A nasal allergen blocking ointment system

Abstract

This invention discloses a nasal allergen blocking ointment system, relating to the field of nasal anti-allergy ointment technology. To facilitate the filling and preparation of ointment products of different specifications, the equipment includes a preparation tank and a conveying mechanism. The preparation tank is equipped with a stirring mechanism, and a filling mechanism is located at the bottom of the tank. The preparation tank is mounted above the conveying mechanism via a first mounting frame. The ointment formulation contains the following raw materials: 65-80 parts white petrolatum, 6.5-8 parts mono- and di-stearyl glycerol, 4-6.5 parts liquid paraffin, 3-7 parts PEG40 hydrogenated castor oil, 1-3 parts menthol, and 1-1.5 parts lanolin. During filling, the invention uses a lifting mechanism to lift the carrier frame along with the ointment container, allowing the bottom end of the filling tube to insert into the ointment container. The extrusion plate is then continuously lifted upwards, squeezing the elastic bladder and extruding the drug from the bladder into the ointment container, thus achieving the filling purpose.

Description

Technical Field

[0001] This invention relates to the field of nasal anti-allergy ointment technology, and more particularly to a nasal allergen blocking ointment system. Background Technology

[0002] An allergy occurs when the body comes into contact with certain substances, causing the production of IgE antibodies against those substances, which are called allergens. These IgE antibodies can then bind to IgE receptors on the surface of cells such as inflammatory cells, basophils, or mast cells, leading to the release of inflammatory factors. These factors, in turn, cause vasodilation, increased exudation, and other allergic reactions. Most allergic reactions are caused by inhaling allergens through the nasal cavity, such as pollen allergies. To prevent allergic reactions, appropriate medications are sprayed into the nasal cavity to prevent or treat allergy symptoms.

[0003] In the processing of anti-allergy ointments, a large batch of ointment is usually prepared at once and then gradually filled to ensure production efficiency. However, considering that product specifications may vary, the filling volume of containers of different capacities will also vary. In this case, a single filling equipment cannot meet the needs of various different filling volumes and needs to be improved.

[0004] A search revealed Chinese patent application CN202020292870.1, which discloses an ointment filling and dispensing device. The device includes a base, a support column on the upper surface of the base, a hydraulic cylinder on the front end of a crossbeam, a telescopic rod extending below the hydraulic cylinder, a rubber stopper on the lower surface of a squeezing disc, a filling cylinder below the hydraulic cylinder, a movable flap at the bottom of the outer circumference of the filling cylinder, a fastening ring fitted on the outer circumference of the filling cylinder, a funnel ring below the fastening ring, and the telescopic rod extending into the interior of the filling cylinder. The ointment filling and dispensing device in the aforementioned patent has the following shortcomings: it is not easy to control and adjust the amount of ointment dispensed in a single batch, therefore further improvement is needed. Summary of the Invention

[0005] The purpose of this invention is to address the shortcomings of existing technologies by proposing a nasal allergen blocking ointment system.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: A nasal allergen blocking ointment system includes a preparation tank and a conveying mechanism. The preparation tank contains a stirring mechanism and a filling mechanism at its bottom. The preparation tank is mounted above the conveying mechanism via a first mounting bracket. The filling mechanism includes: The feeding hopper is located at the center of the bottom of the preparation tank; An elastic bladder is fixed to the bottom of the hopper. The elastic bladder has evenly distributed and identical pleats. A filling tube is provided at the bottom of the elastic bladder. Multiple longitudinally distributed pleats divide the total space inside the elastic bladder into multiple sub-spaces of the same volume. A clamping assembly includes an upper clamping plate and a lower clamping plate, the upper and lower clamping plates having an arc-shaped structure adapted to the elastic bladder, one end of the upper and lower clamping plates being inserted into the gaps of each fold; a first guide rod is fixed to the top outer wall of the lower clamping plate, the upper clamping plate is slidably connected to the outer wall of the first guide rod, and a threaded knob is rotatably connected to the inner wall of the lower clamping plate, the threaded knob being threadedly connected to the inner wall of the upper clamping plate; The extrusion plate is fixed to the outer wall of the bottom of the elastic bladder, and the filling tube passes through the extrusion plate. In addition, multiple carrier frames for transporting ointment containers are movably mounted on the conveying mechanism, and a lifting mechanism is provided directly below the extrusion plate, with the carrier frames located between the extrusion plate and the lifting mechanism.

