Catheter comprising a spray device and a control unit

Abstract

A catheter (1) for delivering a drug liquid or powder in the form of a spray to the trachea of a subject, characterized in that it comprises a deformable body (2) containing a spraying device for emitting a liquid or powder introduced into the catheter (1) in the form of a spray, the body (2) of the catheter (1) being configured to generate a regional image in the longitudinal direction of the body (2).

Description

Technical Field

[0001] This invention relates to a catheter and a system for delivering microdroplets in the trachea of ​​a subject (especially a premature infant). Background Technology

[0002] Today, one in eight newborns in the United States is premature, and in Europe, the figure is one in fourteen. Approximately 20% of premature infants develop respiratory distress syndrome (RDS). If not treated promptly, especially within the first hour of birth, the infant is highly likely to die from RDS.

[0003] In fact, the earlier a baby is born (before 37 weeks of gestation), the smaller their body will be. An infant's lung capacity only increases rapidly when three-quarters of the pregnancy has elapsed. At the same time, the alveolar walls refine, enhancing the area for gas exchange on the lung surface. Interrupting this maturation process in any way will lead to changes in respiratory function and lung physiology.

[0004] Care for premature infants with RDS requires topical administration and initial oxidation. However, existing methods for delivering liquid surfactants into the respiratory tract have many drawbacks.

[0005] The first drawback is that the volume of the liquid surfactant administered into the respiratory tract could cause drowning in newborns. In fact, the volume of medication needed for a premature infant is equivalent to that needed for an adult, approximately 200 ml or 2.5 ml per kilogram of body weight.

[0006] The second drawback is that this method is invasive.

[0007] In fact, it is crucial to approach the larynx using a laryngoscope. The larynx is very narrow, especially in premature infants. This procedure is challenging and difficult to perform, even for an experienced operator. Furthermore, this intrusion is painful for the infant. Therefore, analgesics and / or sedatives are usually needed to alleviate the infant's pain and expedite the process. This presents a significant challenge in administering analgesics and / or sedatives to premature infants. Therefore, the administration of these fluids must be very cautious, and administration is typically intermittent when the infant is uncomfortable.

[0008] The third drawback is the child's tolerance during administration of this liquid surfactant, which acts on the trachea and can cause a drowning effect. This surfactant can cause numerous problems, such as discomfort from reduced oxidation or a slowed heart rate. Therefore, this liquid administration must be done with extreme caution, and administration is usually discontinuous when the infant is uncomfortable.

[0009] In an attempt to overcome these drawbacks, patent document WO2015 / 059037 describes a drug delivery system comprising: a pulmonary surfactant; a conduit including a first channel for transporting a liquid drug to the pharynx of the subject and a second conduit for transporting compressed gas, wherein the connection between the first and second channels allows the liquid drug to be atomized into a spray at the junction of the liquid and compressed gas.

[0010] However, this device often requires a laryngoscope to guide the catheter, a method that addresses all the drawbacks mentioned earlier.

[0011] Furthermore, this type of catheter requires two channels to carry the gas and medication to the distal end of the catheter. Therefore, the catheter must be particularly wide and may not be suitable for insertion into the vocal cords of premature infants.

[0012] In summary, this type of catheter is suitable for delivering atomized medications to the pharyngeal region, a very upstream area that allows some of the surfactant to pass through the esophagus, reducing the efficiency of the medication and increasing the volume of the injected fluid. The injection time is usually more than 1 minute, and can even be as long as 10 to 15 minutes.

[0013] Another drawback of this catheter is that because part of the medication is blocked at the infant's vocal cords, the medication cannot reach and act on the lungs.

[0014] The present invention aims to provide a catheter and drug delivery system that does not have the disadvantages mentioned in the background art.

[0015] One of the objectives of this invention is to provide a catheter that allows medication to be released as close as possible to the lungs in the form of microdroplets, preferably within the trachea.

[0016] Another objective of this invention is to enable the simple and rapid insertion of a catheter into the larynx of a premature infant without the use of a laryngoscope or other invasive methods. Furthermore, this invention aims to allow the procedure to be performed by a single person.

[0017] Another objective of the present invention is to provide a system that enables the treatment of premature infants with respiratory distress syndrome to be performed without the aid of sedatives or analgesics.

[0018] Another objective of this invention is to provide a system that reduces the impact of acute respiratory distress syndrome on the parameters of assisted breathing in patients while treating the syndrome.

[0019] Another objective of this invention is to provide a catheter that is inexpensive, easy to mass-produce, and easy to use. Summary of the Invention

[0020] The present invention relates to a conduit for delivering a liquid or powder in the form of a spray to a target trachea, characterized in that the conduit includes a deformable body; a spraying device for emitting the liquid or powder introduced into the conduit in the form of a spray; the body of the conduit also includes an optical element for manipulating an image of a target area located at the distal extension of the conduit.

[0021] According to the example, this area is located longitudinally at the distal end of the catheter body.

[0022] The present invention also relates to a conduit for delivering a liquid medicine in the form of microdroplets into the trachea of ​​a target. The conduit includes a deformable body comprising: a movable element capable of translation within the conduit; and a spraying device for atomizing the introduced liquid in the form of microdroplets. The conduit body also includes optics for manipulating a distal image of the movable element at a translational position.

[0023] The present invention also relates to a conduit for delivering a liquid or powder in the form of a spray to the trachea of ​​an object (such as a premature newborn). The conduit is designed to be inserted into the trachea via the object's vocal cords and further includes: a deformable body; and a spraying device for emitting the liquid or powder introduced into the conduit in the form of a spray. The body of the conduit further includes: a lumen serving as a channel for an optical element for generating an image of an extension located at the distal end of the conduit; and a movable member for encapsulating the body of the conduit in a predetermined direction.

[0024] The deformation of the catheter body may be elastic deformation or deformation caused by mechanical links such as angular links, fulcrum links or rotational links.

[0025] According to one embodiment, the body of the catheter includes a support for holding the optics. Extended, the body of the catheter can be understood as the body containing the optics. This invention relates to embodiments in which the optics can be removed from the body of the catheter. The invention advantageously provides the possibility of delivering medication to the trachea, i.e., beyond the vocal cords when the catheter is introduced through the mouth or nasal cavity. The invention also advantageously provides the possibility of eliminating the need for a laryngoscope. In fact, the physician can easily guide the distal end and optionally introduce it to the distal end of the body by visualizing the optical image. This embodiment thus provides the possibility of not using analgesia or sedation on premature infants with a laryngoscope before administering care. The invention provides the possibility of using catheters without the disadvantages described in the background art.

[0026] In one embodiment, the conduit includes: a first member for actuating translation of a movable element, the movable element translating a distance between 0.5 cm and 2 cm, or between 0.5 cm and 4.5 cm, within a position range.

[0027] This implementation advantageously makes it possible to insert a movable element into the larynx via the vocal cords when the catheter is in the larynx of a premature infant.

[0028] In one embodiment, the catheter includes a second member for orienteding the distal end of the catheter body relative to the proximal end of the body, thereby controlling the orientation of the distal end within a predetermined direction. This movable member enables the driving, initiation, or control of this orientation.

[0029] This implementation advantageously facilitates distal guidance of the catheter body in the larynx by adjusting the distal orientation through a fixed method or remote operation. The physician can visualize the optical image to determine the larynx inlet and guide the remainder of the catheter through the larynx inlet by triggering the orientation of the catheter orifice. This invention overcomes the disadvantages mentioned in the prior art, accelerates catheter insertion into the larynx, reduces trauma to the patient, and eliminates the need for a laryngoscopy.

[0030] In one embodiment, the catheter includes a positioning element for engaging with the mouth of a subject, the positioning element extending radially to form a buccal support around the catheter at least in a portion, thereby limiting the volume of gas transported between the inside and outside of the oral cavity outside the catheter. The buccal support also facilitates catheter guidance by maintaining the catheter axially in the pharynx.

