Microfluidic chip and microfluidic concentration gradient generator

CN114632560BActive Publication Date: 2026-05-26ZHUHAI DALUE TECH LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHUHAI DALUE TECH LTD
Filing Date
2022-03-07
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing microfluidic chips cannot dynamically adjust or generate arbitrary concentration gradients at fixed sizes during concentration gradient generation, and the concentration gradient within the flow channel is fixed and cannot be changed.

Method used

Design a microfluidic chip containing n-stage flow channels and n microvalves. By adjusting the cross-sectional area and flow resistance of the flow channels, the flow rate ratio can be controlled to achieve dynamic adjustment of the concentration gradient.

Benefits of technology

Without changing the input liquid flow rate and concentration, different concentration gradients can be generated in the same flow channel, and the concentration gradients of multiple flow channels can be dynamically adjusted to achieve flexible control of the concentration gradient.

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Abstract

This invention discloses a microfluidic chip and a microfluidic concentration gradient generator, comprising a chip body and microvalves. The chip body has n levels of channels, where n is a positive integer not less than 1, and the channels are arranged sequentially from smallest to largest number. The first level channel includes a first inlet channel for inputting the liquid to be diluted. Channels from the first to the (n-1)th levels include a second inlet channel, a first outlet channel, and a second outlet channel. The second inlet channel is used to input the diluent, and both the first and second outlet channels are used to output the diluted liquid. The nth level channel has a second inlet channel and a first outlet channel. For all channels, the second outlet channel of the smaller level channel is connected to the second inlet channel of the larger level channel. This microfluidic chip can generate different concentration gradients within the same channel and dynamically adjust the concentration gradients of multiple channels without changing the flow rate and concentration of the input liquid.
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