Sample analysis system and reaction vessel preparation method therefor

Abstract

The application is suitable for the field of medical equipment, and discloses a sample analysis system and a reaction container preparation method of the sample analysis system. The sample analysis system comprises a sample analyzer and a control device; the sample analyzer comprises a detection working state, a cleaning working state and a post-cleaning preparation working state; when the sample analyzer enters the cleaning working state, the sample analyzer performs complete cleaning work on the reaction container after the detection working state; the post-cleaning preparation working state is started after the sample analyzer completes the cleaning working state and before the next batch of samples enters the sample analysis system; when the sample analyzer enters the post-cleaning preparation working state, the sample analyzer performs at least partial cleaning work on the reaction container after the cleaning working state. When the next batch of samples enters the sample control system, complete cleaning work on the reaction container is not needed, and the detection efficiency of the samples is improved.

Description

Technical Field

[0001] This invention relates to the field of medical devices, and more particularly to a sample analysis system and a method for preparing the reaction vessel for the sample analysis system. Background Technology

[0002] Most patients with acute, severe, and complex conditions often first visit the hospital's emergency department, making it a hub for critically ill patients. Emergency laboratory testing is a crucial component of emergency medical care; sufficient emergency testing services and accurate, timely reports are essential for effective treatment of emergency patients within the golden time window. According to the consensus of experts from the Chinese Society of Laboratory Medicine, the TAT (turnaround time) in emergency laboratories should at least meet the following requirements: reports for routine blood, urine, and stool tests should be issued within 30 minutes or less; reports for biochemistry and immunology tests should be issued within 2 hours or less; hospitals with the resources should aim for biochemistry reports to be issued within 1 hour or less. Some hospitals, in order to meet the clinical needs of stroke and chest pain centers, actually require biochemistry reports to be issued within 40 minutes. However, from the time an emergency room doctor issues a prescription to the time the report is issued, a sample typically involves several steps: blood collection by nurses, sample transportation, sample warming, sample centrifugation, sample loading, sample testing, result review, sample retesting, and report generation. The process from blood collection to sample loading takes nearly 20 minutes, and from test completion to result issuance (without retesting) takes another 3 minutes; therefore, the actual testing time for the instrument is only about 20 minutes. Thus, reducing the time required for emergency testing with sample analysis equipment is currently the primary problem that laboratory sample analysis equipment needs to solve.

[0003] Existing high-speed sample analysis systems require the following steps before starting a test: First, pre-test preparation (including instrument reset and checks, such as resetting and component verification) and test preparation (such as water supply preparation and vacuum preparation). After preparation, the instrument needs to perform reaction vessel cleaning, involving multiple stages (including cleaning with cleaning solution containing cleaning agent, rinsing with clean water, and drying) to ensure that each reaction vessel used in the test meets the requirements. However, this preparation time is approximately 3-5 minutes. Considering that a typical biochemical test takes about 10 minutes, a sample test, from the operator placing the sample to the output of the results, generally takes about 15 minutes. This leaves the operator with no time to retest when abnormal results are found. When a clinical sample is abnormal or exceeds a critical value, even if the operator retests, it cannot meet the emergency department's testing time requirements, easily leading to complaints from the emergency department to the laboratory. Summary of the Invention

[0004] The first objective of this invention is to provide a sample analysis system that addresses the technical problem in the prior art where the sample analyzer's preparation time is too long when an emergency sample is detected entering the sample analysis system, thus affecting the detection efficiency.

[0005] To achieve the above objectives, the present invention provides a sample analysis system, comprising a sample analyzer and a control device, wherein the sample analyzer includes a reaction vessel support device, a sample dispensing device, a reagent dispensing device, a sample detection device, and a cleaning device.

[0006] The sample analyzer includes a detection working state, a cleaning working state, and a post-cleaning preparation state.

[0007] When the sample analyzer enters the detection working state, the control device controls the sample dispensing device to dispense the sample into the reaction container on the reaction container carrier, controls the reagent dispensing device to dispense the reagent into the reaction container, and controls the sample detection device to analyze and detect the sample generated by the sample and the reagent in the reaction container.

[0008] When the sample analyzer enters the cleaning working state, the control device controls the cleaning device to perform a complete cleaning of the reaction vessel after the detection working state is completed;

[0009] The post-cleaning preparation state is when the control device starts the cleaning process after obtaining information that the sample analyzer has completed the cleaning process and before obtaining information that the next batch of samples will enter the sample analysis system; when the sample analyzer enters the post-cleaning preparation state, the control device controls the cleaning device to perform at least partial cleaning on the reaction vessel after the cleaning process has been completed.

[0010] A second objective of this invention is to provide a method for preparing a reaction vessel for a sample analysis system, comprising the following steps:

[0011] The cleaning step includes: controlling the cleaning device to perform a complete cleaning of the reaction vessel after the test is completed;

[0012] The post-cleaning preparation step is initiated after the information that the sample analyzer has completed the cleaning step is obtained and before the information that the next batch of samples will enter the sample analysis system is obtained. The post-cleaning preparation step includes controlling the cleaning device to perform at least partial cleaning work on the reaction vessel after the cleaning step has been completed.

[0013] The sample analysis system and reaction vessel preparation method provided by this invention, by placing at least part of the cleaning of the reaction vessel before the sample analyzer performs the complete cleaning of the reaction vessel after the sample analyzer has completed the testing and before the next batch of samples enters the sample analysis system, means that when the control device detects that samples need to enter the sample analysis system, it is not necessary to perform a complete cleaning of the reaction vessel, thereby reducing the preparation time of the sample analyzer and effectively improving the sample detection efficiency. Attached Figure Description

[0014] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0015] Figure 1 This is a schematic flowchart of the reaction vessel preparation method for the sample analysis system provided in this embodiment of the invention;

[0016] Figure 2 This is a schematic diagram of the composition of the sample analysis system provided in an embodiment of the present invention;

[0017] Figure 3 This is a schematic diagram of the layout of the sample analyzer, scanning device, and sample scheduling device provided in an embodiment of the present invention;

[0018] Figure 4 This is a schematic diagram showing the distribution of various devices surrounding the reaction vessel support device provided in an embodiment of the present invention;

[0019] Figure 5 yes Figure 4 A magnified view of a portion of point A in the middle.

[0020] Explanation of icon numbers:

[0021] 100. Sample analyzer; 110. Cleaning device; 111. Water blank detection unit; 112. Liquid injection and cleaning unit; 113. Drying unit; 120. Reaction vessel support device; 130. Sample dispensing device; 140. Reagent dispensing device; 141. First reagent dispensing mechanism; 142. Second reagent dispensing mechanism; 150. Sample detection device; 160. Mixing device; 200. Control device; 300. Sample information acquisition device; 400. Reaction vessel; 500. Sample scheduling device; 510. Sample loading area; 520. Sample unloading area; 530. Scanning position; 540. Sampling position; 600. Scanning device; S10. Cleaning step; S20. Post-cleaning preparation step; S30. Sample information acquisition step; S40. First pre-detection preparation step; S50. Second pre-detection preparation step. Detailed Implementation

[0022] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0023] It should be noted that all directional indications (such as up, down, left, right, front, back, etc.) in the embodiments of the present invention are only used to explain the relative positional relationship and movement of each component in a certain specific posture. If the specific posture changes, the directional indication will also change accordingly.

[0024] It should also be noted that when a component is referred to as being "fixed to" or "set on" another component, it can be directly on the other component or may be connected to an intermediary component. When a component is referred to as being "connected to" another component, it can be directly connected to the other component or indirectly connected to the other component through an intermediary component.

[0025] Furthermore, the use of terms such as "first" and "second" in this invention is for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined with "first" or "second" may explicitly or implicitly include at least one of that feature. Additionally, the technical solutions of the various embodiments can be combined with each other, but only on the basis of being achievable by those skilled in the art. When the combination of technical solutions is contradictory or impossible to implement, such a combination of technical solutions should be considered non-existent and not within the scope of protection claimed by this invention.

[0026] Example 1:

[0027] like Figure 2-4 As shown, the sample analysis system provided in Embodiment 1 of the present invention includes a sample analyzer 100 and a control device 200. The sample analyzer 100 includes a reaction vessel support device 120, a sample dispensing device 130, a reagent dispensing device 140, a sample detection device 150, and a cleaning device 110.

