A composition for muscle and bone pain

Abstract

The application discloses a composition for treating muscle and bone pain, which is prepared from raw medicinal materials in the following weight ratio: Chuanduan 15-25 parts, Baiyun Guapi 10-20 parts, Chanyi 10-20 parts, Tianguihuang 20-30 parts, Mody 10-20 parts, Ruoxiang 15-25 parts, Baizhi 15-25 parts, Chuanqiong 10-20 parts, Taoren 15-25 parts, Duzhong 15-25 parts, Qingpi 10-20 parts, Muxiang 5-15 parts, Xiangfu 10-20 parts, Honghua 20-30 parts, Huoxiang 5-15 parts, Weilingxian 15-25 parts, Dangguwei 10-20 parts, Jiangxiang 5-15 parts and Gushugupu 20-25 parts. The composition can be used externally on swollen joints, cervical spondylosis, contusions and sprains, lumbar muscle strain and shoulder periarthritis, can significantly relieve pain, can reduce or even eliminate the pain of patients, can improve the life quality of patients, and has the clinical popularization and application value.

Description

Technical Field

[0001] This invention specifically relates to a composition for treating musculoskeletal pain. Background Technology

[0002] Pain in the whole body or in a local area (such as the spine, joints of the limbs, etc.) caused by natural degeneration of the human body or by trauma, strain, or exposure to external pathogens is classified as musculoskeletal pain.

[0003] With the advancement of an aging society and changes in lifestyle, musculoskeletal pain, a common ailment among the elderly, is also spreading among middle-aged and young adults, leading to a rapid increase in the demand for its prevention and treatment. At the same time, public understanding of this condition remains insufficient, and treatment often focuses on localized or single-symptom approaches, neglecting the overall systemic and holistic approach. Traditional Chinese medicine offers numerous, simple, and flexible methods for preventing and treating this condition, boasting good efficacy and a long history; however, it often involves many ingredients, has a slow onset of action, and its effects are not always significant.

[0004] Patent CN202011319933 discloses a topical medicinal wine for sprains and bruises, which contains as many as 30 kinds of medicinal ingredients. The cost of the medicine is high and the treatment time is long, which increases the mental burden on patients. Therefore, it is necessary to research and develop a topical medicinal wine with a scientific and reasonable formula and significant efficacy for treating muscle and bone pain. Summary of the Invention

[0005] To address the above problems, the present invention provides a composition for treating musculoskeletal pain, which is a topical preparation made from the following active pharmaceutical ingredients in the indicated weight ratios:

[0006] 15-25 parts of Dipsacus asperoides, 10-20 parts of Cucurbita scabra peel, 10-20 parts of Panax notoginseng, 20-30 parts of Lysimachia christinae, 10-20 parts of Commiphora myrrha, 15-25 parts of Boswellia carterii, 15-25 parts of Angelica dahurica, 10-20 parts of Ligusticum chuanxiong, 15-25 parts of Prunus persica kernel, 15-25 parts of Eucommia ulmoides, 10-20 parts of Citrus reticulata peel, 5-15 parts of Aucklandia lappa, 10-20 parts of Cyperus rotundus, 20-30 parts of Carthamus tinctorius, 5-15 parts of Pogostemon cablin, 15-25 parts of Clematis chinensis, 10-20 parts of Angelica sinensis tail, 5-15 parts of Dalbergia odorifera, and 20-25 parts of Drynaria fortunei.

[0007] Furthermore, it is a topical preparation made from active pharmaceutical ingredients in the following weight ratios:

[0008] 20 parts of Dipsacus asperoides, 15 parts of Melon peel, 15 parts of Panax notoginseng, 25 parts of Lysimachia christinae, 15 parts of Myrrh, 20 parts of Frankincense, 20 parts of Angelica dahurica, 15 parts of Ligusticum chuanxiong, 20 parts of Prunus persica, 20 parts of Eucommia ulmoides, 15 parts of Citrus reticulata peel, 10 parts of Aucklandia lappa, 15 parts of Cyperus rotundus, 25 parts of Carthamus tinctorius, 10 parts of Pogostemon cablin, 20 parts of Clematis chinensis, 15 parts of Angelica sinensis tail, 10 parts of Dalbergia odorifera, and 25 parts of Drynaria fortunei.

