Sample analyzer and sample analysis method

Abstract

The present application relates to a sample analyzer and a sample analysis method. The sample analyzer comprises a sampling distribution module, a routine blood test module, a blood sedimentation test module and a specific protein test module. The sampling distribution module collects a blood sample and distributes at least part of the blood sample to each test module respectively. The routine blood test module performs routine blood parameter test on the distributed blood sample part, the blood sedimentation test module performs blood sedimentation test on the distributed blood sample part, and the specific protein test module performs specific protein parameter test on the distributed blood sample part. A controller is configured to control the sampling distribution module. By integrating routine blood test, specific protein test and blood sedimentation test in the same device, the functions are diversified and the use is more convenient. The integrated device can realize rapid acquisition of the test results of the three parameters, and the integrated device does not occupy additional installation space.

Description

Technical Field

[0001] This application relates to the field of medical device technology, specifically to a sample analyzer and a sample analysis method. Background Technology

[0002] Within the body's bloodstream, red blood cells remain dispersed and suspended due to blood flow and the repulsion of negatively charged surfaces. However, when blood is left to stand outside the body, red blood cells settle due to gravity. In pathological conditions, changes in the types and amounts of proteins in the plasma alter the blood's charge balance, reducing the negative charge on red blood cell surfaces and causing them to form rouleaux, thus accelerating sedimentation. Therefore, the rate of red blood cell sedimentation over one hour, known as the Erythrocyte sedimentation rate (ESR), can be used to aid in disease assessment.

[0003] Although ESR has low sensitivity and specificity in diagnosis, it is still considered a reliable, indirect acute-phase inflammatory response factor and has a long-standing and widespread clinical application. For example, ESR is widely used in the treatment and monitoring of infectious diseases, acute and chronic inflammation, rheumatic diseases, connective tissue diseases, cancer, and Hodgkin's disease.

[0004] C-reactive protein (CRP) is a non-specific inflammatory marker. It rises in various acute inflammations, tissue injuries, myocardial infarction, surgical trauma, and radiation damage. CRP is closely correlated with other inflammatory factors, such as total white blood cell count, erythrocyte sedimentation rate, and polymorphonuclear leukocytes.

[0005] Therefore, in clinical applications, there is an increasing need to combine ESR with complete blood count and / or CRP for the diagnosis of related diseases, such as inflammation. Blood analyzers with only a single detection function can no longer meet clinical needs.

[0006] Existing technologies include automated testing lines capable of multi-parameter detection, which connect various blood testing instruments with single-function capabilities. However, such lines occupy a large area and have a slow overall testing speed. Summary of the Invention

[0007] Therefore, one objective of this application is to provide a sample analyzer and a corresponding sample analysis method, which can easily integrate the erythrocyte sedimentation rate (ESR) detection module into an existing complete blood count-CRP (Cy / R) testing machine without increasing the complexity and size of the instrument. This integrates complete blood count, specific protein detection, and ESR (erythrocyte sedimentation rate) detection on a single device, meeting the clinical need for multiple parameters in a single test, and is particularly suitable for small institutions with small sample volumes.

[0008] To achieve the purpose of this application, the first aspect of this application provides a sample analyzer, including a sample dispensing module, a routine blood test module, an erythrocyte sedimentation rate (ESR) test module, and a specific protein detection module;

[0009] The sampling and distribution module is configured to collect blood samples and to distribute at least a portion of the blood samples to the routine blood test module, the erythrocyte sedimentation rate test module, and the specific protein test module, respectively.

[0010] The routine blood test module includes a routine blood test reaction pool and a routine blood test device. The routine blood test reaction pool is configured to receive a first processing reagent and a portion of blood sample distributed by the sampling and dispensing module. The routine blood test device is configured to perform routine blood test parameters on the test sample solution obtained by mixing and reacting the portion of blood sample in the routine blood test reaction pool with the first processing reagent.

[0011] The erythrocyte sedimentation rate (ESR) detection module includes an ESR detection pipeline, an ESR optical detection device, and an ESR power device connected to the ESR detection pipeline. The ESR power device is configured to transport a portion of the blood sample allocated by the sampling and dispensing module to the ESR detection pipeline. The ESR detection pipeline is configured to provide a detection site for the allocated portion of the blood sample. The ESR optical detection device is configured to irradiate the portion of the blood sample in the ESR detection pipeline with light to detect the erythrocyte sedimentation rate.

[0012] The specific protein detection module includes a specific protein reaction pool and a specific protein detection device. The specific protein reaction pool is configured to receive a second processing reagent and a portion of blood sample distributed by the sampling and dispensing module. The second processing reagent includes a hemolysin and a latex reagent. The specific protein detection device is configured to detect specific protein parameters in the test sample solution obtained by mixing and reacting the blood sample portion in the specific protein reaction pool with the second processing reagent.

[0013] The controller is connected to the sampling allocation module and configured to control the sampling allocation module.

[0014] The sample analyzer provided in the first aspect of this application integrates an erythrocyte sedimentation rate (ESR) detection module, a complete blood count (CBC) parameter detection module, and a specific protein parameter detection module into a single device. This allows for rapid acquisition of these three parameters simultaneously when simultaneous detection of ESR, CBC parameters, and specific protein parameters is required, eliminating the need to transport blood samples to separate instruments for each parameter. Furthermore, the integrated device maintains a similar size to existing CBC testing equipment, thus avoiding the need for additional installation space.

[0015] A second aspect of this application provides a corresponding sample analysis method, the sample analysis method comprising:

[0016] The sampling and distribution module collects a blood sample from a test tube and distributes different blood segments of the collected blood sample to the routine blood test module, the specific protein test module, and the erythrocyte sedimentation rate test module, respectively.

[0017] The blood routine detection module performs blood routine parameter detection on the assigned blood segments;

[0018] The specific protein detection module performs specific protein parameter detection on the assigned blood segments;

[0019] The erythrocyte sedimentation rate (ESR) detection module detects the erythrocyte sedimentation rate of the assigned blood segments.

[0020] In the sample analysis method provided in the second aspect of this application, by assigning different blood segments of a single collected blood sample to a complete blood count (CBC) module, a specific protein detection module, and an erythrocyte sedimentation rate (ESR) module, results for erythrocyte sedimentation rate, CBC parameters, and specific protein parameters can be obtained rapidly. Since different detection modules utilize different blood segments for corresponding detections, parallel detection by each module is possible.

[0021] A third aspect of this application also provides a sample analyzer, including a sample dispensing module, an erythrocyte sedimentation rate (ESR) detection module, and a specific protein detection module;

[0022] The sampling and dispensing module includes a sampling needle, a power delivery line, a sampling and dispensing power device, and a sampling needle moving device. The power delivery line fluidly connects the sampling needle to the sampling and dispensing power device. The sampling and dispensing power device is used to drive the sampling needle to draw blood samples through the power delivery line, and to drive the sampling needle to distribute at least a portion of the drawn blood samples to the specific protein detection module and the erythrocyte sedimentation rate (ESR) detection module, respectively. The sampling needle moving device is used to move the sampling needle at least to the specific protein detection module for sample dispensing.

[0023] The erythrocyte sedimentation rate (ESR) detection module includes an ESR detection pipeline, an ESR optical detection device, and an ESR power device connected to the ESR detection pipeline. The ESR power device is configured to transport a portion of the blood sample allocated by the sampling and dispensing module to the ESR detection pipeline. The ESR detection pipeline is configured to provide a detection site for the allocated portion of the blood sample. The ESR optical detection device is configured to irradiate the portion of the blood sample in the ESR detection pipeline with light to detect the erythrocyte sedimentation rate.

[0024] The specific protein detection module includes a specific protein reaction pool and a specific protein detection device. The specific protein reaction pool is configured to receive a second processing reagent and a portion of blood sample distributed by a sampling distribution module. The second processing reagent includes a hemolysin and a latex reagent. The specific protein detection device is configured to detect specific protein parameters in the test sample solution obtained by mixing and reacting the blood sample portion in the specific protein reaction pool with the second processing reagent.

[0025] The sample analyzer that integrates specific protein detection and erythrocyte sedimentation rate detection provided in the third aspect of this application uses a sampling needle to collect and dispense blood samples, which is low-cost and requires a simple fluid path. Attached Figure Description

[0026] The advantages and features of the above and / or additional aspects of this application will become apparent and readily understood from the description of the embodiments taken in conjunction with the following drawings, in which:

[0027] Figure 1 This is a schematic diagram of the structure of the first embodiment of the sample analyzer provided in the first aspect of this application;

[0028] Figure 2 This is a schematic diagram of the structure of a second embodiment of the sample analyzer provided in the first aspect of this application;

[0029] Figures 3 to 7 These are different detection timing diagrams of the sample analyzer provided in the first aspect of this application;

[0030] Figure 8 This is a schematic diagram of the third embodiment of the sample analyzer provided in the first aspect of this application;

[0031] Figure 9 This is a schematic diagram of the sampling distribution module of the sample analyzer provided in the first aspect of this application;

[0032] Figures 10 to 12 These are different timing diagrams of latex dispensing in the sample analyzer provided in the first aspect of this application;

[0033] Figure 13 This is a schematic diagram of the fourth embodiment of the sample analyzer provided in the first aspect of this application;

[0034] Figure 14 This is a schematic diagram of the fifth embodiment of the sample analyzer provided in the first aspect of this application;

[0035] Figure 15 This is a schematic diagram of the sixth embodiment of the sample analyzer provided in the first aspect of this application;

[0036] Figure 16This is a detection timing diagram of the sample analyzer provided in the second aspect of this application;

[0037] Figure 17 and Figure 18 This is a schematic flowchart illustrating different embodiments of the sample analysis method provided in the third aspect of this application. Detailed Implementation

[0038] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0039] Please refer to Figure 1 The first aspect of this application provides a sample analyzer, including an erythrocyte sedimentation rate (ESR) detection module 10, a complete blood count (CBC) detection module 20, a sample dispensing module 30, a specific protein detection module 40, and a control and information processing module 70. Figure 1 (Not shown).