[0028] The reaction vessel support device 120 has at least one placement position for placing the reaction vessel 400 and incubating the reaction liquid composed of the sample and reagents in the reaction vessel 400. For example, the reaction vessel support device 120 can be a reaction disk, which is arranged in a disk-shaped structure and has one or more placement positions for placing the reaction vessel 400. The reaction disk can rotate and drive the reaction vessel 400 in its placement position to rotate, so as to arrange the reaction vessel 400 and the reaction liquid in the reaction vessel 400 within the reaction disk.

[0029] The sample dispensing device 130 is used to aspirate samples and dispense them into the reaction container 400 to be sampled. The sample dispensing device 130 may include a sample needle, which can be moved in two or three dimensions in space by a two-dimensional or three-dimensional driving mechanism, so that the sample needle can move to the aspiration position 540 to collect samples, and move to the reaction container 400 to dispense samples.

[0030] The reagent dispensing device 140 is used to aspirate reagents and discharge them into the reaction container 400 to which reagents are to be added. In a preferred embodiment, the reagent dispensing device 140 may include a reagent needle, which can move in two or three dimensions in space via a two-dimensional or three-dimensional driving mechanism, thereby allowing the reagent needle to move to aspirate reagents from a reagent bottle, move to the reaction container 400 to which reagents are to be added, and discharge reagents into the reaction container 400. As a preferred embodiment of this example, the reagent dispensing device 140 includes a first reagent dispensing mechanism 141 and a second reagent dispensing mechanism 142, which are spaced apart circumferentially along the reaction container carrying device 120. The first reagent dispensing mechanism 141 is used to dispense a first reagent into the reaction container 400, and the second reagent dispensing mechanism 142 is used to dispense a second reagent into the reaction container 400 to meet the testing requirements of different samples. Of course, in specific applications, the reagent dispensing device 140 may also include only one of the first reagent dispensing mechanism 141 and the second reagent dispensing mechanism 142.

[0031] The sample detection device 150 is used to perform tests on the sample prepared from the sample and reagents in the reaction vessel 400 to obtain test data. For example, in one embodiment, the sample detection device 150 can detect the luminescence intensity of the sample to be tested and calculate the concentration of the analyte in the sample through a calibration curve. Specifically, the sample detection device 150 can be separately disposed on the outer periphery of the reaction vessel support device 120. There can be one or more sample detection devices 150 to meet the needs of different testing items.

[0032] The cleaning device 110 is mainly used to clean the reaction vessel 400 to prevent contamination of the reaction vessel 400 from affecting the accuracy of the test results. The cleaning device 110 includes a water blank detection unit 111, at least one liquid injection cleaning unit 112, and at least one drying unit 113. A complete cleaning operation of the reaction vessel 400 by the cleaning device 110 includes: injecting liquid into the reaction vessel 400 through the liquid injection cleaning unit 112; after the liquid injection cleaning of the reaction vessel 400 is completed by the liquid injection cleaning unit, performing a water blank detection on the reaction vessel 400 through the water blank detection unit 111 to check whether the reaction vessel 400 meets the usage requirements; after the water blank detection is completed and the reaction vessel 400 is confirmed to be usable, drying the reaction vessel 400 through the drying unit 113 to remove the liquid inside the reaction vessel 400.

[0033] The sample analyzer 100 may also include a mixing device 160, which may include a first stirring mechanism and a second stirring mechanism. The first stirring mechanism and the second stirring mechanism are arranged at intervals along the circumference of the reaction vessel support device 120. The first stirring mechanism and the second stirring mechanism are used to stir the reaction liquid in the reaction vessel 400 at different stages. Of course, in specific applications, the mixing device 160 may also include only one of the first stirring mechanism and the second stirring mechanism.

[0034] The sample analyzer 100 includes a detection working state, a cleaning working state, and a post-cleaning preparation state. The cleaning working state is initiated by the control device 200 after receiving information that the sample analyzer 100 has completed the detection working state. The post-cleaning preparation state is initiated by the control device 200 after receiving information that the sample analyzer 100 has completed the cleaning working state and before receiving information that the next batch of samples will enter the sample analysis system. Specifically, in the detection working state, the sample analyzer 100 is mainly used to perform the item detection work on the samples; in the cleaning working state, the sample analyzer 100 is mainly used to perform a complete cleaning of the reaction vessel 400 after the sample item detection is completed, so as to clean the reaction vessel 400 thoroughly and prevent residual liquid in the reaction vessel 400 from affecting subsequent sample detection data. In the post-cleaning preparation state, the sample analyzer 100 is mainly used to perform at least partial cleaning of the reaction vessel 400 after the complete cleaning work is completed, in order to prepare for the detection of the next batch of samples and reduce the preparation time of the sample analyzer 100 when the next batch of samples enters the sample analysis system.

[0035] Specifically, in this embodiment, when the sample analyzer 100 enters the detection working state, the control device 200 controls the sample dispensing device 130 to dispense the sample into the reaction container 400 on the reaction container carrier device 120, controls the reagent dispensing device 140 to dispense the reagent into the reaction container 400, and controls the sample detection device 150 to analyze and detect the sample generated by the sample and reagent in the reaction container 400.

[0036] When the sample analyzer 100 enters the cleaning working state, the control device 200 controls the cleaning device 110 to perform a complete cleaning of the reaction container 400 after the detection working state is completed. That is, the control device 200 controls the liquid injection cleaning unit 112, the water blank detection unit 111, and the drying unit 113 to perform liquid injection cleaning, water blank detection, and drying treatment on the reaction container 400 after the detection working state is completed, respectively.

[0037] When the sample analyzer 100 enters the preparation state after cleaning, the control device 200 controls the cleaning device 110 to perform at least partial cleaning on the reaction vessel 400 after the cleaning state is completed.

[0038] The sample analysis system provided in this embodiment performs at least part of the cleaning work for the reaction vessel 400 in the sample analyzer 100 after the sample detection and complete cleaning work is completed. In this way, when the control device 200 detects that a sample has entered the sample control system and the reaction vessel 400 needs to be prepared, it can directly use the reaction vessel 400 after it has been cleaned and is ready for operation, without having to perform a complete cleaning of the reaction vessel 400. This helps to reduce the preparation time of the sample analyzer 100 and effectively improves the sample detection efficiency.

[0039] Preferably, the sample analyzer 100 further includes a first pre-detection preparation state, which is initiated by the control device 200 after acquiring information that a sample has entered the sample analysis system. When the sample analyzer 100 enters the first pre-detection preparation state, the control device 200 controls the cleaning device 110 to perform a partial cleaning operation on the reaction vessel 400 after the cleaning preparation state has been completed. The sum of at least a partial cleaning operation performed by the sample analyzer 100 on the reaction vessel 400 in the cleaning preparation state and the partial cleaning operation performed on the reaction vessel 400 in the first pre-detection preparation state is greater than or equal to a complete cleaning operation performed by the sample analyzer 100 on the reaction vessel 400 in the cleaning state. This ensures that the reaction vessel 400 is thoroughly cleaned and meets the usage requirements.

[0040] The work performed by the sample analyzer 100 in the post-cleaning preparation state and the work performed in the first pre-detection preparation state constitute the preparation work of the sample analyzer 100 before sample detection. The sample analysis system provided in this embodiment, by placing at least part of the cleaning work for the reaction vessel 400 in the sample analyzer 100 after the completion of sample detection and complete cleaning, and before the next batch of samples enters the sample analysis system, and placing the first pre-detection preparation work when the control device 200 obtains information that a sample has entered the sample analysis system, can directly control the sample analyzer 100 to enter the first pre-detection preparation state when the control device 200 obtains information that a sample requiring expedited processing has entered the sample control system, without needing to perform a complete cleaning of the reaction vessel 400. This reduces the preparation time of the sample analyzer 100 and effectively improves the sample detection efficiency.

