section to the front track section for aspiration of the sample to be tested contained in the sample rack.

[0037] The buffer zone connects the front track section and the sample injection section, and is used to temporarily store the sample to be sampled or the sample after sample collection. The capping mechanism is located in the buffer zone.

[0038] In one example, the control device is also used for:

[0039] The sample positions that need to be decapped are determined based on whether there are samples in the sample positions of the sample rack, the type of sample container in the sample positions, and the current status of the samples in the sample positions.

[0040] The cap removal mechanism is controlled to remove the caps from the covered sample containers at the sample positions that require the cap removal process.

[0041] In one example, when the current state of the sample at the sample position includes at least one of the following states: the sample barcode cannot be recognized, the corresponding test information of the sample cannot be obtained, or an anomaly occurs during the test, and / or when there is no sample at the sample position of the sample rack, and / or when the sample container type at the sample position is a micro-cup, the sample position is a sample position that does not require the cap removal process.

[0042] In one example, the sample loading device includes a sample inlet section and a front track section, wherein the sample inlet section includes a scheduling mechanism, the cap removal mechanism includes a detection sensor, the detection sensor being used to detect whether the sample container has a cap to obtain cap information of the sample container, and the control device is further used for:

[0043] Obtain the lid information of the sample container in the sample rack placed in the analyzer device;

[0044] When the lid information indicates that the sample container in the sample rack has a lid, the lid removal mechanism is controlled to remove the lid from the sample container in the sample rack. Alternatively, when the lid information indicates that the sample container in the sample rack is uncovered, the scheduling mechanism is controlled to schedule the sample rack to the front track section to aspirate the sample to be tested contained in the sample rack.

[0045] The analyzer device of this invention has a capping mechanism that can be used to cap uncapped sample containers, thereby reducing the workload of users. At the same time, since the sample is capped, it can prevent the sample from splashing out and coming into contact with the user due to vibration during transportation, thereby reducing biosafety risks.

[0046] Furthermore, the analyzer device of this embodiment also includes a cap removal mechanism, thus enabling the integration of cap removal function without increasing additional departmental space. Moreover, the cap removal function can effectively accommodate sample containers of different sizes, improving the sample processing compatibility of the analyzer device, saving sample processing time, and enhancing the ease of use of the analyzer device. Attached Figure Description

[0047] To more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0048] Figure 1 A schematic block diagram of an analyzer apparatus according to one embodiment of the present invention is shown;

[0049] Figure 2 A schematic block diagram of an analyzer apparatus according to another embodiment of the present invention is shown;

[0050] Figure 3 A schematic block diagram of the lower region in the sample injection section of an analyzer apparatus according to one embodiment of the present invention is shown;

[0051] Figure 4A schematic diagram of a cap-removing mechanism according to one embodiment of the present invention is shown;

[0052] Figure 5 A schematic block diagram of an analyzer apparatus according to another embodiment of the present invention is shown. Detailed Implementation

[0053] To make the objectives, technical solutions, and advantages of the present invention more apparent, exemplary embodiments according to the present invention will be described in detail below with reference to the accompanying drawings. Obviously, the described embodiments are merely a part of the embodiments of the present invention, and not all of the embodiments of the present invention. It should be understood that the present invention is not limited to the exemplary embodiments described herein. Based on the embodiments of the present invention described herein, all other embodiments obtained by those skilled in the art without inventive effort should fall within the protection scope of the present invention.

[0054] In the following description, numerous specific details are set forth in order to provide a more thorough understanding of the invention. However, it will be apparent to those skilled in the art that the invention can be practiced without one or more of these details. In other instances, certain technical features well-known in the art have not been described to avoid obscuring the invention. It should be understood that the invention can be embodied in various forms and should not be construed as limited to the embodiments set forth herein. Rather, providing these embodiments will make the disclosure thorough and complete, and will fully convey the scope of the invention to those skilled in the art.

[0055] The terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the invention. When used herein, the singular forms “a,” “an,” and “the” are also intended to include the plural forms unless the context clearly indicates otherwise. It should also be understood that the terms “comprising” and / or “including,” when used in this specification, identify the presence of the stated features, integers, steps, operations, elements, and / or components, but do not exclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and / or groups. When used herein, the term “and / or” includes any and all combinations of the associated listed items.

[0056] In view of the aforementioned biosafety risks posed to users by uncapped samples during transport, this application provides an analyzer device comprising: at least one analyzer for testing samples; a cap removal mechanism for removing caps from capped sample containers before aspiration; a capping mechanism for capping uncapped sample containers, wherein the uncapped sample containers contain a sample that has already been aspirated; a sample loading device for dispatching at least a portion of the capped sample containers to the cap removal mechanism for cap removal, and dispatching the capped sample containers to the aspiration area for aspiration; and a sample unloading device for... The analyzer device according to an embodiment of the present invention includes a capping mechanism for capping at least partially uncovered sample containers, wherein the at least partially uncovered sample containers are sample containers that have already been aspirated; a control device, which is communicatively connected to the analyzer, the decapping mechanism, the capping mechanism, the sample loading device, and the sample unloading device, is at least used for: controlling the sample loading device to dispatch at least partially covered sample containers to the decapping mechanism for decapping, dispatching the decapped sample containers to the aspiration area for aspiration, and controlling the sample unloading device to dispatch at least partially uncovered sample containers to the capping mechanism for capping. The analyzer device according to an embodiment of the present invention includes a capping mechanism that can be used to cap uncovered sample containers, thereby reducing the user's workload. Since the samples are capped, it is possible to prevent samples from splashing out and contacting the user during transport due to vibration, thus significantly reducing biosafety risks. In addition, the analyzer device of the present invention also includes a cap removal mechanism, so that the cap removal function can be integrated without increasing the additional department space. Moreover, the cap removal function can effectively accommodate sample containers of different sizes, improve the sample processing compatibility of the analyzer device, save sample processing time, and improve the ease of use of the analyzer device.