[0040] The sampling and distribution module 30 is used to collect blood samples and distribute the blood samples at least partially to the routine blood test module 20, the erythrocyte sedimentation rate test module 10, and the specific protein test module 40, respectively.

[0041] In some embodiments, the sampling distribution module 30 can distribute different portions of a blood sample to the erythrocyte sedimentation rate (ESR) detection tubing 11 of the ESR detection module 10, the routine blood count (RBC) reaction chamber 21 of the RBC detection module 20, and the specific protein reaction chamber 41 of the specific protein detection module 40 by means of single collection and multiple distributions, or by multiple collections and distributions. The blood distribution method of the sampling distribution module 30 will be described in detail below.

[0042] Erythrocyte sedimentation rate (ESR) detection module 10 includes an ESR detection pipeline 11, an ESR optical detection device 12, and an ESR power device 14 connected to the ESR detection pipeline 11. Figure 1 (Not shown) The erythrocyte sedimentation rate (ESR) power device is configured to transport a portion of the blood sample dispensed by the sampling dispensing module 30 to the ESR detection line 11. The ESR detection line 11 provides a detection site for the portion of the blood sample dispensed by the sampling dispensing module 30. The ESR optical detection device 12 is used to irradiate the portion of the blood sample dispensed to the ESR detection line 11 with light to detect the erythrocyte sedimentation rate, for example, by detecting the degree of light absorption or scattering of the portion of the blood sample in the ESR detection line 11.

[0043] The routine blood test module 20 includes a routine blood test reaction pool 21 and a routine blood test device (not shown in the figure). The routine blood test reaction pool 21 is used to receive a first processing reagent and a portion of the blood sample that has been dispensed. The routine blood test device is used to perform routine blood parameter detection on the test sample solution obtained by mixing and reacting the portion of the blood sample in the routine blood test reaction pool 21 with the first processing reagent.

[0044] Those skilled in the art will understand that a complete blood count (CBC) testing device may include at least one of an optical detection unit, an impedance detection unit, and a hemoglobin detection unit. Correspondingly, a CBC reaction chamber may include at least one of an optical reaction chamber, an impedance detection reaction chamber, and a hemoglobin detection reaction chamber. When the CBC testing module 20 performs CBC parameter testing on a blood sample, the blood sample and corresponding first processing reagents (e.g., diluent and / or hemolysin and / or staining agent, etc.) can be added to the CBC reaction chamber 21. The CBC testing device measures the blood sample in the CBC reaction chamber 21 to obtain at least one CBC parameter. The CBC parameter may include, but is not limited to, at least one or more of the following: WBC (White blood cell) five-part differential result, WBC count parameter, HGB (Hemoglobin) parameter, RBC (Red blood cell) and PLT (blood platelet) count parameter. In actual CBC parameter testing, CBC test items may be added or removed as needed, and this is not limited here.

[0045] The specific protein detection module 40 includes a specific protein reaction chamber 41 and a specific protein detection device (not shown in the figure). The specific protein reaction chamber 41 is used to receive a second processing reagent and a portion of blood sample dispensed by the sampling dispensing module 30. The specific protein detection device is used to detect specific protein parameters in the test sample solution obtained by mixing and reacting the blood sample portion in the specific protein reaction chamber 41 with the second processing reagent. The second processing reagent includes a hemolysin and a latex reagent.

[0046] Those skilled in the art will understand that when the specific protein detection module 40 detects specific protein parameters in a blood sample, the blood sample and the corresponding second processing reagent can be added to the specific protein reaction chamber 41. The specific protein detection device can then detect the mixed reaction solution in the specific protein reaction chamber 41 using methods such as scattering immunoturbidimetry, transmission immunoturbidimetry, enzyme transmission immunoassay, colorimetry, or optical methods to obtain the content of the specific protein in the test sample solution, thereby obtaining at least one specific protein parameter. The specific protein reaction chamber 41 may, for example, include multiple reaction chambers to enable the simultaneous detection of multiple specific protein parameters. Specific protein parameters may include, but are not limited to, at least one or more of CRP (C-reactive protein), SAA (Serumamyloid A), hs-CRP (Hypersensitive C-reactive protein), PCT, BNP, and IL-6. In actual specific protein parameter detection, specific protein detection items can be added or removed as needed, and this is not limited here.

[0047] The control and information processing module 70 includes a controller connected to the sampling and distribution module 30. The controller is configured to control the sampling and distribution actions of the sampling and distribution module 30, that is, to control the sampling and distribution module 30 to collect blood samples from test tubes and distribute the collected blood samples to the erythrocyte sedimentation rate detection module 10, the complete blood count detection module 20 and the specific protein detection module 40 respectively.

[0048] The sample analyzer provided in the first aspect of this application integrates an erythrocyte sedimentation rate (ESR) detection module 10, a complete blood count (CBC) detection module 20, and a specific protein detection module 40. In clinical applications, a single device can perform three blood tests, offering diverse functions and greater ease of use. The three detection modules operate independently (e.g., only the ESR detection module 10 is used when only ESR parameters need to be detected), in combination (running both the CBC and ESR modules 20), or in combination (e.g., simultaneously detecting multiple specific protein parameters), allowing for flexible application in different scenarios. Furthermore, the integrated device enables the detection of CBC, ESR, and specific proteins, improving the analyzer's detection speed and reducing its footprint.

[0049] In some embodiments, the sample analyzer also includes a housing (not shown), within which the erythrocyte sedimentation rate (ESR) detection module 10, the complete blood count (CBC) detection module 20, the sample dispensing module 30, and the specific protein detection module 40 are all housed.

[0050] like Figure 1 and Figure 2As shown, in some embodiments, the sample analyzer also includes a liquid path support module 50, which provides fluid drive, reagent filling, liquid path cleaning, and waste liquid discharge functions to the sample distribution module 30, the erythrocyte sedimentation rate detection module 10, the routine blood test module 20, and the specific protein detection module 40.

[0051] In some embodiments, the liquid path support module 50 provides liquid support to the sampling dispensing module 30, the erythrocyte sedimentation rate (ESR) detection module 10, the complete blood count (CBC) detection module 20, and the specific protein detection module 40. For example, the liquid path support module 50 can provide cleaning solutions to the sampling dispensing module 30, the ESR detection module 10, the CBC detection module 20, and the specific protein detection module 40 respectively to clean the sampling dispensing module 30, the ESR detection tubing 11, the CBC reaction chamber 21, and the specific protein reaction chamber 41, avoiding contamination of the blood sample to be tested and resulting in inaccurate test results. Furthermore, the liquid path support module assists in completing reagent addition, reaction mixing, measurement, cleaning, and maintenance of the ESR detection module, the specific protein detection module, and the CBC detection module.

[0052] like Figure 1 and 2 As shown, the sample analyzer may further include a reagent module 60 for providing latex reagents to the specific protein detection module 40. This reagent module may be, for example, a thermostatic reagent module capable of storing the latex reagents at a constant temperature. In some embodiments, the reagent module includes one or more latex reagent positions 61, each containing a different latex reagent. Different latex reagents are used for the measurement of different specific protein items. The reagent module may also have a heat dissipation and ventilation device, for example.

[0053] like Figure 2 As shown, the sample analyzer may also include a sample introduction module 80, which is used to automatically transport the test tube containing the blood sample to be tested to the sample collection position, and the sample dispensing module 30 can collect the blood sample to be tested from the test tube transported to the sample collection position.

[0054] In some embodiments, such as Figure 2 As indicated by the dotted lines with double-headed arrows, the control and information processing module 70 can be connected via control, signal, or communication to the sampling distribution module 30, the erythrocyte sedimentation rate (ESR) detection module 10, the complete blood count (CBC) detection module 20, the specific protein detection module 40, the liquid path support module 50, the reagent module 60, and the sample injection module 80. This allows the sampling distribution module 30, the ESR detection module 10, the CBC detection module 20, the specific protein detection module 40, the liquid path support module 50, the reagent module 60, and the sample injection module 80 to cooperate with each other to complete the detection of erythrocyte sedimentation rate, CBC parameters, and specific protein parameters.

[0055] In some embodiments, the control and information processing module 70 may also be configured to process the erythrocyte sedimentation rate, blood routine parameters and specific protein parameters measured by the erythrocyte sedimentation rate detection module 10, the blood routine detection module 20 and the specific protein detection module 40, and output the processing results, for example, to a display not shown.

[0056] In some embodiments, the control and information processing module 70 may include a processor and a memory. The processor may be a CPU, GPU, or other chip with computing power. The memory stores various computer programs, such as operating systems and application programs, for the processor to execute, as well as the data required to execute those computer programs.

[0057] The following is combined Figures 3 to 13 Some embodiments of the structure and sampling allocation method of the sampling allocation module 30 of this application are described.

[0058] In some embodiments, when a blood sample needs to be tested for routine blood count, specific protein detection, and erythrocyte sedimentation rate (ESR) detection, the sampling allocation module 30 can allocate different blood segments of the blood sample to the ESR detection module 10, routine blood count module 20, and specific protein detection module 40 through a single collection and multiple allocations. That is, the controller is further configured to control the sampling allocation module 30, causing it to allocate different blood segments of a single collected blood sample to the routine blood count module 20, specific protein detection module 40, and ESR detection module 10, respectively. Thus, a single sample aspiration can be used to measure routine blood count parameters, specific protein parameters, and ESR parameters, improving detection efficiency.

