Systems and methods for assessing sample fixation duration and quality using vibrational spectroscopy

CN114341989BActive Publication Date: 2026-07-07VENTANA MEDICAL SYSTEMS INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
VENTANA MEDICAL SYSTEMS INC
Filing Date
2020-08-26
Publication Date
2026-07-07

AI Technical Summary

Technical Problem

Existing techniques are insufficient to accurately assess the fixation status of tissue samples, leading to inconclusive results and misdiagnosis, especially when the fixation time is uncertain.

Method used

Vibrational spectroscopy was employed to quantitatively determine the duration and quality of fixation in biological samples by training a spectral dataset and using a trained fixation estimation engine, including mid-infrared and Raman spectral data. Machine learning algorithms such as dimensionality reduction and neural networks were combined to identify spectral bands associated with the fixation state.

Benefits of technology

It enables high-precision estimation of the fixation state of biological samples, is applicable to different tissue types, provides quantitative fixation duration and quality assessment, and improves the accuracy of medical diagnosis.

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Abstract

The present disclosure relates to automated systems (200) and methods for quantitatively determining a fixation duration of a biological sample using a trained fixation estimation engine (210). In some embodiments, the trained fixation estimation engine (210) comprises a neural network. In some embodiments, the trained fixation estimation engine (210) comprises a supervised classifier.
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