Pressure homogenizing damper and liquid chromatograph
By designing a pressure mixing damper that adapts to different pressure ranges, the problem of insufficient analytical accuracy of liquid chromatographs under wide pressure variation conditions is solved, achieving higher analytical accuracy and stability.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANGHAI HUIZHONG MEDICAL TECH
- Filing Date
- 2022-06-20
- Publication Date
- 2026-07-21
AI Technical Summary
Existing liquid chromatographs' dampers struggle to handle both low and high pressures simultaneously under wide pressure variations, affecting analytical accuracy, especially when detecting human bodily fluids or other organic substances, where pressure variations can be as high as 20 times, leading to inaccurate analytical results.
A pressure mixing damper was designed, including a damping shell and multiple elastic damping mechanisms. The elastic hardness increases sequentially from the liquid inlet end to the liquid outlet end. By storing and releasing high-pressure liquid through the groove structure on the surface of the elastic damping mechanism, it can adapt to different pressure ranges and reduce pressure pulsation.
It effectively suppresses pressure pulsation in the high-pressure pump liquid circuit system, increases the adaptability of pressure range, and improves the analytical accuracy of the liquid chromatograph, especially under conditions of large pressure variation.
Smart Images
Figure CN114878733B_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of liquid chromatography analysis and detection equipment, and in particular to a pressure mixing damper and a liquid chromatograph. Background Technology
[0002] Common liquid chromatographs use miniature high-pressure pumps to drive samples and reagents. Since most of them adopt a plunger pump structure, their output pressure and flow rate are sinusoidal waveforms. Each cycle has a maximum pressure and a minimum pressure of zero, which is unacceptable for precision analytical instruments. Therefore, a pulsation damper, also called a pressure buffer, must be used to absorb pressure and store high-pressure liquid. When the pressure is too low, the high-pressure liquid is released to keep the pressure within a very small fluctuation range.
[0003] In existing technologies, liquid chromatographs use various types of dampers, including compressible fluid dampers, resonant cavity dampers, and spring dampers. Current dampers have stainless steel shells with relatively large internal cavities, resulting in lengthy system cleaning and mobile phase replacement times. Due to advancements in analytical techniques, the time required to analyze a sample has increased from 5 minutes to 60-70 seconds, necessitating the replacement of three or more reagents. Many dampers are bypassed in the high-pressure pipeline, essentially acting as a capacitor in parallel with the reagent line in a DC filter circuit. Furthermore, the larger cavity leads to more residues during reagent replacement, causing reagents to gradually mix and increasing the analytical transition time between two substances during analysis. The relatively long dead volume causes a lag in the analysis results, and the waveform boundaries of several substances are not clear, which seriously affects the accuracy of the analysis. Therefore, it is generally desirable for the dead volume in the damper to be relatively small. As liquid chromatography analysis technology has developed, instead of using multiple reagents with different pH values or different percentages, a new pH value or new ratio is obtained by mixing two reagents in different proportions. The method is to use a separate high-pressure pump to deliver each reagent, adjust the speed ratio of the two pumps, and mix the reagents output by the two pumps evenly to obtain multiple reagents with different pH values or ratios. In order to mix the reagents evenly, a liquid mixer needs to be connected in series after the high-pressure pump.
[0004] However, existing liquid chromatographs for analyzing human body fluids or other organic substances, such as glycated hemoglobin analyzers, suffer from the presence of cells and other organic matter in the samples. During use, these substances gradually clog the pores of the ion exchange resin in the chromatography column. The pressure in the pipeline gradually increases from an initial pressure of approximately 1.2 MPa to around 25 MPa, and sometimes even higher; the pressure variation range is more than 20 times. Therefore, the dampers used in such liquid chromatographs must be able to adapt to a wide pressure range to effectively reduce pressure ripple in the analytical pipeline. Currently, some dampers using elastic solids are difficult to handle both low and high pressure conditions simultaneously. That is, at lower pressures, because the elastomer is relatively hard, its adaptability to low pressures is poor; or at extremely high pressures, the elastomer approaches its compressibility limit, resulting in high output pressure ripple and affecting the analytical accuracy of the instrument. Summary of the Invention
[0005] The purpose of this invention is to provide a pressure mixing damper and a liquid chromatograph to alleviate the technical problem that the pressure change of the elastic solid damper in the prior art cannot meet the pressure change in the organic matter detection process, thus affecting the instrument's analytical accuracy.
[0006] The present invention provides a pressure mixing damper, comprising: a damping shell and a damping elastic component;
[0007] The damping housing is provided with a sealed cavity, and the two ends of the damping housing are respectively provided with a liquid inlet end and a liquid outlet end. The damping elastic component includes at least two elastic damping mechanisms. Multiple elastic damping mechanisms are sequentially housed in the sealed cavity along the direction from the liquid inlet end to the liquid outlet end. The elastic hardness of the multiple elastic damping mechanisms increases sequentially along the direction from the liquid inlet end to the liquid outlet end.