[0031] In one embodiment, the positioning element can be translated within the catheter. In one embodiment, the positioning element includes a guide for determining the direction in which the catheter enters the subject's airway.

[0032] The positioning element acts as a turning point. This turning point advantageously facilitates the physician's guidance of the main body of the catheter.

[0033] The positioning element also enables partial airtightness of air passing through the subject's mouth. The airtightness of the positioning element improves the efficiency of assisted ventilation systems for premature infants, especially when the system is introduced via the nasal cavity.

[0034] The ability of the positioning element to move freely provides an advantage in enhancing the guidance of the subject, similar to how the guidance of the head of the insert is enhanced by the turning point formed by the positioning element and the mouth.

[0035] In summary, this component provides a support point for the catheter, allowing the operator to free up one hand to manipulate the guide catheter.

[0036] In one embodiment, the conduit includes a channel for dispensing liquid from the end of the spray device.

[0037] In one embodiment, the spraying device is designed to deliver aerosolized liquid medicine or aerosolized or sprayed powdered medicine.

[0038] In one embodiment, the spraying device includes:

[0039] An insert disposed inside a channel and capable of extending longitudinally along the channel, the outer surface of the insert including at least a spiral groove extending from the proximal end of the insert to the distal end and adapted to a channel for a drug solution;

[0040] A container for collecting the medicine from the outlet of the groove in the insert;

[0041] Channels are used to pressurize the liquid medicine within the openings of the extended portion of the container.

[0042] Such a spraying device advantageously makes it possible to deliver aerosolized liquid medicines under pressure.

[0043] In one embodiment, the channel further includes a stop for limiting the translational displacement of the insert. This stop advantageously provides the possibility of ensuring that the insert remains within the channel despite the flow of pressurized fluid.

[0044] In one embodiment, the optical element is disposed at the distal end of the conduit.

[0045] The optical component's channel lumen is designed to receive an optical fiber that can extend along the lumen. The optical fiber can extend along the lumen, preferentially reaching the distal end of the catheter body. In one embodiment, the optical fiber channel includes a transparent, sealed wall at the distal end of the catheter body to protect the optical fiber channel from external environmental contamination; this wall is a sterile wall. In one embodiment, the optical fiber is designed to illuminate an area of ​​the distal extension of the catheter.

[0046] In one embodiment, the distal end of the body includes a circle. This circle advantageously provides the possibility of reducing the pain experienced by the subject when the distal end of the catheter body comes into contact with the subject's airway.

[0047] In one embodiment, the outer diameter of the body of the catheter used for insertion into the airway needs to be between 1 mm and 5 mm or less than 5 mm, with catheters less than 3 mm preferred. One advantage of this diameter is that it can be used for insertion into the airway of premature infants when needed.

[0048] The present invention also relates to a medical system, including the catheter and command unit of the invention. The command unit includes: a reservoir for collecting drug solution; and a device for driving a high-pressure pump to control the administration of the drug solution.

[0049] A reservoir includes a device for controlling the temperature of liquid or powdered medicines.

[0050] In one embodiment, the medical system includes a device for detecting and / or measuring the respiratory cycle of a subject, and directing the administration of a drug solution to be synchronized with the subject's respiratory cycle. Drug administration can be effectively performed during the subject's inhalation.

[0051] This synchronization advantageously facilitates the delivery of medication to the alveoli of the subject in the form of microdroplets via the subject's respiration, and reduces the outflow from the respiratory tract to the trachea.

[0052] In one embodiment, the medical system further includes a ventilation device for assisting the subject's breathing. The medical system also includes a display screen for displaying optical images.

[0053] In one embodiment, the instruction unit includes a method for driving the conduit by driving a second component.

[0054] The present invention also relates to an intubation system comprising: the catheter mentioned in the invention; and an intubation probe. The catheter is designed for at least partial insertion of the intubation probe. This system advantageously allows the physician to rapidly introduce the probe by sliding it along the catheter during catheter use. Even when the patient is in significant discomfort, the intubation probe can be inserted into the larynx more quickly than with a laryngoscope, while ensuring the patient's cardiopulmonary condition is safe. Attached Figure Description

[0055] The foregoing and other advantages and features will be more fully understood with reference to the accompanying drawings and the following detailed description of the embodiments, in which:

[0056] Figure 1A This is a perspective view of the main body of the catheter according to the first embodiment of the present invention;

[0057] Figure 1B It is a cross-sectional view of the main body of the catheter, in which there is a concentric part at the channel retraction position;

[0058] Figure 2A It is a perspective view of the main body of the catheter according to the first embodiment, wherein the channel moves distally inside the main body of the catheter;

[0059] Figure 2B It is a cross-sectional view of the main body of the catheter, in which the channel has concentric parts at the translational position outside the main body of the catheter;

[0060] Figure 3 This is a cross-sectional view of the main body of the catheter according to the first embodiment of the present invention;

[0061] Figure 4This is a cross-sectional view of the main body of the conduit according to the second embodiment, wherein the main body includes: an activation wire; and a ventilation lumen;

[0062] Figure 5 This is a perspective view of a medical system including a catheter according to a first embodiment of the present invention, wherein the main body of the catheter includes an orientable portion, and the medical system includes a display device.

[0063] Figure 6 This is a cross-sectional view of the movable element of the channel according to the first embodiment, which makes it possible to deliver aerosolized liquid medicine.

[0064] Figure 7 This is a schematic diagram of an object being introduced into the distal end of a catheter;

[0065] Figure 8 This is a schematic diagram of the guide rod being introduced into the throat of the object;

[0066] Figure 9 This is a magnified view of the distal end of the duct reaching the vocal cords in the larynx;

[0067] Figure 10 It is an enlarged view of the distal end of the duct pull rod reaching the vocal cords and the movable element being introduced into the trachea through the vocal cords;

[0068] Figure 11 This is an enlarged view of the medicine being sprayed into the trachea in the form of microdroplets;

[0069] Figure 12 This is an enlarged view of the distal end of the catheter being inserted into the trachea via the vocal cords;

[0070] Figure 13 This is a cross-sectional view of the main body of the catheter according to another embodiment of the present invention.

[0071] Detailed description

[0072] In the remainder of the instruction manual, the following terms should be understood according to their definitions:

[0073] "Distal" refers to the end of the catheter that is furthest from the point of handhold when the doctor is using the catheter.

[0074] "Proximal end" refers to the end of the catheter that is closest to the handhold when the doctor is using it.

[0075] "Channel" refers to an artificial channel that can transport liquids.

[0076] "Lumen" refers to the opening that extends longitudinally along the body of the catheter.

[0077] "Microdroplets" are liquid droplets separated by air or a gas, with diameters ranging from 5 micrometers to 1000 micrometers.

[0078] "Spray" refers to a liquid or a solid substance broken down into fine particles. If it is a liquid, a spray will form droplets. If it is a solid, it will cause the substance to decompose, such as powder.

[0079] In one embodiment, "spray" may include atomization or aerosolization.

[0080] "Atomization" refers to the formation of micro-droplet sprays from liquids and pressurized gases.

[0081] "Aerosolization" refers to the process of pressurized liquid passing through a conduit, where droplets are formed at the outlet of the conduit, thus creating a micro-droplet spray.

[0082] This invention relates to a catheter 1 comprising a body 2 for administering medication, particularly for administration via the trachea of ​​premature infants. The invention provides a possibility for treating respiratory distress syndrome requiring the use of surfactants due to lung immaturity, and also for all pulmonary pathologies requiring medication delivery into the lungs. Accordingly, other pulmonary pathologies in patients, such as pulmonary hemorrhage, pneumonia, bronchopulmonary dysplasia, and chronic respiratory dysfunction, may be brought to the attention of the patient. The invention also provides a possibility for treating neonatal secondary surfactant deterioration or compensating for deficiencies in surfactant recovery.

[0083] In one implementation, the liquid medicine may be replaced by powder medicine. Thus, the spray becomes a powder spray.

