Novel pyrimidine derivatives and compositions for preventing or treating neurodegenerative diseases and cancers comprising the same

CN115413278BActive Publication Date: 2025-01-10WHANIN PHARMA CO LTD +1
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Patent Information

Application Number
CN202180023549.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Priority Date
2021-02-09
Filing Date
2021-03-12
Publication Date
2025-01-10
Estimated Expiration
2041-03-12

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Abstract

The present invention relates to a novel pyrimidine derivative and a composition for preventing or treating neurodegenerative diseases and cancers comprising the same. The pyrimidine derivative has excellent LRRK2 protein inhibitory activity and effectively permeates the blood-brain barrier (BBB), and can therefore be effectively used as a pharmaceutical composition for preventing or treating neurodegenerative diseases and cancers.
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Citation Information

Patent Citations

  • Pharmaceutical composition for treating or preventing Parkinson's disease comprising compound having inhibitory effect of LRRK2 kinase activity

    KR101208198B1

  • Pyrazole aminopyrimidine derivatives as LRRK2 modulators

    KR101566091B1

  • Pyrimidin-2-ylamino-1H-pyrazole as a LRRK2 inhibitor for use in the treatment of neurodegenerative disorders

    KR1020190018676A

  • 2-(phenyl or pyrid-3-yl) aminopyrimidine derivatives as kinase lrrk2 modulators for the treatment of parkinson's disease

    KR102025451B1

  • New pyrimidine derivatives and their use in therapy as well as the use of pyrimidine derivatives in the manufacture of a medicament for prevention and / or treatment of alzheimer's disease

    CN101326179A