[0059] In other alternative embodiments, the sampling allocation module 30 can allocate different blood segments of the blood sample to be tested to the erythrocyte sedimentation rate (ESR) detection module 10, the complete blood count (CBC) detection module 20, and the specific protein detection module 40 through multiple sampling and allocation. Here, the controller is further configured to control the sampling allocation module 30 such that it collects blood samples multiple times from the same test tube, at least partially allocating the first collected blood sample to at least one of the CBC detection module 10, the specific protein detection module 40, and the ESR detection module 10, and then at least partially allocating the second collected blood sample to at least one additional detection module among the CBC detection module 20, the specific protein detection module 40, and the ESR detection module 10.

[0060] For example, under the control of the controller, the sampling distribution module 30 first collects a blood sample from the test tube and distributes at least a portion of the first collected blood sample to one of the blood routine reaction pool 21, the specific protein reaction pool 41, and the erythrocyte sedimentation rate (ESR) detection line 11; then the sampling distribution module 30 collects a blood sample from the same test tube a second time and distributes at least a portion of the second collected blood sample to another of the blood routine reaction pool 21, the specific protein reaction pool 41, and the ESR detection line 11; the sampling distribution module 30 continues to collect a blood sample from the same test tube a third time and distributes at least a portion of the third collected blood sample to the last of the blood routine reaction pool 21, the specific protein reaction pool 41, and the ESR detection line 11.

[0061] In some embodiments, the sampling allocation module 30 can allocate samples serially, i.e., in a predetermined order. Specifically, the controller is further configured to control the sampling allocation module 30, such that the sampling allocation module 30 allocates the collected blood samples to the complete blood count (CBC) testing module 20, the specific protein testing module 40, and the erythrocyte sedimentation rate (ESR) testing module 10 in a predetermined order. The CBC testing module 20, the specific protein testing module 40, and the ESR testing module 10 can perform corresponding tests on the allocated blood sample portions in parallel with each other. In other words, after the sampling allocation module 30 allocates the blood sample to the corresponding testing module, the corresponding measurement module can immediately begin executing the testing sequence (e.g., hemolysis, mixing, measurement, etc.), without waiting for the sampling allocation module 30 to complete the sample allocation to all testing modules, nor waiting for other testing modules that have already allocated blood to complete their tests. Since the routine blood test module 20, the specific protein test module 40, and the erythrocyte sedimentation rate (ESR) test module 10 can perform tests in parallel, for example, when performing the three tests on the same blood sample, the time for the routine blood test module 20 to detect routine blood parameters, the time for the specific protein test module 40 to detect specific protein parameters, and the time for the ESR test module 10 to detect erythrocyte sedimentation rate overlap, which can further improve the detection efficiency and shorten the waiting time for test results.

[0062] In some specific examples, under the control of the controller, after the sampling distribution module 30 collects a blood sample, it sequentially distributes different portions of the collected blood sample to the blood routine reaction pool 21 of the blood routine detection module 20, the specific protein reaction pool 41 of the specific protein detection module 40, and the erythrocyte sedimentation rate (ESR) detection pipeline 11 of the ESR detection module 10 in a predetermined order. In other words, the sampling distribution module 30 distributes different portions of the collected blood sample sequentially to the blood routine detection module 20, the specific protein detection module 40, and the ESR detection module 10. This scheme of single sample aspiration, serial blood distribution, and parallel detection significantly improves detection efficiency.

[0063] It should be understood that in the embodiment where the sampling allocation module 30 allocates samples in a predetermined order, the order in which the sampling allocation module 30 performs blood segmentation is interchangeable; that is, the blood segmentation order of the routine blood test module 20, the specific protein test module 40, and the erythrocyte sedimentation rate (ESR) test module 10 is not limited. The blood segmentation order can be determined, for example, based on the precision requirements of the parameters to be tested. Parameters with high precision requirements are often segmented first. It is also understood that each test module can be further divided into several sub-modules based on different measurement parameters, and the blood segmentation order between these sub-modules can also be interchanged, for example, determined based on the precision requirements of the parameters to be tested.

[0064] In some preferred embodiments, to ensure the accuracy of the measurement results of routine blood parameters and specific protein parameters, when the same blood sample needs to be tested for routine blood parameters, specific protein parameters, and ESR parameters, the sampling allocation module 30 can first allocate blood to the routine blood test module 20 and the specific protein test module 40, and then allocate blood to the erythrocyte sedimentation rate (ESR) test module 10. Here, the controller is further configured to control the sampling allocation module 30, such that the sampling allocation module 30 allocates at least a portion of the collected blood sample to the routine blood test module 20 and / or the specific protein test module 40, and then allocates at least a portion of the collected blood sample to the ESR test module 10.

[0065] For example, in a scheme of one collection and multiple allocations, the controller is further configured to control the sampling allocation module 30, such that the sampling allocation module 30 first allocates at least a portion of the blood sample collected in one collection to the blood routine test module 20 and / or the specific protein test module 40, and then allocates at least another portion of the blood sample collected in one collection to the erythrocyte sedimentation rate test module 10.

[0066] Here, the sampling allocation module 30 preferentially allocates the initial blood segment C (the portion of the blood sample furthest from the diluent) of a single blood sample to the complete blood count (CBC) module 20 or the specific protein detection module 40, and then allocates a portion A of the remaining blood sample to the erythrocyte sedimentation rate (ESR) detection module 10. Because the initial blood segment C is far from the diluent, there is no risk of dilution, ensuring the precision of blood sampling and thus guaranteeing the accuracy of the measurement results for CBC parameters or specific protein parameters.

[0067] For example, in a scheme involving multiple collections and allocations, the controller is further configured to control the sampling allocation module 30, such that the sampling allocation module 30 first collects a blood sample and allocates at least a portion of the first collected blood sample to the blood routine test module 20 and / or the specific protein test module 40, and then collects a blood sample a second time and allocates at least a portion of the second collected blood sample to the erythrocyte sedimentation rate test module 10.

[0068] In some embodiments, since the detection of specific protein parameters requires higher precision in blood sampling and takes a longer time, blood can be sampled first for the specific protein detection module 40. Here, the controller is further configured to control the sampling distribution module 30 to collect blood samples, first allocating at least a portion of the collected blood samples to the specific protein detection module 40, and then allocating at least a portion of the collected blood samples to the complete blood count module 20 and / or the erythrocyte sedimentation rate (ESR) detection module 10.

[0069] In one example, such as Figure 3 and Figure 13 As shown, the controller is further configured to control the sampling allocation module 30, such that the sampling allocation module 30 first allocates the first part of the blood sample collected in one go, namely the first blood segment C, to the specific protein detection module 40, then allocates the second part of the blood sample collected in one go, namely the second blood segment B, to the blood routine detection module 20, and finally allocates the third part of the blood sample collected in one go, namely the third blood segment A, to the erythrocyte sedimentation rate detection module 10. The first part, the second part, and the third part of the blood sample collected in one go are different from each other.

[0070] like Figure 3 As shown, specifically, the sampling and distribution module 30 first collects a blood sample, and then distributes the first blood segment C of the collected blood sample to the specific protein reaction pool 41 of the specific protein detection module 40. The specific protein detection module 40 then processes the first blood segment C and the corresponding second processing reagent (as shown). Figure 3 After (not shown in the image), the detection process can be started. During the detection process of the specific protein detection module 40, the sampling distribution module 30 allocates the second blood segment B of the blood sample collected in one go to the blood routine reaction pool 21 of the blood routine detection module 20. The blood routine detection module 20 is then assigned the second blood segment B and the corresponding first processing reagent (…). Figure 3 After (not shown in the image), the detection process can be started. During the detection process of the blood routine detection module 20, the sampling distribution module 30 allocates the third blood segment A of the blood sample collected in one go to the erythrocyte sedimentation rate (ESR) detection pipeline 11 of the ESR detection module 10. The ESR detection module 10 can start the detection process after the third blood segment A is allocated.

[0071] like Figure 4 As shown, in another example, the controller is further configured to control the sampling allocation module 30 such that the sampling allocation module 30 first allocates the first part of the blood sample collected once, namely the first blood segment C, to the specific protein detection module 40, then allocates the second part of the blood sample collected once, namely the second blood segment B, to the erythrocyte sedimentation rate detection module 10, and finally allocates the third part of the blood sample collected once, namely the third blood segment A, to the blood routine detection module 20.

[0072] Specifically, the sampling and distribution module 30 first collects a blood sample, and then allocates the first blood segment C of the collected blood sample to the specific protein reaction tank 41 of the specific protein detection module 40. The specific protein detection module 40 can start the detection process after being allocated the first blood segment C and the corresponding second processing reagent. During the detection process of the specific protein detection module 40, the sampling and distribution module 30 allocates the second blood segment B of the collected blood sample to the erythrocyte sedimentation rate (ESR) detection line 11 of the ESR detection module 10. The ESR detection module 10 can start the detection process after being allocated the second blood segment B. During the detection process of the ESR detection module 10 or after the ESR detection module 10 completes the detection, the sampling and distribution module 30 allocates the third blood segment A of the collected blood sample to the routine blood count (RBC) detection module 20. The RBC detection module 20 can start the detection process after being allocated the third blood segment A and the corresponding first processing reagent. Figure 4 (Not shown in the image) After that, the detection process can be started.

[0073] In yet another example, such as Figure 5 As shown, the controller is further configured to control the sampling allocation module 30, such that the sampling allocation module 30 first allocates the first part of the blood sample collected once, namely the first blood segment C, to the blood routine detection module 20, then allocates the second part of the blood sample collected once, namely the second blood segment B, to the specific protein detection module 40, and finally allocates the third part of the blood sample collected once, namely the third blood segment A, to the erythrocyte sedimentation rate detection module 10.