[0084] The present invention also relates to a medical system 300, which includes the catheter 1 mentioned in the invention.

[0085] Guide rod

[0086] The proximal end of the main body 2 may be connected to the instruction unit 100, also referred to as the instruction unit. The instruction unit 100 includes a user interface. Depending on the implementation, the instruction unit may be equipped with a calculator and a memory. The instruction unit enables the transmission of instructions to the command component to calculate status variables, generate different alarms, and store configuration information.

[0087] The main body 2 of the conduit 1 has a pull rod shape.

[0088] The main body 2 extends longitudinally to the distal end 14. The main body 2 is soft or elastically deformable. The flexibility of the main body advantageously provides the possibility of not damaging the tissues and organs of the preterm infant, especially the tissues of the airway and the pharynx 202. According to the sample, the main body 2 and the conduit 1 have sufficient rigidity to ensure that the operator can guide the posterior portion, and sufficient softness to allow the main body to bend to move in the pharynx, laryngeal region, and pharynx, reaching beyond the vocal cords and passing through the trachea if necessary. The main body 2 of the conduit 1 is considered to be deformable from a stage of variable curvature, such as elastic deformation.

[0089] The outer diameter of the body 2 used for premature infants must be small enough to be inserted into the trachea of ​​the recipient (especially premature infants) and pass through the vocal cords. According to one embodiment, the outer diameter of the body 2 is such that a conventional intubation probe can be inserted. Advantageously, the outer diameter of the body 2 is between 5 mm and 1 mm, with a preferred outer diameter between 3 mm and 2 mm. An outer diameter less than 3 mm or less than 2.5 mm makes it possible to use a catheter for newborns who have already had a tracheal probe inserted but are not using an auxiliary channel. In fact, the diameter of a newborn's trachea can decrease to 2 or 3 mm. Therefore, the newborn can benefit from a medical spray.

[0090] Priority should be given to main body 2 with a length of less than 50 cm or between 10 cm and 30 cm.

[0091] The main body 2 extends from the proximal end (not shown) to the distal end 14.

[0092] The body 2 of conduit 1 is preferably designed for standalone use. Preferably, the body of the conduit is designed to receive optical fibers and to remove the optical fibers before discarding the body 2 of conduit 1.

[0093] The present invention also relates to a medical system 300. The medical system includes an instruction unit 100. The instruction unit 100 is designed to connect to the inventive catheter 1. The instruction unit advantageously includes a user interface to ensure control of the catheter 1. Once used, the catheter 1 or the catheter body may lose connection with the instruction unit 100 and be discarded. In this case, in new use, a new catheter 1 will be connected to the instruction unit.

[0094] Body 2 includes multiple catheters or lumens. The catheters or lumens extend longitudinally along the body.

[0095] Preferably, the catheter or lumen extends to the distal end 14 of the body 2 and / or originates from the proximal end of the body 2.

[0096] Preferredly, the distal end 14 of catheter 1 should include sufficient roundness. Sufficient roundness ensures that the catheter can reduce the risk of trauma to the subject during catheter insertion.

[0097] aisle

[0098] The main body 2 includes a first channel lumen 31. The conduit 1 includes a liquid channel 3 and is disposed within the first channel lumen 31.

[0099] Channel 3 is designed to transport the liquid medicine from the reservoir. In this case, the proximal end of channel 3 is preferentially connected to the reservoir of the liquid medicine. The liquid medicine may be replaced by powder, gel, or paste.

[0100] According to the example, channel 3 includes a conduit within lumen 31. In another embodiment, channel 3 is a conduit composed of lumen 31. The channel surface includes, for example, an internal coating for facilitating the delivery of the drug solution. The internal coating provides the possibility of protecting the chemical properties of the drug solution from contamination by the walls of lumen 31.

[0101] In the first embodiment, the channel 3 includes a movable element 5. The movable element 5 is capable of delivering the drug solution within the volume. The movable element 5 translates within the body 2 of the conduit 1. This translation is initiated primarily from the proximal end by means of a drive member.

[0102] The movable element 5 is designed to discharge the drug solution in the form of microdroplets through the remote port 501. The remote port 501 of the movable element 5 can be flow-connected to the channel 3.

[0103] The movable element 5 preferably includes a distal port, which is designed to reduce trauma to the subject when the airway comes into contact with the distal end of the movable element 5. A movable element with a rounded or curved distal end is preferred.

[0104] Remote transportation

[0105] The movable element 5 in channel 3 can be freely translated relative to the distal end 14, the main body 2, or the optical element 6 of the main body 2.

[0106] Preferably, the movable element 5 is translated to a translational position outside the body 2. The movable element moves to a position at least 5 cm beyond the body 2 of the conduit 1, more preferably 0.5 cm or 1 cm beyond. In one embodiment, the movable element 5 can be driven to a position between 0.5 cm and 2 cm outside the body 2. In one embodiment, at its maximum translational position, the distal end of the movable element 5 has a distance of approximately 0.5 cm to 2 cm or 0.5 cm to 4.5 cm, measured from the distal end 14 of the body.

[0107] like Figure 2A and 2B The movable element 5 of channel 3 is placed outside the distal end 14 of the body 2 of conduit 1.

[0108] According to one embodiment, the diameter of the movable element 5 of the channel 3 is smaller than the diameter of the body 2 of the catheter 1. This solution makes it possible to combine the movable element 5 with the channel 3. One advantage of the movable element 5 being able to translate freely is that it can enter the trachea 203 of the premature infant 200 through the vocal cords 204. Free translation is understood as free mechanical movement, but it can be activated and directed by the operator. Preferably, a predetermined distance will be pre-configured. According to another embodiment, the operator arranges the movable part while proceeding step by step, particularly by means of optics placed in the catheter. Another advantage is that the movable element 5 can be moved forward from the channel 3 to the image capture area of ​​the optics 6. This facilitates translation and ensures real-time control of the delivery of the medication.

[0109] The movable element 5 is at least in the retracted position within the body 2 of the conduit 1 (see...). Figure 1A and 1B It is movable between translational and translational positions, at which at least a portion of the movable element 5 extends beyond the lumen 31 and the body 2 of the catheter (see...). Figure 2A and 2B ).

[0110] Another advantage is that the movable element 5 of the channel 3 can be kept in the retracted position to reduce the risk of breakage or deformation when the body 2 of the catheter 1 is inserted into the airway of the object 200.

[0111] exist Figure 1B and 2B In one embodiment, the channel 3 includes at least one concentric portion 32 with the lumen 31. The concentric portion 32 includes a movable element 5.

[0112] The concentric part 32 can be translated within the lumen 31.

[0113] In one embodiment, it is not shown that the channel 3 includes at least two telescopic concentric portions 32.

[0114] The telescopic concentric parts are capable of relative translational movement within the channel. The concentric parts advantageously increase the rigidity of the extended portion of the movable element and the portion of the channel outside the body 2 of the conduit 1.

[0115] Channel replacement system

[0116] Channel 1 may include a first member for driving the translation of movable element 5. This first driving member may include a control lever. Preferably, the control lever (not shown) is connected to the concentric portion 32. The control lever extends the proximal end of the body 2 of catheter 1. This control lever allows a physician to replace the concentric portion 32 by activating the lever.

[0117] The first driving member enables the movement of the movable element 5. This first driving member enables the displacement of the channel 3 distal to the body 2 of the catheter 1 by moving the movable element and / or concentric portion 32 within the body of the catheter in this method.

[0118] For example, if the channel 3 includes multiple telescopic concentric portions 32, the first drive member makes it possible to extend the movable element from the body 2 of the conduit 1 by translating the telescopic portion relative to another portion.

[0119] The instruction unit 100 preferably includes a first control member. This control member is connected to a first drive member. This member enables control of the displacement of the first drive member and the distal end 5 of the channel 3. To achieve this, it may be necessary to display an indication of the position and layout of the catheter. In a more typical embodiment, the distal end of the catheter includes a force feedback sensor, enabling the control member to automatically stop the translational layout of the movable element when it encounters an obstruction, such as the laryngeal wall, tracheal wall, vocal cords, or any other organ tissue. In this case, the instruction unit 100 recalls an audible sound or alarm from the operator.

