一种8-苄氧羰基-2-叔丁氧羰基-2,5-双氮杂螺[3,5]壬烷的制备方法
The five-step synthetic route solved the problem of efficient preparation of the 2,5-diazaspiro[3,5]nonane skeleton, achieving high-yield and atom-economical compound synthesis suitable for industrial production.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- HITGEN INC
- Filing Date
- 2021-03-04
- Publication Date
- 2026-07-17
AI Technical Summary
There is a lack of efficient, easy-to-control, and high-yield synthetic methods for the 2,5-diazaspiro[3,5]nonane skeleton in the existing technology.
The five-step synthetic route includes the reaction of compound 1 and compound 2 in potassium carbonate to generate compound 3, the reaction of compound 3 with lithium hydroxide to generate compound 4, the reaction of compound 4 with benzyl bromide to generate compound 5, the Sven oxidation reaction of compound 5 with dimethyl sulfoxide and oxalyl chloride, and finally the hydrogenation of compound 6 under nickel catalysis to generate compound 7.
The preparation of 8-benzyloxycarbonyl-2-tert-butoxycarbonyl-2,5-diazaspiro[3,5]nonane with high yield was achieved. It has high atom economy, is simple to operate, and is suitable for industrial production.
Smart Images
Figure BDA0002961366260000021 
Figure BDA0002961366260000031 
Figure FDA0002961366250000011