[0057] To fully understand this invention, a detailed structure will be presented in the following description to illustrate the technical solution proposed by this invention. Optional embodiments of the invention are described in detail below; however, in addition to these detailed descriptions, the invention may have other embodiments.

[0058] Specifically, the analyzer apparatus of this application will be described in detail below with reference to the accompanying drawings. Unless otherwise specified, the features of the following embodiments and implementations can be combined with each other.

[0059] First, such as Figure 1As shown, this embodiment of the invention provides an analyzer device 200, which includes at least one analyzer 201 for testing a sample. The analyzer device may include one or more analyzers, and can be used to perform at least one test on the sample. Optionally, the analyzer 201 may be a biochemical analyzer or an immunoassay analyzer.

[0060] For example, analyzer 201 can be an immunoassay analyzer, which can be used to analyze and detect samples to obtain corresponding test results to meet user needs. It should be noted that the specific type of sample to be tested is not limited; in some embodiments, the sample to be tested includes liquid samples. Further samples to be tested include, but are not limited to, blood samples.

[0061] Immunoassay analyzers can test for a wide range of substances, including but not limited to various antigens, haptens, antibodies, hormones, enzymes, and fatty acids. They can also test for autoimmune-related substances, such as low-level antibodies and sensitized lymphocytes produced by the body's immune system in response to its own antigens. Autoimmune-related tests typically involve testing for autoantibodies / antigens.

[0062] An immunoassay analyzer may also include various components, such as reagent injection devices, incubation devices, centrifugation devices, and detection devices. Their specific structures will not be described in detail here.

[0063] like Figure 1 As shown, the analyzer device 200 includes a sample loading device 202 and a cap removal mechanism 203. The sample loading device 202 is used to dispatch at least partially uncapped sample containers to the cap removal mechanism 203 for the cap removal process, and to dispatch the capped sample containers to the aspiration area for aspiration. The cap removal mechanism 203 is used to remove the caps from the capped sample containers before aspiration.

[0064] like Figure 1 As shown, the analyzer device 200 also includes a control device 204, which is communicatively connected to the analyzer 201, the cap removal mechanism 203 and the sample loading device 202. The control device 204 can be used to: control the sample loading device 202 to dispatch at least partially uncapped sample containers to the cap removal mechanism 203 for cap removal processing, and dispatch the capped sample containers to the sampling area for sampling.

[0065] In one example, such as Figure 2As shown, the sample loading device includes a front track section and a sample delivery device (SDM) section. The SDM section is divided into two layers. The upper layer is the sample input / output area, including at least one placement area (e.g., two or more), a placement channel, a placement area propulsion mechanism, a longitudinal push mechanism, a transverse push mechanism, at least one retrieval area (e.g., two or more), a retrieval channel, a retrieval area longitudinal push mechanism, a transverse push mechanism, at least one emergency channel, an emergency channel transverse push mechanism, and related sensors. The lower layer is the sample barcode scanning area, the cap removal area, and the buffer area, including multiple sample rack buffer channels, at least one sample rack and sample barcode scanning channel, and cap removal function-related components. In addition, the SDM section also includes a scheduling mechanism, such as a scheduling trolley, capable of moving between the upper and lower layers and longitudinally. The movement in these two directions is driven by the scheduling trolley's Y-axis and Z-axis mechanisms. The scheduling trolley also has guide grooves and scheduling forks with X-axis and Z-axis mechanisms, which can drive the sample rack to move in the X-axis direction, entering and exiting from the sample rack buffer channel and the sample rack and sample barcode scanning channel.

[0066] The front track section includes multiple sample rack channels, such as an emergency channel, a regular channel, and a return channel. The front track section also includes a belt conveyor assembly, a blocking mechanism, a suction positioning mechanism, a sample rack track-changing assembly, and related sensor detection devices. The emergency channel is used for suction of emergency sample racks and for the transport of sample racks. It has at least one sample suction area and is equipped with an emergency suction positioning and blocking mechanism, sensor detection devices, etc. The regular channel is used for the transport of regular sample racks. The regular channel includes a suction position area, at least one buffer position area (e.g., two or more), a regular suction positioning blocking mechanism, a buffer blocking mechanism, sensor detection devices, etc. The return channel is used for the return of sample racks after suction. The return channel includes a positioning blocking mechanism and sensor detection devices. Furthermore, a sample rack track switching mechanism and corresponding sensor detection devices are provided between the emergency channel, the regular channel, and the return channel.

