An insecticidal composition comprising brofenoxam and deltamethrin and its application

Abstract

This invention provides an insecticidal composition comprising bromfenac and cypermethrin, wherein the active ingredients are bromfenac and cypermethrin, and the mass ratio of bromfenac to cypermethrin is 1:20-20:1; it can be used to control crop pests, including Coleoptera, Hemiptera, Homoptera and Lepidoptera pests; particularly for the control of diamondback moth or cabbage caterpillar.

Description

Technical Field

[0001] This invention belongs to the field of pesticides, specifically relating to an insecticidal composition comprising brofenoxam and deltamethrin and its application. Background Technology

[0002] Brofenoxam is a m-diamid (m-formylaminobenzamide) insecticide jointly developed by Mitsui Chemicals and BASF. Its mechanism of action is significantly different from existing o-diamid insecticides such as chlorantraniliprole. It is an allosteric modulator of γ-aminobutyric acid (GABA)-gated chloride ion channels, inhibiting neurotransmission in target insects, leading to convulsions and ultimately death. Currently, it is the only agent with this mechanism of action.

[0003] Cypermethrin has contact and stomach poison effects and a long residual effect. It is suitable for insecticidal control on plants such as cotton, fruit trees, vegetables, tea trees, tobacco, and soybeans. It can effectively control Coleoptera, Hemiptera, Homoptera, and Lepidoptera pests on cereal crops, cotton, fruit trees, and vegetables.

[0004] There are no reports in the existing technology regarding the combined use of bromoxynil and cypermethrin. Summary of the Invention

[0005] This invention belongs to the field of pesticide formulations, specifically providing an insecticidal composition comprising bromfenoxam and deltamethrin and its application. The specific technical solution is as follows:

[0006] An insecticidal composition comprising brofenoxam and lambda-cyhalothrin, wherein the active ingredients are brofenoxam and lambda-cyhalothrin, and the mass ratio of brofenoxam to lambda-cyhalothrin is 1:20-20:1. Preferably, the mass ratio of brofenoxam to lambda-cyhalothrin is 1:1-1:20. A more preferred mass ratio is 1:10.

[0007] The insecticidal composition contains 5-80% by weight of the active ingredient. Preferably, the active ingredient contains 10-50% by weight.

[0008] The insecticidal composition also contains agricultural adjuvants and can be prepared as a suspension concentrate, wettable powder, water-dispersible granule, emulsifiable concentrate, granule, or suspension emulsion. For example, the formulation and preparation process of a 12% bromfenac-methyl cyanide suspension emulsion are as follows:

[0009] Components: Contains the following components in weight percentage:

[0010] Brombutamide 6%, Tristyrene-based phenol polyoxyethylene ether ammonium sulfate (Soprophor FD) 2-2.5%, EO / PO block copolymer (500LQ) 1-1.5%, Cypermethrin 6%, 200# aromatic solvent oil 19.0-20.0%, C16-18 alcohol polyoxyethylene ether 9-10%, propylene glycol 4-5%, xanthan gum 0.1-0.3%, polydimethylsiloxane emulsion 0.1-1%, benzisothiazol-3-one 0.01-0.03%, water to make up to 100%.

[0011] Process: (1) Add deionized water, propylene glycol, and polydimethylsiloxane emulsion (defoamer) to a mixing tank, start stirring, add tristyrene-phenylphenol polyoxyethylene ether ammonium sulfate and EO / PO copolymer, stir for 15-30 min until the additives are completely dissolved, add bromoxynil dimethyl ether, continue stirring for 30 min, introduce into a bead mill, and sand mill for 3 h. Take a sample to test the particle size. Stop sand milling when D50 is around 1.5 μm. In another mixing tank, add 200# aromatic solvent oil, start stirring, add cypermethrin, and after the original drug is completely dissolved, add C16-18 alcohol polyoxyethylene ether, stir for 30 min and set aside.

[0012] (2) Preparation of 2% xanthan gum solution;

[0013] (3) Pour the suspension into a shearing vessel, add polydimethylsiloxane emulsion defoamer, and simultaneously turn on the shearing machine and stirrer. Add the prepared oil phase solution, and after high shearing for 1.5 hours, take a sample to test the particle size. If the D50 is around 2.0 μm, stop shearing (Note: do not stop stirring). Test the content of bromofenac and cypermethrin. Add an appropriate amount of xanthan gum solution, benzisothiazol-3-one solution (100% concentration), and an appropriate amount of deionized water (calculated and supplemented according to the tested content). Test the final content, pH, persistent foaming, suspension rate, pourability, average particle size, and other indicators. If they meet the standards, it is acceptable!