[0007] Preferably, the conveying mechanism includes: The second mounting bracket has multiple sprockets rotatably mounted on it, and the sprockets on both sides are connected by a shaft. The conveyor chain consists of two conveyor chains mounted on sprockets on both sides, with each sprocket forming a transmission relationship through the conveyor chain. The transmission motor is fixed to the outer wall of one side of the second mounting bracket, and the output end of the transmission motor is fixed to the shaft of a sprocket. Side supports, multiple side supports are fixed equidistantly and symmetrically to the outer wall of one side of two adjacent conveyor chains. A lifting guide rod is fixed to the top of the side support. The two ends of the transport frame are slidably connected to the outer wall of the lifting guide rod. The transport frame is installed on the two side supports by support springs.

[0008] Furthermore: the lifting mechanism includes: The lifting hydraulic cylinder is mounted below the elastic bladder via a third mounting bracket. The slide cylinder is fixed to the output end of the lifting hydraulic cylinder; The extrusion rod has one end movably mounted inside the slide cylinder via a spring, and an annular limiting block is provided on the side wall of one end of the extrusion rod. In addition, a second guide rod is fixed to the outer wall of the bottom of the preparation tank, and the extrusion plate is slidably connected to the outer wall of the second guide rod; a first insertion hole is opened on the carrier frame, a second insertion hole is opened on the extrusion plate, and a positioning groove is opened at the bottom of the lower clamping plate. The first insertion hole, the second insertion hole, and the positioning groove are adapted to the position of the extrusion rod; the inner diameter of the first insertion hole and the positioning groove is smaller than the diameter of the annular limiting block.

[0009] A further preferred embodiment: the outer wall of the top of the preparation tank is provided with an annular guide plate; the stirring mechanism includes: The stirring motor is mounted on the inner wall of the annular guide plate via a motor frame, and the stirring motor is located at the center of the top of the preparation tank; The mixing rack has a central rotating rod fixed to its top, and the top of the central rotating rod is fixed to the output end of the mixing motor. A stirring rod is fixed to the outer side of the bottom of the stirring frame. A stirring ball is provided at one end of the stirring rod. An annular groove adapted to the stirring ball is opened on the inner side wall of the bottom of the preparation tank. The stirring ball is slidably connected to the inner wall of the annular groove.

[0010] In a preferred embodiment of the present invention, the stirring rod is provided with an auxiliary stirring part, the auxiliary stirring part comprising: The stirring plate is fixed on the stirring rod and has a ring-shaped structure. A fixed shaft is installed at both ends on the inner walls of the two sides of the stirring plate; A cross-shaped blade is rotatably mounted on the outer wall of a fixed shaft, and multiple through holes are provided on the cross-shaped blade.

[0011] As a further preferred embodiment of the present invention: the preparation tank is provided with a screening and blocking mechanism, the screening and blocking mechanism comprising: The central cylinder is fixed to the inner wall of the bottom of the preparation tank. The central cylinder is located on the outer side of the top of the feeding hopper. The outer circumference of the central cylinder is provided with evenly distributed leakage holes. The barrier cylinder is slidably connected to the inner wall of the central cylinder and can seal the leaks on the central cylinder.

[0012] As a further embodiment of the present invention: a ball seat is fixed at the top of the barrier cylinder, a ball head rod is rotatably installed inside the ball seat, a cylindrical cavity for inserting the ball head rod is opened at the bottom of the central rotating rod, pin holes are opened on the side walls of the central rotating rod and the ball head rod, and a fixing pin for fixing the ball head rod is movably installed on the outer wall of one side of the central rotating rod. In addition, the stirring rod is provided with an inclined blade on the side near the central cylinder, and multiple inclined blades are distributed in a cyclone shape with the central cylinder as the center.

[0013] A nasal allergen blocking ointment formulation comprises the following ingredients: 65-80 parts white petrolatum, 6.5-8 parts glyceryl mono- and di-stearates, 4-6.5 parts liquid paraffin, 3-7 parts PEG40 hydrogenated castor oil, 1-3 parts menthol, 1-1.5 parts lanolin, 0.5-1.5 parts chitosan quaternary ammonium salt, and 4-7 parts purified water.

[0014] Based on the aforementioned scheme, the preferred raw materials include: 72.5% white petrolatum, 7.4% glyceryl mono- and di-stearates, 5.4% liquid paraffin, 5% PEG40 hydrogenated castor oil, 2% menthol, 1.2% lanolin, 1% chitosan quaternary ammonium salt, and 5.5% purified water.