[0067] like Figure 3 As shown, the cap removal mechanism and related components are integrated into the sample rack and sample barcode scanning channel area. The sample rack and sample barcode scanning channel include a sample presence / absence detection sensor, a micro-cube presence / absence detection sensor, and a sample / sample rack barcode scanner. Figure 4 As shown, the cap removal mechanism includes a sample rack clamping mechanism, a sample rack clamping and lifting mechanism, a sample tube rotation cap removal mechanism, a waste cap collection mechanism, and a waste cap bin full detection sensor. The sample rack clamping mechanism can move in the X-axis direction to ensure that both ends of the sample rack are always clamped, and can move in the Z-axis direction to clamp and release the sample rack. In addition to being able to move up and down, the sample rack clamping and lifting mechanism also has a sample tube clamping gripper, which grasps and releases the sample tube by opening and closing.

[0068] The cap removal mechanism also includes a detection sensor (also referred to herein as a sample cap presence / absence detection sensor), which is used to detect whether the sample container has a cap in order to obtain cap information of the sample container.

[0069] Because the analyzer includes a capping mechanism, it possesses a capping function. Therefore, the analyzer can integrate this function without increasing additional departmental space. This capping function is effectively compatible with test tubes of different sizes, provides preset capping options and a full / empty cap function, improving the system's sample processing compatibility, saving sample processing time, and enhancing ease of use. It effectively solves various problems existing in current analyzers, such as the need for manual capping and transport of uncapped samples in analyzers lacking capping functionality, which could lead to user infection when these samples are highly pathogenic. It also addresses the issue of large space requirements associated with independent capping mechanisms integrated into the analyzer, hindering efficient use of departmental space.

[0070] In one example, such as Figure 1 As shown, the analyzer device 200 includes a control device 204 for: determining the sample position requiring cap removal based on whether there is a sample on the sample position of the sample rack, the type of sample container on the sample position, and the current state of the sample on the sample position; and controlling the cap removal mechanism to remove the caps from the covered sample containers on the sample positions requiring cap removal. Optionally, when the current state of the sample on the sample position includes at least one of the following states: the sample barcode cannot be recognized, the corresponding test information of the sample cannot be obtained, or an abnormality occurs during the test; and / or, when there is no sample on the sample position of the sample rack; and / or, when the sample container type on the sample position is a micro-volume cup, the sample position is a sample position that does not require cap removal. That is, after identifying the presence or absence of samples, sample container type, and sample barcode ID on the sample rack and sample barcode scanning area, the control device determines which sample positions need to be decapped and meet the conditions for decapping (removing micro-cup samples, empty samples, samples for which no corresponding test information can be found, samples with barcodes that cannot be recognized or are abnormal), and then controls the decapping mechanism to decappate the samples in the corresponding sample positions.

[0071] In one example, the presence or absence of samples on the sample rack, the type of sample container, the presence or absence of sample caps, sample barcodes, and sample rack barcodes are identified by a vision system. This is then linked to the cap removal action. The vision system can identify whether sample tubes have caps before the samples are picked up, saving the time spent on cap detection for uncapped samples. The system also eliminates the need to pre-set the attributes of sample tube caps on the sample rack in the basket; the vision system can identify them quickly and easily. The cap removal function linked to the vision system is even more efficient. In one example, such as... Figure 3 As shown, the sample loading device includes a sample inlet section and a front track section. The sample inlet section includes a scheduling mechanism, such as a scheduling trolley. The control device is further configured to: acquire the lid information of the sample containers in the sample rack placed in the analyzer device; when the lid information indicates that the sample containers in the sample rack have lids, control the lid removal mechanism to remove the lids from the sample containers in the sample rack; or, when the lid information indicates that the sample containers in the sample rack are uncovered, control the scheduling mechanism to schedule the sample rack to the front track section for aspiration of the samples to be tested contained in the sample rack. For example, the sample rack is first scheduled to the sample rack and sample barcode scanning channel area to detect the presence or absence of samples, the presence or absence of micro-volume cups, and to identify the identity information of the samples, and then the scheduling mechanism is controlled to schedule the sample rack to the buffer zone, and then to the front track section for aspiration.

[0072] Specifically, when loading samples, users can preset the lid status of the samples on the sample rack in the basket through the operation interface of the analyzer. If the basket is preset to a sample basket with a lid or if this attribute is not set, the analyzer will perform lid detection and decapping processing on the samples with sample tube positions on the sample rack. If the basket is preset to a basket without a lid, after the barcode scanning channel checks the presence of micro-cubes and barcodes for all samples in the basket, no further decapping detection and decapping actions are performed. The samples are directly dispatched to the buffer and then sample aspiration is performed. This can save the detection time for the presence or absence of lids on the uncapped sample tubes and improve the detection efficiency of the analyzer.

[0073] After the samples loaded onto the analyzer are capped and aspirated, the analyzer's control device 204 is configured to return the samples to the corresponding areas according to user presets. The user can set whether different types of samples should be returned to the flow line or the flow line. The user can also set whether to use the flow line strategy or the flow line strategy if there are different types of samples on the same sample rack, with some samples needing to be returned to the flow line and others needing to be returned to the flow line. Optionally, the analyzer has a default anti-biocontamination strategy; for example, if there are samples on the same sample rack that need to be returned to the flow line and others that need to be returned to the flow line, the flow line strategy is used.