[0008] The surface of the elastic damping mechanism is provided with a groove structure. The damping housing delivers high-pressure liquid to the groove structure through the liquid inlet. Multiple elastic damping mechanisms deliver and mix the high-pressure liquid through the groove structure. The groove structure of each elastic damping mechanism can store high-pressure liquid by deformation.
[0009] In a preferred embodiment of the present invention, the trench structure includes a first trench structure and a second trench structure;
[0010] The elastic damping mechanism is a cylindrical mechanism. The first groove structure is located at both ends of the cylindrical elastic damping mechanism, and the second groove structure extends along the circumferential sidewall of the cylindrical elastic damping mechanism. The first groove structure and the second groove structure are connected.
[0011] The elastic damping mechanism located near the liquid inlet end is connected to the liquid inlet end through the corresponding first groove structure, and the elastic damping mechanism located near the liquid outlet end is connected to the liquid outlet end through the corresponding first groove structure.
[0012] In a preferred embodiment of the present invention, the first groove structure includes two sets of involute grooves with opposite directions. Each set of involute grooves includes 2-8 involute circles, and the involute spiral of each involute circle is 0.5-2 circumference lines. The number of involute spirals with opposite directions in each set of involute grooves is 2-6.
[0013] The second groove structure extends along the circumferential surface of the elastic damping mechanism in multiple spiral lines in opposite directions, and the second groove structure is connected to the first groove structure at both ends of the elastic damping mechanism.
[0014] In a preferred embodiment of the present invention, a transverse groove is provided between two intersecting spirals along the extension direction of the elastic damping mechanism, the transverse groove being used to offset the spirals located on both sides of the transverse groove.
[0015] In a preferred embodiment of the present invention, the trench structure further includes a liquid inlet trench structure;
[0016] The liquid inlet groove structure is provided in multiple ways, and the multiple liquid inlet groove structures are arranged at intervals along the circumferential direction of the elastic damping mechanism of the cylindrical structure. The first groove structure is connected to the second groove structure through the liquid inlet groove structure, and each liquid inlet groove structure is connected to the spiral lines of at least two second groove structures.
[0017] In a preferred embodiment of the present invention, the first trench structure and the second trench structure have the same cross-sectional shape, and the cross-sectional shape of the first trench structure and the second trench structure is V-shaped;
[0018] The included angle between the two sides of the V-shaped structure of the first groove structure and the second groove structure is 15°-22°, the opening range is 0.1mm-2mm, and the sharp corner of the V-shaped structure is transitioned by a rounded arc.
[0019] In a preferred embodiment of the present invention, each of the elastic damping mechanisms is interference-fitted with the inner wall of the damping housing.
[0020] In a preferred embodiment of the present invention, a planar partition is also included;
[0021] The planar partition is located between any two adjacent elastic damping mechanisms. The planar partition is slidably connected to the inner wall of the damping housing. The planar partition has a through hole, and the groove structures of any two adjacent elastic damping mechanisms are connected through the through hole.
[0022] In a preferred embodiment of the present invention, a pressure sensor is also included;
[0023] The liquid inlet includes a liquid inlet, a mountain-shaped pipe, a converging pipe, and a detection pipe. There are two sets of liquid inlets, which are symmetrically arranged relative to the damping housing. The two sets of liquid inlets are connected through the two ends of the mountain-shaped pipe.
[0024] The converging pipe is connected to the converging position of the zigzag pipe, the zigzag pipe is connected to the sealing cavity through the converging pipe, the detection pipe is connected to the side of the zigzag pipe away from the converging pipe, and the zigzag pipe is connected to the pressure sensor through the detection pipe.
[0025] The present invention provides a liquid chromatograph, including the aforementioned pressure mixing damper.
[0026] This invention provides a pressure mixing damper, comprising: a damping shell and a damping elastic component; the damping shell is provided with a sealed cavity, and its two ends are respectively provided with a liquid inlet and a liquid outlet; the damping elastic component includes at least two elastic damping mechanisms; the surface of each elastic damping mechanism has a groove structure; the damping shell delivers high-pressure liquid to the groove structure through the liquid inlet; multiple elastic damping mechanisms mix the high-pressure liquid through the groove structure; by utilizing the groove structure of each elastic damping mechanism, high-pressure liquid can be stored through pressure deformation, that is, each elastic damping mechanism can gradually increase the pressure after being subjected to the resistance of the load end; the high-pressure liquid in the groove structure compresses the elastic damping mechanism, causing the cross-sectional area of the groove structure to expand; when the pressure is basically stable, the volume formed by the groove structure remains relatively stable; by utilizing the deformation of the groove structure of the elastic damping mechanism to store high-pressure liquid, pressure peaks are reduced. When the high-pressure pump output is at a low point, the elastic damping mechanism reduces the volume of the groove structure under its own deformation, and discharges the high-pressure liquid to compensate for the sudden pressure drop. This ensures that the pressure drop of the mobile phase is compensated when it flows through the elastic damping mechanism, thus suppressing the pressure pulsation of the mobile phase in the high-pressure pump's liquid circuit system. Furthermore, multiple elastic damping mechanisms are sequentially housed in the sealed cavity along the direction from the inlet to the outlet. The elastic hardness of the multiple elastic damping mechanisms increases sequentially along the direction from the inlet to the outlet. That is, by using elastic damping mechanisms with different elastic hardness, the damping elastic component can adapt to different pressure ranges, increasing the pressure range of the pressure homogenizing damper. This allows it to adapt to a wider range of applications and alleviates the technical problem in the existing technology where the pressure change of the elastic solid damper cannot meet the requirements of excessive pressure changes in the organic matter detection process, which affects the instrument's analytical accuracy. Attached Figure Description
[0027] To more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.