[0015] A further preferred embodiment of the aforementioned scheme is the ointment processing and packaging method, which includes the following steps: S1: Prepare the raw materials according to the proportions; S2: Process the raw materials into an ointment using the above-mentioned production equipment; S3: Inspect the ointment. If it passes the inspection, proceed to step S4; otherwise, proceed to step S9. S4: Filled into polyethylene composite ointment tubes; S5: Seal the end of the polyethylene composite ointment tube; S6: Filling quantity and sealing inspection. If the inspection is qualified, proceed to step S7; otherwise, proceed to step S9. S7: Sampling and inspection at intermediate stations. If the inspection is qualified, proceed to step S8; otherwise, proceed to step S9. S8: After affixing the label, proceed with the outer packaging process; complete. S9: Transfer to the non-conforming goods warehouse for centralized processing.

[0016] The beneficial effects of this invention are as follows: 1. In standby mode, due to the small diameter of the filling tube, the ointment inside the elastic bladder can remain static based on its own tension without being subjected to external force, and will not drip from the bottom of the filling tube. During filling, the ointment container can be transported to the bottom of the filling tube by the carrier frame, and the carrier frame and the ointment container can be lifted by the lifting mechanism, so that the bottom of the filling tube is inserted into the ointment container, and the extrusion plate continues to be lifted upward, thereby squeezing the elastic bladder and squeezing the medicine inside the elastic bladder into the ointment container, thus achieving the purpose of filling.

[0017] 2. Because the elastic bladder of this invention has multiple folds, the user can fold the corresponding number of folds according to the single filling volume requirement, thereby changing the volume of the elastic bladder. The upper and lower clamps are then inserted into the upper and lower sides of the folded folds, and the threaded knob is turned to clamp and fix them, preventing the folds from springing back. Since the volume of the elastic bladder changes, the amount of ointment discharged from the elastic bladder through the filling tube changes accordingly when the lifting mechanism lifts, thus achieving the purpose of adjusting the single filling volume. This meets the filling needs of ointment containers of different capacities and improves practicality.

[0018] 3. This invention enables the conveyor motor to drive the sprocket to rotate, and the conveyor chain to drive each carrier frame to transport ointment containers, realizing continuous filling operations; when the ointment container is transported to the bottom of the filling tube, the lifting mechanism lifts the carrier frame, and the lifting guide rod can guide the carrier frame to ensure that the filling tube is accurately inserted into the ointment container. The support spring can assist the carrier frame to reset after filling, improving practicality.

[0019] 4. The present invention can lift the extrusion rod upward based on the operation of the lifting hydraulic cylinder, so that the top of the extrusion rod passes through the first insertion hole and the second insertion hole in sequence and is inserted into the positioning groove. Since the inner diameter of the first insertion hole and the positioning groove is smaller than the diameter of the annular limiting block, the annular limiting block can lift the carrier frame during lifting, thereby completing the extrusion filling operation and improving reliability.

[0020] 5. By setting up a stirring mechanism, the present invention can stir and mix materials to meet processing requirements. Furthermore, due to the addition of stirring balls and annular chute, the annular chute can limit the movement of the stirring balls during stirring, ensuring the stability of the stirring process. By setting up an auxiliary stirring part, the stirring plate and cross blades can be used for auxiliary stirring while the stirring rod is rotating, further improving the stirring effect.

[0021] 6. During the preparation process, the barrier tube can be used to seal the leakage hole on the central tube to prevent the material from flowing into the elastic bladder. After the preparation is completed, the barrier tube only needs to be lifted so that the ointment can enter the elastic bladder through the leakage hole, thus improving its practicality.

[0022] 7. This invention utilizes a stirring motor to drive the stirring frame to rotate, which in turn causes the inclined blades to rotate around the central cylinder, squeezing the ointment into the central cylinder, thus improving practicality. By incorporating structures such as a ball-head rod and a fixing pin, the ball-head rod can be inserted into the central rotating rod when the barrier cylinder is lifted, and the fixing pin can be inserted into the pin holes of the central rotating rod and the ball-head rod to fix the ball-head rod. This prevents the barrier cylinder from sliding down into the central cylinder due to gravity, facilitating the discharge of the ointment into the central cylinder and further improving practicality.