[0074] Specifically, the sampling and distribution module 30 first collects a blood sample, and then distributes the first blood segment C of the collected blood sample to the blood routine reaction pool 21 of the blood routine detection module 20. The blood routine detection module 20 then processes the first blood segment C and the corresponding first processing reagent ( Figure 5 After (not shown in the image), the detection process can be started. During the detection process of the blood routine detection module 20, the sampling distribution module 30 allocates the second blood segment B of the collected blood sample to the specific protein reaction pool 41 of the specific protein detection module 40. The specific protein detection module 40, after being allocated the second blood segment B and the corresponding second processing reagent (…),… Figure 5 After (not shown in the image), the detection process can be started. During the detection process of the specific protein detection module 40, the sampling distribution module 30 allocates the third blood segment A of the blood sample collected in one go to the erythrocyte sedimentation rate (ESR) detection pipeline 11 of the ESR detection module 10. The ESR detection module 10 can start the detection process after the third blood segment A is allocated.

[0075] In addition, the erythrocyte sedimentation rate (ESR) detection module 10, the complete blood count (CBC) detection module 20, and the specific protein detection module 40 all need to be cleaned after each test to prepare for the next test, in order to avoid the residue of the previous blood sample affecting the test results of the next blood sample. The sampling and dispensing module 30 also needs to be cleaned in order to collect the next blood sample.

[0076] In one example of a protocol for collecting and distributing blood samples multiple times, such as Figure 6 As shown, the sampling and dispensing module 30 collects a blood sample from the test tube for the first time, and at least partially allocates the first collected blood sample to the specific protein reaction chamber 41 of the specific protein detection module 40. The specific protein detection module 40 then dispenses the blood sample and the corresponding second processing reagent ( Figure 6 After (not shown in the image), the detection process can be started. During the detection process of the specific protein detection module 40, the sampling distribution module 30 will clean and collect a second blood sample from the same test tube, and at least partially distribute the second blood sample to the blood routine reaction pool 21 of the blood routine detection module 20. The blood routine detection module 20 will then process the distributed blood sample and the corresponding first processing reagent (…). Figure 6 (Not shown in the image) After this, the testing process can be started. During the testing process of the blood routine test module 20, the sampling distribution module 30 will clean and collect a third blood sample from the same test tube, and distribute at least a portion of the third blood sample to the blood sedimentation rate (ESR) detection tubing 11 of the ESR detection module 10. The ESR detection module 10 can start the testing process after the blood sample is distributed. After the ESR detection module 10, the blood routine test module 20, and the specific protein detection module 40 are completed, they all need to be cleaned for the next test.

[0077] exist Figure 6 In the illustrated sequence of operations, the sampling allocation module 30 collects blood samples from the same test tube three times and allocates at least partially of each collected blood sample to one of the following detection modules: the complete blood count (CBC) detection module 20, the specific protein detection module 40, and the erythrocyte sedimentation rate (ESR) detection module 10. It is understood that the sampling allocation module 30 can also collect blood samples from the same test tube twice, allocating at least partially of the first collected blood sample to two different detection modules (CBC, Specific Protein, and ESR) and then at least partially allocating the second collected blood sample to the other detection module that has not been allocated blood; or the sampling allocation module 30 allocates at least partially of the first collected blood sample to one of the following detection modules (CBC, Specific Protein, and ESR) and then at least partially allocating the second collected blood sample to the other two detection modules that have not been allocated blood.

[0078] In a specific example, such as Figure 7 As shown, the sampling and dispensing module 30 collects a blood sample from the first test tube and dispenses the first portion of the first collected blood sample into the specific protein reaction chamber 41 of the specific protein detection module 40. The specific protein detection module 40 then dispenses the first portion of the blood sample and the corresponding second processing reagent. Figure 7 After (not shown in the image), the detection process can be started. During the detection process of the specific protein detection module 40, the sampling distribution module 30 distributes the second part of the first collected blood sample to the blood routine reaction pool 21 of the blood routine detection module 20. The blood routine detection module 20, after being allocated the second part of the blood sample and the corresponding first processing reagent (…),… Figure 7 (Not shown in the image) After this, the testing process can be started. During the testing process of the blood routine test module 20, the sampling distribution module 30 will clean and then collect a second blood sample from the same test tube, and at least a portion of the second blood sample will be distributed to the blood sedimentation rate (ESR) detection tubing 11 of the ESR test module 10. The ESR test module 10 can start the testing process after the blood sample is distributed. After the ESR test module 10, the blood routine test module 20, and the specific protein detection module 40 are completed, they all need to be cleaned for the next test.

[0079] Understandably, in a multi-collection and distribution scheme, the blood distribution order of the sampling and distribution module 30 can be interchanged, meaning the blood distribution order among the complete blood count (CBC) module 20, the specific protein detection module 40, and the erythrocyte sedimentation rate (ESR) detection module 10 is not limited. However, since the detection time for specific proteins is often long, in order to improve the detection speed, in a multi-collection and distribution scheme, the sampling and distribution module 30 can also preferentially distribute blood to the specific protein detection module 40.

[0080] Furthermore, with the sample analyzer provided in this application embodiment, during the detection process of the current blood sample, the sampling and allocation module can immediately start the sampling and allocation of the next sample after being cleaned and idle. The actions of different detection modules for the current sample and the next sample can be performed in parallel, thereby improving the detection speed of continuous detection of multiple samples.

[0081] In some embodiments, please refer to Figure 8 The sampling and dispensing module 30 may include a sampling needle 31, a power delivery line 32, a sampling and dispensing power unit 33, and a sampling needle moving device 34. The power delivery line 32 is configured to fluidly connect the sampling needle 31 to the sampling power unit 33. The sampling and dispensing power unit 33 is configured to drive the sampling needle 31 to draw blood samples via the power delivery line 32, and to drive the sampling needle 31 to dispense the drawn blood samples. The sampling needle moving device 34 is used to move the sampling needle 31 to the detection module where the blood samples to be dispensed are located for sample dispensing.

[0082] like Figure 8 As shown, the sampling dispensing power unit 33 is connected to the end 312 of the sampling needle 31 away from the needle tip 311 via a power delivery line 32. The sampling dispensing power unit 33 is used to drive the sampling needle 31 through the power delivery line 32 to aspirate or expel blood samples through the needle tip 311. For example, the sampling dispensing power unit 33 is used to provide negative pressure to the sampling needle 31 through the power delivery line 32 to aspirate blood samples and to provide positive pressure to expel blood samples. The sampling dispensing power unit 33 can be a pump, a syringe, or other pressure source capable of providing power, such as a positive or negative pressure source. Advantageously, the sampling dispensing power unit 33 is constructed as a syringe.

[0083] In some embodiments, such as Figure 8 and Figure 9 As shown, the sampling needle moving device 34 may include a moving component and a driving component for driving the moving component to move. For example, the moving component may include a horizontal moving component 341 and a vertical moving component 344, with the sampling needle fixed on the vertical moving component 344 and the vertical moving component 344 disposed on the horizontal moving component 341. The sampling needle moving device 34 may also include a horizontal moving guide rail 342 and a vertical moving guide rail 343, with the vertical moving guide rail 343 fixed on the horizontal moving component 341. The horizontal moving component 341 can move horizontally along the horizontal moving guide rail 342 in the Y direction under the drive of the driving component, thereby driving the vertical moving component 344 disposed on the horizontal moving component 341 and the sampling needle 31 fixed on the vertical moving component 344 to move in the Y direction, so that the sampling needle can move to the corresponding detection module (e.g., blood routine reaction pool 21, specific protein reaction pool 41, reagent module 60, etc.) for blood separation. The vertical motion component 344 can move vertically along the Z direction along the vertical motion guide rail 343 under the drive of the drive component, thereby driving the sampling needle 31 fixed on the vertical motion component 344 to move along the Z direction, so that the sampling needle can be inserted into the test tube to collect blood samples.

[0084] In a specific example, the sampling needle moving device 34 drives the sampling needle 31 disposed on the moving part to move horizontally via the driving component, so that the sampling needle 31 distributes at least a portion of the collected blood sample to the blood routine test module 20 blood routine reaction pool 21 and the specific protein test module 40 specific protein test pool 41.

[0085] like Figure 8As shown, blood samples are typically stored in test tube 100, and the top of test tube 100 is provided with a cap for sealing. The sampling needle moving device 34, via a driving component, drives the sampling needle 31, which is mounted on a moving component, to first move horizontally above test tube 100, and then drives the sampling needle 31 to move vertically. The sampling needle 31, with its tip or one end of the needle head 311, pierces the cap of test tube 100 and then extends into test tube 100 to draw blood samples from within. In other embodiments, test tube 100 may not have a cap, and the sampling needle 31 can directly extend into the test tube to draw blood samples.

[0086] An embodiment of the sampling needle moving device 34 is as follows: Figure 9 As shown, the driving components may include motor 42 and motor 43. The sampling needle 31 can move horizontally (Y1, Y2 directions) under the drive of motor 43 (driven by horizontal movement component 341) and vertically (Z1, Z2 directions) under the drive of motor 42 (driven by vertical movement component 344). For example, the sampling needle 31 can first move horizontally above the test tube 100 under the drive of motor 43, and then move vertically under the drive of motor 42 to insert into the test tube 100 to aspirate blood samples from the test tube.

[0087] In some embodiments, the sampling needle 31 of the sampling distribution module 30 may also be configured to absorb latex reagent and transfer the absorbed latex reagent to a specific protein reaction pool 41.

[0088] In some embodiments, the sampling distribution module 30 may further include a cleaning device configured to clean the sampling needles 31 of the sampling distribution module 30.

[0089] In some embodiments, the controller is further configured to control the sampling dispensing module 30, such that the sampling needle 31 is cleaned by the cleaning device after dispensing the corresponding blood sample portions to the routine blood testing module 20, the specific protein testing module 40, and the erythrocyte sedimentation rate testing module 10, and the latex reagent is aspirated after cleaning is completed.