[0041] Preferably, the control device 200 has a preset time. After the sample analyzer 100 completes the cleaning process, the control device 200 further determines whether to control the sample analyzer 100 to enter the post-cleaning preparation state based on whether the reaction container 400 has completed the detection process and requires the sample analyzer 100 to enter the cleaning process within the preset time. If the control device 200 detects that no reaction container 400 has completed the detection process and requires the sample analyzer 100 to enter the cleaning process within the preset time, the control device 200 determines and controls the sample analyzer 100 to enter the post-cleaning preparation state. That is, if no reaction vessel 400 needs to be completely cleaned within a preset time after the cleaning operation is completed, the sample analyzer 100 is controlled to enter the post-cleaning preparation state. This helps to avoid the post-cleaning preparation state from affecting the normal operation of the sample analyzer 100.

[0042] Preferably, the preset time is between 3 and 5 minutes. If the preset time is too short, the sample analyzer 100 may need to enter the cleaning state before the preparation state after cleaning is completed, thus affecting the normal operation of the sample analyzer 100. If the preset time is too long, the sample analyzer 100 may not be able to complete the preparation state after cleaning within the preset time, resulting in unnecessary waste of the sample analyzer 100's resources. A preset time between 3 and 5 minutes ensures that if no reaction vessel 400 needs to undergo complete cleaning within the preset time, the preparation state after cleaning can be completed first, facilitating full utilization of resources and preventing the need to enter the cleaning state before the preparation state is finished. Of course, in specific applications, the preset time can also be set slightly less than 3 minutes or slightly more than 5 minutes.

[0043] Preferably, when the sample analyzer 100 enters the post-cleaning preparation state, the control device 200 controls the cleaning device 110 to perform at least partial cleaning of the reaction vessel 400, including: the control device 200 controls the liquid injection cleaning unit 112 to perform at least partial liquid injection cleaning of the reaction vessel 400 after the cleaning process is completed. When the sample analyzer 100 is in the post-cleaning preparation state and / or the first pre-detection preparation state, the control device 200 also controls the water blank detection unit 111 to perform water blank detection on the reaction vessel 400 after liquid injection cleaning in the post-cleaning preparation state. In other words, during the post-cleaning preparation state, the partial cleaning work performed by the cleaning device 110 on the reaction vessel 400 under the control of the control device 200 mainly includes liquid injection cleaning of the reaction vessel 400. This liquid injection cleaning can be a complete liquid injection cleaning (all stages of liquid injection cleaning units 112 have completed the cleaning of the reaction vessel 400), or it can be only a partial liquid injection cleaning (only some stages of liquid injection cleaning units 112 have completed the cleaning of the reaction vessel 400; for example, if a complete liquid injection cleaning includes six stages of liquid injection cleaning, then partial liquid injection cleaning can only perform the first three, four, or five stages of liquid injection cleaning, etc.). However, if the liquid injection cleaning performed by the cleaning device 110 on the reaction vessel 400 under the control of the control device 200 during the post-cleaning preparation state is a complete liquid injection cleaning, then the partial cleaning work performed by the cleaning device 110 on the reaction vessel 400 under the control of the control device 200 during the post-cleaning preparation state may include not only liquid injection cleaning of the reaction vessel 400, but also water blank detection of the reaction vessel 400.

[0044] When the sample analyzer 100 is in the first pre-detection preparation state, the control device 200 controls the cleaning device 110 to perform partial cleaning work on the reaction vessel 400 after cleaning and preparation. This includes the control device 200 controlling the drying unit 113 to dry the reaction vessel 400 after cleaning and / or after water blank detection in the first pre-detection preparation state. Specifically, in the first pre-detection preparation state, the control device 200 controls the cleaning device 110 to perform at least some additional cleaning work on the reaction vessel 400, which mainly includes drying the reaction vessel 400, or may include water blank detection and drying of the reaction vessel 400, or may include partial-stage liquid injection cleaning, water blank detection, and drying of the reaction vessel 400.

[0045] As a preferred embodiment of this example, when the sample analyzer 100 enters the post-cleaning preparation state, the control device 200 controls the cleaning device 110 to perform at least part of the cleaning work on the reaction vessel 400, including: the control device 200 controls the liquid injection cleaning unit 112 to perform a complete liquid injection cleaning on the reaction vessel 400 after the cleaning work is completed, and controls the water blank detection unit 111 to perform a water blank detection on the reaction vessel 400 after the liquid injection cleaning in the post-cleaning preparation state.

[0046] When the sample analyzer 100 enters the first pre-detection preparation state, the control device 200 controls the sample analyzer 100 to perform partial cleaning work on the reaction vessel 400 after cleaning and preparation state, including: the control device 200 controls the water blank detection unit 111 to perform water blank detection on the reaction vessel 400 after cleaning and preparation state, and controls the drying unit 113 to perform drying treatment on the reaction vessel 400 after completing the water blank detection in the first pre-detection preparation state.

[0047] In a preferred embodiment of this invention, the sample analyzer 100 performs a complete liquid injection cleaning and water blank test on the reaction vessel 400 in the post-cleaning preparation state. In the pre-detection preparation state, the reaction vessel 400 undergoes water blank test and drying treatment. In this way, the water blank test in the pre-detection preparation state can further ensure that the reaction vessel 400 meets the usage requirements, and also achieve the purpose of reducing the running time of the pre-detection preparation state (at least saving the time of liquid injection cleaning).

[0048] Preferably, if the sample analyzer 100 performs water blank testing on the reaction vessel 400 in both the post-cleaning preparation state and the pre-detection preparation state, then the water blank testing performed by the sample analyzer 100 on the reaction vessel 400 in the post-cleaning preparation state is performed on each of the reaction vessels 400 individually. That is, in the post-cleaning preparation state, the sample analyzer 100 performs water blank testing on only one reaction vessel 400 per rotation of the reaction vessel support device 120. This helps to ensure the accuracy of the test. However, in the pre-detection preparation state, the water blank testing unit 1... The water blank test performed on the 11 reaction vessels 400 after cleaning and preparation is carried out in batches during one rotation of the reaction vessel support device 120. That is, during the preparation state before the first test, the sample analyzer 100 performs batch water blank tests on multiple reaction vessels 400 simultaneously during one rotation of the reaction vessel support device 120. This results in a faster testing speed. In this way, the water blank test during the preparation state before the first test can further ensure that the reaction vessels 400 meet the usage requirements and also help to further reduce the running time of the preparation state before the first test.

[0049] Preferably, the sample analyzer 100 further includes a second pre-detection preparation state. When the sample analyzer 100 enters the second pre-detection preparation state, the control device 200 controls the liquid injection cleaning unit 112, the water blank detection unit 111, and the drying unit 113 to respectively perform liquid injection cleaning on the reaction container 400 after the cleaning preparation state is completed, perform water blank detection on the reaction container 400 after the liquid injection cleaning is completed, and perform drying treatment on the reaction container 400 after the water blank detection is completed.

[0050] After the sample analyzer 100 completes cleaning and is ready for operation, and when the control device 200 detects that a sample has entered the sample analysis system, the control device 200 further determines whether to control the sample analyzer 100 to enter the first pre-detection preparation state or the second pre-detection preparation state. In specific applications, the control device 200 can determine whether to control the sample analyzer 100 to enter the first pre-detection preparation state or the second pre-detection preparation state by receiving information entered by the operator or by receiving detection feedback information from other electrical components of the sample analysis system.

[0051] Preferably, the sample analysis system further includes a sample information acquisition device 300, which is used to acquire sample information entering the sample analysis system and feed the sample information back to the control device 200. The control device 200 is used to determine whether the sample is an emergency sample based on the feedback information from the sample information acquisition device 300. Based on whether the sample is an emergency sample, the control device 200 determines whether to control the sample analyzer 100 to enter the first pre-detection preparation state or the second pre-detection preparation state. The sample information acquisition device 300 can be at least one of a button, a touch screen, or a scanning component. When the sample information acquisition device 300 is a button, the operator can manipulate the button to transmit information to the control device 200 about whether the sample is an emergency sample. For example, it can be set so that the control device 200 determines the sample as an emergency sample when the operator double-clicks the button, and determines the sample as a non-emergency sample when the operator single-clicks the button. When the sample information acquisition device 300 is a touch screen, the operator can manipulate the touch screen to transmit information to the control device 200 about whether the sample is an emergency sample. For example, the operator can input or select "emergency sample" on the touch screen. When the sample information acquisition device 300 is a scanning component, when the sample enters the sample analysis system, the scanning component scans the identification code on the sample container to transmit information to the control device 200 about whether the sample is an emergency sample. For example, the scanning component can scan the barcode or QR code on the sample container and feed the scan information back to the control device 200 to determine whether the sample is an emergency sample.