[0009] Furthermore, it is a topical preparation made from the active ingredient of a pharmaceutical powder or an aqueous or organic solvent extract of a pharmaceutical raw material, plus pharmaceutically acceptable excipients.

[0010] Furthermore, the external preparation is a solution, spray, aerosol, ointment, or emulsion; the solution is preferably a topical medicated wine.

[0011] Furthermore, the total weight of the raw materials in the external medicinal wine is in the volume ratio of 1 kg to 10-30 L of wine.

[0012] Furthermore, the wine in question is rice wine with an alcohol content of 50-60%.

[0013] The present invention also provides a method for preparing the aforementioned composition, comprising the following steps:

[0014] 1) Weigh the raw materials according to the mixing ratio;

[0015] 2) Take peach kernels, cyperus rhizome and green tangerine peel, stir-fry them until cooked, then add them together with drynaria rhizome and notoginseng to rice wine and soak for 5 to 10 days. Then add the remaining raw materials and continue to soak for 25 to 30 days. Filter to obtain the final product.

[0016] Furthermore: the stir-frying process involves stir-frying over a low heat until the color is darker than the raw material, with slight bulging or popping sounds, and the inherent aroma of the raw material is released; the soaking process involves soaking for 7 days; the continued soaking process involves soaking for 28 days; and the filtration process involves passing the material through a 200-mesh sieve.

[0017] Finally, the present invention provides the use of the aforementioned composition in the preparation of a medicament for treating musculoskeletal pain.

[0018] Furthermore, the medication is for treating pain caused by joint swelling, cervical spondylosis, sprains and strains, lumbar muscle strain, and / or frozen shoulder.

[0019] In the composition for treating muscle and bone pain in this invention, Panax notoginseng can disperse blood stasis, stop bleeding, reduce swelling and relieve pain. It has a warm, sweet and slightly bitter taste and is a medicine for the blood aspect of Yangming and Jueyin meridians. It can treat all blood diseases. It is not only an essential medicine for stopping bleeding, but also good at resolving blood stasis and promoting the growth of new blood to relieve pain. It can break up all blood stasis caused by falls, carbuncles, knife wounds and so on. Therefore, it is the principal medicine. Frankincense, myrrh, chuanxiong, and dalbergia odorifera can all invigorate blood, promote qi circulation, and relieve pain. Citrus reticulata peel, costus root, and cyperus rotundus mainly enter the liver meridian, effectively promoting qi circulation, relieving bloating, and alleviating pain; these are the assistant herbs. Peach kernel, safflower, and angelica sinensis tail descend to the blood sea, enter the foot jueyin meridian to expel blood and relieve pain. Clematis chinensis treats all kinds of wind, unblocks the five internal organs, can ascend and descend, and is good at moving, entering all meridians, and can treat fractures. Eucommia ulmoides and Dipsacus asperoides can both tonify the liver and kidneys, strengthen tendons and bones, and heal fractures. Lysimachia christinae enters the blood and can disperse blood stasis and reduce swelling, and can also promote diuresis. Angelica dahurica and agastache rugosa have a fragrant aroma and are good at dispelling wind, relieving pain, and drying and resolving dampness. Cucurbita trifoliata peel is good at resolving phlegm and unblocking the meridians; these are the adjuvant herbs. The combination of the whole formula can invigorate blood, relieve pain, unblock the meridians, treat fractures, disperse blood stasis, reduce swelling, and treat traumatic injuries.

[0020] This invention discloses a composition for treating muscle and bone pain. Through specific medicinal ingredients and dosage ratios, it can be applied externally to joint swelling, cervical spondylosis, sprains and strains, lumbar muscle strain, and frozen shoulder, which can significantly relieve pain, reduce or even eliminate the patient's pain, improve the patient's quality of life, and has clinical application value.

[0021] Obviously, based on the above description of the present invention, and according to common technical knowledge and conventional methods in the field, various other modifications, substitutions or alterations can be made without departing from the basic technical concept of the present invention.