[0090] Please refer to Figure 10After the sampling needle 31 of the sampling dispensing module 30 distributes at least partially the collected blood sample to the specific protein detection module 40, the complete blood count (CBC) detection module 20, and the erythrocyte sedimentation rate (ESR) detection module 10 in a predetermined order, the sampling dispensing module 30 is immediately cleaned by a cleaning device to remove residual blood sample. Then, the sampling needle 31 of the cleaned sampling dispensing module 30 aspirates latex reagent, for example, from the reagent module 60, and distributes the aspirated latex reagent to the specific protein detection module 40. For combined detection of multiple different specific protein parameters, the sampling needle 31 can be cleaned again, and the above actions of aspirating and dispensing latex reagent can be repeated until all suitable latex reagents for the specific protein parameters to be detected have been dispensed. After all suitable latex reagents have been dispensed, the sampling needle is cleaned again, for example, to prepare for the collection and dispensing of the next sample.

[0091] In the multiple collection and distribution scheme, the sampling needle 31 of the sampling distribution module 30 collects blood samples multiple times from the same test tube, and at least partially distributes each collected blood sample to at least one of the following detection modules: the complete blood count module 20, the specific protein detection module 40, and the erythrocyte sedimentation rate (ESR) detection module 10. The sampling needle 31 of the sampling distribution module 30 can be cleaned after each blood collection. Specifically, after collecting blood for the specific protein detection module 40 and cleaning the sampling needle 31 of the sampling distribution module 30, the cleaned sampling needle 31 can be used to draw latex reagent and distribute the drawn latex reagent to the specific protein detection module 40 for mixing and reaction.

[0092] Please refer to Figure 11 Since the detection time for specific protein parameters is often long, to further improve the testing speed, after the sampling needle 31 has dispensed blood samples to the specific protein measurement module 40 and the blood routine module 20, the sampling needle 31 can draw in a section of air to form an isolation air column, and then draw in latex reagent and dispense the drawn latex reagent to the specific protein detection module 40. After the latex reagent is dispensed, the sampling needle 31 can dispense the remaining blood segment in the sampling tube to the erythrocyte sedimentation rate (ESR) detection module 10 for ESR detection. By using an isolation air column instead of cleaning the sampling needle, the measurement efficiency can be improved. That is, the controller is further configured to control the sampling dispensing module, so that after the sampling needle 31 dispenses the corresponding blood sample portion to the blood routine detection module 20 and the specific protein detection module 40, it draws in air to form an isolation air column, then draws in the latex reagent and discharges the drawn latex reagent into the specific protein reaction cell 41, and then dispenses the corresponding blood sample portion to the ESR detection module 10.

[0093] In some alternative embodiments, the sample analyzer may include a separate sampling needle, independent of sampling needle 31, which draws up and dispenses the latex reagent. Further features of this separate sampling needle can be found in the above description of sampling needle 31.

[0094] In other alternative embodiments, unlike the method of using a sampling needle to transport latex reagents, the sample analyzer may also include a latex transport module for transporting latex reagents, which includes latex transport tubing leading to a specific protein reaction chamber. In this case, the transport and dispensing of latex reagents can be performed simultaneously with the collection and blood separation actions of the sampling needle 31; that is, the sampling needle 31 can directly perform the collection and blood separation actions of the next sample after cleaning.

[0095] like Figure 12 As shown, after the sampling and distribution module 30 collects blood samples and distributes the first blood segment C of the collected blood samples to the specific protein detection module 40, the latex transport module can start the latex transport and distribution operations. During the latex transport process, the sampling needle 31 can continue to distribute the second blood segment B of the collected blood samples to the blood routine detection module and the third blood segment C of the collected blood samples to the erythrocyte sedimentation rate detection module.

[0096] The following uses Figure 1 , Figure 8 as well as Figures 13 to 15 Some embodiments of the erythrocyte sedimentation rate (ESR) detection module of this application are described.

[0097] Please refer to Figure 8 Advantageously, the erythrocyte sedimentation rate (ESR) driving device 14 can be configured as a syringe. This configuration not only facilitates rapid and accurate detection of ESR (due to the precise quantitative action of the syringe, blood samples can be accurately aspirated into the detection area 113 of the ESR detection tubing 11), but also allows for simple and low-cost integration of the ESR detection module 10 into existing complete blood count analyzers, with minimal or no increase in the size of the analyzer.

[0098] In some embodiments, the erythrocyte sedimentation rate power unit 14 may also be a pump or other pressure source that can provide power.

[0099] Please refer to Figure 1 and Figure 8A portion of the power delivery line 32 can be used as the erythrocyte sedimentation rate (ESR) detection line 11. For example, the portion of the power delivery line 32 near the sampling needle 31 can be configured as the ESR detection line 11. In this case, the sampling dispensing power device 33 is preferably used as the ESR power device 14 and further used to aspirate a portion of the blood sample (e.g., the third blood segment A) from the sampling needle 31 into the ESR detection line 11. Meanwhile, the sampling needle 31 still dispenses another portion of the blood sample (e.g., the first blood segment C) from the sampling needle 31 to the specific protein reaction chamber 41 for specific protein parameter detection, and dispenses yet another portion of the blood sample (e.g., the second blood segment B) from the sampling needle 31 to the routine blood count reaction chamber 21 for routine blood count parameter detection. That is, in this embodiment, the sampling dispensing power device 33 is reused as the ESR power device 14 and the power delivery line 32 of the sampling needle 31 is reused as the ESR detection line 11, eliminating the need for separate reaction chambers and power devices, thus simplifying the structure and reducing costs.

[0100] In other words, the erythrocyte sedimentation rate (ESR) detection line 11 can be directly coupled to the rear end line of the sampling needle 31, i.e., the power delivery line 32, thereby enabling the ESR detection module 10 to be easily integrated into existing blood analyzers or complete blood count-CRP (Cellular Blood Count-Recovery) machines without increasing the complexity of the instrument and with minimal modifications.

[0101] In some embodiments, Figure 8 and Figure 13 A specific working process of blood sample dispensing in the sample analyzer shown can be as follows: The controller controls the sampling dispensing power unit 33 to drive the sampling needle 31 to dispense the first blood segment C of the collected blood sample into the specific protein reaction chamber 40 through the needle tip 311. Then, the second blood segment B of the collected blood sample is dispensed into the blood routine reaction chamber 21. Then, the erythrocyte sedimentation rate (ESR) power unit 14 controls the third blood segment A of the collected blood sample to be drawn from the end 312 of the sampling needle 31 away from the needle tip 311 into the ESR detection tubing 11. Here, the third blood segment A, the second blood segment B, and the first blood segment C are different parts of the blood sample collected in one operation. This can reduce the contamination of the blood sample parts used for blood routine parameter detection and specific protein parameter detection, thereby improving the accuracy of blood routine parameter detection and specific protein parameter detection.

[0102] In some embodiments, such as Figure 8 As shown, the sampling and dispensing power device 33 and the erythrocyte sedimentation rate (ESR) power device 14 can be the same power device, especially the same syringe. Since the syringes used for quantitative blood dispensing in routine blood tests usually require high precision, using the same syringe as the ESR power device can not only achieve rapid and accurate detection of erythrocyte sedimentation rate, but also further reduce the cost of sample analysis.

[0103] In some embodiments, during ESR detection, the blood sample can be driven to reciprocate within the ESR detection tubing 11 by the ESR power unit 14 to depolymerize the blood sample. Here, when the same power unit is used for sampling needle aspiration, blood dispensing, and ESR depolymerization, the power unit is required during depolymerization. The power unit can only be released for the next step after the blood sample depolymerization and ESR detection are completed. Furthermore, the ESR detection time is often short. Therefore, to improve overall detection efficiency, the sampling distribution module 30 can be configured to dispense blood to the ESR detection module 10 last.

[0104] A further advantage here is that, Figure 1 and Figure 8 As shown, the erythrocyte sedimentation rate (ESR) optical detection device 12 is mounted, for example, on the moving part of the sampling needle moving device 34, preferably on the horizontal moving part 341.

[0105] By mounting the erythrocyte sedimentation rate (ESR) optical detection device 12 onto the moving part of the sampling needle moving device 34, the length of the tubing through which the blood sample flows when it reaches the vicinity of the ESR optical detection device 12 is shortened, effectively reducing blood sample loss and thus reducing the amount of blood required for erythrocyte sedimentation rate (ESR) detection. Furthermore, the reduced tubing length reduces the difficulty of tubing cleaning, decreasing the consumption of diluent and cleaning time, reducing contamination rates, saving reagent costs, and increasing detection speed.

[0106] Through such Figure 1 and Figure 8 The miniaturized erythrocyte sedimentation rate (ESR) detection module shown is well compatible with the existing mainstream blood analyzer structure and effectively solves the problems of integrating ESR measurement into blood analyzers.

[0107] This is understandable, such as Figure 13 As shown, the syringe, which serves as both the sampling and dispensing power unit 33 and the erythrocyte sedimentation rate (ESR) power unit 14, is connected to the power delivery line 32 and the diluent storage unit 36 ​​via a control valve 35. When the control valve 35 connects the syringe to the diluent storage unit 36 ​​via the diluent supply line 22, the syringe draws diluent from the diluent storage unit 36 ​​via the diluent supply line 22; when the control valve 35 connects the syringe 33 to the power delivery line 32, the syringe 33 provides suction or discharge power to the sampling needle 31 via the power delivery line 32.

[0108] Figure 13 An exemplary specific working process of blood dispensing in the sample analyzer shown is as follows: Under the control of the controller,

[0109] The sampling needle moving device 34 first moves the sampling needle 31 to the test tube 100 containing the blood sample.

[0110] The sampling dispensing power unit 33 (here, a syringe) provides negative pressure to the sampling needle 31 so that the sampling needle 31 draws blood samples from the test tube 100 until the blood samples flow into the erythrocyte sedimentation rate (ESR) detection tubing 11.

[0111] The sampling needle moving device 34 moves the sampling needle 31 above the specific protein reaction pool 41, and the syringe 33 provides positive pressure to the sampling needle 31 to drip the first blood segment C of the blood sample in the sampling needle 31 into the specific protein reaction pool 41 through the needle tip 311 to detect specific protein parameters.