[0052] Specifically, the first pre-test preparation state is the expedited preparation channel of the sample analyzer 100, and the second pre-test preparation state is the non-expedited preparation channel of the sample analyzer 100. When the control device 200 determines that the sample is a non-emergency sample based on the feedback information from the sample information acquisition device 300, the control device 200 determines and controls the sample analyzer 100 to enter the second pre-test preparation state; when the control device 200 determines that the sample is an emergency sample based on the feedback information from the sample information acquisition device 300, the control device 200 determines and controls the sample analyzer 100 to enter the first pre-test preparation state.

[0053] Preferably, when the sample analyzer 100 enters the preparation state after cleaning, the control device 200 controls the liquid injection cleaning unit 112 and the water blank detection unit 111 to perform liquid injection cleaning on the reaction container 400 after cleaning and to perform water blank detection on the reaction container 400 after liquid injection cleaning, and records the water blank detection time of each reaction container 400; when the control device 200 determines that the sample is an emergency sample based on the feedback information from the sample information acquisition device 300, the control device 200 also determines whether to control the sample analyzer 100 to enter the first detection preparation state based on the relationship between the time when the emergency sample enters the sample analysis system and the water blank detection time recorded in the preparation state after cleaning. In this way, it can avoid failure due to the previous water blank detection time being too long, which would affect the accuracy of the sample detection results.

[0054] Preferably, the control device 200 has a preset effective time for water blank detection. If the control device 200 determines that the difference between the time when the emergency sample enters the sample analysis system and the water blank detection time in the preparation state after cleaning does not exceed the effective time, the control device 200 determines that the water blank detection in the preparation state after cleaning is valid and controls the sample analyzer 100 to enter the first pre-detection preparation state, that is, the sample analyzer 100 only performs partial cleaning. If the control device 200 determines that the difference between the time when the emergency sample enters the sample analysis system and the water blank detection time in the preparation state after cleaning exceeds the effective time, the control device 200 determines that the water blank detection in the preparation state after cleaning is invalid and controls the sample analyzer 100 to enter the second pre-detection preparation state, that is, the sample analyzer 100 still needs to perform complete cleaning.

[0055] Preferably, the effective time is taken within 3 to 24 hours. Theoretically, the shorter the effective time, the more reliable the water blank detection value in the preparation state after cleaning; however, if the effective time is too short, it is easy to have the water blank detection value of the reaction vessel 400 in the preparation state after cleaning still be valid, but be judged as invalid, resulting in repeated cleaning work. In this embodiment, the effective time is set within 3 to 24 hours, which is beneficial to ensure the timeliness of water blank detection and to reduce unnecessary repeated cleaning work. Of course, in specific applications, the effective time is not limited to 3 to 24 hours. For example, it can also be set slightly shorter than 3 hours or slightly longer than 24 hours.

[0056] More preferably, the effective time is taken within 6 to 12 hours, which yields better overall results. As a preferred embodiment of this invention, the effective time preset in the control device 200 is 6 hours.

[0057] Preferably, when the sample analyzer 100 enters the preparation state after cleaning, the control device 200 controls the liquid injection cleaning unit 112 and the water blank detection unit 111 to perform liquid injection cleaning and water blank detection on the reaction container 400 after cleaning, and records the first water blank detection value of each reaction container 400; in the preparation state before the first detection, the control device 200 also controls the water blank detection unit 111 to perform water blank detection on the reaction container 400 after cleaning, and records the second water blank detection value of each reaction container 400; when the control device 200 determines that the sample is an emergency sample based on the feedback information from the sample information acquisition device 300, the control device 200 also determines whether to control the sample analyzer 100 to enter the preparation state before the first detection based on the relationship between the first water blank detection value and the second water blank detection value. This helps to avoid excessive changes in the water blank detection values ​​before and after the reaction container 400, which could affect the accuracy of the detection results.

[0058] Preferably, the control device 200 has a preset threshold for the difference between the first water blank detection value and the second water blank detection value. If the control device 200 determines that the difference between the first water blank detection value and the second water blank detection value is less than or equal to the threshold, it determines that the reaction vessel 400 can be used and controls the sample analyzer 100 to enter the first detection preparation state. If the control device 200 determines that the difference between the first water blank detection value and the second water blank detection value is greater than the threshold, it determines that the reaction vessel 400 cannot be used and controls the sample analyzer 100 to stop using the reaction vessel 400. This helps to avoid the reaction vessel 400 that does not meet the usage requirements from being used and affecting the accuracy of the detection results.

[0059] Preferably, the threshold is set between 1% and 2% of the first water blank detection value. Setting the threshold within this range ensures that all reaction vessels 400 meeting the usage requirements are fully utilized, while also preventing the use of non-compliant vessels that could affect the accuracy of the detection results. Of course, in specific applications, the threshold range is not limited to this; for example, it can be set slightly smaller than 1% of the first water blank detection value, or slightly larger than 2% of the first water blank detection value.

[0060] Preferably, the sample analysis system further includes a sample scheduling device 500 and a scanning device 600. The sample scheduling device 500 includes a sample loading area 510, a sample unloading area 520, a scanning position 530, a sampling position 540, and a sample carrier transport mechanism (not shown). The sample loading area 510 is used to place the sample carrier loaded with the sample to be tested. The sample unloading area 520 is used to unload the sample carrier after sampling. The sample carrier transport mechanism is used to drive the sample carrier from the sample loading area 510 to the scanning position 530, to drive the sample carrier from the scanning position 530 to the sampling position 540, and to drive the sample carrier from the sampling position 540 to the sample unloading area 520.

[0061] The sample dispensing device 130 is used to aspirate samples from the sample carrier rack at the aspiration position 540 and dispense them into the reaction vessel 400 on the sample carrier device;

[0062] The number of sample analyzers 100 is one or more, and the sample scheduling device 500 includes a number of sampling positions 540 that are the same as the number of sample analyzers 100, and each sampling position 540 is set up one-to-one with each sample analyzer 100.

[0063] The sample scheduling device 500 is used to automatically schedule samples to ensure continuous testing of the sample analysis system. When a sample enters the sample analysis system, it is first placed in the sample loading area 510 of the sample scheduling device 500, then scheduled to the scanning position 530. After being scanned by the scanning device 600 to obtain relevant sample information, it is scheduled to the sample suction position 540. After being suctioned by the sample dispensing device 130, it is then scheduled to the sample unloading area 520 for unloading.

[0064] In a preferred embodiment of this invention, the sample analysis system includes two or more sample analyzers 100, with each sample analyzer 100 having a corresponding sampling position 540 distributed between the sample loading area 510 and the sample unloading area 520 of the sample scheduling device 500. The control device 200 will only activate the corresponding sample analyzer 100 when it detects a sample belonging to the target sample analyzer 100, allowing the analyzer 100 to perform preparation work and enter the detection state. This avoids frequently activating unused sample analyzers 100 after samples not belonging to a specific analyzer 100 are placed on the sample scheduling device 500, effectively reducing waste of sample analyzer consumables and interference unrelated to the sample analysis system.

[0065] Preferably, when the control device 200 determines that the sample is an emergency sample based on the feedback information from the sample information acquisition device 300, the control device 200 controls the activation of all sample analyzers 100 (i.e., the activation of all sample analyzers 100 for detection preparation, including instrument reset, reset check and component confirmation, water supply preparation and vacuum preparation, etc.), and controls the sample carrier transport mechanism to transport the sample carrier carrying the sample to the scanning position 530. The control device 200 controls the scanning device 600 to scan the sample located at the scanning position 530 and feeds back the scanning data to the control device 200. The control device 200 determines the sample detection item information based on the scanning data of the scanning device 600, and confirms the sample analyzer 100 that is closest to the scanning position 530 and can perform the sample detection items as the target analyzer. The control device 200 controls the sample carrier transport mechanism to transport the sample carrier carrying the sample from the scanning position 530 to the sampling position 540 corresponding to the target analyzer. In this implementation scheme, when the sample is confirmed to be an emergency sample, all sample analyzers 100 are immediately started, and the sample scheduling device 500 is controlled to schedule the sample to the sampling position 540 of the target analyzer according to the fastest path. During the sample scheduling process, the target analyzer is simultaneously controlled to immediately perform the cleaning and preparation work of the reaction vessel 400, so as to achieve the purpose of quickly scheduling emergency samples and quickly starting the target analyzer.