[0120] In another embodiment, the spray device 50 is fixed at the distal end 14 of the body of the conduit. The spray device 50 is positioned at the distal end of the channel 3 to facilitate spraying within the distal extension of the body of the conduit. This arrangement also allows the spray device to pass through the lumen of the channel. In this embodiment, the body 2 of the conduit is designed to be able to pass through the vocal cords of the subject (especially a premature subject) and be inserted into the trachea.

[0121] Microdroplet spray

[0122] The movable element 5 includes a spraying device 50.

[0123] In one embodiment, the spray device 50 is designed for spraying powder, especially pharmaceutical powder.

[0124] In a second preferred embodiment, the spray device 50 is designed to emit liquid medicine in the form of microdroplets.

[0125] In the first option (not shown), the drug solution is obtained in droplet form through atomization. The body 2 of the conduit 1 includes a channel for delivering compressed gas. The conduit is designed so that the compressed gas can meet the drug solution near the distal end of the channel 3. The compressed gas enables the atomization of the drug solution.

[0126] The medication is then sprayed into the trachea in the form of atomized droplets. In this option, the body 2 of the catheter 1 includes a lumen for delivering the gas.

[0127] In such Figure 6In the second option, the medication is delivered as microdroplets via an aerosol. This aerosol is made by passing pressurized liquid through a conduit, the conduit's orifice having a specific shape for creating the microdroplets.

[0128] In such Figure 6 In the specific example mentioned, the spray device 50 of channel 3 includes atomizing tools 502, 503, 504, 506 and 501 for spraying liquid medicine in atomized form.

[0129] The atomizing tool includes an insert 502 that is elongated and placed within the channel 3.

[0130] The insert 502 includes an outer surface. This outer surface includes at least one groove 503 wound along the outer surface of the insert 502. This groove 503 is adapted to a channel for delivering a liquid medicine. The groove 503 is preferably threaded. The groove 503 extends from the proximal end to the distal end of the insert 502.

[0131] The protrusion on the outer surface of the insert, that is, between the two consecutive passages of the groove 503, contacts or creates an airtight seal with the inner surface of the channel 3 to drive the liquid medicine along the groove 503. Therefore, the liquid medicine passes through the groove 503 between the outer surface of the insert 502 and the inner wall 508 of the channel 3.

[0132] The atomizing device is preferably housed within the channel 3 of the receiving chamber 505. The receiving chamber is located at the outlet of the groove 503 at the distal end of the insert 502. Preferably, the receiving chamber is located at the distal end of the insert and the spraying device 50.

[0133] The spraying device 50 includes a remote port 501, preferably located at the remote end of the spraying device 50.

[0134] The nebulizer also includes an outflow channel 509. The outflow channel 509 extends into an extension of the containment chamber. The outflow channel 509 is adapted to a channel for the medication. The outflow channel 509 is capable of pressurizing the medication, particularly through its shape. In one embodiment, the shape of the channel includes at least a first portion connected to the containment chamber, the cross-section of which decreases distally. The shape of the outflow channel 509 includes a second portion connected to the distal port 501, the cross-section of which is highly stable. In one embodiment, the first and second portions are adjacent.

[0135] In one embodiment, the outflow channel 509 is composed of a forming body 504. The body 504 is disposed within the channel 3, between the distal end 501 of the channel 3 and the insert.

[0136] The diameter of the distal port 501 is preferably between 20 micrometers and 100 micrometers, and more preferably between 40 micrometers and 80 micrometers. In one embodiment, the diameter of the distal port 501 is between 20 micrometers and 250 micrometers, especially when it is necessary to manufacture larger droplets.

[0137] When the liquid medicine in channel 3 is pressurized by a pump, the liquid is forced to move along a spiral groove 503 between the outer surface of the insert 502 and the inner wall 508 of channel 3. This groove 503 acts as a vortex generator. At the outlet of the spiral groove 503, the liquid medicine enters the containment chamber 505 and its direction is basically a circular path following the inner circumference of channel 3.

[0138] At the far end of containment chamber 505, the rotating liquid enters outflow channel 509, which is used to create a contact surface between the rotating liquid in containment chamber 505 and the ambient atmosphere at port 501.

[0139] The shape of an aerosol can be changed in a variety of ways, such as the pressure applied to the liquid product, the rotation angle of the liquid in the containment chamber, the geometric parameters of the containment chamber, and the geometric parameters of the main body and the distal port.

[0140] The spraying device 50 also includes a stop 506 for limiting the translational movement of the insert 502.

[0141] The spraying device 50 also includes a stop 507 for restricting the translational movement of the forming body 504.

[0142] Stops 506 and 507 advantageously provide conditions for maintaining the position within channel 3 despite the distal pressure exerted by the liquid on channel 3.

[0143] In one embodiment, the movable element includes a plurality of parallel spray devices 50. Increasing the number of spray devices 50 makes it possible to increase the flow rate of the drug solution ejected by the microdroplets. The conduit also includes a plurality of parallel movable elements 5, each including a spray device 50.

[0144] Surfactant administration

[0145] The medical system 300 includes a reservoir for administering a drug solution to a subject. This reservoir is fluidly connected to channel 3. The drug solution preferably contains a surfactant. One component of this surfactant is a porcine lung extract. Another artificial surfactant may also be used. In summary, any surfactant that can effectively treat acute respiratory distress syndrome is potentially suitable for use.

[0146] Preferably, the reservoir for the medication includes a device for heating the medication. One advantage is that it reduces the viscosity of the medication, facilitating its passage through the smaller diameter channel 3, thereby enabling miniaturization of the catheter. Another advantage is that it allows the temperature of the medication delivered to the recipient's respiratory tract to be closer to body temperature. To achieve this, the medical system 300 may include a temperature control device to ensure that the temperature of the medication in the reservoir reaches a target value.

[0147] In one embodiment, not shown, the reservoir includes a syringe. The heating device may include a heating band placed around the reservoir of the syringe.

[0148] The reservoir and pump are fluidly connected. The pump includes a high-pressure pump. The pump advantageously provides the possibility of pressurizing the drug solution in channel 3. The high pressurization of the drug solution within the channel makes controlled administration via aerosol possible. High pressure refers to a pressure between 80 bar and 200 bar, preferably between 100 bar and 180 bar, and more preferably between 120 bar and 160 bar. Furthermore, the pressure can also be selected between 80 bar and 350 bar, particularly for the crucial distal port diameter.

[0149] The pump is connected to a pump control device. This pump control device enables the control of the pump's activation and its intensity.

[0150] In one embodiment, the pump's control device can be controlled by a doctor. Preferably, the pump's control device includes a "pistol"-style trigger or another control method.

[0151] In another embodiment, the reservoir contains a powder. The powder preferably includes a surfactant. Specifically, the surfactant also includes a component of porcine lung extract. Additionally, an artificial surfactant may also be used. In summary, any surfactant that can effectively treat acute respiratory distress syndrome may be used.

[0152] The present invention also relates to a medical system and a catheter in which a channel 3 for dispensing medication is fixedly connected to the body of the catheter. In this embodiment, movable elements cannot or do not have free translation. The spray device 50 for dispensing medication in the form of microdroplets is consistent with that described above. In this embodiment, the diameter of the catheter body is small enough that it can pass through the vocal cords. Preferably, a catheter body with a diameter less than 2.5 mm can be used for newborns, while a catheter body with a diameter less than 5 mm can be used for adult subjects.

[0153] Measurement of respiratory cycle

[0154] In one embodiment, the medical system 300 includes a device for measuring the respiratory cycle of a subject 200. The device includes sensors for the subject's breathing and / or sensors for chest expansion.