[0112] The sampling needle moving device 34 continues to move the sampling needle 31 above the blood routine reaction pool 21. The syringe 33 provides positive pressure to the sampling needle 31 to drip the second blood segment B of the blood sample in the sampling needle 31 into the blood routine reaction pool 21 through the needle tip 311 to detect blood routine parameters.

[0113] Next, the syringe 33 provides negative pressure to the sampling needle 31, drawing the third blood segment A of the remaining blood sample in the sampling needle 31 into the erythrocyte sedimentation rate detection tubing 11 for erythrocyte sedimentation rate detection.

[0114] In an alternative embodiment, the sampling and dispensing power device 33 and the erythrocyte sedimentation rate (ESR) power device 14 can be independent power devices, specifically independent syringes, thereby allowing different syringes to be used for different scenarios. ESR detection typically requires syringes with a flow rate of 100 μL / s (high flow rate requirement) to better achieve the erythrocyte deagglomeration process, which will be described in detail later. However, sampling and dispensing do not require a large flow rate (high accuracy requirement), and in this regard, the flow rate of the syringe serving as the ESR power device 14 can be greater than the flow rate of the syringe 33 serving as the sampling and dispensing power device 33.

[0115] In some alternative embodiments, the sampling dispensing power unit 33 may further include two independent syringes, one for dispensing 20 parts of blood to the routine blood testing module and the other for dispensing 40 parts of blood to the specific protein testing module. Those skilled in the art will understand that the aforementioned functions of the two syringes in the sampling dispensing power unit 33 can be achieved through valve control technology.

[0116] In some embodiments, the erythrocyte sedimentation rate (ESR) power device 14 is configured to drive the blood sample portion dispensed by the sampling dispensing module 30 to flow in the ESR detection pipeline 11 and stop moving after the dispensed blood sample portion flows to the detection area 113 of the ESR detection pipeline 11 and remains stationary, so that the ESR optical detection device 12 can detect the erythrocyte sedimentation rate of the dispensed blood sample portion.

[0117] In one example, the working process of detecting erythrocyte sedimentation rate (ESR) provided in this application embodiment is as follows: The ESR driving device 14 drives a portion of the allocated blood sample to flow into the ESR detection line 11. When the allocated blood sample reaches a specific position (detection zone 113) in the ESR detection line 11, the ESR driving device 14 suddenly stops and momentarily interrupts the flow of the allocated blood sample in the ESR detection line 11, causing the allocated blood sample to suddenly decelerate (or stop flowing), followed by erythrocyte aggregation. During the erythrocyte aggregation process, the signal detected by the ESR optical detection device 12 changes, thereby obtaining information for determining the ESR. In other words, the ESR driving device 14 can immediately stop driving after driving the allocated blood sample to the detection zone 113 of the ESR detection line 11, thus keeping the allocated blood sample stationary in the detection zone 113 so that the ESR optical detection device 12 can detect the erythrocyte aggregation rate of the allocated blood sample, thereby obtaining the ESR.

[0118] Compared to the Widmanstätten method in the prior art, the sample analyzer provided in this application embodiment can limit the length of the erythrocyte sedimentation rate (ESR) detection tubing 11, which not only reduces the overall size of the instrument, but also reduces the amount of blood required for detection and analysis, as well as the amount of cleaning solution used to clean the ESR detection tubing 11, thereby greatly reducing the cost of the sample analyzer that integrates ESR detection, specific protein parameter detection, and routine blood tests.

[0119] To ensure that the red blood cells in the blood sample of the erythrocyte sedimentation rate (ESR) detection tube 11 are as dispersed as possible before the ESR optical detection device 12 measures the ESR, thus enabling more accurate measurement, an ESR power device 14 reciprocates to drive the blood sample in the ESR detection tube 11. Especially when the ESR power device 14 is constructed as a syringe, the speed and direction of the syringe movement can be flexibly set, allowing for efficient deagglomeration of the blood sample and conserving blood volume. Particularly when using a high-flow, high-speed syringe, the number of reciprocating strokes can be reduced to achieve the desired deagglomeration effect.

[0120] Therefore, in some embodiments, the erythrocyte sedimentation rate (ESR) driving device 14 can drive the blood sample of the ESR detection tube 11 to flow back and forth in the ESR detection tube 11 a predetermined number of times; then the ESR driving device 14 can immediately stop driving after driving the blood sample of the ESR detection tube 11 to the detection area 113 of the ESR detection tube 11, so that the blood sample of the ESR detection tube 11 remains stationary in the detection area 113 of the ESR detection tube 11, so that the ESR optical detection device 12 can detect the red blood cell aggregation rate in the blood sample of the ESR detection tube 11, thereby obtaining the red blood cell sedimentation rate.

[0121] In one specific embodiment, when the erythrocyte sedimentation rate (ESR) power device 14 drives the blood sample in the ESR detection line 11 to flow back and forth in the ESR detection line 11 a predetermined number of times, the ESR power device 14 can perform the following actions a predetermined number of times:

[0122] The blood sample in the erythrocyte sedimentation rate (ESR) detection line 11 is driven to flow in the ESR detection line 11 in the first direction for a first stroke at a first speed;

[0123] Then, the blood sample in the erythrocyte sedimentation rate (ESR) detection line 11 is driven at a second speed to flow in the ESR detection line 11 in a second direction opposite to the first direction for a second stroke.

[0124] Preferably, the first speed and the second speed are the same, and the first stroke and the second stroke are the same. This enables simple control of the erythrocyte sedimentation rate (ESR) power unit 14.

[0125] Furthermore, during the detection period of the erythrocyte sedimentation rate (ESR) detection module 10, at least one of the first speed, second speed, first stroke, second stroke, and predetermined number of times can be adjusted based on at least one blood routine parameter measured by the blood routine detection module 20, so as to achieve a better depolymerization effect and thus obtain better consistency of ESR results.

[0126] In some embodiments, the erythrocyte sedimentation rate (ESR) driving device 14 can also drive a portion of the dispensed blood sample to flow through the ESR detection line 11 after the ESR detection is completed, so as to discharge the ESR detection line 11 and prepare for the next test.

[0127] In some alternative embodiments, such as Figure 14 As shown, the erythrocyte sedimentation rate (ESR) detection module 10 can also function as an independent detection module, similar to the routine blood count measurement module 20 and the specific protein measurement module 40, fixed to a mechanical partition inside the sample analyzer, rather than fixed to the sampling dispensing module 30. The ESR detection tubing 11 branches off from the power delivery tubing 32, and the sampling needle 31 is connected to the ESR power unit 14 and the sampling dispensing power unit 33 via a three-way valve 37 located in the power delivery tubing 32.

[0128] In other alternative embodiments, please refer to Figure 15 Unlike embodiments where the erythrocyte sedimentation rate (ESR) detection tubing 11 is directly connected to the rear end of the sampling needle 31, the ESR detection module 10 also includes a separate ESR reaction chamber 13. The ESR reaction chamber 13 is connected to one end of the ESR detection tubing 11 and is used to receive a portion of the blood sample dispensed by a sampling dispensing module, such as the sampling needle 31. The ESR detection tubing 11 connects the ESR reaction chamber 13 to the ESR power unit 14, which is configured to transport at least a portion of the blood sample from the ESR reaction chamber 13 into the ESR detection tubing 11.

[0129] Here, the erythrocyte sedimentation rate (ESR) power device 14 is used to drive the blood segment in the ESR reaction tank 13 to flow into the ESR detection pipeline 11, and to make the blood segment stop moving and remain stationary after flowing into the detection area in the ESR detection pipeline 11, so that the ESR optical detection device 12 can detect the erythrocyte sedimentation rate of the blood segment.

[0130] exist Figure 15 In the illustrated embodiment, a specific working process of blood dispensing in the sample analyzer provided in this application is as follows: Under the control of the controller,

[0131] The sampling needle moving device 34 first moves the sampling needle 31 to the test tube 100 containing the blood sample.

[0132] The sampling and dispensing power unit 33 provides negative pressure to the sampling needle 31 so that the sampling needle 31 can draw blood samples from the test tube 100.

[0133] Then, the sampling needle moving device 34 moves the sampling needle 31 above the blood routine reaction pool 21, and the sampling dispensing power device 33 provides positive pressure to the sampling needle 31 to drip a portion of the blood sample in the sampling needle 31 into the blood routine reaction pool 21 to detect blood routine parameters.

[0134] The sampling needle moving device 34 continues to move the sampling needle 31 to the specific protein reaction chamber 41. Figure 15 Above (not shown), the sampling dispensing power unit 33 provides positive pressure to the sampling needle 31 to drip another portion of the blood sample in the sampling needle 31 into a specific protein reaction pool to detect specific protein parameters.

[0135] Next, the sampling needle moving device 34 moves the sampling needle 31 above the erythrocyte sedimentation rate (ESR) reaction chamber 13, and the sampling dispensing power device 33 provides positive pressure to the sampling needle 31 to drip the remaining blood sample in the sampling needle 31 into the ESR reaction chamber 13. Then, the ESR power device 14 aspirates the blood sample from the ESR reaction chamber 13 into the ESR detection tubing 11 to detect the erythrocyte sedimentation rate.

[0136] In some embodiments, please refer to Figure 1 , Figure 8 , Figure 14 and Figure 15The erythrocyte sedimentation rate (ESR) optical detection device 12 includes a light emitter 121 and a light receiver 122. The light emitter 121 and light receiver 122 are located on opposite sides of the detection area 113 of the ESR detection pipeline 11. The light emitter 121 is used to illuminate the dispensed blood sample portion within the detection area 113. The light receiver 122 is used to detect the change in the amount of light emitted by the light emitter 121 after illuminating the dispensed blood sample portion (e.g., receiving light transmitted and / or scattered by the blood sample portion), and to detect the degree of light absorption or scattering by the dispensed blood sample portion by detecting the amount of light received.

