咪唑类化合物及其制备方法和用途

By designing imidazole compounds as selective EP4 antagonists, the shortcomings of existing drugs in immunosuppressive effects in the tumor microenvironment have been overcome, achieving effective antagonism of the EP4 receptor and therapeutic effects on a variety of diseases.

CN114790176BActive Publication Date: 2026-07-17WUHAN HUMANWELL INNOVATIVE DRUG RES & DEV CENT LTD CO +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
WUHAN HUMANWELL INNOVATIVE DRUG RES & DEV CENT LTD CO
Filing Date
2022-01-24
Publication Date
2026-07-17

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Abstract

本发明提供了一种咪唑类化合物，其为式I所示化合物、其互变异构体、立体异构体、水合物、溶剂化物、药学上可接受的盐或前药；该咪唑类化合物具有较好的EP4受体拮抗作用，
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