[0155] The device for measuring the respiratory cycles of a subject 200 includes an air sensor or a sensor for changes in airflow. This sensor is placed in the subject's airway, such as in the nasal cavity or oral cavity. Alternatively, the sensor may be placed on a duct for connection to the subject's airway.

[0156] In another embodiment, the device for measuring the respiratory cycle of subject 200 includes at least one electrical pulse sensor. The electrical pulse sensor is used to capture electrical pulses from the respiratory muscles, particularly the diaphragm. This sensor is advantageous for collecting electrical signals that cause muscle activity and for understanding the initiation and cessation cycles in advance.

[0157] The device for measuring the respiratory cycle of a subject 200 also includes an optical element (not shown) for collecting the start and stop cycles of the target.

[0158] Preferably, the control device is configured to administer medication in sync with the subject's respiratory cycle. The control device is then connected to a device for measuring the subject's 200 respiratory cycles. For example, the control device controls the medication administration to synchronize with the start of the subject's respiratory cycle.

[0159] This synchronization is advantageous in supporting the recipient's breathing by delivering the medication to the lungs in the form of microdroplets and reducing the amount of medication expelled from the respiratory tract to the trachea.

[0160] In another embodiment, the spraying device can be replaced by a collection device, especially a suction device or a device for conveying liquids, pastes or gels.

[0161] lens

[0162] The body 2 of the conduit 1 includes an optical element 6. This optical element is preferably configured or arranged to generate an image of the distal end of the movable element 5 in a translational position.

[0163] These optical components include lenses and miniature lenses.

[0164] This optical component preferably includes an optical fiber. The optical fiber has a distal end that is located at or near the distal end 14 of the main body 2.

[0165] Preferably, the optical components are configured or arranged to generate an image of the distal end of the movable element 5 or the distal end of the movable element 5 horizontally in a translational position.

[0166] In one embodiment, the optical element 6 is positioned near the distal end 14 of the body 2 or at the level of that distal end. The body 2 includes a second cavity 4 for connecting the optical element 6, such as a cable or optical fiber.

[0167] Preferably, the optics 6 are used to capture images of the region toward the distal end 14 of the body 2. The optics 6 are also used to capture images of the region longitudinally within the body 2 of the catheter 1. In this way, the physician can advantageously visualize the glottis of the subject during catheter insertion. This visualization allows for the acquisition of valuable intervention time, especially during emergency treatment of the subject. Once the body of the catheter has passed the vocal cords, the optics also enable visualization of the bifurcation point between the two bronchi (also known as the carina), facilitating the placement of the catheter body at an appropriate distance from this bifurcation point.

[0168] The channel cavity 4 for optical fiber, also known as the optical fiber cavity, extends longitudinally within the body 2 of the conduit 1. The optical fiber cavity 4 extends from the proximal end of the body 2 to the distal end 14 or optical element 6 of the body 2.

[0169] The near end of the optical fiber is coupled to a signal processing device used to generate an image from the signal generated by the optical fiber.

[0170] Optical fiber has the advantage of being smaller than a lens, and the device for processing light signals is placed outside the main body 2 or near the main body 2.

[0171] In another embodiment, not shown, the optical fiber extends to the outer wall of the body 2 of the conduit. The optical fiber can be retained on the wall in a variety of different ways, such as as a steel tube, groove, or rib on the surface of the body 2 of the conduit.

[0172] In another embodiment, not shown, the main body 2 includes a wireless transmission device for transmitting images acquired by the optical element 6.

[0173] The conduit 1 includes a device for the emission area of ​​the directional optics 6. This directional device can be preferentially controlled remotely. This directional device makes it possible to change the orientation of the optics 6 while using the conduit 1. To achieve this, the optics 6 can be mounted on a pivot or rotating shaft.

[0174] The conduit 1 also includes a device for placing the optical element 6 relative to the body 2. The optical element is capable of translational movement relative to the body 2 of the conduit 1. To achieve this, it may be integrated with a rod capable of translational movement (or translational movement).

[0175] Optical components are preferably positioned within the visible range to acquire images. In another embodiment, the optical components may be monochromatic. They may be configured to use black and white or a range of infrared frequencies to acquire images.

[0176] In a preferred embodiment, the optical fiber is translated within its channel lumen 4. This movement advantageously allows for the use of the conduit alone while retaining the optical fiber in a second conduit for subsequent use according to the invention.

[0177] In this embodiment, the fiber optic channel lumen 4 includes a sealing wall at its distal end. This sealing wall provides the possibility of isolating the optical fiber and the fiber optic channel lumen 4 from the external environment of the conduit. The sealing wall protects the optical fiber from contamination and advantageously allows the optical fiber to be reused without the need for purification between uses. The sealing wall also ensures the sterility of the optical fiber. The sealing wall is preferably transparent to allow the distal end of the optical fiber to capture images. "Transparent" here means that light captured by the optics is allowed to pass through. This light includes visible light, infrared light, or other light.

[0178] illumination

[0179] Preferably, the conduit 1 includes a light source 7. The light source 7 is positioned to illuminate at least a portion of the area captured by the optics 6. The light source 7 may include one or more light-emitting diodes. The light source 7 is connected to a cable. The body 2 of the conduit 1 may include a third cavity 11 formed within the body 2. At least a portion of the cable of the light source 7 is placed within the third cavity 11. According to one embodiment, the cavity enables the transmission of a cable or optical fiber to deliver electrical power for the light source.

[0180] The light source 7 advantageously provides the ability to emit light to illuminate the area captured by the optics 6 and allows the physician to visualize the portion of the catheter body 2 prior to its distal end. This facilitates the guidance of the catheter body within the larynx 206.

[0181] The light source 7 is used to emit light that can be detected by the optical component 6. For example, if the optical component 6 is an infrared camera, the light source 7 may contain an infrared light source.

[0182] In one preferred embodiment, the light source is an optical fiber used for image capture. The optical fiber serves two functions: image capture and acting as a light source. One advantage is that it avoids the creation of an additional lumen within the main body 2 of the catheter for the light source, thus improving the miniaturization of the catheter. Another advantage is the reduction in the amount of work required before discarding a single-use catheter.

[0183] Optical fibers may be used such that a first radial portion of their cross-section is configured to emit light while a second radial portion is used for image capture. For example, the outer ring of the fiber's cross-section acts as a light source. To achieve this, a suitable device is placed near the fiber's proximal end. In this example, the inner ring of the cross-section is used for image capture.

[0184] System for controlling optical equipment

[0185] According to one embodiment, the medical system 300 also includes means for controlling optics. This means for controlling optics enables the activation of optics 6 and / or the light source 7.

[0186] The medical system also includes information transmission equipment, in particular a display screen 101. The display screen 101 enables the real-time display of images of the catheter 1 captured by the optics 6.

[0187] According to one embodiment, the user interface includes an interface for controlling the optical device. This control interface includes control over the activation and / or adjustment of the intensity of the light source 7 and / or the optical element 6. The control interface of the optical device is configured in an operator-controllable position for controlling the orientation and / or displacement of the optical element 6. This control is numerically controlled. Additionally, this control is also mechanically controlled, such as via a handle.

[0188] In one typical implementation, the display device generates numerical values ​​superimposed on the acquired image. These values ​​are organ contours, such as the vocal cords. These contours may be generated by a shape recognition algorithm. One feature is enhanced information retrieval by the operator within a limited time interval. According to another example, distance and orientation values ​​improve the readability of the ongoing situation. For example, the translational distance of a movable element or the orientation of a distal catheter or deflectable portion. According to yet another example, the values ​​displayed superimposed on the acquired image indicate the number of interventions, indicators of the subject's inspiratory / expiratory volume, etc.

[0189] Deflectable part

[0190] The main body 2 of the catheter 1 includes a second drive device. This device enables the orientation of the distal end 81 of the main body 2 of the catheter 1 relative to the proximal end 82 of the main body 2, so that the orientation of the distal end 81 can be controlled to be performed in a preset plane and / or preset direction.