[0023] 8. This invention adds chitosan quaternary ammonium salt, whose antibacterial activity mainly stems from its polycationic nature. This property allows it to form electrostatic interactions with the negatively charged components on the surface of microbial cells. At low concentrations, this electrostatic interaction causes bacteria to flocculate. At high concentrations, it adsorbs onto the surface of bacterial cells, forming a polymer membrane that hinders the exchange of substances between bacteria and the external environment, leading to metabolic disorders and death of the bacterial cells. Attached Figure Description

[0024] Figure 1 This is a schematic diagram of the structure of a nasal allergen blocking ointment system proposed in this invention; Figure 2 This is a cross-sectional schematic diagram of the preparation container for a nasal allergen blocking ointment system proposed in this invention; Figure 3 This is a schematic diagram of the stirring mechanism of a nasal allergen blocking ointment system proposed in this invention; Figure 4This is a cross-sectional schematic diagram of the central rotating rod and ball seat of a nasal allergen blocking ointment system proposed in this invention. Figure 5 This is a schematic diagram of the structure of a partial cross-shaped blade of a nasal allergen blocking ointment system proposed in this invention, which is removed from a fixed shaft. Figure 6 This is a cross-sectional schematic diagram of the feed hopper and elastic capsule of a nasal allergen blocking ointment system proposed in this invention. Figure 7 This is a schematic diagram of the structure of a nasal allergen blocking ointment system proposed in this invention, showing the ointment container mounted on a carrier frame during use. Figure 8 This is a schematic diagram of the carrier and side support of a nasal allergen blocking ointment system proposed in this invention; Figure 9 This is a flowchart of a processing and packaging method for a nasal allergen blocking ointment system proposed in this invention; Figure 10 This is a comparison chart showing the effects of products made using different formulations according to the present invention.

[0025] In the diagram: 1. Preparation tank; 2. Motor frame; 3. Agitator motor; 4. Annular guide plate; 5. First mounting frame; 6. Conveyor chain; 7. Conveyor motor; 8. Second mounting frame; 9. Third mounting frame; 10. Lifting hydraulic cylinder; 11. Sprocket; 12. Agitator frame; 13. Agitator plate; 14. Leakage hole; 15. Elastic bladder; 16. Central cylinder; 17. Annular chute; 18. Agitator ball; 19. Inclined blade; 20. Baffle set; 21. Agitator rod; 22. Ball seat; 23. Fixing pin; 24. Central rotating rod. 25 Ball head rod, 26 Cross blade, 27 Fixed shaft, 28 First guide rod, 29 Threaded knob, 30 Upper clamping plate, 31 Lower clamping plate, 32 Positioning groove, 33 Second insertion hole, 34 Filling tube, 35 Extrusion plate, 36 Folded part, 37 Second guide rod, 38 Discharge hopper, 39 First insertion hole, 40 Ointment container, 41 Extrusion rod, 42 Annular limit block, 43 Slide cylinder, 44 Support spring, 45 Transport frame, 46 Lifting guide rod, 47 Side bracket. Detailed Implementation

[0026] The technical solution of this patent will be further described in detail below with reference to specific embodiments.

[0027] The embodiments of this patent are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this patent, and should not be construed as limiting this patent.

[0028] In the description of this patent, it should be understood that the terms “center,” “upper,” “lower,” “front,” “back,” “left,” “right,” “vertical,” “horizontal,” “top,” “bottom,” “inner,” and “outer,” etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this patent and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this patent.

[0029] In the description of this patent, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "setting" should be interpreted broadly. For example, they can refer to a fixed connection or setting, a detachable connection or setting, or an integral connection or setting. Those skilled in the art can understand the specific meaning of the above terms in this patent according to the specific circumstances. Example 1