[0066] When the control device 200 determines that the sample is a non-emergency sample based on the feedback information from the sample information acquisition device 300, the control device 200 controls the sample carrier transport mechanism to transport the sample carrier carrying the sample to the scanning position 530. The control device 200 controls the scanning device 600 to scan the sample located at the scanning position 530 and feeds back the scanning data to the control device 200. The control device 200 determines the test item information of the sample based on the scanning data of the scanning device 600, and confirms the sample analyzer 100 that is closest to the scanning position 530 and can perform the test items of the sample as the target analyzer. The control device 200 controls the sample carrier transport mechanism to transport the sample carrier carrying the sample from the scanning position 530 to the sampling position 540 corresponding to the target analyzer, and controls the start of the target analyzer. In this implementation plan, when a sample is confirmed to be a non-emergency sample, no sample analyzer 100 is immediately started. Instead, after obtaining the sample's testing information, the plan with the shortest testing time for the sample is selected and the sample is scheduled. At the same time, the preparation work of the target analyzer is started (such as instrument reset, reset check and component confirmation, water supply preparation, vacuum preparation, cleaning and preparation of reaction vessel 400, etc.) in order to achieve the purpose of quickly scheduling samples and quickly starting the target analyzer.

[0067] Furthermore, referring to Figure 1 , Figure 2 and Figure 4 As shown, this embodiment also provides a method for preparing the reaction vessel 400 of a sample analysis system, which includes the following steps:

[0068] Cleaning step S10 includes: controlling the cleaning device 110 to perform a complete cleaning of the reaction vessel 400 after the test is completed.

[0069] The post-cleaning preparation step S20 is initiated after the sample analyzer 100 has completed the cleaning step S10 and before the next batch of samples enters the sample analysis system. The post-cleaning preparation step S20 includes controlling the cleaning device 110 to perform at least partial cleaning on the reaction vessel 400 after the cleaning work is completed.

[0070] The sample analysis system reaction vessel 400 preparation method provided in this embodiment cleans the reaction vessel 400 after the detection items are completed through cleaning step S10. After the sample analyzer 100 has completed the cleaning process and before the next batch of samples enters the sample analysis system, the cleaning device 110 is controlled to perform at least partial cleaning of the reaction vessel 400 after cleaning step S10 through post-cleaning preparation step S20. In this way, when the next batch of samples enters the sample analysis system, it is not necessary to perform a complete cleaning of the reaction vessel 400, thereby reducing the preparation time of the sample analyzer 100 and effectively improving the sample detection efficiency.

[0071] Preferably, the method for preparing the reaction vessel for the sample analysis system further includes the following steps:

[0072] The sample information acquisition step S30 includes: acquiring information about the sample entering the sample analysis system;

[0073] The first pre-detection preparation step S40 is carried out after the information that a sample has entered the sample analysis system is obtained in the sample information acquisition step S30. The first pre-detection preparation step S40 includes: controlling the cleaning device 110 to perform partial cleaning work on the reaction vessel 400 after the cleaning preparation step S20 is completed.

[0074] The sum of the partial cleaning of the reaction vessel 400 in the first pre-detection preparation step S40 and the partial cleaning in the post-cleaning preparation step S20 is greater than or equal to a complete cleaning of the reaction vessel 400 in the cleaning step S10.

[0075] When the control device 200 receives a sample that needs expedited processing and enters the sample analysis system, it can directly control the sample analyzer 100 to enter the first pre-detection preparation step S40 without having to perform a complete cleaning of the reaction container 400. This helps to reduce the preparation time of the sample analyzer 100 and effectively improves the sample detection efficiency.

[0076] Preferably, the cleaning preparation step S20, which involves cleaning the reaction vessel 400 after cleaning step S10, includes controlling the liquid injection cleaning unit 112 to perform at least partial liquid injection cleaning on the reaction vessel 400 after cleaning step S10.

[0077] As a preferred embodiment of this example, the cleaning preparation step S20 includes at least a partial cleaning of the reaction vessel 400 after the cleaning step S10, which includes: controlling the liquid injection cleaning unit 112 to perform a complete liquid injection cleaning of the reaction vessel 400 after the cleaning step S10, controlling the water blank detection unit 111 to perform a water blank detection of the reaction vessel 400 after the complete liquid injection cleaning, and recording the water blank detection time and the first water blank detection value of each reaction vessel 400.

[0078] Preferably, the reaction vessel preparation method of the sample analysis system provided in this embodiment further includes a time validity judgment step between the sample information acquisition step S30 and the first pre-detection preparation step S40: judging whether the difference between the time when the sample enters the sample analysis system and the water blank detection time in the post-cleaning preparation step S20 exceeds a preset valid time; if the difference between the time when the sample enters the sample analysis system and the water blank detection time in the post-cleaning preparation step S20 does not exceed the preset valid time, then the water blank detection in the post-cleaning preparation step S20 is determined to be valid, and the sample analyzer 100 is controlled to enter the first pre-detection preparation working state; and if the control device 200 judges that the difference between the time when the sample enters the sample analysis system and the water blank detection time in the post-cleaning preparation step S20 exceeds the valid time, then the control device 200 judges that the water blank detection in the post-cleaning preparation step S20 is invalid, and the sample analyzer 100 is controlled to enter the second pre-detection preparation step S50.

[0079] Preferably, the second pre-detection preparation step S50 includes: controlling the cleaning device 110 to perform a complete cleaning of the reaction vessel 400 after the cleaning preparation step S20, that is: controlling the liquid injection cleaning unit 112, the water blank detection unit 111 and the drying unit 113 to perform liquid injection cleaning, water blank detection on the reaction vessel 400 after the cleaning preparation step S20, and drying treatment on the reaction vessel 400 after the water blank detection, respectively.

[0080] Preferably, the partial cleaning work performed on the reaction vessel 400 after the cleaning preparation step S20 in the first pre-detection preparation step S40 includes: controlling the water blank detection unit 111 to perform water blank detection on the reaction vessel 400 after the cleaning preparation step S20, and recording the second water blank detection value of each reaction vessel 400, and determining the relationship between the difference between the first water blank detection value and the second water blank detection value and the threshold; if it is determined that the difference between the first water blank detection value and the second water blank detection value is less than or equal to the threshold, then it is determined that the reaction vessel 400 can be used, and the drying unit 113 is controlled to dry the reaction vessel 400; if the control device 200 determines that the difference between the first water blank detection value and the second water blank detection value is greater than the threshold, then it is determined that the reaction vessel 400 cannot be used, and the control device skips the reaction vessel 400 and no longer uses the reaction vessel 400.

[0081] As a preferred embodiment of this invention, the working principle of the sample analysis system is as follows:

[0082] After all reaction vessels 400 are prepared for each batch, the cleaning device 110 continues to clean the reaction vessels 400 (i.e., the sample analyzer 100 enters the post-cleaning preparation state). These reaction vessels 400 undergo only liquid injection cleaning and water blank testing. The liquid injection cleaning of the reaction vessels 400 includes cleaning agent injection cleaning and water injection cleaning, without performing the vacuuming action of the reaction vessels 400, to ensure that the reaction vessels 400 retain the water used for the water blank test at the beginning of the next batch of tests. This action allows for advance preparation of the reaction vessels 400 for the start of the next batch of tests. During water blank testing, after determining whether the water blank value of the reaction vessel 400 is usable, it is necessary to record the reaction vessels 400 a1, a2, a3... that have passed the water blank test, the first water blank test values ​​AD1, AD2, AD3... of the reaction vessels 400, and the time of the water blank test.