[0137] In some embodiments, the erythrocyte sedimentation rate (ESR) detection line 11 is made of a flexible tube, and the detection area 113 of the ESR detection line 11 is made of a light-transmitting material. Therefore, the ESR detection line 11 can be arbitrarily and flexibly arranged, for example, it can be arranged vertically, horizontally, or inclined, or it can be bent, without limitation.

[0138] In some embodiments, the erythrocyte sedimentation rate (ESR) detection line 11 is configured as a capillary.

[0139] In some embodiments, the erythrocyte sedimentation rate (ESR) detection line 11 is made of FEP (Fluorinated ethylene propylene copolymer). When the ESR detection line 11 is part of the power delivery line 32, the power delivery line 32 is made of FEP.

[0140] Furthermore, in some embodiments, such as Figure 8 and Figure 14 As shown, the erythrocyte sedimentation rate (ESR) detection module 10 may further include a temperature sensor 15 and a heater 16 disposed near the detection zone 113 of the ESR detection pipeline 11 and communicated with the control and information processing module 70. The temperature sensor 15 is used to detect the temperature value of the blood sample in the ESR detection pipeline 11 and transmit the temperature value to the control and information processing module 70. The control and information processing module 70 is configured to control the heater 16 to heat the blood sample in the ESR detection pipeline 11 when the temperature value is lower than a predetermined temperature.

[0141] A second aspect of this application also provides a sample analyzer, including an erythrocyte sedimentation rate (ESR) detection module 10, a sample dispensing module 30, and a specific protein detection module 40.

[0142] The sampling dispensing module 30 includes a sampling needle 31, a power delivery line 32, a sampling dispensing power unit 33, and a sampling needle moving device 34. The power delivery line 32 fluidly connects the sampling needle 31 to the sampling dispensing power unit 33. The sampling dispensing power unit 33 is used to drive the sampling needle 31 to draw blood samples through the power delivery line 32, and to drive the sampling needle 31 to at least partially distribute the drawn blood samples to the specific protein detection module 40 and the erythrocyte sedimentation rate detection module 10, respectively. The sampling needle moving device 34 is used to move the sampling needle 31 at least to the specific protein detection module 40 for sample dispensing.

[0143] The erythrocyte sedimentation rate (ESR) detection module 10 includes an ESR detection pipeline 11, an ESR optical detection device 12, and an ESR power device 14 connected to the ESR detection pipeline 11. The ESR power device 14 is configured to transport a portion of the blood sample dispensed by the sampling distribution module 30 to the ESR detection pipeline 11. The ESR detection pipeline 11 provides a detection site for the portion of the blood sample dispensed by the sampling distribution module 30. The ESR optical detection device 12 is used to irradiate the portion of the blood sample dispensed to the ESR detection pipeline 11 with light to detect the erythrocyte sedimentation rate.

[0144] The specific protein detection module 40 includes a specific protein reaction pool 41 and a specific protein detection device. The specific protein reaction pool 41 is used to receive a second processing reagent and a portion of blood sample distributed by the sampling distribution module 30. The second processing reagent includes a hemolysin and a latex reagent. The specific protein detection device is used to detect specific protein parameters in the test sample solution obtained by mixing and reacting the blood sample portion in the specific protein reaction pool 41 with the second processing reagent.

[0145] The sample analyzer provided in this application embodiment integrates an erythrocyte sedimentation rate (ESR) detection module 10 and a specific protein detection module 40. By using a sampling needle to separate blood, it can achieve simple, low-cost, and rapid simultaneous detection of erythrocyte sedimentation rate and specific protein parameters.

[0146] In some embodiments, the erythrocyte sedimentation rate (ESR) driving device 14 is configured to immediately stop driving after driving a portion of the blood sample distributed by the sampling distribution module 30 into the detection area 113 of the ESR detection pipeline 11, thereby keeping the distributed portion of the blood sample stationary in the detection area of ​​the ESR detection pipeline, so that the ESR optical detection device 12 can detect the erythrocyte aggregation rate of the portion of the blood sample in the detection area 113, thereby obtaining the erythrocyte sedimentation rate.

[0147] In some embodiments, the erythrocyte sedimentation rate (ESR) driving device 14 is configured to immediately stop driving after driving the blood sample in the ESR detection line 11 to flow back and forth in the ESR detection line 11 a predetermined number of times, thereby keeping the distributed blood sample portion stationary in the detection area 113 of the ESR detection line 11, so that the ESR optical detection device can detect the red blood cell aggregation rate of the blood sample portion in the detection area, thereby obtaining the erythrocyte sedimentation rate.

[0148] The erythrocyte sedimentation rate (ESR) detection module 10 of the sample analyzer provided in this application detects the erythrocyte sedimentation rate by detecting the degree of light scattering or absorption during the aggregation of red blood cells in a blood sample (i.e., by detecting the red blood cell aggregation speed). Compared with the detection method that waits for red blood cells to settle naturally under gravity (Widmanstätten method), the detection speed is faster, and the ESR detection can be completed in a very short time (e.g., 20 seconds), and the blood consumption is less, only about 100 μL. In addition, for the Widmanstätten method, the rigid detection tube must be set in a straight line and vertically or slightly tilted, which can easily make the instrument too large. However, the ESR detection tube 11 provided in this embodiment of the application is not limited in setting angle and can be flexibly adjusted according to the setting of other internal structures of the sample analyzer, thereby reducing the overall size of the sample analyzer and making the sample analyzer occupy less space.

[0149] In some embodiments, a portion of the power delivery line 32 can be an erythrocyte sedimentation rate (ESR) detection line 11. For example, the portion of the power delivery line 32 closest to the sampling needle 31 can be configured as the ESR detection line 11. In this case, the sampling dispensing power unit 33 is preferably used as the ESR power unit 14 and further used to aspirate a portion of the blood sample in the sampling needle 31 into the ESR detection line 11. This eliminates the need for a separate reaction chamber and power unit, resulting in a simpler structure and reduced costs.

[0150] like Figure 16The timing diagram shows that the sampling dispensing power unit 33 drives the sampling needle 31 to draw blood samples from the test tube. Then, the sampling needle moving device 34 moves the sampling needle 31 to the specific protein reaction chamber 41 of the specific protein detection module 40 for blood separation (segment E). Next, the sampling dispensing power unit 33 draws the remaining blood sample (segment D) from the sampling needle 31 into the erythrocyte sedimentation rate (ESR) detection tubing 11. After the sampling needle 31 completes the blood separation, it is cleaned. After cleaning, the sampling needle 31 continues to draw latex reagent and dispense it into the specific protein detection module 40 until all the appropriate latex reagents for the specific protein parameters have been dispensed. The sampling needle 31 is then cleaned again to prepare for the next sample test. The specific protein detection module 40 can start the detection process after receiving the blood sample and corresponding latex reagent. After each module's detection action is completed, each module and tubing is cleaned.

[0151] In some embodiments, the sampling needle moving device 34 may include a moving component and a driving component for driving the moving component to move. For example, the moving component of the sampling needle moving device 34 may include a horizontal moving component 341 and a vertical moving component 344.

[0152] Advantageously, the sampling needle 31 and the erythrocyte sedimentation rate (ESR) optical detection device 12 of the ESR detection module 10 are mounted on the moving parts of the sampling needle moving device 34. For example, the sampling needle 31 is mounted on the vertical moving part 344, the ESR optical detection device 12 is mounted on the horizontal moving part 341, and the vertical moving part 344 is mounted on the horizontal moving part 241.

[0153] Other embodiments and advantages of the sample analyzer provided in the second aspect of this application can be found in the above description of the sample analyzer provided in the first aspect of this application, and will not be detailed here.

[0154] A third aspect of this application also provides a sample analysis method, such as... Figure 17 As shown, the sample analysis method may include the following steps:

[0155] Sampling and allocation step S200: The sampling and allocation module 30 collects a blood sample from the test tube 100 and allocates different blood segments of the collected blood sample to the blood routine test module 20, the specific protein test module 40 and the erythrocyte sedimentation rate test module 10 respectively.

[0156] Blood routine test step S210: Blood routine test module 20 performs blood routine parameter tests on the assigned blood segments;

[0157] Specific protein detection step S220: The specific protein detection module 40 performs blood routine parameter detection on the assigned blood segment;

[0158] Erythrocyte sedimentation rate (ESR) detection step S230: The ESR detection module 10 performs ESR detection on the assigned blood segments.

[0159] In some embodiments, steps S210, S220 and S230 can be performed independently and in parallel.

[0160] In some embodiments, the sampling allocation step S200 may include: the sampling allocation module 30 collecting a blood sample from the test tube 100 at one time, and then sequentially allocating different blood segments of the collected blood sample to the blood routine detection module 20, the specific protein detection module 40, and the erythrocyte sedimentation rate detection module 10 in a predetermined order.

[0161] In some embodiments, the sampling allocation step S200 may include: the sampling allocation module 30 collecting a blood sample from the test tube 100 at one time, then allocating at least a portion of the blood sample collected at one time to the blood routine detection module 20 and / or the specific protein detection module 40, and then allocating another portion of the blood sample collected at one time to the erythrocyte sedimentation rate detection module 10.

[0162] In some embodiments, the erythrocyte sedimentation rate (ESR) power unit 14 and the sampling dispensing power unit 33 may be the same power unit, particularly the same syringe. Here, it is particularly preferred that the ESR detection tubing 11 is part of the power delivery tubing 32.

[0163] like Figure 18 As shown, the sampling allocation step S200 may include:

[0164] S300, the sampling distribution module 30 collects a blood sample from the collection tube 100.

[0165] S310, the sampling distribution module 30 allocates the first blood segment of a blood sample collected in one go to the specific protein reaction pool 41 of the specific protein detection module 40 to detect specific protein parameters.