[0030] Production equipment for nasal allergen blocking ointment, such as Figure 1-8 As shown, the device includes a preparation tank 1 and a conveying mechanism. The preparation tank 1 is equipped with a stirring mechanism, and a filling mechanism is located at the bottom of the preparation tank 1. The preparation tank 1 is mounted above the conveying mechanism via a first mounting bracket 5. The filling mechanism includes: The feeding hopper 38 is integrally set at the center of the bottom of the preparation tank 1; The elastic bladder 15 is bonded to the bottom of the hopper 38. The elastic bladder 15 is provided with uniformly distributed and identical pleated parts 36. The bottom of the elastic bladder 15 is integrally provided with a filling tube 34. The multiple longitudinally distributed pleated parts 36 divide the total space inside the elastic bladder 15 into multiple sub-spaces with the same volume. The clamping assembly includes an upper clamping plate 30 and a lower clamping plate 31. The upper clamping plate 30 and the lower clamping plate 31 are arc-shaped structures adapted to the elastic bladder 15. One end of the upper clamping plate 30 and the lower clamping plate 31 is inserted into the gap between the pleats 36. A first guide rod 28 is fixed to the top outer wall of the lower clamping plate 31 by screws. The upper clamping plate 30 is slidably connected to the outer wall of the first guide rod 28. A threaded knob 29 is rotatably connected to the inner wall of the lower clamping plate 31. The threaded knob 29 is threadedly connected to the inner wall of the upper clamping plate 30. An extrusion plate 35 is fixed to the bottom outer wall of the elastic bladder 15, and a filling tube 34 passes through the extrusion plate 35. In addition, a plurality of carrier frames 45 for carrying ointment containers 40 are movably mounted on the conveying mechanism, and a lifting mechanism is provided directly below the extrusion plate 35, with the carrier frames 45 located between the extrusion plate 35 and the lifting mechanism. By setting up a filling mechanism, when in standby mode, because the diameter of the filling tube 34 is small, the ointment in the elastic bladder 15 can remain static based on its own tension without being subjected to external force, and will not drip from the bottom of the filling tube 34. During filling, the ointment container 40 can be transported to the bottom of the filling tube 34 by the carrier frame 45. The lifting mechanism lifts the carrier frame 45 along with the ointment container 40, so that the bottom of the filling tube 34 is inserted into the ointment container 40. The extrusion plate 35 is then lifted upward, thereby squeezing the elastic bladder 15 and squeezing the medicine in the elastic bladder 15 into the ointment container 40, thus achieving the purpose of filling. Furthermore, since the elastic bladder 15 has multiple pleats 36, the user can fold the corresponding number of pleats 36 according to the single filling volume requirement, thereby changing the volume of the elastic bladder 15. The upper clamp 30 and the lower clamp 31 are inserted into the upper and lower sides of the folded pleats 36, and the threaded knob 29 is turned to clamp and fix them to prevent the pleats 36 from springing back. Since the volume of the elastic bladder 15 changes, the amount of ointment discharged from the elastic bladder 15 through the filling tube 34 changes when the lifting mechanism is lifting, thereby achieving the purpose of adjusting the single filling volume, meeting the filling needs of ointment containers 40 with different capacities, and improving practicality.

[0031] To facilitate continuous filling; such as Figure 6 , Figure 7 As shown, the conveying mechanism includes: The second mounting bracket 8 has multiple sprockets 11 rotatably mounted on it, and the sprockets 11 on both sides are connected by a shaft. Conveyor chains 6, two conveyor chains 6 are installed on sprockets 11 on both sides, and each sprocket 11 forms a transmission relationship through the conveyor chains 6; The transmission motor 7 is fixed to the outer wall of one side of the second mounting bracket 8 by screws, and the output end of the transmission motor 7 is fixed to the shaft of a sprocket 11. Side brackets 47, multiple side brackets 47 are fixed equidistantly and symmetrically on the outer wall of one side adjacent to two conveyor chains 6. A lifting guide rod 46 is fixed on the top of the side bracket 47. The two ends of the transport frame 45 are slidably connected to the outer wall of the lifting guide rod 46. The transport frame 45 is installed on the two side brackets 47 through a support spring 44. By setting up a conveying mechanism, the conveyor motor 7 can work to drive the sprocket 11 to rotate, and the conveyor chain 6 can drive each carrier frame 45 to transport the ointment container 40, realizing continuous filling operation. When the ointment container 40 is transported to the bottom of the filling tube 34, the lifting mechanism lifts the carrier frame 45, and the lifting guide rod 46 can guide the carrier frame 45 to ensure that the filling tube 34 is accurately inserted into the ointment container 40. The support spring 44 can assist the carrier frame 45 to return to its original position after filling, improving practicality.

[0032] To facilitate top pressure; such as Figure 6 , Figure 7 , Figure 8 As shown, the lifting mechanism includes: The lifting hydraulic cylinder 10 is mounted below the elastic bladder 15 via the third mounting bracket 9. Slide cylinder 43 is fixed to the output end of lifting hydraulic cylinder 10; The extrusion rod 41 has one end movably mounted inside the slide cylinder 43 via a spring, and an annular limiting block 42 is integrally provided on the side wall of one end of the extrusion rod 41. In addition, a second guide rod 37 is fixed to the outer wall of the bottom of the preparation tank 1, and the extrusion plate 35 is slidably connected to the outer wall of the second guide rod 37; a first insertion hole 39 is provided on the carrier frame 45, a second insertion hole 33 is provided on the extrusion plate 35, and a positioning groove 32 is provided at the bottom of the lower clamping plate 31. The first insertion hole 39, the second insertion hole 33, and the positioning groove 32 are adapted to the position of the extrusion rod 41; the inner diameter of the first insertion hole 39 and the positioning groove 32 is smaller than the diameter of the annular limiting block 42. By setting up a lifting mechanism, the extrusion rod 41 can be lifted upwards based on the operation of the lifting hydraulic cylinder 10. Then, the top of the extrusion rod 41 passes through the first insertion hole 39 and the second insertion hole 33 in sequence and is inserted into the positioning groove 32. Since the inner diameter of the first insertion hole 39 and the positioning groove 32 is smaller than the diameter of the annular limiting block 42, the annular limiting block 42 can lift the carrier frame 45 during lifting, thereby completing the extrusion filling operation and improving reliability.