[0083] After the control device 200 determines the presence of an emergency sample and quickly starts the sample analyzer 100, the control device 200 first determines whether the difference between the sample entry time and the water blank detection time performed in the post-cleaning preparation state exceeds the valid water blank detection time. If it exceeds the valid time, the previous water blank detection is considered invalid, and the reaction vessel 400 still needs to be cleaned according to the normal cleaning method (i.e., complete cleaning work) without expedited processing. If the difference between the sample entry time and the water blank detection time performed in the post-cleaning preparation state is less than or equal to the valid time, the previous water blank detection value is considered valid. The sample analyzer 100 rotates the reaction vessel 400 that was prepared last in the previous batch of tests to the vicinity of the photoelectric acquisition position of the water blank detection unit 111, performs reaction disk rotation and performs photoelectric acquisition, and acquires and obtains the new water blank detection value (i.e., the second water blank detection value) AD of the previously prepared reaction vessel 400. 01 AD 02 AD 03 ... Determine AD 01 AD 02 AD 03 The relative difference between AD1, AD2, AD3, etc., is considered significant if it exceeds a threshold. If the relative difference exceeds a threshold, the water blank detection value of reaction vessel 400 is deemed unusable and skipped. If the relative difference is less than or equal to the threshold, the water blank detection value of reaction vessel 400 is considered acceptable and used directly for absorbance calculation. Afterward, following a cyclical progression, only two more vacuum cycles are needed to complete the preparation of the first reaction vessel 400. Compared to existing technologies requiring two stages of cleaning agent injection, five stages of clean water injection, and two stages of vacuum treatment, this method ensures that the transmittance (water blank) of reaction vessel 400 meets requirements while maintaining consistency between residual water in the reaction vessel 400 and that of normal testing. Furthermore, the cleaning process consumes only about 22% of the time required in existing technologies, significantly improving the preparation efficiency of reaction vessel 400.

[0084] Example 2:

[0085] The main difference between the sample analysis system and the reaction vessel preparation method of the sample analysis system provided in this embodiment and that in Embodiment 1 is that the cleaning work performed by the sample analyzer 100 in the post-cleaning preparation state and the pre-detection preparation state is different.

[0086] Specifically, in this embodiment, when the sample analyzer 100 enters the post-cleaning preparation state, the control device 200 controls the cleaning device 110 to perform at least part of the cleaning work on the reaction vessel 400, including: the control device 200 controls the liquid injection cleaning unit 112 to perform a complete liquid injection cleaning on the reaction vessel 400 after the cleaning work is completed, and controls the water blank detection unit 111 to perform water blank detection on the reaction vessel 400 after the liquid injection cleaning in the post-cleaning preparation state.

[0087] When the sample analyzer 100 enters the first pre-detection preparation state, the control device 200 controls the sample analyzer 100 to perform partial cleaning work on the reaction vessel 400 after cleaning and preparation state, including: the control device 200 controls the drying unit 113 to dry the reaction vessel 400 after water blank detection after cleaning and preparation state.

[0088] In this embodiment, the sample analyzer 100 only performs water blank detection in the preparation state after cleaning, and does not perform water blank detection in the preparation state before the first detection; in the preparation state before the first detection, the sample analyzer 100 only controls the drying unit 113 to dry the reaction vessel 400 after the preparation state after cleaning is completed.

[0089] Apart from the differences mentioned above, the configuration schemes of other parts of the sample analysis system and the reaction vessel preparation method of the sample analysis system provided in this embodiment can be optimized and designed with reference to Embodiment 1, and will not be described in detail here.

[0090] Example 3:

[0091] The main difference between the sample analysis system and the sample analysis system reaction vessel preparation method provided in this embodiment and those in Embodiments 1 and 2 is that the cleaning work performed by the sample analyzer 100 in the post-cleaning preparation state and the pre-detection preparation state are different.

[0092] Specifically, in this embodiment, when the sample analyzer 100 enters the preparation state after cleaning, the control device 200 controls the cleaning device 110 to perform at least part of the cleaning work on the reaction vessel 400, including: the control device 200 controls the liquid injection cleaning unit 112 to perform a complete liquid injection cleaning work on the reaction vessel 400 after the cleaning work is completed.

[0093] When the sample analyzer 100 enters the first pre-detection preparation state, the control device 200 controls the sample analyzer 100 to perform partial cleaning work on the reaction vessel 400 after cleaning and preparation state, including: the control device 200 controls the liquid injection cleaning unit 112 to perform the final liquid injection cleaning work on the reaction vessel 400 after cleaning and preparation state, controls the water blank detection unit 111 to perform water blank detection on the reaction vessel 400 after completing the final liquid injection cleaning work, and controls the drying unit 113 to perform drying treatment on the reaction vessel 400 after completing the water blank detection in the first pre-detection preparation state.

[0094] In this embodiment, the sample analyzer 100 performs only a complete liquid injection cleaning process in the post-cleaning preparation state, without performing a water blank test. In the first detection preparation state, the sample analyzer 100 first performs a final liquid injection cleaning process on the reaction vessel 400 after the post-cleaning preparation state, then controls the water blank test unit 111 to perform a water blank test on the reaction vessel 400 after the final liquid injection cleaning process, and finally controls the drying unit 113 to dry the reaction vessel 400 after the water blank test in the first detection preparation state.

[0095] Apart from the differences mentioned above, the configuration schemes of other parts of the sample analysis system and the reaction vessel preparation method of the sample analysis system provided in this embodiment can be optimized and designed with reference to Embodiment 1, and will not be described in detail here.

[0096] Example 4:

[0097] The main difference between the sample analysis system and the reaction vessel preparation method of the sample analysis system provided in this embodiment and those in embodiments one to three is that the cleaning work performed by the sample analyzer 100 in the post-cleaning preparation state and the pre-detection preparation state are different.

[0098] Specifically, in this embodiment, when the sample analyzer 100 enters the preparation state after cleaning, the control device 200 controls the cleaning device 110 to perform at least part of the cleaning work on the reaction vessel 400, including: the control device 200 controls the liquid injection cleaning unit 112 to perform a complete liquid injection cleaning work on the reaction vessel 400 after the cleaning work is completed.

[0099] When the sample analyzer 100 enters the first pre-detection preparation state, the control device 200 controls the sample analyzer 100 to perform partial cleaning work on the reaction vessel 400 after cleaning and preparation state, including: the control device 200 controls the water blank detection unit 111 to perform water blank detection on the reaction vessel 400 after cleaning and preparation state, and controls the drying unit 113 to perform drying treatment on the reaction vessel 400 after water blank detection in the first pre-detection preparation state.

[0100] Similar to Embodiment 3, in this embodiment, the sample analyzer 100 only performs a complete liquid injection cleaning process in the preparation state after cleaning, without performing a water blank test. However, unlike Embodiment 3, in this embodiment, the sample analyzer 100 directly controls the water blank detection unit 111 to perform a water blank test on the reaction vessel 400 after the preparation state following cleaning in the first pre-detection preparation state, and then controls the drying unit 113 to dry the reaction vessel 400 after the water blank test in the first pre-detection preparation state; that is, in this embodiment, the sample analyzer 100 does not perform the final liquid injection cleaning process on the reaction vessel 400 after the preparation state following cleaning in the first pre-detection preparation state before performing the water blank test.

[0101] Apart from the differences mentioned above, the configuration schemes of other parts of the sample analysis system and the reaction vessel preparation method of the sample analysis system provided in this embodiment can be optimized and designed with reference to Embodiment 1, and will not be described in detail here.

[0102] Example 5:

[0103] The main difference between the sample analysis system and the reaction vessel preparation method of the sample analysis system provided in this embodiment and those in embodiments one to four is that the cleaning work performed by the sample analyzer 100 in the post-cleaning preparation state and the pre-detection preparation state are different.

[0104] Specifically, in this embodiment, when the sample analyzer 100 enters the preparation state after cleaning, the control device 200 controls the cleaning device 110 to perform at least part of the cleaning work on the reaction vessel 400, including: the control device 200 controls the liquid injection cleaning unit 112 to perform partial liquid injection cleaning work on the reaction vessel 400 after the cleaning work is completed.

[0105] When the sample analyzer 100 enters the first pre-detection preparation state, the control device 200 controls the sample analyzer 100 to perform partial cleaning of the reaction vessel 400 after cleaning preparation. This includes: the control device 200 controls the liquid injection cleaning unit 112 to perform partial liquid injection cleaning of the reaction vessel 400 after cleaning preparation; the control device 200 controls the water blank detection unit 111 to perform water blank detection of the reaction vessel 400 after liquid injection cleaning; and the control device 113 to perform drying treatment on the reaction vessel 400 after the water blank detection in the first pre-detection preparation state. The sum of the partial liquid injection cleaning performed by the cleaning device 110 on the reaction vessel 400 in the cleaning preparation state and the partial cleaning performed by the cleaning device 110 on the reaction vessel 400 in the first pre-detection preparation state is greater than or equal to the sum of the partial liquid injection cleaning performed by the liquid injection cleaning unit 112 controlled by the control device 200 on the reaction vessel 400 after cleaning preparation.

