A method of synthesizing decitabine

CN114644668BActive Publication Date: 2026-04-14LUNAN PHARMA GROUP CORPORATION
View PDF 5 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
LUNAN PHARMA GROUP CORPORATION
Filing Date
2020-12-18
Publication Date
2026-04-14

Smart Images

  • Figure QLYQS_1
    Figure QLYQS_1
  • Figure QLYQS_2
    Figure QLYQS_2
  • Figure BDA0002844840250000011
    Figure BDA0002844840250000011
Patent Text Reader

Abstract

The present application provides a method for synthesizing decitabine. The method improves the yield of decitabine by improving the proportion of beta configuration product of decitabine glycosylation reaction and simplifying the isomer separation process. The present application uses a silicon-based protecting group to selectively generate a beta configuration glycosylation product, and realizes the recrystallization separation of isomers, and finally removes the protecting group under neutral conditions, avoids the generation of open ring impurities, and improves the yield.
Need to check novelty before this filing date? Find Prior Art

Citation Information

Patent Citations

  • Decitabine synthesis and industrial production method

    CN102827224A

  • Preparation method of decitabine

    CN103130855B

  • Preparation method of decitabine intermediate

    CN103739636A

  • Preparation method of beta-nucleoside compound

    CN108239128A

  • Method of manufacturing 1-(2-deoxy-alpha-d-erythro-pentofuranosyl)-5-azacytosine

    WO2008101448A2