[0033] In this embodiment, the user loads the ointment container 40 into the carrier frame 45. The conveyor motor 7 drives the conveyor chain 6 to run, so that the carrier frame 45 carries the ointment container 40 to the bottom of the filling tube 34. The lifting mechanism lifts the carrier frame 45 and the ointment container 40 together, so that the bottom end of the filling tube 34 is inserted into the ointment container 40. The extrusion plate 35 is then lifted upward, which in turn squeezes the elastic bladder 15, squeezing the medicine in the elastic bladder 15 into the ointment container 40, thus achieving the purpose of filling. Furthermore, since the elastic bladder 15 has multiple pleats 36, the user can fold the corresponding number of pleats 36 according to the single filling volume requirement, thereby changing the volume of the elastic bladder 15. The upper clamp 30 and the lower clamp 31 are inserted into the upper and lower sides of the folded pleats 36, and the threaded knob 29 is turned to clamp and fix them to prevent the pleats 36 from springing back. Since the volume of the elastic bladder 15 changes, the amount of ointment discharged from the elastic bladder 15 through the filling tube 34 changes when the lifting mechanism is lifting, thereby achieving the purpose of adjusting the single filling volume, meeting the filling needs of ointment containers 40 with different capacities, and improving practicality. Example 2

[0034] Production equipment for nasal allergen blocking ointment, such as Figure 1-8 As shown, to facilitate the preparation of ointment, this embodiment makes the following improvements based on Embodiment 1: An annular guide plate 4 is integrally provided on the outer wall of the top of the preparation tank 1; the stirring mechanism includes: The stirring motor 3 is mounted on the inner wall of the annular guide plate 4 via the motor frame 2, and the stirring motor 3 is located at the center of the top of the preparation tank 1. The mixing rack 12 has a central rotating rod 24 fixed on its top, and the top of the central rotating rod 24 is fixed to the output end of the mixing motor 3. A stirring rod 21 is fixed to the outer side of the bottom end of the stirring frame 12. A stirring ball 18 is integrally provided at one end of the stirring rod 21. An annular groove 17 adapted to the stirring ball 18 is opened on the inner side wall of the bottom of the preparation tank 1. The stirring ball 18 is slidably connected to the inner wall of the annular groove 17. By setting up a stirring mechanism, the materials can be stirred and mixed to meet the processing requirements. Furthermore, due to the setting of stirring balls 18 and annular chute 17, the annular chute 17 can limit the stirring balls 18 during stirring, ensuring the stability of the stirring.

[0035] To improve the mixing effect; such as Figure 2 , Figure 3 , Figure 5 As shown, the stirring rod 21 is provided with an auxiliary stirring section, which includes: Stirring plate 13 is fixed on stirring rod 21 and has a ring structure. Fixed shaft 27, with both ends of fixed shaft 27 installed on the inner walls of both sides of stirring plate 13; A cross blade 26 is rotatably mounted on the outer wall of a fixed shaft 27, and the cross blade 26 has multiple through holes. By setting up an auxiliary stirring section, the stirring plate 13 and the cross blade 26 can be used for auxiliary stirring while the stirring rod 21 rotates, thereby further improving the stirring effect.

[0036] To facilitate control of material feeding; such as Figure 2-5 As shown, the preparation tank 1 is equipped with a screening and blocking mechanism, which includes: The central cylinder 16 is fixed to the inner wall of the bottom of the preparation tank 1. The central cylinder 16 is located on the outer side of the top of the feeding hopper 38. The outer circumferential wall of the central cylinder 16 is provided with evenly distributed leakage holes 14. The barrier cylinder 20 is slidably connected to the inner wall of the central cylinder 16 and can block the leakage hole 14 on the central cylinder 16. By setting the central cylinder 16 and the barrier cylinder 20, the leakage hole 14 on the central cylinder 16 can be blocked by the barrier cylinder 20 during the preparation process to prevent the material from flowing into the elastic bladder 15. After the preparation is completed, the barrier cylinder 20 only needs to be lifted so that the ointment can enter the elastic bladder 15 through the leakage hole 14, which improves the practicality.