[0022] The following detailed embodiments further illustrate the above-described content of the present invention. However, this should not be construed as limiting the scope of the present invention to the following examples. All technologies implemented based on the above-described content of the present invention fall within the scope of the present invention. Detailed Implementation

[0023] The raw materials and equipment used in the specific embodiments of the present invention are all known products and can be obtained by purchasing commercially available products. In particular, rice wine can also be made by fermenting and distilling rice and yeast.

[0024] Example 1: Preparation of the composition of the present invention

[0025] Formula: 20g of Dipsacus asperoides, 15g of Cucurbita scabra peel, 15g of Panax notoginseng, 25g of Lysimachia christinae, 15g of Commiphora myrrha, 20g of Boswellia carterii, 20g of Angelica dahurica, 15g of Ligusticum chuanxiong, 20g of Prunus persica kernel, 20g of Eucommia ulmoides, 15g of Citrus reticulata peel, 10g of Aucklandia lappa, 15g of Cyperus rotundus, 25g of Carthamus tinctorius, 10g of Pogostemon cablin, 20g of Clematis chinensis, 15g of Angelica sinensis tail, 10g of Dalbergia odorifera, and 25g of Drynaria fortunei.

[0026] Preparation method:

[0027] 1) Weigh the raw materials according to the mixing ratio;

[0028] 2) Take peach kernels, cyperus rhizome, and green tangerine peel, heat them over a low flame (very low heat) and stir-fry until they are darker in color than the original medicinal materials, and they swell slightly or make popping sounds, and their inherent aroma is released.

[0029] 3) Add the stir-fried herbs from step 2) along with Drynaria fortunei and Panax notoginseng to rice wine (the rice wine ratio is 10-30 times the total weight of the herbs, L / kg), and soak for 7 days in an earthenware jar.

[0030] 4) After 7 days, add the remaining medicinal materials to step 3) and continue soaking for 28 days;

[0031] 5) Take the supernatant obtained in step 4), filter it, and use a sieve with a mesh size of 200 to obtain the medicinal wine.

[0032] Rice wine is made by the following method: take southern rice, steam it for 2-4 hours, cool it to 30-40℃, mix it with Guilin koji (the weight ratio of koji to rice is 1:50-70), put it in a jar and let it stand for 18-21 days, dilute it with spring water at a mass ratio of 1:2, and distill it to obtain rice wine with an alcohol content of 50-60 degrees.

[0033] Example 2: Preparation of the composition of the present invention

[0034] Formula: 15g of Dipsacus asperoides, 10g of Cucurbita scabra peel, 10g of Panax notoginseng, 20g of Lysimachia christinae, 10g of Commiphora myrrha, 10g of Boswellia carterii, 15g of Angelica dahurica, 10g of Ligusticum chuanxiong, 15g of Prunus persica kernel, 15g of Eucommia ulmoides bark, 10g of Citrus reticulata peel, 5g of Aucklandia lappa, 10g of Cyperus rotundus, 20g of Carthamus tinctorius, 5g of Pogostemon cablin, 15g of Clematis chinensis, 10g of Angelica sinensis tail, 5g of Dalbergia odorifera, and 25g of Drynaria fortunei.

[0035] Preparation method:

[0036] 1) Weigh the raw materials according to the mixing ratio;

[0037] 2) Take peach kernels, cyperus rhizome, and green tangerine peel, heat them over a low flame (very low heat) and stir-fry until they are darker in color than the original medicinal materials, and they swell slightly or make popping sounds, and their inherent aroma is released.

[0038] 3) Add the stir-fried herbs from step 2) along with Drynaria fortunei and Panax notoginseng to rice wine (the rice wine ratio is 10-30 times the total weight of the herbs, L / kg), and soak for 7 days in an earthenware jar.

[0039] 4) After 7 days, add the remaining medicinal materials to step 3) and continue soaking for 28 days;

[0040] 5) Take the supernatant obtained in step 4), filter it, and use a sieve with a mesh size of 200 to obtain the medicinal wine.