[0074] Furthermore, such as Figure 1As shown, the analyzer device 200 of this application may further include a capping mechanism 206 and a sample unloading device 205. The capping mechanism 206 is used to cap uncapped sample containers, wherein the uncapped sample containers contain samples that have been aspirated. The sample unloading device 205 is used to dispatch at least a portion of the uncapped sample containers to the capping mechanism 206 for capping, wherein the at least a portion of the uncapped sample containers are sample containers that have been aspirated. The control device 204 is used to control the sample unloading device 205 to dispatch at least a portion of the uncapped sample containers to the capping mechanism 206 for capping, thereby reducing the user's workload. At the same time, when the user takes out or transports the sample, since the sample has been capped, the biosafety risk is significantly reduced.

[0075] The control device 204 is communicatively connected to the capping mechanism 206 and the sample unloading device 205. The control device 204 includes at least a processing component, RAM, ROM, a communication interface, a memory, and an I / O interface. The processing component, RAM, ROM, communication interface, memory, and I / O interface communicate via a bus. The processing component can be a CPU, GPU, or other chip with computing power. The memory contains various computer programs, such as operating systems and application programs, for the processing component to execute, as well as the data required to execute these programs. Additionally, during sample detection, any data that needs to be stored locally can be stored in the memory.

[0076] The I / O interface consists of serial interfaces such as USB, IEEE 1394, or RS-232C; parallel interfaces such as SCSI, IDE, or IEEE 1284; and analog signal interfaces composed of D / A converters and A / D converters. Input devices, such as keyboards, mice, touchscreens, or other control buttons, can be connected to the I / O interface, allowing users to directly input data into the control device. Additionally, displays with image capabilities, such as LCD screens, touchscreens, or LED displays, can be connected to the I / O interface. The control device can output processed data as images to the display for viewing, such as analysis data and instrument operating parameters. The communication interface can use any known communication protocol. The communication interface communicates with the outside world via a network. The control device can transmit data with any device connected through this network using a specific communication protocol via the communication interface.

[0077] In one example, the control device 204 is further configured to: determine whether to control the sample unloading device to dispatch the uncapped sample container to the capping mechanism for capping processing based on the biohazard level of the sample contained in the uncapped sample container. Specifically, when the biohazard level of the sample is higher than a threshold risk level, the control device controls the sample unloading device to dispatch the uncapped sample container to the capping mechanism for capping processing; when the biohazard level of the sample is lower than the threshold risk level, the control device controls the sample unloading device to transfer the sample to a user processing channel to await user processing. The user processing channel is, for example, a sample storage device or output module on the analyzer. The biohazard level value can be reasonably set according to actual needs. For example, biohazard levels can be divided into levels 1, 2, 3, and 4, where a smaller value represents a higher risk level. Alternatively, in other examples, a larger value may represent a lower risk level. The specific setting method can be reasonably selected according to user needs. By reasonably setting the risk level and capping samples with a biohazard level higher than the threshold risk level, the transmission efficiency of the analyzer can be improved, thereby improving the detection efficiency of the analyzer.

[0078] In this paper, the sample unloading device can be, for example, a scheduling mechanism (e.g., a scheduling trolley), or other mechanisms such as those with robotic arms, pushers, claws, etc.

[0079] The threshold risk level can be set by the user, or it can be a preset default risk level threshold. In one example, when the control device does not receive a user instruction to set the threshold risk level, the control device is configured to determine whether to control the sample unloading device to dispatch the uncapped sample container to the capping mechanism for the capping process based on the preset default risk level threshold (e.g., level 2).

[0080] In one example, the analyzer device is configured to make the biological risk level and / or threshold risk level adjustable, so that the user can adjust the biological risk level and / or threshold risk level at any time as needed.

[0081] The prerequisite for a capping facility to cap samples is setting the correct risk levels for different sample types. That is, which types of samples require capping before removal and transport, and which can be removed and transported without capping. In one example, the biorisk level of a sample is determined based on the risk level of the test item it is used for. For example, if the test item has a high risk level, the corresponding biorisk level of the sample should also be set to high risk. In another example, the biorisk level of a tested sample is determined based on the test results. For a positive test result, a first biorisk level is set; for a negative test result, a second biorisk level is set. The first biorisk level is higher than a threshold risk level, and the second biorisk level is lower than a threshold risk level. Alternatively, in other examples, the biorisk level of a sample can be determined based on its source. For example, a sample from an infected patient, which is likely to contain a highly infectious or pathogenic virus, is set to a high biorisk level, which is higher than a threshold biorisk level.

[0082] In other examples, the biological risk level of the tested sample is determined based on the test results of the tested sample. When the test results are higher than a set concentration range, the corresponding tested sample is set to a first biological risk level. When the test results are lower than a set concentration range, the corresponding tested sample is set to a second biological risk level. The first biological risk level is higher than a threshold risk level, and the second biological risk level is lower than a threshold risk level.

[0083] By setting reasonable biological risk levels for samples, if the biological risk level of a sample is higher than the risk level threshold, the sample unloading device will schedule it back to the analyzer for subsequent processing, such as capping, after the sample test is completed. If the biological risk level is lower than the risk level threshold, the sample unloading device will schedule it to the production line, such as the output module or sample storage device, to await direct processing by the user. The user can also set the sample to return to the online processing regardless of the situation. For example, the control device can control the sample unloading device, such as the scheduling mechanism, to schedule the samples to the capping mechanism and control the capping mechanism to cap all uncapped sample containers that have been aspirated. In this way, the analyzer can centrally handle subsequent processing, such as capping, which can reduce the user's workload and avoid biosafety risks.

