流感病毒的核酸适配体及检测
By developing highly specific nucleic acid aptamers and shortening them, the problem of identifying the influenza virus A/H1N1pdm09 subtype was solved, enabling efficient identification and detection of the influenza virus.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- ARKRAY INC
- Filing Date
- 2021-10-29
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies are insufficient to effectively identify subtypes of influenza virus A/H1N1pdm09, especially due to mutations in viral surface proteins that reduce aptamer binding affinity, making it impossible to continuously identify circulating strains.
Nucleic acid aptamers capable of binding to influenza A/H1N1pdm09 virus were developed. Highly specific nucleic acid aptamers were screened using the SELEX method, and their secondary structures were shortened to maintain binding ability while improving adaptability.
It achieves efficient identification and detection of influenza A/H1N1pdm09 virus, and can maintain high binding force even when the viral surface protein is mutated, making it suitable for the subtype identification and detection of influenza virus.
Smart Images
Figure CN114438089B_ABST