[0191] In one embodiment, the body 2 of the catheter includes at least one orientable portion 8. This portion is designed to bend in a predetermined plane and / or predetermined direction. Preferably, the orientable portion is designed to bend in a controllable manner when activated. The catheter 1 includes an activation device 9 for triggering and controlling the folding or curvature of the orientable portion 8.

[0192] "Controllable mode" refers to the operator's ability to adjust the angle of curvature or the angle between the distal end 81 and proximal end 82 of the catheter body 2 within a preset range. Therefore, the operator can gradually increase or decrease the orientation angle of the distal end 81 between two extreme values ​​of the preset plane.

[0193] Advantageously, the control of the orientation angle of the distal end 81 makes it possible to insert the body 2 of the catheter 1 into the larynx 206 of the object without the aid of a laryngoscope.

[0194] The maximum folding angle of the main body within the preset plane is at least 45°, and preferably at least 70°.

[0195] exist Figure 4 and 5 In the illustrated embodiment, the second drive member includes an activation wire 9 placed along the conduit, such as within the body 2 of the conduit 1.

[0196] The activation lead 9 may be placed within the longitudinal lumen of the body 2 of the catheter 1. This lumen and lead 9 are preferably radially offset from the center relative to the longitudinal axis of the body 2 of the catheter 1. This radial arrangement advantageously provides the possibility of changing the orientation of the distal end 81 of the body 1 of the catheter within a predetermined plane. The predetermined plane includes the longitudinal axis of the body 2 of the catheter 1 and the longitudinal axis containing the lumen of the activation lead 9.

[0197] According to one embodiment, the catheter 1 includes an anchoring device 12. This device is a region within which the activation lead 9 cannot translate relative to the body 2 of the catheter 1. At least, the anchoring device 12 prevents translational movement of the proximal lead relative to the body 2 of the catheter 1.

[0198] According to one example, the anchoring device 12 is positioned in the region of the distal end 14 of the body 2 of the conduit 1. According to another example, the anchoring device 12 is formed inside the body 2 of the conduit, between the distal end of the directional portion 8 and the distal end 14 of the body 2.

[0199] The anchoring device 12 is formed by connecting or coiling. The anchoring device 12 may also include a stop, block, or node for the wire between the distal end of the body 2 and the retaining device.

[0200] According to another embodiment, the activation lead 9 is placed along the outer surface of the body 2 of the conduit 1. The outer surface includes a channel device for the activation lead 9. This channel device is preferably fixed to the outer surface of the body 2 to prevent arcing during the folding of the activation lead.

[0201] When the activation wire 9 is installed, a traction force along the longitudinal direction of the body 2 is applied to the proximal end of the anchoring device 12. This force advantageously provides the possibility for folding the directional device and generating an angle between the distal end 81 and proximal end 82 of the body 2 of the conduit 1 within a predetermined plane.

[0202] In another example Figure 13In the illustrated embodiment, the second drive member is included within the lumen 20 of the body 2 as a pre-formed conduit 9. This conduit extends into the directional lumen 20 of the body 2. The conduit is pre-designed such that, when stationary, it has a curved pre-formed portion, including an angle between the two ends of this portion within a pre-designed plane. The second drive member also includes a rigid rod 22 extending into the pre-formed lumen 9. This rigid rod 22 has a distinctly straight shape when stationary. The rigid rod 22 has a stiffness greater than that of the pre-formed tube 9. Preferably, the rigid rod 22 extends from at least the proximal end of the pre-formed tube 9 to the pre-formed portion or at some point between the pre-formed portion and the distal end of the pre-formed tube 9. This rigid rod may move relative to the pre-formed tube.

[0203] In this case, when the pull rod is inserted into the preformed tube 9, the lumen deforms into the shape of the rigid rod. When the rigid rod 22 is moved, the preformed tube 9 will return to its original shape when at rest and exert a force on the body of the catheter. This force advantageously prevents the oriented portion of the catheter body from folding and, as... Figure 5 A certain angle is generated between the distal end 81 and the proximal end 82 of the main body 2 of the conduit 1, which represents the preset plane. Preferably, the preformed tube allows the distal end of the pipe to deform between 20° and 40°.

[0204] This implementation advantageously provides the possibility of controlling the folding angle of the distal end of the conduit body within a predetermined plane by progressively removing the rigid rod from the preformed tube.

[0205] Preformed tubes preferably contain plastic or metal materials. Rigid rods contain rigid metal.

[0206] The orientable portion 8 may include at least one region in which the stiffness of the portion is lower than that of the distal end 81 or proximal end 82 of the body 2. This stiffness allows for the use of brittle regions and the curvature of the orientable portion 8. The orientable portion 8 may include lateral regions of the orientable portion 8 with lower stiffness than the retained portions of the body 2. These lateral regions advantageously allow for support of the curvature of the body 2 within a predetermined plane containing the aforementioned lateral regions.

[0207] In one embodiment, the directional portion 8 of the catheter body extends 20 mm to 30 mm. End displacement facilitates passage of the catheter 1 between the nasopharynx and oropharynx.

[0208] The low-stiffness region contains less rigid material than the retained portion or cavity of body 2.

[0209] Preferably, the aforementioned side region is contained within a plane that includes the longitudinal axis of the body 2 and a cavity containing the activation wire 9. This configuration advantageously supports the folding of the oriented portion 8 within a predetermined plane during activation.

[0210] In the first example, activation is achieved by activating the traction force of the conductor 9. The orientation of the distal end 81 within the preset plane can only be controlled by applying stronger or weaker traction forces.

[0211] In the second example, the activation wire 9 is made of shape memory alloy. The conduit 1 also includes means for transmitting current through the shape memory alloy wire. Activation of the shape memory alloy wire is performed by applying a voltage to the wire. The use of voltage makes it possible to increase the temperature of the wire through the Joule effect until the phase transition temperature limit of the shape memory alloy wire is reached.

[0212] Activation of the shape memory alloy wire facilitates the wire's preset curvature. The orientation change angle of the distal end 81 can be controlled by temperature or by voltage applied to the shape memory alloy wire.

[0213] These examples are not limited to and may also include aspects of the invention that facilitate curvature within a predetermined plane relative to the proximal end 82 of the body 2 by activating any other means. In one embodiment, the oriented portion 8 extends from 2 cm to 5 cm.

[0214] In one embodiment, the distal end of the directional portion is located 15 mm to 100 mm from the distal end of the body 2 of the catheter 1.

[0215] In one embodiment, the body 2 of the conduit includes at least two second driving members, enabling the orientation of the distal end 81 in at least two predetermined planes and / or in at least two predetermined directions. This solution can be achieved by two interconnected wires, each activated within a given plane. According to another embodiment, these two interconnected wires may have shape memory, with the shape memory wires possessing different alloys and specific preforms.

[0216] Preferably, the catheter includes a mark indicating the orientation of a predetermined plane of the body 2 to be pre-formed by the operator. Such a mark may be located at the proximal end and / or on the outer surface of the catheter.

[0217] Activate the directional part of the system

[0218] In one embodiment, the medical system 300 further includes a means for activating the drive member. This activation means is designed to apply a pulling force to the activation lead 9. When the activation lead 9 is made of a shape memory alloy, the activation is designed to generate tension along the shape memory alloy lead.

[0219] This activation device also makes it possible to control the curvature angle of the orientable portion 8 by adjusting the intensity of the traction force or current acting on the activation wire 9.

[0220] The user interface includes an interface for controlling the orientation of the distal end 81 of the body 2 of the catheter 1. This interface connects to and controls the activation device, which also provides the possibility of controlling the curvature of the orientable portion and directly controlling the curvature.

[0221] When the drive component includes a preformed tube and the aforementioned rigid rod, activation of the drive component is performed by movement of the rigid rod. Movement is preferentially performed via the proximal end of the preformed tube or the body of the conduit.