[0041] Example 3: Preparation of the composition of the present invention

[0042] Formula: 25g of Dipsacus asperoides, 20g of Cucurbita scabra peel, 20g of Panax notoginseng, 30g of Lysimachia christinae, 20g of Commiphora myrrha, 25g of Boswellia carterii, 25g of Angelica dahurica, 20g of Ligusticum chuanxiong, 25g of Prunus persica kernel, 25g of Eucommia ulmoides bark, 20g of Citrus reticulata peel, 15g of Aucklandia lappa, 20g of Cyperus rotundus, 30g of Carthamus tinctorius, 15g of Pogostemon cablin, 25g of Clematis chinensis, 20g of Angelica sinensis tail, 15g of Dalbergia odorifera, and 20g of Drynaria fortunei.

[0043] Preparation method:

[0044] 1) Weigh the raw materials according to the mixing ratio;

[0045] 2) Take peach kernels, cyperus rhizome, and green tangerine peel, heat them over a low flame (very low heat) and stir-fry until they are darker in color than the original medicinal materials, and they swell slightly or make popping sounds, and their inherent aroma is released.

[0046] 3) Add the stir-fried herbs from step 2) along with Drynaria fortunei and Panax notoginseng to rice wine (the rice wine ratio is 10-30 times the total weight of the herbs, L / kg), and soak for 7 days in an earthenware jar.

[0047] 4) After 7 days, add the remaining medicinal materials to step 3) and continue soaking for 28 days;

[0048] 5) Take the supernatant obtained in step 4), filter it, and use a sieve with a mesh size of 200 to obtain the medicinal wine.

[0049] The following experimental examples illustrate the beneficial effects of the present invention.

[0050] Clinical Application of Case Study 1

[0051] 1. General Information:

[0052] This study included 118 patients aged 16-70 years with musculoskeletal pain admitted to Batun Health Center from January 2018 to December 2020. Among them, 25 cases were sprains and strains, 19 cases were joint swelling and pain, 22 cases were lumbar muscle strain, 20 cases were cervical pain, and 32 cases were frozen shoulder, totaling 118 patients. There were 65 males and 53 females. Age distribution: 16-30 years: 33 patients; 31-40 years: 31 patients; 41-50 years: 28 patients; 51-70 years: 26 patients. None of these patients had used any medications for their respective conditions within the past 30 days.

[0053] 2. Evaluation and Indicators:

[0054] 1) Selection of methods and timing for evaluating, recording, and analyzing validity parameters.

[0055] The Numerical Rating Scale (NRS) was used: a 10cm horizontal line was drawn on a piece of paper, and the numbers 0-10 were marked on the line at 1cm intervals; patients were asked to convert the severity of their pain into numbers and mark them on the line according to their own feelings (see Table 1 for pain sensations), and the changes in pain intensity were recorded in this way.

[0056] Table 1 Pain Level

[0057] 0 painless 1 No sensation when not touched. 2 It is painful to the touch. 3 It causes intense pain when touched. 4 There is a slight pain when not touched. 5 It hurts when not touched. 6 The pain is intense even when not touched. 7 I have persistent and severe pain and am unable to fall asleep. 8 The pain is persistent and severe, and difficult to endure. 9 The pain was excruciating and unbearable. 10 The pain was unbearable, worse than death.

[0058] 2) Evaluation time: before treatment (day 0), day 3 of treatment, day 5 of treatment, and day 7 of treatment.

[0059] When eligible subjects are selected, the therapeutic product is used in accordance with the prescribed quality methods, and the medication follow-up is recorded as shown in Table 2 below.

[0060] Table 2. Efficacy Basis

[0061]

[0062]

[0063] 3) Evaluation criteria

[0064] ① Pain disappears, score: None (0 points);

[0065] ②Significant effect: Pain decreases from severe (7-10 points) to mild (below 3 points);

[0066] ③ Effective: Pain ranges from severe (7-10 points) to moderate (4-6 points), or from moderate (4-6 points) to mild (below 3 points);

[0067] ④ Ineffective: The pain did not improve compared to before treatment.