[0106] Apart from the differences mentioned above, the configuration schemes of other parts of the sample analysis system and the preparation method of the reaction vessel 400 of the sample analysis system provided in this embodiment can be optimized and designed with reference to Embodiment 1, and will not be described in detail here.

[0107] The above description is merely a preferred embodiment of the present invention and does not limit the patent scope of the present invention. Any equivalent structural transformations made using the contents of the present invention's specification and drawings under the inventive concept of the present invention, or direct / indirect applications in other related technical fields, are included within the patent protection scope of the present invention.

Claims

1. A sample analysis system, characterized in that: It includes a sample analyzer and a control device, wherein the sample analyzer includes a reaction vessel support device, a sample dispensing device, a reagent dispensing device, a sample detection device, and a cleaning device; The sample analyzer includes a detection working state, a cleaning working state, and a post-cleaning preparation state. When the sample analyzer enters the detection working state, the control device controls the sample dispensing device to dispense the sample into the reaction container on the reaction container carrier, controls the reagent dispensing device to dispense the reagent into the reaction container, and controls the sample detection device to analyze and detect the sample generated by the sample and the reagent in the reaction container. When the sample analyzer enters the cleaning working state, the control device controls the cleaning device to perform a complete cleaning of the reaction vessel after the detection working state is completed; The post-cleaning preparation state is when the control device starts the process after obtaining information that the sample analyzer has completed the cleaning process and before obtaining information that the next batch of samples will enter the sample analysis system; when the sample analyzer enters the post-cleaning preparation state, the control device controls the cleaning device to perform at least partial cleaning on the reaction vessel after the cleaning process has been completed. The sample analyzer also includes a first pre-detection preparation state, which is initiated by the control device after acquiring information that a sample has entered the sample analysis system. When the sample analyzer enters the first pre-detection preparation state, the control device controls the cleaning device to perform partial cleaning of the reaction vessel after the cleaning preparation state has been completed.

2. The sample analysis system as described in claim 1, characterized in that: The sum of the at least partial cleaning performed by the sample analyzer on the reaction vessel in the post-cleaning preparation state and the partial cleaning performed on the reaction vessel in the first pre-detection preparation state is greater than or equal to a complete cleaning operation performed by the sample analyzer on the reaction vessel in the cleaning state.

3. The sample analysis system as described in claim 2, characterized in that: The cleaning device includes a water blank detection unit, at least one liquid injection cleaning unit, and at least one drying unit; When the sample analyzer enters the cleaning working state, the control device controls the cleaning device to perform the complete cleaning work on the reaction vessel, including: the control device controls the liquid injection cleaning unit, the water blank detection unit and the drying unit to respectively perform liquid injection cleaning on the reaction vessel after completing the detection working state, perform water blank detection on the reaction vessel after completing the liquid injection cleaning, and perform drying treatment on the reaction vessel after completing the water blank detection; When the sample analyzer enters the post-cleaning preparation state, the control device controls the cleaning device to perform at least partial cleaning work on the reaction vessel, which includes: the control device controls the liquid injection cleaning unit to perform at least partial liquid injection cleaning work on the reaction vessel after the cleaning work state is completed. When the sample analyzer is in the post-cleaning preparation state and / or the first pre-detection preparation state, the control device also controls the water blank detection unit to perform water blank detection on the reaction vessel after liquid injection cleaning in the post-cleaning preparation state. When the sample analyzer is in the first pre-detection preparation state, the partial cleaning work performed by the cleaning device on the reaction vessel after the cleaning preparation state includes: the control device controlling the drying unit to dry the reaction vessel after the water blank test and / or the water blank test after the first pre-detection preparation state.

4. The sample analysis system as described in claim 3, characterized in that: When the sample analyzer enters the post-cleaning preparation state, the control device controls the cleaning device to perform at least part of the cleaning work on the reaction vessel, including: the control device controls the liquid injection cleaning unit to perform a complete liquid injection cleaning on the reaction vessel after completing the cleaning work state, and controls the water blank detection unit to perform water blank detection on the reaction vessel after completing the liquid injection cleaning in the post-cleaning preparation state. When the sample analyzer enters the first pre-detection preparation state, the partial cleaning work performed by the sample analyzer after the completion of the cleaning preparation state includes: the control device controls the drying unit to perform drying treatment on the reaction vessel after the completion of the water blank test in the cleaning preparation state.

5. The sample analysis system as described in claim 3, characterized in that: When the sample analyzer enters the post-cleaning preparation state, the control device controls the cleaning device to perform at least part of the cleaning work on the reaction vessel, including: the control device controls the liquid injection cleaning unit to perform a complete liquid injection cleaning on the reaction vessel after completing the cleaning work state, and controls the water blank detection unit to perform water blank detection on the reaction vessel after completing the liquid injection cleaning in the post-cleaning preparation state. When the sample analyzer enters the first pre-detection preparation state, the control device controls the sample analyzer to perform the partial cleaning work on the reaction vessel after completing the cleaning preparation state, including: the control device controls the water blank detection unit to perform water blank detection on the reaction vessel after completing the water blank detection in the cleaning preparation state, and controls the drying unit to perform drying treatment on the reaction vessel after completing the water blank detection in the first pre-detection preparation state.

6. The sample analysis system as described in claim 3, characterized in that: When the sample analyzer enters the post-cleaning preparation state, the control device controls the cleaning device to perform at least part of the cleaning work on the reaction vessel, including: the control device controls the liquid injection cleaning unit to perform a complete liquid injection cleaning work on the reaction vessel after the cleaning work state is completed. When the sample analyzer enters the first pre-detection preparation state, the control device controls the sample analyzer to perform the partial cleaning work on the reaction vessel after completing the cleaning preparation state, including: the control device controls the liquid injection cleaning unit to perform the final liquid injection cleaning work on the reaction vessel after completing the cleaning preparation state, controls the water blank detection unit to perform water blank detection on the reaction vessel after completing the final liquid injection cleaning work, and controls the drying unit to perform drying treatment on the reaction vessel after completing the water blank detection in the first pre-detection preparation state.

7. The sample analysis system as described in claim 3, characterized in that: When the sample analyzer enters the post-cleaning preparation state, the control device controls the cleaning device to perform at least part of the cleaning work on the reaction vessel, including: the control device controls the liquid injection cleaning unit to perform a complete liquid injection cleaning work on the reaction vessel after the cleaning work state is completed. When the sample analyzer enters the first pre-detection preparation state, the control device controls the sample analyzer to perform the partial cleaning work on the reaction vessel after completing the cleaning preparation state, including: the control device controls the water blank detection unit to perform water blank detection on the reaction vessel after completing the cleaning preparation state, and controls the drying unit to perform drying treatment on the reaction vessel after completing the water blank detection in the first pre-detection preparation state.

8. The sample analysis system as described in claim 3, characterized in that: When the sample analyzer enters the post-cleaning preparation state, the control device controls the cleaning device to perform at least part of the cleaning work on the reaction vessel, which includes: the control device controls the liquid injection cleaning unit to perform partial liquid injection cleaning work on the reaction vessel after the cleaning work state is completed. When the sample analyzer enters the first pre-detection preparation state, the control device controls the sample analyzer to perform the partial cleaning work on the reaction vessel after completing the cleaning preparation state, including: the control device controls the liquid injection cleaning unit to perform partial liquid injection cleaning on the reaction vessel after completing the cleaning preparation state, controls the water blank detection unit to perform water blank detection on the reaction vessel after completing the partial liquid injection cleaning work in the first pre-detection preparation state, and controls the drying unit to perform drying treatment on the reaction vessel after completing the water blank detection in the first pre-detection preparation state.