[0028] Figure 1 This is an exploded structural diagram of the overall structure of the pressure mixing damper provided in an embodiment of the present invention;
[0029] Figure 2 This is a schematic diagram of the overall structure of the pressure mixing damper provided in an embodiment of the present invention;
[0030] Figure 3 This is a schematic diagram of the overall cross-sectional structure of the pressure mixing damper provided in an embodiment of the present invention;
[0031] Figure 4 for Figure 3 A schematic cross-sectional view of the pressure mixing damper at position CC provided in the embodiment;
[0032] Figure 5 for Figure 3 A partially enlarged structural diagram of the pressure mixing damper at position A provided in the embodiment;
[0033] Figure 6 For Figure 3 A partially enlarged structural diagram of the pressure mixing damper at position B provided in the embodiment;
[0034] Figure 7 for Figure 3 A partially enlarged structural diagram of the pressure mixing damper at position D provided in the embodiment;
[0035] Figure 8 This is a schematic diagram of the internal structure of the damping shell of the pressure mixing damper provided in an embodiment of the present invention;
[0036] Figure 9 for Figure 8 A schematic diagram of a pressure mixing damper with a pressure sensor installed, provided in the embodiment;
[0037] Figure 10 A schematic diagram of the first groove structure of the pressure mixing damper provided in an embodiment of the present invention;
[0038] Figure 11 This is a schematic diagram of the unfolded planar structure of the elastic damping mechanism of the pressure mixing damper provided in an embodiment of the present invention.
[0039] Icons: 100-Damping housing; 101-Liquid inlet; 121-H-shaped pipe; 131-Converging pipe; 141-Detection pipe; 102-Liquid outlet; 200-Damping elastic component; 201-Elastic damping mechanism; 212-First groove structure; 222-Second groove structure; 232-Liquid inlet groove structure; 242-Transverse groove; 300-Planar partition; 301-Through hole; 400-Pressure sensor. Detailed Implementation
[0040] The technical solution of the present invention will be clearly and completely described below with reference to the embodiments. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.
[0041] like Figures 1-11As shown, the pressure mixing damper provided in this embodiment includes: a damping housing 100 and a damping elastic component 200; the damping housing 100 is provided with a sealed cavity, and an inlet end 101 and an outlet end 102 are respectively provided at both ends of the damping housing 100; the damping elastic component 200 includes at least two elastic damping mechanisms 201, and multiple elastic damping mechanisms 201 are sequentially housed in the sealed cavity along the direction from the inlet end 101 to the outlet end 102, and the elastic hardness of the multiple elastic damping mechanisms 201 increases sequentially along the direction from the inlet end 101 to the outlet end 102; the surface of the elastic damping mechanism 201 is provided with a groove structure, and the damping housing 100 delivers high-pressure liquid to the groove structure through the inlet end 101; the multiple elastic damping mechanisms 201 deliver and mix the high-pressure liquid through the groove structure, and the groove structure of each elastic damping mechanism 201 can store high-pressure liquid by deformation. The high-pressure liquid is a liquid with a pressure higher than 1 MPa.
[0042] It should be noted that the pressure mixing damper provided in this embodiment can be applied to the pressure variation range of liquid chromatographs containing human bodily fluids or other organic materials. Specifically, the damping housing 100 can be made of stainless steel or engineering plastic, and the damping elastic component 200 can be made of elastic engineering plastic or synthetic rubber. The damping elastic component 200 can store high-pressure liquid through the deformation of the groove structure, thereby reducing pressure peaks and compensating for abrupt pressure troughs, thus suppressing pressure pulsations in the mobile phase of the high-pressure pump system. The wide pressure range specifically refers to the use of the damping elastic component 200. Because liquid chromatographs used for measuring and analyzing human bodily fluids or other organic materials are prone to clogging the ion exchange resin particles in the chromatography column, the internal pipeline pressure of the instrument increases from approximately 2.5 MPa initially to over 25 MPa later, with the highest pressure being more than 10 times the lowest pressure. If the volume of the damping elastic component 200 is reduced proportionally to the pressure, the volume of reagent stored in the damper will increase more than tenfold. An ideal damper is one that shrinks non-linearly, so that the volume of the reagent stored in the damper increases non-linearly.