[0222] The drive mechanism and optics advantageously allow the distal end 14 to be rapidly inserted into the larynx via the epiglottis. In practice, the physician can simply locate the junction of the larynx and esophagus and activate the curvature of the body near the junction to allow the body 2 to enter the larynx.

[0223] ventilation

[0224] Assisting the premature infant with breathing is usually very important when administering medication to them.

[0225] The main body 2 of catheter 1 may be designed such that at least a portion is inserted into the endotracheal probe. Breathing assistance may also be accomplished via a face mask or an endotracheal tube inserted independently of catheter 1 into the nose.

[0226] In this embodiment, catheter 1 may be readily usable for patients who have already been intubated by inserting catheter 1 into an intubation probe. Therefore, the present invention relates to an intubation probe suitable for adaptation to the aforementioned catheter 1. This adaptation is achieved by elements within the intubation probe that have ergonomic guidance or physical means for guiding the movement of catheter 1 within the intubation device. The intubation probe includes its distal end for connection to a ventilation device, such as a ventilator or any other respiratory support device.

[0227] Another advantage of the cannula, which is compatible with the cannula of the present invention, is its ability to be rapidly inserted into the subject's larynx when the cannula is introduced into the subject's throat for the purpose of delivering a spray. In fact, in this case, the cannula probe is positioned upstream of the cannula and can slide freely along the body 2 of the cannula 1. This option is particularly important in cases of cardiac and / or respiratory abnormalities in the subject. When the cannula 1 is already in the subject's throat, the use of a laryngoscope is less necessary.

[0228] In another embodiment, the body 2 of the conduit 1 includes a ventilation cavity within it. This cavity is connected to a ventilator, air pump, or breathing assistance system, preferably to the proximal end of the cavity. The ventilation cavity 10 preferably extends to the distal end 14 of the body 2 of the conduit.

[0229] The ventilation lumen 10 advantageously provides the possibility of integrating an auxiliary ventilation system with the conduit 1. Thus, healthcare professionals caring for premature infants require fewer procedures before administering medication. The ventilation lumen 10 advantageously provides the possibility of maintaining respiratory support for the subject during medication administration. The ventilation lumen 10 also allows for the introduction of a suction tube into the lumen to aspirate secretions from the subject.

[0230] ventilation system

[0231] In embodiments where the duct 1 includes a ventilation system, a device for measuring the subject's respiratory cycle is connected to a ventilator. This ventilator is connected to the intubation probe or ventilation lumen 10. Preferably, the air pump of the ventilation system is connected to the device for measuring the respiratory cycle. The ventilation system is configured to be operated in sync with the subject's respiratory cycle. This synchronization advantageously provides the possibility of assisting the subject's breathing and supporting the delivery of microdroplets to the lungs of the subject 200, particularly to the alveoli of the lungs.

[0232] Positioning components

[0233] In one embodiment, the body 2 of the catheter 1 includes a positioning element 13. The positioning element 13 is designed to mate with the mouthpiece 201 of the object 200. The positioning element is designed to be partially or completely introduced into the mouthpiece 201 of the object 200.

[0234] The positioning element 13 extends radially to at least part of the body 2 of the conduit 1.

[0235] Positioning element 13 forms a cheek support. Positioning element 13 is designed to limit the volume of gas leaking from the conduit 1 between the inside and outside of the mouth 201.

[0236] The positioning element may be designed to be placed on or inside the mouth 201 of the object 200.

[0237] The aforementioned positioning element 13 is designed to ensure at least a partial airtight seal at the mouth of the subject. This airtight seal advantageously provides the possibility of improving the efficiency of the respiratory support system during drug administration, independent of the respiratory support system passing through the nose of the subject 200 or through the catheter 1.

[0238] In one embodiment, the positioning element 13 includes a guide for orienting the catheter 1 into the airway of the object 200. This guide may include an inner wall of the positioning element 13. These inner walls are connected to the surface of the body 2 of the catheter 1.

[0239] Positioning element 13 acts as a turning point. This turning point advantageously facilitates the physician's introduction of the main body of the catheter.

[0240] The positioning element 13 can slide along the body 2 of the catheter 1. When the positioning element 13 engages with the nozzle 201, the body 2 can translate relative to the positioning element. This freedom of translation advantageously provides the possibility of improved guidance of the body 2 when inserted by means of the inflection point configured through the engagement of the positioning element 13 with the nozzle 201.

[0241] The aforementioned positioning element 13 is preferably made of a material that promotes the airtightness of the calcium positioning element 13. The positioning element 13 may be made of plastic or an elastic material that is compatible with patient contact. In one embodiment, the positioning element is made of a malleable material. The shape of the positioning element 13 may be designed such that the element 13 is inserted into the mouth 201 of the subject and held in the mouth 201 of the subject 200 during intervention.

[0242] In one embodiment, the positioning member 13 includes a stop 131 at the proximal end of the positioning member. The stop 131 of the positioning member 13 advantageously provides the possibility of preventing an object from swallowing the positioning member. Another advantage of the stop 131 of the positioning member 13 is that it facilitates the transport of the body 2 relative to the positioning member 13.

[0243] In one embodiment, the positioning element 13 is designed to allow translation within the cannula probe. Indeed, it is crucial to rapidly introduce the cannula probe when the distal end 14 of the body 2 is at the throat 206, should the patient experience discomfort. The cannula probe is, in effect, used to slide around the catheter. Therefore, the positioning element 13 allows this sliding and is designed to allow air passage through the cannula probe.

[0244] In one embodiment, the positioning element 13 is included within a mask for securing it to the head of an object, thereby airtightly isolating the mouth and nose from the external environment. According to the airtight method of the invention, this mask includes channel ports.

[0245] Instruction Unit

[0246] Instruction unit 100 preferably includes one or more of the following elements:

[0247] - A container used to receive a certain volume of liquid or powdered medicine;

[0248] - A control device for controlling the administration of the drug solution and driving the high-pressure pump;

[0249] -A ventilation device used to assist the breathing of the subject;

[0250] - A device for measuring the respiratory cycle of a subject;

[0251] -Activation device for controlling the curvature angle of the orientable part 8;

[0252] - An interface used to control the orientation of the remote 81;

[0253] -Light control device.

[0254] The instruction unit 100 may include a user interface. Depending on the implementation, the instruction unit may be paired with a calculator and a memory. The instruction unit may be able to send instructions to the control component to calculate state variable values, thereby generating different alarms, and to store configuration information.

[0255] Command unit 100 may include an isolation device. This isolation device advantageously provides the possibility of bacterial contamination within the command unit, especially during two interventions following catheter replacement.

[0256] The medical system 300 preferably includes a connection device that allows the catheter 1 to be connected to the command unit 100 in either direction.

[0257] Embodiments of the present invention

[0258] Figures 7 to 11 A method for administering a drug solution via a medical system 300 or a catheter 1 similar to the catheter described above is presented.

[0259] exist Figure 7 As shown in the first step, the distal end 81 of the body 2 of the catheter 1 is inserted into the mouth 201 of the object 200. This insertion is performed by a doctor.

[0260] The doctor can then align the positioning element 13 with the mouth 201 of the object 200. The positioning element will enable improved ventilation system efficiency. The positioning element 13 will also enable the doctor to create support or turning points to guide the body 2. The body 2 is pushed by the doctor through the pharynx 202.

[0261] In the second step, the doctor activates the component used to orient the distal end 81 via the user interface. The orientable portion 8 then begins to bend within a preset plane. The distal end 81 is oriented relative to the proximal end 82 within the preset plane.

[0262] When the main body 2 is folded, the doctor can control the position of the distal end 14 via the screen 101. The doctor can adjust the direction of the distal end until the entrance to the larynx 206 or esophagus 205 is visualized on the screen 101. When the entrance to the larynx 206 is visualized, the doctor can insert the distal end 14 of the main body 2 into the larynx 206.