[0014] The insecticidal composition is used for the control of crop pests. These pests include Coleoptera, Hemiptera, Homoptera, and Lepidoptera; it is particularly effective for the control of diamondback moths or cabbage caterpillars.

[0015] Compared with the prior art, the present invention has the following beneficial effects:

[0016] 1. When the mass ratio of brofentanil to cypermethrin is 1:5-1:20, the compound pesticide exhibits a synergistic effect against diamondback moth. In particular, when the mass ratio of brofentanil to cypermethrin is 1:10, the CTC value is 170.3, demonstrating a significant synergistic effect.

[0017] 2. Compared with other formulations of the same dosage, the 12% bromfenac-fluorinated cyanide suspension and 22% bromfenac-fluorinated cyanide suspension prepared by this invention have a higher control effect on diamondback moth or cabbage caterpillar, that is, the formulation of adjuvants in the suspension formulation plays a good role in promoting the improvement of the biological activity of active ingredients.

[0018] 3. When bromfenac is used in combination with cypermethrin, the dosage of active ingredients can be effectively reduced, thus slowing down the development of pesticide resistance. Detailed Implementation

[0019] The present invention can be better understood from the following embodiments. However, those skilled in the art will readily understand that the descriptions in the embodiments are for illustrative purposes only and should not, and will not, limit the invention as detailed in the claims.

[0020] Example 1: Indoor toxicity test of compound pesticide against diamondback moth

[0021] Test pest: Diamondback moth of cabbage. Healthy 3rd instar larvae of uniform size were selected as test pests.

[0022] Test reagents: Brofenoxam technical grade, Cypermethrin technical grade; purchased from the market;

[0023] Test Method: Leaf immersion method was used. Based on the preliminary experiment, seven concentration gradients were set for each pesticide, with water as a blank control. The experiment was repeated four times, with 24 third-instar larvae of the diamondback moth used in each replicate. Clean cabbage leaves were punched into discs approximately 2 cm in diameter. The leaves were immersed in the corresponding pesticide concentration for 10 seconds, then removed and allowed to air dry. They were then placed in 12-well plates, with one disc in each well and two larvae starved for 4 hours. A layer of paper was placed on top of the 12-well plate (to prevent larvae escape). The experiment was conducted in an insect rearing room, and the mortality of 48 larvae was observed. A larva was considered dead if it did not move when gently touched with a brush. DPS software was used as a statistical tool to calculate the toxicity regression equation and LC50.

[0024] The co-toxicity coefficients of each compound preparation were calculated using Sun Yunpei's co-toxicity coefficient method. The co-toxicity coefficients were used to represent the combined effect of each compound preparation. A co-toxicity coefficient >120 indicates that the compound preparation has a significant synergistic effect, <80 indicates that the compound preparation has an antagonistic effect, and a coefficient between 80 and 120 indicates an additive effect.

[0025] Test Results: Table 1 shows that the LC50 values ​​of the stomach toxicity activities of bromfenac-methyl and lambda-cyhalothrin against diamondback moth were 0.055 mg / L and 26.590 mg / L, respectively, indicating that bromfenac-methyl technical exhibits higher stomach toxicity activity against diamondback moth compared to lambda-cyhalothrin technical. The combination of bromfenac-methyl and lambda-cyhalothrin technicals showed both additive and synergistic effects on diamondback moth. When the mass ratio of bromfenac-methyl to lambda-cyhalothrin was 20:1-5:1, the combined pesticide showed an additive effect; when the mass ratio was 1:1-1:20, the combined pesticide showed a synergistic effect. In particular, when the mass ratio of bromfenac-methyl to lambda-cyhalothrin was 1:10, the CTC value was 170.3, demonstrating a significant synergistic effect.

[0026] Table 1. Results of indoor toxicity tests of the compound pesticide against diamondback moth.

[0027]

[0028] Note: "-" indicates none.