[0043] Furthermore, the damping elastic component 200 includes at least two elastic damping mechanisms 201. For example, when the damping elastic component 200 includes two elastic damping mechanisms 201, the two elastic damping mechanisms 201 are a first elastic damping mechanism and a second elastic damping mechanism, respectively. The elastic hardness of the first elastic damping mechanism is less than that of the second elastic damping mechanism. The first elastic damping mechanism is located at the end of the damping housing 100 near the liquid inlet 101, and the second elastic damping mechanism is located at the end of the damping housing 100 near the liquid outlet 102. When the pipeline pressure received by the pressure equalization damper is in the initial low pressure range, the first elastic damping mechanism with softer elastic hardness mainly bears the pressure deformation, while the second elastic damping mechanism with harder elastic hardness bears very little pressure deformation. When the pipeline pressure exceeds one-third of the maximum pressure, the second elastic damping mechanism and the first elastic damping mechanism bear approximately two-thirds and one-third of the elastic deformation, respectively. When the pipeline pressure exceeds two-thirds to the maximum pressure range, the elastic deformation of the first elastic damping mechanism and the second elastic damping mechanism becomes less pronounced. Once the soft first elastic damping mechanism reaches its deformation limit under pressure, it stops deforming. At this point, the deformation under pressure is mainly borne by the second elastic damping mechanism, which has a harder elasticity. When the pressure in the pipeline reaches a stable value, the deformation of the first and second elastic damping mechanisms under pressure is basically stable. The pulsating pressure output by the micro high-pressure pump will further compress the damping elastic component 200. At this time, the volume of the groove structure increases, absorbing the excessive pressure, i.e., high-pressure liquid. When the output of the micro high-pressure pump reaches a low point, the pressure decreases slightly, the damping elastic component 200 contracts, the volume of the groove structure decreases, and the pressure homogenizing damper can continue to output high-pressure liquid, and the high-pressure pump continues to operate. Although there will still be some small pressure fluctuations at the outlet 102 of the pressure homogenizing damper, since the pressure and flow rate fluctuate synchronously, that is, the output flow rate fluctuates slightly, the ripple of this fluctuation is very small. By observing the ripple with a specific micro-flowmeter, when its amplitude is less than 1 / 80 of the average flow rate, it can meet the requirements of analytical precision. The cylinder volume of the miniature plunger high-pressure pump in a liquid chromatograph is very small, only about 25 μL. When the total volume of the groove structure and gaps of the pressure homogenizing damper is not under high pressure, it is generally more than 30 times the cylinder capacity of the high-pressure plunger pump, easily meeting the above requirements. With the rated high pressure applied, the reagent volume of the liquid homogenizing damper should increase to more than 90 times the cylinder capacity to achieve a good damping effect. As the reagent pressure increases, the reagent volume inside the damper will also increase proportionally with the pressure increase.
[0044] Optionally, the elastic damping mechanism 201 can be machined using engineering plastics such as polytetrafluoroethylene (PTFE), polyetheretherketone (PEEK), polyphenylene sulfide (PPS), or polyoxymethylene (POM) via CNC machining, or it can be injection molded or compression molded; among them, thermoplastic elastomers can be used for slightly lower pressure applications. Thermoplastic elastomers (TPES) are high-strength, high-performance materials. Their elasticity (elastic limit) and strength recovery fall between those of rigid engineering plastics and rubber. Thermoplastic elastomer alloys can be selected, possessing many superior properties, combining the characteristics of both thermosetting rubbers and thermoplastic resins. There are generally six types of thermoplastic elastomers: styrene-based block copolymers, polyolefin blends (TPOS), elastomer alloys, thermoplastic polyurethanes (TPUS), thermoplastic copolyesters, and thermoplastic polyamides. The hardness of commercial thermoplastic elastomers ranges from Shore A30 to Shore 75D, with the brand number increasing with hardness. As hardness increases, the rubber-like properties of thermoplastic elastomers gradually decrease, while their plastic properties gradually increase. Alternatively, relatively hard and appropriately elastic synthetic rubbers such as polyurethane rubber, fluorosilicone rubber, nitrile rubber, and silicone rubber can be molded. This embodiment uses two sections of elastic materials with different hardness to form the first elastic damping mechanism and the second elastic damping mechanism, which are designed for the pressure environment required by the pressure equalization damper. In addition, when the pressure range is relatively narrow, a single-section first elastic damping mechanism can be used. When the pressure range is relatively wide, two, three or more sections of elastic materials with different hardness can be used to form the elastomer, that is, a second elastic damping mechanism, a third damping elastic mechanism, etc. can be used to adapt to a wider range of applications. This is not limited here. Preferably, the damping elastic component 200 includes two elastic damping mechanisms 201.