[0068] 3. Experimental Grouping:

[0069] The patients were randomly divided into a control group (57 people) and an experimental group (61 people) using a double-blind method. The experimental group used the medicinal wine in Example 1 of this invention, while the control group used the national protected traditional Chinese medicine "Dieda Qili Pian" (ZYB2072015018).

[0070] 4. Treatment methods:

[0071] Experimental group: Take an appropriate amount of the medicinal wine prepared in this embodiment, apply it to the applicable area, and then gently massage the area with your hands and face until the medicine is completely absorbed. Repeat the "apply-massage" process three times. Apply 2-3 times a day.

[0072] Control group: Take 1-3 tablets of Dieda Qili Pian (oral), 3 times a day; it can also be taken with wine.

[0073] Usage period: 7 days.

[0074] 5. Statistical Analysis

[0075] Table 3. Effectiveness of Medicated Wine Treatment

[0076]

[0077] Note: Effective rate = (Number of effective cases + Number of cases with significant effects) / Total number of cases x 100%

[0078] 6. Conclusion:

[0079] Compared with the control group, the medicinal wine prepared by this invention has better efficacy in treating sprains and joint swelling and pain. The effective rate in treating lumbar muscle strain, cervical pain, and frozen shoulder is higher than that in the control group, and the difference is significant.

[0080] In summary, the composition of the present invention, through specific medicinal ingredients and dosage ratios, can be applied externally to joint swelling, cervical spondylosis, sprains and strains, lumbar muscle strain, and frozen shoulder, and can significantly relieve pain in a short period of time, reducing or even eliminating the patient's pain, improving the patient's quality of life, and has clinical application value.

Claims

1. The use of a composition in the preparation of a medicament for treating musculoskeletal pain, characterized in that: The composition is a topical preparation made from the following active pharmaceutical ingredients in the indicated weight ratios: 20 parts of Dipsacus asperoides, 15 parts of Melon peel, 15 parts of Panax notoginseng, 25 parts of Lysimachia christinae, 15 parts of Commiphora myrrha, 20 parts of Boswellia carterii, 20 parts of Angelica dahurica, 15 parts of Ligusticum chuanxiong, 20 parts of Prunus persica, 20 parts of Eucommia ulmoides, 15 parts of Citrus reticulata peel, 10 parts of Aucklandia lappa, 15 parts of Cyperus rotundus, 25 parts of Carthamus tinctorius, 10 parts of Pogostemon cablin, 20 parts of Clematis chinensis, 15 parts of Angelica sinensis tail, 10 parts of Dalbergia odorifera, and 25 parts of Drynaria fortunei. The drug is effective in treating pain caused by joint swelling, cervical spondylosis, sprains and strains, lumbar muscle strain and / or frozen shoulder.

2. The use according to claim 1, characterized in that: The composition is a topical preparation made from a powder of a pharmaceutical raw material, or an aqueous or organic solvent extract of the pharmaceutical raw material as the active ingredient, plus pharmaceutically acceptable excipients.

3. The use according to claim 2, characterized in that: The external preparations are solutions, sprays, aerosols, ointments, and emulsions; the solutions are external medicated wines.

4. The use according to claim 3, characterized in that: The total weight of the raw materials in the external medicinal wine is 1 kg to 10-30 L in volume.

5. The use according to claim 4, characterized in that: The wine in question is rice wine with an alcohol content of 50-60%.

6. A method for preparing a drug for treating muscle and bone pain, characterized in that: It includes the following steps: 1) Weigh the active pharmaceutical ingredient according to the proportions described in claim 1; 2) Take peach kernels, cyperus rhizome and green tangerine peel, stir-fry them until cooked, then add them together with drynaria rhizome and notoginseng to rice wine and soak for 5-10 days. Then add the remaining raw materials and continue soaking for 25-30 days. Filter to obtain the final product.

7. The preparation method according to claim 6, characterized in that: The stir-frying process involves stir-frying over a low heat until the color is darker than the raw material, with slight bulging or popping sounds, and the inherent aroma of the raw material is released; the soaking process is 7 days; the continued soaking process is 28 days; and the filtration process involves passing the material through a 200-mesh sieve.

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