亲和型传感器、特别是QCM传感器

By designing the interface between the nanoscale region and the passivation region, the adsorption of analytes is restricted to the nanoscale region, thus solving the problem of the unknown influence of nanopatterns on adsorption and improving the adsorption quality and sensitivity of the sensor.

CN114556097BActive Publication Date: 2026-07-17LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY (LIST)

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY (LIST)
Filing Date
2020-08-18
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

In the prior art, it is not yet clear how nanopatterns affect the adsorption of solutes, and it is difficult to confine adsorption events to a predetermined molecular size region, especially for high-density analysis and measurement on relatively large surfaces.

Method used

Design an affinity sensor comprising an interface between nanoscale regions and passivated regions, wherein the nanoscale regions are separated by passivated regions to restrict the adsorption of analytes within the nanoscale regions, and the nanoscale regions occupy at least 15% of the surface area of ​​the interface, employing a hexagonal lattice arrangement and selective functionalization.

Benefits of technology

It significantly affects acceptor density and adsorption kinetics, improving adsorption quality and sensitivity, even with a reduced available surface area, and even exceeding the adsorption quality of unpatterned sensors.

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Abstract

本发明的一个方面涉及一种用于感测流体中的分析物(生物分子)的亲和型生物传感器,该亲和型生物传感器包括用于接触该流体和吸附该分析物的界面。该界面包括对该分析物具有亲和力的纳米级区域的二元图案、和钝化区域。这些纳米级区域通过该钝化区域彼此隔开,其方式为使得该分析物在该界面上的吸附被限制于这些纳米级区域。这些纳米级区域具有包括在从5至200nm的范围内的直径。这些纳米级区域一起具有等于该界面的表面积的至少15%的表面积。本发明的另一方面涉及一种使用这种传感器的方法。
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