[0045] This embodiment provides a pressure mixing damper that utilizes the deformation of the groove structure of the elastic damping mechanism 201 to store high-pressure liquid and reduce pressure peaks. When the output of the high-pressure pump is at a low point, the elastic damping mechanism 201 reduces the volume of the groove structure under its own deformation, and discharges the high-pressure liquid to compensate for the sudden pressure trough. This ensures that the pressure trough of the mobile phase is compensated when it flows through the elastic damping mechanism 201, thereby suppressing the pressure pulsation of the mobile phase in the high-pressure pump liquid circuit system. Furthermore, multiple elastic damping mechanisms 201 are sequentially housed in a sealed cavity along the direction from the inlet end 101 to the outlet end 102. The elastic hardness of the multiple elastic damping mechanisms 201 increases sequentially along the direction from the inlet end 101 to the outlet end 102. That is, by using elastic damping mechanisms 201 with different elastic hardness, the damping elastic component 200 can adapt to different pressure ranges, increasing the pressure range of the pressure mixing damper. This allows it to adapt to a wider range of applications and alleviates the technical problem in the prior art where the pressure change of the damper cannot meet the pressure change in the organic matter detection process, affecting the instrument's analytical accuracy.
[0046] Based on the above embodiments, in a preferred embodiment of the present invention, the groove structure includes a first groove structure 212 and a second groove structure 222; the elastic damping mechanism 201 is a cylindrical mechanism, the first groove structure 212 is located at both ends of the cylindrical elastic damping mechanism 201, and the second groove structure 222 extends along the circumferential sidewall of the cylindrical elastic damping mechanism 201, and the first groove structure 212 and the second groove structure 222 are connected; the elastic damping mechanism 201 located near the liquid inlet end 101 is connected to the liquid inlet end 101 through the corresponding first groove structure 212, and the elastic damping mechanism 201 located near the liquid outlet end 102 is connected to the liquid outlet end 102 through the corresponding first groove structure 212.
[0047] In this embodiment, two sets of first groove structures 212 are provided. The two sets of first groove structures 212 are respectively arranged on the two end faces of the elastic damping mechanism 201. One set of first groove structures 212 can communicate with the liquid inlet end 101, and the other set of first groove structures 212 can communicate with the adjacent first groove structure 212 of the elastic damping mechanism 201. Thus, the first groove structure 212 of the elastic damping mechanism 201 located near the liquid outlet end 102 communicates with the liquid outlet end 102. That is, the first groove structure 212 can receive the high-pressure liquid delivered by the liquid inlet end 101, and can also communicate with the liquid outlet end 102 through the first groove structure 212. That is, the first groove structure 212 can discharge the high-pressure liquid in the damping housing 100.
[0048] like Figure 8 , Figure 9 and Figure 10As shown, in a preferred embodiment of the present invention, the first groove structure 212 includes two sets of involute grooves with opposite directions. Each set of involute grooves includes 2-8 involute circles, and the involute spiral of each involute circle is 0.5-2 circumferential lines. The number of involute spirals with opposite directions in each set of involute grooves is 2-6. The second groove structure 222 extends along the circumferential surface of the elastic damping mechanism 201 in the form of multiple spirals with opposite directions. The second groove structure 222 and the first groove structure 212 at both ends of the elastic damping mechanism 201 are connected through the liquid inlet groove structure 232.
[0049] In this embodiment, the first groove structure 212 can be composed of two sets of involute grooves with opposite directions; each set has 2 to 8 involute circles. Each involute circle starts from a small circumference at the center of the end face of the elastic damping mechanism 201 of the cylindrical structure and ends at a circumference with a diameter slightly smaller than the outer circumference of the elastic damping mechanism 201. The involute spiral is one circumference. 0.5 to 2 circumferences are acceptable. When there are too many spiral circumferences, the angle formed will be too small, affecting the mechanical strength of the first groove structure 212. Each set of circumferences has 2 to 6 involute circles with opposite directions, preferably 4, so that the angle of the grooves is not too small, and the first groove structure 212 has the most intersection points when the elastic damping mechanism 201 has sufficient strength.
[0050] Furthermore, when the high-pressure liquid delivered by the inlet end 101 enters the first groove structure 212, it undergoes multiple cross-mixing processes during the multiple cross-spiral delivery process. Furthermore, the second groove structure 222 extends along the circumferential surface of the elastic damping mechanism 201 in multiple opposite spirals. That is, after the high-pressure liquid is cross-mixed in the first groove structure 212 and re-enters the second groove structure 222, it can also undergo mutual cross-mixing in multiple opposite spirals. Finally, the high-pressure liquid that has completed mixing in the second groove structure 222 will complete the final cross-mixing in the first groove structure 212 at the other end, thereby enabling the reagent to undergo multiple cross-mixing processes during delivery.