[0084] In one example, such as Figure 1As shown, the analyzer device 200 can be used to test samples for at least one test item, and the control device 204 is also used to: control the sample unloading device to dispatch the uncapped sample container to the capping mechanism for capping processing according to the test status of the sample. For example, when the sample's testing status indicates that all tests of the analyzer have been completed, the control device 204 controls the sample unloading device to dispatch the uncapped sample container to the capping mechanism for capping. Tested samples often need to be returned offline for storage or processing, thus requiring output. Capping them avoids biosafety risks. Alternatively, when the sample's testing status indicates that an abnormal event has occurred during testing, the control device 204 is used to: obtain a user-inputted selection instruction regarding whether to cap the sample container experiencing the abnormal event; when the selection instruction indicates that the sample container needs to be capped, the control device controls the sample unloading device to dispatch the corresponding sample container to the capping mechanism for capping. These samples are capped or uncapped according to the user's selection, facilitating sample processing while also mitigating biosafety risks by capping some samples.

[0085] In one example, the abnormal event includes at least one of the following events: needle blockage during testing, barcode unreadable, inability to obtain test information for the sample, or other events that cause abnormal sample testing.

[0086] When the analyzer is connected to the production line and the sample has untested test items in the analyzer, the control device controls the sample unloading device to dispatch the sample to the production line for testing other test items without needing to cover the sample container, thereby improving testing efficiency.

[0087] In one example, the analyzer device is configured to connect to a pipeline, which also includes a sample storage device and / or an output module. When the analyzer device is connected to the pipeline, the control device 204 is further configured to control the sample unloading device 205 to dispatch the sample container, capped by the capping mechanism 206, to the pipeline to store the capped sample container in the sample storage device, or to output the capped sample container from the output module, thereby preventing users from contacting uncapped samples and reducing biosafety risks. The pipeline includes a track system with multiple tracks as a channel for sample transport.

[0088] Optionally, the sample storage device may be, for example, a refrigerator, for refrigerating the samples. The output module of the pipeline may be an output channel with a user interface, through which samples are transported to the user interface for user processing.

[0089] In one example, when the sample's testing status indicates that all test items of the analyzer device have been tested, the control device is used to:

[0090] Depending on the sample type, the sample unloading device can be controlled to dispatch the sample to the capping mechanism for capping, and then dispatch the capped sample to the production line. Alternatively, the sample unloading device can be controlled to dispatch the sample to the output area, which can refer to the output area of ​​the analyzer or the output module in the production line. For example, the analyzer can be configured to select which types of samples are capped and dispatched to the production line, and which types are dispatched to the output area. When the sample type is a preset type that requires capping, the sample is capped and dispatched to the production line; when the sample type is a preset type that does not require capping, the sample is dispatched to the output area. This allows for accurate capping of specific sample types, improving the testing efficiency of the analyzer while effectively avoiding biosafety risks.

[0091] In one example, when the sample's testing status indicates that all test items of the analyzer have been tested, the control device is configured to: control the sample unloading device to schedule the sample to the sample storage device of the pipeline for storage, or control the sample unloading device to schedule the sample to the output area, which may refer to the output area of ​​the analyzer or the output module in the pipeline. For example, the analyzer can be configured to return samples containing a first type of test item to the pipeline for storage, and samples containing a second type of specific test item can be scheduled to the output area. The first and second types of test items can be reasonably set according to the characteristics of the actual test items. The test items included are as follows: the first type of test items may include one or more test items, and the second type of test items may include one or more test items, and the second type of test items may include one or more test items, where a test item can refer to at least two test items tested together. When the test items tested by the sample include one or more test items of the first type of test items, the sample is scheduled to the pipeline for storage. When the test items tested by the sample include one or more test items of the second type of test items, the sample is scheduled to the output area. This accurately sets the samples that need to be returned to the pipeline for storage or scheduled to the output area, thereby improving the sample processing efficiency.

[0092] Furthermore, the front track section of the analyzer device connects the sample injection section and the analyzer. The sample injection section is used to move the sample rack placed in the sample injection section to the front track section to aspirate the sample to be tested contained in the sample rack, such as... Figure 3 As shown, the analyzer device further includes at least one buffer, which connects the front track section and the sample injection section, and is used to temporarily store the sample to be sampled or the sample after sample aspiration. The capping mechanism may be located at the buffer.

[0093] Below, for reference Figure 5 The working process of the analyzer device with integrated cap removal function is explained below:

[0094] First, the user inserts the covered sample container into the sample rack, then places the sample rack into the basket, and loads the sample into the placement area of ​​the SDM section in the form of a basket. Then, the user clicks the corresponding placement area button or the start button on the software interface to start the sample test.

[0095] Next, after the analyzer performs a series of mechanical reset actions before testing, the sample rack is pushed into the sample rack channel by the placement area propulsion mechanism. At the same time, the scheduling trolley moves along the Y and Z axes to the sample rack receiving position in the placement area. Then, the placement area horizontal push mechanism pushes the sample rack onto the scheduling trolley.