[0037] To facilitate the fixing of the barrier cylinder 20; such as Figure 3 , Figure 4 As shown, a ball seat 22 is fixed to the top of the barrier cylinder 20, and a ball head rod 25 is rotatably installed inside the ball seat 22. A cylindrical cavity for inserting the ball head rod 25 is opened at the bottom of the central rotating rod 24. Pin holes are opened on the side walls of the central rotating rod 24 and the ball head rod 25. A fixing pin 23 for fixing the ball head rod 25 is movably installed on one side of the outer wall of the central rotating rod 24. In addition, the stirring rod 21 is integrally provided with an inclined blade 19 on the side near the central cylinder 16, and multiple inclined blades 19 are distributed in a cyclone shape with the central cylinder 16 as the center. By setting the inclined blades 19 in a cyclone distribution, the stirring motor 3 can work to drive the stirring frame 12 to rotate, which in turn drives the inclined blades 19 to rotate around the central cylinder 16, squeezing the ointment into the central cylinder 16, thus improving practicality.

[0038] By setting up structures such as ball-head rod 25 and fixing pin 23, when the barrier cylinder 20 is lifted, the top of the ball-head rod 25 can be inserted into the central rotating rod 24, and the fixing pin 23 can be inserted into the pin hole of the central rotating rod 24 and the ball-head rod 25, thereby fixing the ball-head rod 25. This prevents the barrier cylinder 20 from sliding down into the central cylinder 16 due to gravity, which is conducive to the ointment being discharged into the central cylinder 16 and improves its practicality. Example 3

[0039] A nasal allergen blocking ointment formulation comprises the following ingredients: 65-80 parts white petrolatum, 6.5-8 parts glyceryl mono- and di-stearates, 4-6.5 parts liquid paraffin, 3-7 parts PEG40 hydrogenated castor oil, 1-3 parts menthol, 1-1.5 parts lanolin, 0.5-1.5 parts chitosan quaternary ammonium salt, and 4-7 parts purified water. Example 4

[0040] A nasal allergen blocking ointment formulation comprises the following ingredients: 72.5% white petrolatum, 8% glyceryl mono- and di-stearates, 6% liquid paraffin, 6% PEG40 hydrogenated castor oil, 2.5% menthol, 1.4% lanolin, 1.2% chitosan quaternary ammonium salt, and 6.5% purified water. Example 5

[0041] A nasal allergen blocking ointment formulation comprises the following ingredients: 72.5% white petrolatum, 7% glyceryl mono- and di-stearates, 5% liquid paraffin, 4% PEG40 hydrogenated castor oil, 1.5% menthol, 1% lanolin, 0.8% chitosan quaternary ammonium salt, and 5.5% purified water. Example 6

[0042] A nasal allergen blocking ointment formulation comprises the following ingredients: 72.5% white petrolatum, 7.4% glyceryl mono- and di-stearates, 5.4% liquid paraffin, 5% PEG40 hydrogenated castor oil, 2% menthol, 1.2% lanolin, 1% chitosan quaternary ammonium salt, and 5.5% purified water.

[0043] By adding chitosan quaternary ammonium salt, the antibacterial activity of chitosan quaternary ammonium salt mainly comes from its polycationic nature. This property allows it to form mutual electrostatic interaction with the negatively charged components on the surface of microbial cells. At low concentrations, the bacteria flocculate through electrostatic interaction. At high concentrations, it is adsorbed on the surface of bacterial cells, forming a polymer membrane that hinders the exchange of substances between bacteria and the outside world, leading to metabolic disorders and death of bacterial cells.

[0044] In addition, its antibacterial mechanism includes: binding to negatively charged proteins, teichoic acid, lipopolysaccharides, etc. on the surface of bacterial cells, changing the permeability of bacterial cell membranes and causing leakage of cell contents; low molecular weight chitosan quaternary ammonium salts can also cross the cell wall and bind to negatively charged DNA, inhibiting DNA transcription and translation; its amino groups can also selectively chelate metal ions that play a key role in microbial growth, especially enzyme cofactors, thereby inhibiting microbial growth and reproduction, etc. Example 7

[0045] A nasal allergen blocking ointment formulation, wherein the processing and packaging method of the ointment includes the following steps: S1: Prepare the raw materials according to the proportions; S2: Process the raw materials into an ointment using the above-mentioned production equipment; S3: Inspect the ointment. If it passes the inspection, proceed to step S4; otherwise, proceed to step S9. S4: Filled into polyethylene composite ointment tubes; S5: Seal the end of the polyethylene composite ointment tube; S6: Filling quantity and sealing inspection. If the inspection is qualified, proceed to step S7; otherwise, proceed to step S9. S7: Sampling and inspection at intermediate stations. If the inspection is qualified, proceed to step S8; otherwise, proceed to step S9. S8: After affixing the label, proceed with the outer packaging process; complete. S9: Transfer to the non-conforming goods warehouse for centralized processing.