[0051] In a preferred embodiment of the present invention, a transverse groove is provided between two intersecting helical lines along the extension direction of the elastic damping mechanism 201. The transverse groove is used to offset the helical lines located on both sides of the transverse groove.
[0052] In a preferred embodiment of the present invention Figure 11The groove structure also includes a liquid inlet groove structure 232; multiple liquid inlet groove structures 232 are provided, and the multiple liquid inlet groove structures 232 are arranged at intervals along the circumferential direction of the elastic damping mechanism 201 of the cylindrical structure. The first groove structure 212 is connected to the second groove structure 222 through the liquid inlet groove structure 232, and each liquid inlet groove structure 232 is connected to the spiral lines of at least two second groove structures 222.
[0053] like Figure 11 As shown, in this embodiment, three liquid inlet groove structures 232 are provided. Each liquid inlet groove structure 232 is composed of two, four or six intersecting grooves. At the second intersection of the grooves, a transverse groove is provided. The upper and lower groove lines of the transverse groove are staggered, so that the high-pressure liquid makes a sharp turn in the transverse groove. The high-pressure liquid will tumble rapidly at this point, which is conducive to better mixing of different high-pressure liquids.
[0054] Optionally, the second groove structure 222 may have two or more grooves engraved on the surface of the cylindrical elastic damping mechanism 201. Through more than two intersections and the cross-displacement of the transverse grooves, a good mixing effect can be achieved. Theoretically, the more intersections, the more times the intersections and the more cross-displacement of the transverse grooves, the better the mixing effect.
[0055] In a preferred embodiment of the present invention, the first groove structure 212 and the second groove structure 222 have the same cross-sectional shape, and the cross-sectional shape of the first groove structure 212 and the second groove structure 222 is V-shaped; the included angle between the two sides of the V-shaped structure of the first groove structure 212 and the second groove structure 222 is 15°-22°, the opening range is 0.1mm-2mm, and the sharp corner of the V-shaped structure is transitioned by a rounded arc.
[0056] In a preferred embodiment of the present invention, each elastic damping mechanism 201 is interference-fitted with the inner wall of the damping housing 100.
[0057] In this embodiment, when high-pressure liquid is injected into the V-shaped groove, gradually filling the entire V-shaped groove, the pressure gradually increases after encountering resistance at the load end. At this time, the high-pressure liquid in the V-shaped groove compresses the elastic damping mechanism 201, causing the cross-sectional area of the V-shaped groove to expand. Simultaneously, the cylindrical bottom surface of the elastic damping mechanism 201 from the liquid inlet 101 is squeezed by the high-pressure liquid, forming a triangular gap at the end face. When the pressure is basically stable, the volume formed by the triangular gap and the V-shaped groove remains relatively stable. Once the triangular gap is formed at the bottom of the elastic damping mechanism 201, some of the high-pressure liquid will be higher than the V-shaped groove on the end face, which may result in insufficient mixing. Because the elastic damping mechanism 201 and the inner wall of the damping housing 100 are interference-fitted, the high-pressure liquid presses against the end face of the elastic damping mechanism 201, and the corresponding pressure will be transmitted to the elastic damping mechanism 201, causing it to exert a circumferential squeezing force, making the two fit more tightly; the high-pressure liquid squeezes the V-shaped groove, forming pressure on the two side walls of the V-shaped structure, and also squeezes... The elastic damping mechanism 201 is pressed tightly against the damping housing 100, preventing the high-pressure liquid from overflowing outside the V-shaped groove. The high-pressure liquid undergoes multiple cross-mixing processes through the V-shaped grooves of the second groove structure 222 and the first groove structure 212 of the elastic damping mechanism 201, ensuring uniform mixing for liquids with low viscosity. Since the high-pressure reagent liquid enters from the inlet end 101 of the damping housing 100, and the pressure at the outlet end 102 is lower than the inlet pressure, the triangular... The gap is formed only at the position of the elastic damping mechanism 201 near the liquid inlet 101, that is, at the lower end of the elastic damping mechanism 201 near the liquid inlet 101. Under the influence of high pressure liquid, the vertical surface of the cylindrical elastic damping mechanism 201 and the bottom plane will be in close contact with the damping shell 100, ensuring that the reagent will flow in the V-shaped groove. Through the above structure, the reagent can be cross-impacted and mixed multiple times at least at one end of the cylindrical elastic damping mechanism 201 and in the groove of the cylindrical surface of the cylinder, so as to obtain a uniformly mixed reagent.
[0058] Additionally, it should be noted that when the elastic damping mechanism 201 and the inner wall of the damping housing 100 are fitted with a clearance, some reagent will overflow from the groove, resulting in insufficient mixing of the reagents.