[0096] Next, the dispatching trolley dispatches the sample rack to the receiving position of the sample rack and sample barcode scanning channel. The dispatching fork lifts and pushes the sample rack into the barcode scanning channel. During this process, the sample presence detection sensor and the micro-volume cup presence detection sensor in the barcode scanning channel detect the presence of the sample and the type of the container. It can identify whether there is a sample or a micro-volume cup at the sample tube position on the sample rack. The sample / sample rack barcode scanner can scan the sample barcode and the sample rack barcode to identify the sample ID and the sample rack ID, so as to query the test work order of the corresponding sample and bind the position of the sample in the sample rack.

[0097] Next, after identifying the presence or absence of samples on the sample rack, the type of sample container, and the sample barcode ID, the control device of the analyzer determines which sample positions need to be decapped and meet the conditions for decapping (removing micro-cup samples, empty samples, samples for which no corresponding test information can be found, samples with barcodes that cannot be recognized or are abnormal), and then decapping the samples in the corresponding sample positions.

[0098] Next, refer to Figure 4The cap removal process is as follows: The dispatch fork positions the sample rack at sample position #1 (if there is no sample at position #1 or the conditions for cap removal are not met, this is the first sample position that needs cap removal) below the sample cap removal position. At the same time, the sample rack clamping mechanism moves horizontally to the corresponding pressing position and descends vertically to press the sample rack. Then, the clamping and lifting mechanism descends to the sample tube clamping position, closes the gripper to clamp the sample tube, and then rises to the rotating cap removal position. The vertical position of the rotating cap removal is not fixed for the clamping and lifting mechanism and is determined by the height of the sample tube. During the clamping and lifting process, the photoelectric sensor detects the top edge of the test tube and then moves a fixed displacement (to ensure compatibility with test tubes of different heights). Afterwards, the sensor on the other sample tube cap detects whether the sample tube cap is present. Different handling can be performed for the following two situations:

[0099] Scenario 1: If the sample tube cap is detected, the gripper of the rotating cap removal mechanism clamps the sample tube and then rotates. During the rotation, the clamping and lifting mechanism gradually descends until it stops descending after a certain distance. The rotating cap removal mechanism then stops rotating, indicating that cap removal is complete. The waste cap collection mechanism extends to the waste cap collection position, the gripper of the rotating cap removal mechanism releases, and the waste cap falls into the guide groove of the waste cap collection mechanism and then into the waste cap bin. During the process, a sensor detects whether a cap has fallen. If a signal is detected, it indicates that cap removal was successful; otherwise, cap removal failed, and corresponding fault handling is performed. After successful cap removal, the waste cap collection mechanism retracts, and at the same time, the clamping and lifting mechanism descends to insert the sample into the sample holder. The gripper is then released, and the mechanism rises back to the initial position.

[0100] Scenario 2: If the sample tube cap is not detected, skip the capping process. The clamping and lifting mechanism descends and directly inserts the sample into the sample holder, then releases the gripper and rises to the initial position. Afterward, the sample holder clamping mechanism rises to the initial position and releases the sample holder.

[0101] The above process describes the cap removal process for only one sample tube. After the cap of one sample tube is removed, the scheduling fork moves the next sample tube in the sample rack that needs to be capped to the cap removal position, and repeats the above process to remove the cap.

[0102] Subsequently, after all the sample tubes in a sample rack have been capped, the scheduling fork moves the sample rack back to the scheduling trolley, and then moves the sample rack to the buffer zone. Based on the sample test information on the sample rack and the scheduling and sampling status of the sample racks on the front track, the scheduling trolley moves the sample rack to the front track for sampling at an appropriate time. After the samples on the sample rack have been sampled on the front track, the scheduling trolley receives the sample rack that has been sampled and moves the sample rack to the buffer zone. Based on the retest rules set by the system, it chooses to wait for the test results or directly move the sample rack back to the recycling area. If the retest is completed, the sample rack is also directly moved to the recycling area.

[0103] It should be noted that users can preset the lid status of samples on the sample rack in the operating software when loading samples. If the basket is preset to a sample basket with a lid or if this attribute is not set, the system will perform lid detection and decapping processing on samples with sample tube positions on the sample rack. If the basket is preset to a lidless basket, after the barcode scanning channel checks the presence of micro-cubes and barcodes for all samples on the sample rack, no further decapping detection or decapping action will be performed. The samples will be directly scheduled to the buffer and then sample aspiration will be performed. This can save time for detecting the presence or absence of lids on lidless sample tubes.

[0104] In addition, the waste cap bin is designed in the lower layer of the SDM section, such as the -2 layer, so that users can quickly and easily take it out and put it back. The waste cap bin provides a warning function for when the bin is about to be full and an alarm function for when it is full. When the number of waste caps in the waste cap bin reaches the warning value, a warning function for when the waste cap bin is about to be full is issued. If it is already full, an alarm function for when the waste cap bin is full is issued. This can be achieved through a counter.

[0105] Furthermore, after the sample to be tested has been aspirated, the uncapped sample container can be capped as needed using the capping mechanism of the analyzer. The specific timing for capping is described above and will not be repeated here.

