线性小分子肽类似物在制备抗肥胖和降糖药物中应用
CN115252758BActive Publication Date: 2026-07-17SOUTH CHINA SEA INST OF OCEANOLOGY CHINESE ACAD OF SCI
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SOUTH CHINA SEA INST OF OCEANOLOGY CHINESE ACAD OF SCI
- Filing Date
- 2022-08-16
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
[0002]近年来肥胖的发病率逐年增加，成为导致人类死亡的直接或间接原因，治疗肥胖的药物疗效及其副作用难以令人满意
Benefits of technology
[0009]本发明的第二个目的是提供一种抗肥胖、降脂、降糖的药物，其特征在于，含有如式(Ⅰ)所示的任一化合物或其药用盐作为活性成分。
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Smart Images
Figure CN115252758B_ABST
Abstract
本发明公开了线性小分子肽类似物在制备抗肥胖和降糖药物中应用。所述的线性小分子肽Simplicilliumtide C，methylated simplicilliumtide C,Simplicilliumtide D和Simplicilliumtide H，Hirsutellic Acid A和Sinulariapeptide B的结构式如式(Ⅰ)所示。经试验证明，本发明的Simplicilliumtide C，methylated simplicilliumtide C,Simplicilliumtide D和Simplicilliumtide H能抑制3T3‑L1前脂肪细胞分化过程中甘油三酯的积累，Hirsutellic Acid A和Sinulariapeptide B能促进3T3‑L1前脂肪细胞分化过程中甘油三酯的积累，Simplicilliumtide H能显著降低DIO模型小鼠体重，Hirsutellic Acid A对2型糖尿病模型小鼠有一定的降糖作用。这些化合物可用于抗肥胖、降脂和降糖药物中的应用。
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