[0046] The test indicators for the ointment are as follows: dynamic viscosity: greater than 10 mPa·s; microbiological indicators: total number of aerobic bacteria (cfu / g) ≤ 102; total number of molds and yeasts (cfu / g) ≤ 101; Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli must not be detected. The testing index for fill volume is: not less than 93% of the labeled amount; The test index for heat resistance is: the paste does not melt or flow at 40℃±1℃; The pH test criteria are: phenolphthalein indicator solution should be added, and the pH should be colorless; methyl orange indicator solution should be added, and the pH should not turn pink.

[0047] Experiment 1: To improve product efficacy, the products were processed according to the formulations in Examples 4-6, and clinical trials were conducted on the resulting products. Evaluations were performed after the trials, and the following conclusions were drawn:

[0048] As can be seen from the above, the ointment prepared using Example 6 has good performance in antibacterial effect, relieving nasal itching effect and relieving sneezing symptoms. Therefore, it is preferable to use the formula of Example 6 for preparation.

[0049] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A production system for a nasal allergen blocking ointment, characterized in that, The system includes a preparation tank and a conveying mechanism. The preparation tank contains a stirring mechanism and a filling mechanism at its bottom. The preparation tank is mounted above the conveying mechanism via a first mounting bracket. The filling mechanism includes: The feeding hopper is located at the center of the bottom of the preparation tank; An elastic bladder is fixed to the bottom of the hopper. The elastic bladder has evenly distributed and identical pleats. A filling tube is provided at the bottom of the elastic bladder. Multiple longitudinally distributed pleats divide the total space inside the elastic bladder into multiple sub-spaces of the same volume. A clamping assembly includes an upper clamping plate and a lower clamping plate, the upper and lower clamping plates having an arc-shaped structure adapted to the elastic bladder, one end of the upper and lower clamping plates being inserted into the gaps of each fold; a first guide rod is fixed to the top outer wall of the lower clamping plate, the upper clamping plate is slidably connected to the outer wall of the first guide rod, and a threaded knob is rotatably connected to the inner wall of the lower clamping plate, the threaded knob being threadedly connected to the inner wall of the upper clamping plate; The extrusion plate is fixed to the outer wall of the bottom of the elastic bladder, and the filling tube passes through the extrusion plate. The conveying mechanism is movably mounted with multiple carrier frames for transporting ointment containers, and a lifting mechanism is provided directly below the extrusion plate, with the carrier frames located between the extrusion plate and the lifting mechanism. The conveying mechanism includes: a second mounting frame on which multiple sprockets are rotatably mounted, and the sprockets on both sides are connected by a shaft; two conveying chains mounted on the sprockets on both sides, and the sprockets are connected by the conveying chains; a conveying motor fixed to one outer wall of the second mounting frame, and the output end of the conveying motor fixed to the shaft of one sprocket; and side supports, multiple side supports equidistantly and symmetrically fixed to the outer wall of the two adjacent conveying chains, with lifting guide rods fixed to the top of the side supports, and the two ends of the transport frame slidably connected to the outer wall of the lifting guide rods, and the transport frame mounted on the two side supports by support springs. The lifting mechanism includes: a lifting hydraulic cylinder, which is mounted below the elastic bladder via a third mounting bracket; a sliding cylinder, which is fixed to the output end of the lifting hydraulic cylinder; a pressing rod, one end of which is movably mounted inside the sliding cylinder via a spring, and an annular limiting block is provided on the side wall of one end of the pressing rod; a second guide rod is fixed to the outer wall of the bottom of the preparation tank, and the pressing plate is slidably connected to the outer wall of the second guide rod; a first insertion hole is provided on the carrier frame, a second insertion hole is provided on the pressing plate, and a positioning groove is provided at the bottom of the lower clamping plate; the first insertion hole, the second insertion hole, and the positioning groove are adapted to the position of the pressing rod; the inner diameter of the first insertion hole and the positioning groove is smaller than the diameter of the annular limiting block; an annular guide plate is provided on the outer wall of the top of the preparation tank; the stirring mechanism includes: a stirring motor, which is mounted on the inner wall of the annular guide plate via a motor frame, and the stirring motor is located at the center of the top of the preparation tank.

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