[0029] Example 2: Formulation of compound drug

[0030] 12% bromfenac-methyl cyanide suspension concentrate. Contains the following ingredients in weight percentage:

[0031] 2% bromofenac, 10% deltamethrin, 3% dispersant NNO, 2% sodium lignosulfonate, 1% SP-SC3, 1.5% magnesium aluminum silicate, 1% xanthan gum, 1% propylene glycol, 2% silicone defoamer, and deionized water to make up to 100%.

[0032] 22% bromfenac-methyl cyanamide suspension concentrate. Contains the following ingredients in weight percentage:

[0033] 2% bromofenac, 20% deltamethrin, 4% dispersant NNO, 1% sodium lignosulfonate, 32% SP-SC, 2% magnesium aluminum silicate, 0.5% xanthan gum, 2% propylene glycol, 1% silicone defoamer, and deionized water to make up to 100%.

[0034] 33% bromfenac-methyl·flufenican wettable powder. Contains the following ingredients in weight percentage:

[0035] 3% bromonitrile dimethoate, 30% deltamethrin, 4% sodium dodecylbenzene sulfonate, 3% sodium lignosulfonate, 2% silica, and 100% kaolin.

[0036] 21% bromfenac-methyl·flufenican wettable powder. Contains the following ingredients in weight percentage:

[0037] 1% bromonitrile dimethoate, 20% deltamethrin, 3% sodium dodecylbenzene sulfonate, 5% sodium lignosulfonate, 3% silica, and 100% kaolin.

[0038] 24% bromfenac-methyl·flufenican water-dispersible granules. Contains the following ingredients in weight percentage:

[0039] 4% bromonitrile dimethoate, 20% deltamethrin, 6% chlorpyrifos, 3% calcium lignosulfonate, 2% carboxymethyl cellulose, 3% urea, and 100% kaolin.

[0040] 21% bromfenac·flufenican water-dispersible granules. Contains the following ingredients in weight percentage:

[0041] 1% bromonitrile dimethoate, 20% deltamethrin, 4% chlorpyrifos, 5% calcium lignosulfonate, 3% carboxymethyl cellulose, 2% urea, and 100% kaolin.

[0042] Example 3: Field efficacy test of compound pesticide against diamondback moth in cabbage

[0043] Test Method: The experiment consisted of 6 treatments, with water as a blank control. Each treatment was replicated 3 times, randomly arranged, with a plot area of ​​approximately 25 m2. The water consumption was 40 kg / mu, applied before the diamondback moth larvae reached the 3rd instar. Before and 7 days after application, a five-point sampling method was used, with the number of insects on 5 plants at each point to calculate the insect population reduction rate and corrected control efficacy.

[0044] Test results: As shown in Table 2, compared with other formulations of the same dosage, the 12% bromfenac-fluorinated cyanide suspension and the 22% bromfenac-fluorinated cyanide suspension prepared in this invention have higher control effects on diamondback moth of cabbage, with control efficacies of 94.5% and 91.6% respectively. That is, the formulation of adjuvants in the suspension formulation plays a good role in promoting the improvement of the bioactivity of active ingredients.

[0045] Table 2. Field control efficacy test results of compound pesticides against diamondback moth in cabbage.

[0046]

[0047] Example 3: Field efficacy test of compound pesticide against cabbage caterpillar

[0048] Test method: The experiment was set up with 6 treatments, with water as a blank control. Each treatment was replicated 3 times, randomly arranged, with a plot area of ​​approximately 25 m2 and a water consumption of 40 kg / mu. Before and 3 days after application, a five-point sampling method was used to investigate the number of insects at each point, and the insect population reduction rate and corrected control efficacy were calculated.

[0049] Test results:

[0050] Table 3. Field control efficacy test results of compound pesticides against cabbage caterpillars.

[0051]

[0052] The above description is only a preferred embodiment of the present invention. For those skilled in the art, appropriate improvements can be made without departing from the original material of the present invention, and these improvements are also within the protection scope of the present invention.

Claims

1. The use of an insecticidal composition comprising bromfenac and deltamethrin for controlling the diamondback moth, characterized in that, The active ingredients include bromfenac and cypermethrin, with a mass ratio of bromfenac to cypermethrin of 1:

10. The composition is formulated as a suspension containing the following components by weight percentage: bromfenac 2%, cypermethrin 20%, dispersant NNO 4%, sodium lignosulfonate 1%, SP-SC3 2%, magnesium aluminum silicate 2%, xanthan gum 0.5%, propylene glycol 2%, silicone defoamer 1%, and deionized water to make up to 100%.

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