[0106] In summary, the analyzer device of this invention has a capping mechanism that can be used to cap uncapped sample containers, thereby reducing the workload of users. At the same time, since the sample is capped, it can prevent the sample from splashing out and coming into contact with the user due to vibration during transportation, thereby reducing biosafety risks.

[0107] Furthermore, the analyzer device of this embodiment also includes a capping mechanism, which is integrated into the sample injection section of the analyzer device. Therefore, the capping function can be integrated without increasing additional departmental space. Moreover, the capping function can effectively accommodate test tubes of different specifications, providing preset functions for whether capping is enabled or disabled, as well as functions for filling the waste cap container. This improves the sample processing compatibility of the system, saves sample processing time, and enhances the ease of use of the system. It effectively solves various problems existing in current analyzer devices. For example, it solves the problem that current analyzer devices without capping functions require manual capping and manual transfer of samples without caps, which may lead to user infection when these samples are highly pathogenic. It also solves the problem that the capping mechanism, which is integrated into the analyzer device as a separate module, occupies a large space and is not conducive to saving and efficiently utilizing departmental space.

[0108] Although exemplary embodiments have been described herein with reference to the accompanying drawings, it should be understood that the above exemplary embodiments are merely illustrative and are not intended to limit the scope of the invention. Various changes and modifications can be made therein by those skilled in the art without departing from the scope and spirit of the invention. All such changes and modifications are intended to be included within the scope of the invention as claimed in the appended claims.

[0109] In the several embodiments provided in this application, it should be understood that the disclosed devices and methods can be implemented in other ways. For example, the device embodiments described above are merely illustrative. For instance, the division of units is only a logical functional division, and in actual implementation, there may be other division methods. For example, multiple units or components may be combined or integrated into another device, or some features may be ignored or not executed.

[0110] Numerous specific details are set forth in the specification provided herein. However, it will be understood that embodiments of the invention may be practiced without these specific details. In some instances, well-known methods, structures, and techniques have not been shown in detail so as not to obscure the understanding of this specification.

[0111] Those skilled in the art will understand that, apart from the mutual exclusion of features, all features disclosed in this specification (including the accompanying claims, abstract, and drawings) and all processes or elements of any method or apparatus so disclosed can be combined in any combination. Unless otherwise expressly stated, each feature disclosed in this specification (including the accompanying claims, abstract, and drawings) may be replaced by an alternative feature serving the same, equivalent, or similar purpose.

[0112] Furthermore, those skilled in the art will understand that although some embodiments described herein include certain features but not others included in other embodiments, combinations of features from different embodiments are intended to be within the scope of the invention and form different embodiments. For example, in the claims, any of the claimed embodiments can be used in any combination.

Claims

1. An analyser device, characterised in that, The analyzer device includes: At least one analyzer, a sample loading device, a sample unloading device, a capping mechanism, and a control device; The at least one analyzer is used to test the sample to be tested and is connected to the front track section, which includes a sample suction area; The sample loading device includes a sample injection section and the front track section; The sample injection section includes a sample input / output area, a cap removal area, and a sample scheduling mechanism. The sample injection section has two layers, with the sample input / output area located on the upper layer and the cap removal area located on the lower layer. The sample input / output area is used to receive the sample rack to be tested placed in the analyzer device, and to receive the sample rack after being tested by the analyzer. The decapping area is equipped with a decapping mechanism for removing the caps from covered sample containers before sample aspiration. The capping mechanism is used to cap an uncapped sample container, wherein the uncapped sample container contains a sample that has been aspirated; the sample scheduling mechanism is used to schedule the sample rack in the sample input / output area, the cap removal area, the capping mechanism, and the front track section, and the sample scheduling mechanism is configured to move between the upper and lower layers of the sample injection section to schedule the sample. The sample loading device is used to dispatch at least some of the covered sample containers to the cap removal mechanism for cap removal processing, and to dispatch the capped sample containers to the sampling area for sampling. The sample unloading device is used to dispatch at least partially uncovered sample containers to the capping mechanism for capping, wherein the at least partially uncovered sample containers are sample containers that have already been aspirated, and wherein the sample loading device and the sample unloading device share the sample dispatching mechanism. The control device is communicatively connected to the at least one analyzer, the capping mechanism, the capping mechanism, and the sample scheduling mechanism, and is used for at least: The sample scheduling mechanism is controlled to schedule at least some of the covered sample containers to the cap removal mechanism for cap removal processing; The sample scheduling mechanism controls the removal of the cap from the sample container and directs it to the aspiration area for sample aspiration, so that the analyzer can test the aspirated sample; and The sample scheduling mechanism is controlled to schedule at least some of the uncovered sample containers that have already been sampled to the capping mechanism for capping.

2. The analyzer apparatus of claim 1, wherein, It also includes a buffer, which is used to temporarily store the sample to be aspirated or the sample after aspiration.

3. The analyzer apparatus as described in claim 1, characterized in that, It also includes a buffer, which is used to temporarily store the sample to be aspirated or the sample after aspiration. The covering mechanism is located at the buffer zone.

4. The analyzer apparatus of claim 3, wherein, The control device is also used to: after the capping process and before the sampling process, control the sample scheduling mechanism to schedule the sample to be sampled to the buffer for temporary storage; after the sampling is completed, control the sample scheduling mechanism to schedule the sample that has been sampled to the buffer for temporary storage, and control the capping mechanism to cap at least some of the sample containers.