[0059] Preferably, the V-shaped structure can adopt a single groove cross-sectional area with an upper opening of 1mm and an included angle of 18°. In addition, the conveying cross-sectional area of the first groove structure 212, the second groove structure 222, and the liquid inlet groove structure 232 needs to be less than twice the cross-sectional area of the high-pressure pump output pipe of the chromatograph.
[0060] Specifically, the cross-section of the groove structure adopts a V-shaped structure with an included angle of no more than 18 degrees, so that no centripetal force is generated. Instead, lateral pressure is generated on both sides of the V-shaped groove, which is transformed into a centrifugal extrusion force in the circumferential direction by the elastic damping mechanism 201. This force is closely matched with the damping shell 100, ensuring that the reagent can only flow in the groove structure and produce cross-mixing.
[0061] In a preferred embodiment of the present invention, a planar partition 300 is further included; the planar partition 300 is located between any two adjacent elastic damping mechanisms 201, the planar partition 300 is slidably connected to the inner wall of the damping housing 100, and a through hole 301 is provided on the planar partition 300, through which the groove structures of any two adjacent elastic damping mechanisms 201 are connected.
[0062] like Figure 3 , Figure 8 and Figure 9 As shown, in this embodiment, the planar partition 300 can ensure the spacing between any two adjacent elastic damping mechanisms 201. The elastic damping mechanism 201 is in an interference fit with the inner wall of the damping housing 100, while the planar partition 300 is in a sliding fit with the inner wall of the damping housing 100. The planar partition 300 can form a tight fit at the position of the first groove structure 212 of the adjacent elastic damping mechanism 201, thereby ensuring that the high-pressure liquid forms a uniform flow inside the first groove structure 212. At the same time, the planar partition 300 can transport the high-pressure liquid of the elastic damping mechanism 201 located near the liquid inlet end 101 to the adjacent elastic damping mechanism 201 through the through hole 301.
[0063] Optionally, the cross-sectional shape of the planar partition 300 can be circular, and the through hole 301 can be located at the center of the planar partition 300. In addition, the end positions of the elastic damping mechanism 201 and the damping housing 100 can also be provided with planar partitions 300. The planar partition 300 can ensure the flow of high-pressure liquid and also allow the first groove structure 212 to deform and store liquid better.
[0064] In a preferred embodiment of the present invention, a pressure sensor 400 is also included; the liquid inlet 101 includes a liquid inlet, a zigzag pipe 121, a converging pipe 131, and a detection pipe 141. Two sets of liquid inlets are provided, and the two sets of liquid inlets are symmetrically arranged relative to the damping housing 100. The two sets of liquid inlets are connected through the two ends of the zigzag pipe 121; the converging pipe 131 is connected to the converging position of the zigzag pipe 121, and the zigzag pipe 121 is connected to the sealing cavity through the converging pipe 131; the detection pipe 141 is connected to the side of the zigzag pipe 121 away from the converging pipe 131, and the zigzag pipe 121 is connected to the pressure sensor 400 through the detection pipe 141.
[0065] In this embodiment, two sets of liquid inlets are provided, symmetrically arranged at the end of the damping housing 100. The two sets of liquid inlets are connected by a zigzag pipe 121, and a converging port is formed in the middle of the zigzag pipe 121. The converging pipe 131 and the detection pipe 141 form a relatively extended pipe at the converging port. The converging pipe 131 can collect and transport the liquid entering from the two sets of liquid inlets into the damping housing 100. The converging pipe 131 and the zigzag pipe 121 can form a zigzag pipe. The detection pipe 141 can directly connect the liquid at the converging port to the pressure sensor. The pressure sensor 400 has a pressure detection point. Because the reagent piping in the liquid chromatograph requires strict air exclusion, vertically bent or horizontal pipes with too small a diameter are prone to trapping air bubbles, making them difficult to remove. Therefore, a V-shaped pipe 121 is used. To ensure a small internal volume within the damping housing 100 and facilitate rapid reagent replacement, the internal piping and V-shaped structure must be as small as possible. The diameter of the V-shaped pipe 121 is generally less than 1 mm. Therefore, the detection pipe 141 connected to the detection point of the pressure sensor 400 should have a diameter greater than 2 mm to ensure that no air bubbles are left during liquid injection and that all air is smoothly expelled. Optionally, one or three inlets can be provided; this will not be elaborated further here.
[0066] It should be noted that the pressure mixing damper provided in this embodiment should be cleaned of grease before assembly. After installation, anhydrous alcohol should be poured into the test bench first to clean the grease, and then pure water should be poured in to test the pressure and the flow ripple of the damper. Only products that meet the requirements can be considered qualified.
[0067] This embodiment provides a liquid chromatograph, including the pressure mixing damper mentioned above; since the technical effect of the liquid chromatograph provided in this embodiment is the same as that of the pressure mixing damper provided in the above embodiment, it will not be described again here.