9. The sample analysis system as described in claim 3 or 5, characterized in that: The sample analyzer also includes a second pre-detection preparation state. When the sample analyzer enters the second pre-detection preparation state, the control device controls the liquid injection cleaning unit, the water blank detection unit, and the drying unit to respectively perform liquid injection cleaning, water blank detection, and drying treatment on the reaction container after completing the cleaning preparation state. After the sample analyzer completes the cleaning and preparation state, and when the control device obtains information that a sample has entered the sample analysis system, the control device is further configured to determine whether to control the sample analyzer to enter the first pre-detection preparation state or to control the sample analyzer to enter the second pre-detection preparation state.

10. The sample analysis system as described in claim 9, characterized in that: The sample analysis system further includes a sample information acquisition device, which is used to acquire sample information entering the sample analysis system and feed the acquired sample information back to the control device. The control device is used to determine whether the sample is an emergency sample based on the feedback information from the sample information acquisition device. The control device determines whether to control the sample analyzer to enter the first pre-detection preparation state or the second pre-detection preparation state based on whether the sample is an emergency sample.

11. The sample analysis system as described in claim 10, characterized in that: When the control device determines that the sample is a non-emergency sample based on the feedback information from the sample information acquisition device, the control device determines and controls the sample analyzer to enter the second pre-detection preparation state. When the control device determines that the sample is an emergency sample based on the feedback information from the sample information acquisition device, the control device determines and controls the sample analyzer to enter the first pre-detection preparation state.

12. The sample analysis system as described in claim 11, characterized in that: When the sample analyzer enters the preparation state after cleaning, the control device controls the liquid injection cleaning unit and the water blank detection unit to respectively perform liquid injection cleaning on the reaction vessel after completing the cleaning state, and perform water blank detection on the reaction vessel after completing the liquid injection cleaning, and record the water blank detection time of each reaction vessel. When the control device determines that the sample is an emergency sample based on the feedback information from the sample information acquisition device, the control device also determines whether to control the sample analyzer to enter the first pre-detection preparation state based on the relationship between the time when the emergency sample enters the sample analysis system and the water blank detection time recorded in the post-cleaning preparation state.

13. The sample analysis system as described in claim 12, characterized in that: The control device has a preset effective time for water blank detection; If the control device determines that the difference between the time when the emergency sample enters the sample analysis system and the water blank detection time in the post-cleaning preparation state does not exceed the effective time, then the control device determines that the water blank detection in the post-cleaning preparation state is effective and controls the sample analyzer to enter the first pre-detection preparation state. If the control device determines that the difference between the time when the emergency sample enters the sample analysis system and the water blank detection time in the post-cleaning preparation state exceeds the effective time, the control device determines that the water blank detection in the post-cleaning preparation state is invalid and controls the sample analyzer to enter the second pre-detection preparation state.

14. The sample analysis system as described in claim 13, characterized in that: The effective time is taken from 3 hours to 24 hours.

15. The sample analysis system as described in claim 14, characterized in that: The effective time is taken within 6 to 12 hours.

16. The sample analysis system as described in claim 11, characterized in that: When the sample analyzer enters the preparation state after cleaning, the control device controls the liquid injection cleaning unit and the water blank detection unit to respectively perform liquid injection cleaning on the reaction container after completing the cleaning state, and perform water blank detection on the reaction container after completing the liquid injection cleaning, and record the first water blank detection value of each reaction container. In the first pre-detection preparation state, the control device also controls the water blank detection unit to perform water blank detection on the reaction vessel after the cleaning preparation state is completed, and records the second water blank detection value of each reaction vessel. When the control device determines that the sample is an emergency sample based on the feedback information from the sample information acquisition device, the control device also determines whether to control the sample analyzer to enter the first detection preparation state based on the relationship between the first water blank detection value and the second water blank detection value.

17. The sample analysis system as described in claim 16, characterized in that: The control device is pre-set with a threshold for the difference between the first water blank detection value and the second water blank detection value; If the control device determines that the difference between the first water blank detection value and the second water blank detection value is less than or equal to the threshold, it determines that the reaction vessel can be used and controls the sample analyzer to enter the first detection preparation state. If the control device determines that the difference between the first water blank detection value and the second water blank detection value is greater than the threshold, it determines that the reaction vessel cannot be used and controls the sample analyzer to stop using the reaction vessel.

18. The sample analysis system as described in claim 17, characterized in that: The threshold value is taken between 1% and 2% of the first water blank detection value.

19. The sample analysis system according to any one of claims 5 or 16 to 18, characterized in that: In the first pre-detection preparation state, the water blank detection unit performs water blank detection on the reaction vessel after the cleaning and preparation state is completed in batches during one rotation of the reaction vessel support device.

20. The sample analysis system according to any one of claims 1 to 8 or any one of claims 10 to 18, characterized in that: The control device has a preset time; After the sample analyzer completes the cleaning process, the control device further determines whether to control the sample analyzer to enter the post-cleaning preparation state based on whether a reaction vessel has completed the detection process within the preset time and the sample analyzer needs to enter the cleaning process. If the control device detects that no reaction vessel has completed the detection process within the preset time and the sample analyzer needs to enter the cleaning process, the control device determines and controls the sample analyzer to enter the post-cleaning preparation state.

21. The sample analysis system according to any one of claims 10 to 18, characterized in that: The sample analysis system further includes a sample scheduling device and a scanning device. The sample scheduling device includes a sample loading area, a sample unloading area, a scanning position, a sampling position, and a sample carrier transport mechanism. The sample loading area is used to place the sample carrier loaded with the sample to be tested. The sample unloading area is used to unload the sample carrier after sampling. The sample carrier transport mechanism is used to drive the sample carrier from the sample loading area to the scanning position, to drive the sample carrier from the scanning position to the sampling position, and to drive the sample carrier from the sampling position to the sample unloading area. The sample dispensing device is used to draw samples from the sample carrier at the aspiration position and dispense them into the reaction vessel on the sample carrier device; The number of sample analyzers is two or more, and the sample scheduling device includes a number of sampling positions equal to the number of sample analyzers, with each sampling position and each sample analyzer being respectively matched one-to-one; When the control device determines that the sample is an emergency sample based on the feedback information from the sample information acquisition device, the control device controls the activation of all the sample analyzers and controls the sample carrier transport mechanism to transport the sample carrier carrying the sample to the scanning position. The control device controls the scanning device to scan the sample located at the scanning position and feeds back the scanning data to the control device. The control device determines the detection item information of the sample based on the scanning data of the scanning device and identifies the sample analyzer that is closest to the scanning position and capable of performing the detection items of the sample as the target analyzer. The control device controls the sample carrier transport mechanism to transport the sample carrier carrying the sample from the scanning position to the sampling position corresponding to the target analyzer. When the control device determines that the sample is a non-emergency sample based on the feedback information from the sample information acquisition device, the control device controls the sample carrier transport mechanism to transport the sample carrier carrying the sample to the scanning position. The control device controls the scanning device to scan the sample located at the scanning position and feeds back the scanning data to the control device. The control device determines the detection item information of the sample based on the scanning data of the scanning device, and confirms the sample analyzer that is closest to the scanning position and capable of performing the detection items of the sample as the target analyzer. The control device controls the sample carrier transport mechanism to transport the sample carrier carrying the sample from the scanning position to the sampling position corresponding to the target analyzer, and controls the start of the target analyzer.

22. A method for preparing a reaction vessel for a sample analysis system, characterized in that: Includes the following steps: The cleaning step includes: controlling the cleaning device to perform a complete cleaning of the reaction vessel after the test is completed; The post-cleaning preparation step is initiated after the information that the sample analyzer has completed the cleaning step is obtained and before the information that the next batch of samples enters the sample analysis system is obtained. The post-cleaning preparation step includes: controlling the cleaning device to perform at least partial cleaning work on the reaction vessel after the cleaning step has been completed. The sample information acquisition step includes: acquiring information about the sample entering the sample analysis system; The first pre-detection preparation step is performed after the sample information acquisition step obtains information that a sample has entered the sample analysis system. The first pre-detection preparation step includes: controlling the cleaning device to perform partial cleaning on the reaction vessel in the prepared working state after cleaning.

23. The method for preparing the reaction vessel for the sample analysis system as described in claim 22, characterized in that: The sum of the partial cleaning performed on the reaction vessel in the first pre-detection preparation step and the at least partial cleaning performed in the post-cleaning preparation step is greater than or equal to a complete cleaning of the reaction vessel in the cleaning step.

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