5. The analyzer apparatus of claim 1, wherein, The control device is further configured to: determine, based on the biohazard level of the sample contained in the uncovered sample container, whether to control the sample unloading device to dispatch the uncovered sample container to the capping mechanism for capping processing, wherein... When the biological risk level of the sample is higher than the threshold risk level, the control device controls the sample unloading device to dispatch the uncovered sample container to the capping mechanism for capping. When the biological risk level of the sample is lower than the threshold risk level, the control device controls the sample unloading device to transfer the sample to the user processing channel to wait for the user to process it.

6. The analyzer apparatus of claim 5, wherein, The biological risk level of the sample is determined based on the risk level of the test item used to test the sample.

7. The analyzer apparatus of claim 5, wherein, The biological risk level of the tested samples is determined based on the test results of the tested samples. For tested samples with positive test results, a first biological risk level is set, and for tested samples with negative test results, a second biological risk level is set. The first biological risk level is higher than the threshold risk level, and the second biological risk level is lower than the threshold risk level.

8. The analyzer apparatus of claim 5, wherein, The biological risk level of the tested sample is determined based on the test results of the tested sample. When the test result is higher than a set concentration range, the corresponding tested sample is set to a first biological risk level. When the test result is lower than the set concentration range, the corresponding tested sample is set to a second biological risk level. The first biological risk level is higher than a threshold risk level, and the second biological risk level is lower than a threshold risk level.

9. The analyzer apparatus of claim 1, wherein, The analyzer device can be connected to a production line for testing samples using at least one test item, and the control device is further used for: Based on the test status of the sample, the sample unloading device is controlled to dispatch the uncapped sample container to the capping mechanism for capping.

10. The analyzer apparatus of claim 9, wherein, When the sample's testing status indicates that all tests of the analyzer have been completed, the control device controls the sample unloading device to move the uncovered sample container to the capping mechanism for capping; or... When the test status of the sample is that an abnormal event occurred during the test, the control device is used to: Obtain the user's input selection instruction regarding whether to cover the sample container where the abnormal event occurred; When the selection instruction indicates that the sample container needs to be capped, the sample unloading device is controlled to dispatch the corresponding sample container to the capping mechanism for capping.

11. The analyzer apparatus of claim 10, wherein, The abnormal events include at least one of the following: needle blockage during testing, barcode unreadable, and inability to obtain test information for the sample.

12. The analyzer apparatus of claim 9, wherein, When the analyzer is connected to the production line and the sample is in a testing state where there are still untested test items in the analyzer, the control device controls the sample loading device to schedule the sample to the production line.

13. The analyzer apparatus of claim 1, wherein, The analyzer device is configured to connect to a production line, the production line including a sample storage device and / or an output module. When the analyzer device is connected to the production line, the control device is further configured to: The sample unloading device controls the sample container, after being capped by the capping mechanism, to be dispatched to the production line, so as to save the capped sample container to the sample storage device, or to output the capped sample container from the output module.

14. The analyzer apparatus of claim 1, wherein, When the sample's testing status indicates that all test items of the analyzer have been completed, the control device is used to: Depending on the sample type, the sample unloading device can be controlled to dispatch the sample to the capping mechanism for capping, and then dispatch the capped sample to the production line; or, the sample unloading device can be controlled to dispatch the sample to the output area; and / or Based on the test items tested on the sample, the sample unloading device is controlled to schedule the sample to the pipeline for storage, or the sample unloading device is controlled to schedule the sample to the output area.

15. The analyzer apparatus as claimed in claim 1, characterized in that, The front track section connects the sample injection section and the analyzer. The sample injection section is used to move the sample rack placed in the sample injection section to the front track section to aspirate the sample to be tested contained in the sample rack.

16. The analyzer apparatus of claim 1, wherein, The control device is also used for: The sample positions that need to be decapped are determined based on whether there are samples in the sample positions of the sample rack, the type of sample container in the sample positions, and the current status of the samples in the sample positions. The cap removal mechanism is controlled to remove the caps from the covered sample containers at the sample positions that require the cap removal process.

17. The analyzer apparatus of claim 16, wherein, When the current state of the sample at the sample position includes at least one of the following states: the sample barcode cannot be recognized, the corresponding test information of the sample cannot be obtained, or an abnormality occurs during the test, and / or when there is no sample at the sample position of the sample rack, and / or when the sample container type at the sample position is a micro-cup, the sample position is a sample position that does not require the cap removal process.

18. The analyzer apparatus of claim 1, wherein, The sample loading device includes a sample inlet section and a front track section. The cap removal mechanism includes a detection sensor, which is used to detect whether the sample container has a cap to obtain cap information of the sample container. The control device is also used for: Obtain the lid information of the sample container in the sample rack placed in the analyzer device; When the lid information indicates that the sample container in the sample rack has a lid, the lid removal mechanism is controlled to remove the lid from the sample container in the sample rack. Alternatively, when the lid information indicates that the sample container in the sample rack is uncovered, the sample scheduling mechanism is controlled to schedule the sample rack to the front track section to aspirate the sample to be tested contained in the sample rack.

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