[0068] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.
Claims
1. A pressure mixing damper, characterized in that, include: Damping housing (100) and damping elastic component (200); The damping housing (100) is provided with a sealed cavity. The two ends of the damping housing (100) are respectively provided with a liquid inlet end (101) and a liquid outlet end (102). The damping elastic component (200) includes at least two elastic damping mechanisms (201). Multiple elastic damping mechanisms (201) are sequentially housed in the sealed cavity along the direction from the liquid inlet end (101) to the liquid outlet end (102). The elastic hardness of the multiple elastic damping mechanisms (201) increases sequentially along the direction from the liquid inlet end (101) to the liquid outlet end (102). The surface of the elastic damping mechanism (201) is provided with a groove structure. The damping housing (100) delivers high-pressure liquid to the groove structure through the liquid inlet end (101). Multiple elastic damping mechanisms (201) deliver and mix the high-pressure liquid through the groove structure. The groove structure of each elastic damping mechanism (201) can store high-pressure liquid by deformation. Each of the elastic damping mechanisms (201) is interference-fitted with the inner wall of the damping housing (100); The pressure mixing damper also includes a planar partition (300); the planar partition (300) is located between any two adjacent elastic damping mechanisms (201), the planar partition (300) is slidably connected to the inner wall of the damping housing (100), and a through hole (301) is provided on the planar partition (300), and the groove structure of any two adjacent elastic damping mechanisms (201) is connected through the through hole (301).
2. The pressure mixing damper according to claim 1, characterized in that, The trench structure includes a first trench structure (212) and a second trench structure (222); The elastic damping mechanism (201) is a cylindrical mechanism. The first groove structure (212) is located at both ends of the cylindrical elastic damping mechanism (201). The second groove structure (222) extends along the circumferential sidewall of the cylindrical elastic damping mechanism (201). The first groove structure (212) and the second groove structure (222) are connected. The elastic damping mechanism (201) located near the liquid inlet end (101) is connected to the liquid inlet end (101) through the corresponding first groove structure (212), and the elastic damping mechanism (201) located near the liquid outlet end (102) is connected to the liquid outlet end (102) through the corresponding first groove structure (212).
3. The pressure mixing damper according to claim 2, characterized in that, The first groove structure (212) includes two sets of involute grooves with opposite directions. Each set of involute grooves includes 2-8 involute circles. The involute spiral of each involute circle is 0.5-2 circumference lines. The number of involute spirals with opposite directions in each set of involute grooves is 2-6. The second groove structure (222) extends along the circumferential surface of the elastic damping mechanism (201) in multiple spiral lines in opposite directions, and the second groove structure (222) is connected to the first groove structure (212) at both ends of the elastic damping mechanism (201).
4. The pressure mixing damper according to claim 3, characterized in that, A transverse groove is provided between two intersecting spirals along the extension direction of the elastic damping mechanism (201), the transverse groove being used to offset the spirals located on both sides of the transverse groove.
5. The pressure mixing damper according to claim 4, characterized in that, The trench structure also includes a liquid inlet trench structure (232). Multiple liquid inlet groove structures (232) are provided, and the multiple liquid inlet groove structures (232) are arranged at intervals along the circumferential direction of the elastic damping mechanism (201) of the cylindrical structure. The first groove structure (212) is connected to the second groove structure (222) through the liquid inlet groove structure (232), and each liquid inlet groove structure (232) is connected to the spiral lines of at least two second groove structures (222).
6. The pressure mixing damper according to claim 4, characterized in that, The first trench structure (212) and the second trench structure (222) have the same cross-sectional shape, and the cross-sectional shape of the first trench structure (212) and the second trench structure (222) is V-shaped; The included angle between the two sides of the V-shaped structure of the first groove structure (212) and the second groove structure (222) is 15°-22°, the opening range is 0.1mm-2mm, and the sharp corner of the V-shaped structure is transitioned by a rounded arc.
7. The pressure mixing damper according to any one of claims 1-6, characterized in that, It also includes a pressure sensor (400); The liquid inlet (101) includes a liquid inlet, a mountain-shaped pipe (121), a converging pipe (131) and a detection pipe (141). There are two sets of liquid inlets, which are symmetrically arranged with respect to the damping housing (100). The two sets of liquid inlets are connected through the two ends of the mountain-shaped pipe (121). The converging pipe (131) is connected to the converging position of the mountain-shaped pipe (121), the mountain-shaped pipe (121) is connected to the sealing cavity through the converging pipe (131), the detection pipe (141) is connected to the side of the mountain-shaped pipe (121) away from the converging pipe (131), and the mountain-shaped pipe (121) is connected to the pressure sensor (400) through the detection pipe (141).
8. A liquid chromatograph, characterized in that, Includes the pressure mixing damper as described in any one of claims 1-7.