[0263] When the distal end 14 of the body 2 is introduced into the larynx 206, the physician is able to deactivate the second actuating member. The curvature on the directional portion is relieved. The body is thus able to restore its flexibility and enter the larynx 206 by pushing the body 2 of the catheter 1.

[0264] Devices for driving the distal end 81, such as the optics 6 and the display screen, advantageously make it possible to introduce the distal end 14 of the body 2 of the catheter 1 into the larynx 206 of the subject without the use of a laryngoscope and with reduced pain to the subject 200.

[0265] like Figure 8 and 9 As shown, the body 2 of the catheter 1 is advanced into the airway until the distal end 14 of the body 2 of the catheter 1 reaches the vocal cords 204 of the object 200.

[0266] The doctor can control the advancement of the catheter 1 to reach the entrance of the vocal cord 204 by displaying the image captured by the optical component 6 on the screen 101.

[0267] In such Figure 10 In the first embodiment shown, when the distal end 14 of the body 2 of the conduit 1 is close to the vocal cord 204, the movable element 5 of the channel 3 is planarly advanced outside the body 2 of the conduit 1. The movable element 5 is advanced until the distal end of the movable element 5 passes through... Figure 12 The vocal cords are shown. Preferably, the distal end of the movable element 5 is advanced into the trachea 203 of the object 200. The optics 6 are used to capture an image of the area containing the vocal cords 204 and the movable element 5 of the channel 3. The doctor can guide the movable element between the two vocal cords by using the screen 101.

[0268] like Figure 11 As shown, when the movable element 5 is placed in the trachea 203, the doctor can administer the medication in the form of microdroplets 207 through the distal end 501 into the subject's trachea 203.

[0269] In such Figure 12 In the second embodiment shown, the distal end 14 of the body 2 of the catheter is advanced so that the body of the catheter passes through the vocal cords 204.

[0270] Optical component 6 is used to capture an image of the area containing the vocal cords 204. The doctor guides the body 2 of the catheter between the two vocal cords 204 using screen 101. When the distal end 14 is placed in the trachea 203, the doctor can administer medication in the form of microdroplets into the patient's trachea through the distal end.

[0271] The administration of the drug solution is achieved by activating a pump connected to the drug solution reservoir. As described above, the administration of the drug solution may be synchronized with the respiratory cycle of the subject 200; preferably, the administration of the drug solution is performed only when the subject 200 inhales.

[0272] The medication is thus delivered to the subject's trachea 203 in the form of microdroplets 207, which advantageously supports the distribution of the medication in the lungs, while preventing the "drowning" effect that the subject would experience when the medication is administered to the subject 200 without the use of a laryngoscope.

[0273] As mentioned earlier, the liquid medicine can be replaced by powder and enter the trachea in the form of a spray.

[0274] Other applications

[0275] The body of the catheter of the present invention is preferably designed for insertion into narrow constricted trachea, such as through the vocal cords of a premature infant into the trachea. The diameter of such a trachea can reach 2 or 3 millimeters.

[0276] Those skilled in the art understand that this type of catheter, designed for insertion into the trachea via the vocal cords of a premature infant, can be used for other similar applications, such as those involving the genital and urinary systems. In particular, the diameter of the catheter's body allows for insertion into the urethra and / or fallopian tubes. "Designed for insertion into the trachea via the vocal cords of a premature infant" means that the catheter's body is manufactured in such a way that it can be inserted into a narrow container or tube similar in size to the trachea of ​​a premature infant, such as the urethra, cerebral blood vessels, or fallopian tubes.

[0277] The catheter of this invention can also be used laparoscopically in the ORL, digestive tract, endometrium, or endpleura. The catheter body is preferably designed to insert into narrow passages less than 10 mm or 5 mm, more preferably less than 3 mm.

Claims

1. A catheter (1) for delivering a liquid or powdered medicine in the form of a spray to the trachea (203) of a subject (200), said subject (200) being a premature newborn, characterized in that, The conduit (1) includes: a deformable body (2) designed to be inserted into the trachea via the vocal cords of an object (200); and a spray device (50) for emitting a liquid or powdered medicine introduced into the conduit (1) in the form of a spray. The body (2) of the conduit (1) further includes: a first lumen (4) configured to house an optic (6) for generating a regional image of the distal extension of the conduit (1); and a drive member for folding the body of the conduit in a predetermined direction. The spraying device (50) includes an insert (502) disposed within the channel (3) of the liquid or powder and including an outer surface, the outer surface including at least one groove (503) adapted to the channel (3) of the liquid or powder and wound around the outer surface of the insert (502). The remote port (501) has a diameter between 20 micrometers and 100 micrometers; A receiving chamber (505) is disposed between the outlet of the at least one groove (503) of the insert (502) and the distal port (501); and Outflow channel (509) includes a first portion and a second portion, the first portion being connected to the containment chamber (505) and the cross-section of the first portion decreasing in the distal direction, and the second portion being connected to the distal port (501) and the cross-section of the second portion being substantially constant; The distal port (501), the insert (502), the at least one groove (503), the molding body (504), and the stop (506) constitute an atomizing device for emitting atomized liquid medicine; The molding body (504) is arranged within the channel (3) of the liquid or powder, located between the distal port (501) and the insert (502); and The stop (506) is arranged in the channel (3) of the liquid medicine to restrict the translational movement of the insert (502).

2. The catheter (1) according to claim 1, characterized in that, The main body (2) of the conduit includes: a second lumen for defining the channel (3) for supplying the liquid or powder medicine to the spray device (50); and a third lumen (20) containing a drive member.

3. The catheter (1) according to claim 1 or 2, characterized in that, The driving member orients the distal end (81) of the body (2) of the driving conduit (1) relative to the proximal end (82) of the body (2) so as to provide the possibility of controlling the orientation of the distal end (81) within a preset direction.

4. The catheter (1) according to claim 1, comprising: A positioning element (13) for engaging with the mouth (201) of an object (200) extends radially to at least partially surround the body (2) of the conduit (1) to form a cheek support for limiting the volume of gas leaking from the conduit (1) between the outside and inside of the mouth.

5. The catheter according to claim 4, characterized in that, The positioning element (13) is capable of translational movement at the body of the catheter.

6. The catheter (1) according to claim 4 or 5, characterized in that, The positioning element (13) includes a guide for orienting the catheter (1) into the airway of the object (200).

7. The catheter according to claim 1, characterized in that, The driving component includes: A preformed tube (9) extends into the third lumen (20) of the main body of the conduit; A movable rigid rod (22) extends into the cavity of the preformed tube (9); The preformed tube is designed to include: a preformed portion that bends and forms an angle between multiple portions of the tube at either end of this portion within a preset plane when the movable rigid rod moves.

8. The catheter (1) according to claim 1, characterized in that, The first lumen (4) is designed to receive an optical fiber that extends along the first lumen to the distal end (14) of the body (2) of the conduit (1).

9. The catheter (1) according to claim 8, characterized in that, The first lumen (4) includes a transparent and sealed wall located at the distal end (14) of the body (2) of the conduit, which is used to prevent the first lumen (4) from being contaminated by the external environment.

10. The catheter (1) according to claim 8, characterized in that, The optical fiber is also designed to illuminate the area of ​​the distal extension of the conduit (1).

11. A medical system (300) comprising the catheter (1) according to any one of the preceding claims, the medical system (300) comprising: Instruction unit (100), the instruction unit (100) comprising: A container used to receive a certain volume of liquid or powdered medicine. A device for controlling a pump, used to drive a high-pressure pump to indicate the administration of liquid or powdered medicine, respectively.

12. The medical system (300) according to claim 11, characterized in that, The medical system (300) includes a display screen (101) for displaying images of the optical components (6).

13. The medical system (300) according to claim 11, wherein, The container includes a temperature control device for controlling the temperature of the liquid or powder medicine in the container.

14. An intubation system, characterized in that, The cannulation system includes: a catheter according to any one of claims 1 to 10; and a cannulation probe designed to receive a catheter (1) capable of moving within the cannulation probe.

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