[0166] S320, the sampling distribution module 30 distributes the second blood segment of the collected blood sample to the blood routine reaction pool 21 of the blood routine detection module 20 to detect blood routine parameters.

[0167] S330, the sampling distribution module 30 distributes the third blood segment of a blood sample collected once to the erythrocyte sedimentation rate detection pipeline 11 of the erythrocyte sedimentation rate detection module 10 to detect the erythrocyte sedimentation rate.

[0168] S340, after the sampling and allocation module completes the sampling and allocation actions, clean the sampling and allocation module 30.

[0169] In this embodiment, S300, S310, S320, S330 and S340 are implemented sequentially.

[0170] The sample analysis method provided in the third aspect of this application can be applied to the sample analyzer provided in the first aspect of this application. The advantages and further embodiments of the sample analysis method provided in this application can be found in the above description of the sample analyzer, and will not be repeated here.

[0171] It should be noted that, in this document, relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Unless otherwise specified, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes the element.

[0172] The features mentioned above in the specification, drawings, and claims can be freely combined with each other, provided they are meaningful within the scope of this application. The features and advantages described for the sample analyzer according to this application are applied accordingly to the sample analysis method according to this application, and vice versa.

[0173] The above are merely specific embodiments of this application, enabling those skilled in the art to understand or implement this application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of this application. Therefore, this application is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features claimed herein.

Claims

1. A sample analyzer, characterized in that, include: The system includes a sampling and distribution module, a complete blood count (CBC) testing module, an erythrocyte sedimentation rate (ESR) testing module, and a specific protein testing module. The sampling and distribution module is configured to collect blood samples and to distribute at least a portion of the blood samples to the routine blood test module, the erythrocyte sedimentation rate test module, and the specific protein test module, respectively. The routine blood test module includes a routine blood test reaction pool and a routine blood test device. The routine blood test reaction pool is configured to receive a first processing reagent and a portion of blood sample distributed by the sampling and dispensing module. The routine blood test device is configured to perform routine blood test parameters on the test sample solution obtained by mixing and reacting the portion of blood sample in the routine blood test reaction pool with the first processing reagent. The erythrocyte sedimentation rate (ESR) detection module includes an ESR detection pipeline, an ESR optical detection device, and an ESR power device connected to the ESR detection pipeline. The ESR power device is configured to transport a portion of the blood sample allocated by the sampling and dispensing module to the ESR detection pipeline. The ESR detection pipeline is configured to provide a detection site for the allocated portion of the blood sample. The ESR optical detection device is configured to irradiate the portion of the blood sample in the ESR detection pipeline with light to detect the erythrocyte sedimentation rate. The specific protein detection module includes a specific protein reaction pool and a specific protein detection device. The specific protein reaction pool is configured to receive a second processing reagent and a portion of blood sample distributed by the sampling and dispensing module. The second processing reagent includes a hemolysin and a latex reagent. The specific protein detection device is configured to detect specific protein parameters in the test sample solution obtained by mixing and reacting the blood sample portion in the specific protein reaction pool with the second processing reagent. A controller is connected to and configured to control the sampling allocation module. The controller is further configured to control the sampling allocation module, such that the sampling allocation module allocates different portions of a blood sample collected in one go to the routine blood test module, the specific protein test module, and the erythrocyte sedimentation rate test module, respectively. The controller is further configured to control the sampling allocation module, such that the sampling allocation module allocates the collected blood samples to the routine blood test module, the specific protein test module, and the erythrocyte sedimentation rate (ESR) test module in a predetermined order, and the routine blood test module, the specific protein test module, and the ESR test module can perform corresponding tests on the allocated blood sample portions in parallel with each other.

2. The sample analyzer according to claim 1, characterized in that, The sampling and dispensing module includes a sampling needle, a power delivery pipeline, a sampling and dispensing power device, and a sampling needle moving device. The power delivery pipeline is configured to fluidly connect the sampling needle to the sampling and dispensing power device. The sampling and dispensing power device is configured to drive the sampling needle to draw blood samples through the power delivery pipeline and to drive the sampling needle to dispense the drawn blood samples. The sampling needle moving device is configured to move the sampling needle to the detection module where the blood samples to be dispensed are located for sample dispensing.

3. The sample analyzer according to claim 2, characterized in that, The erythrocyte sedimentation rate (ESR) detection pipeline is part of the power delivery pipeline.

4. The sample analyzer according to claim 2 or 3, characterized in that, The sampling needle moving device includes a moving part and a driving part for driving the moving part to move. The sampling needle and the erythrocyte sedimentation rate optical detection device are disposed on the moving part.

5. The sample analyzer according to any one of claims 1 to 3, characterized in that, The controller is further configured to control the sampling allocation module, such that the sampling allocation module allocates at least a portion of the collected blood sample to the complete blood count (CBC) testing module and / or the specific protein detection module, and then allocates at least a portion of the collected blood sample to the erythrocyte sedimentation rate (ESR) testing module; and / or The controller is further configured to control the sampling allocation module such that the sampling allocation module first allocates at least a portion of the collected blood sample to the specific protein detection module, and then allocates at least a portion of the collected blood sample to the routine blood test module and / or the erythrocyte sedimentation rate (ESR) test module.

6. The sample analyzer according to any one of claims 1 to 3, characterized in that, The controller is further configured to control the sampling allocation module such that the sampling allocation module first allocates at least a portion of a blood sample collected in one go to the routine blood test module and / or the specific protein test module, and then allocates at least another portion of the blood sample collected in one go to the erythrocyte sedimentation rate (ESR) test module.

7. The sample analyzer according to claim 6, characterized in that, The controller is further configured to control the sampling allocation module, such that the sampling allocation module first allocates a first portion of a blood sample collected in one go to the specific protein detection module, then allocates a second portion of the blood sample collected in one go to the routine blood test module, and finally allocates a third portion of the blood sample collected in one go to the erythrocyte sedimentation rate (ESR) test module.

8. The sample analyzer according to claim 2 or 3, characterized in that, The sampling and distribution power device and the erythrocyte sedimentation rate (ESR) power device are the same power device; or the sampling and distribution power device and the ESR power device are different power devices.

9. The sample analyzer according to claim 2 or 3, characterized in that, The sampling needle of the sampling and dispensing module is also configured to draw up the latex reagent and transfer the drawn-up latex reagent to the specific protein reaction chamber.

10. The sample analyzer according to claim 9, characterized in that, The sampling distribution module also includes a cleaning device, which is configured to clean the sampling needle; The controller is further configured to control the sampling distribution module, such that after the sampling needle distributes the corresponding blood sample portion to the routine blood test module, the specific protein test module and the erythrocyte sedimentation rate test module, it is cleaned by the cleaning device, and the latex reagent is aspirated after cleaning is completed.

11. The sample analyzer according to claim 9, characterized in that, The controller is further configured to control the sampling distribution module, such that after the sampling needle distributes the corresponding blood sample portion to the routine blood test module and the specific protein test module, it draws in air to form an isolation air column, then draws in the latex reagent and discharges the drawn latex reagent into the specific protein reaction pool, and then distributes the corresponding blood sample portion to the erythrocyte sedimentation rate test module.

12. The sample analyzer according to claim 1, characterized in that, The erythrocyte sedimentation rate (ESR) detection module further includes an ESR reaction chamber, which is configured to receive a portion of the blood sample allocated by the sampling and distribution module. The ESR detection pipeline is connected between the ESR reaction chamber and the ESR power device, which is configured to transport at least a portion of the blood sample in the ESR reaction chamber to the ESR detection pipeline.

13. The sample analyzer according to any one of claims 1 to 3, characterized in that, The erythrocyte sedimentation rate (ESR) power device is also configured to drive the blood sample in the ESR detection pipeline to flow back and forth in the ESR detection pipeline a predetermined number of times.

14. A sample analyzer, characterized in that, include: Sampling and distribution module, erythrocyte sedimentation rate (ESR) detection module, and specific protein detection module; The sampling and dispensing module includes a sampling needle, a power delivery line, a sampling and dispensing power device, and a sampling needle moving device. The power delivery line fluidly connects the sampling needle to the sampling and dispensing power device. The sampling and dispensing power device is used to drive the sampling needle to draw blood samples through the power delivery line, and to drive the sampling needle to distribute at least a portion of the drawn blood samples to the specific protein detection module and the erythrocyte sedimentation rate (ESR) detection module, respectively. The sampling needle moving device is used to move the sampling needle at least to the specific protein detection module for sample dispensing. The erythrocyte sedimentation rate (ESR) detection module includes an ESR detection pipeline, an ESR optical detection device, and an ESR power device connected to the ESR detection pipeline. The ESR power device is configured to transport a portion of the blood sample allocated by the sampling and dispensing module to the ESR detection pipeline. The ESR detection pipeline is configured to provide a detection site for the allocated portion of the blood sample. The ESR optical detection device is configured to irradiate the portion of the blood sample in the ESR detection pipeline with light to detect the erythrocyte sedimentation rate. The specific protein detection module includes a specific protein reaction chamber and a specific protein detection device. The specific protein reaction chamber is configured to receive a second processing latex reagent and a portion of a blood sample dispensed by a sampling dispensing module. The second processing reagent includes a hemolysin and a latex reagent. The specific protein detection device is configured to detect specific protein parameters in the test sample solution obtained by mixing and reacting the blood sample portion in the specific protein reaction chamber with the second processing reagent. A controller is connected to and configured to control the sampling allocation module. The controller is further configured to control the sampling allocation module, such that the sampling allocation module allocates different portions of a blood sample collected in one go to the specific protein detection module and the erythrocyte sedimentation rate detection module, respectively. The controller is further configured to control the sampling allocation module, such that the sampling allocation module allocates the collected blood samples to the specific protein detection module and the erythrocyte sedimentation rate (ESR) detection module in a predetermined order, and the specific protein detection module and the ESR detection module can perform corresponding detections on the allocated blood sample portions in parallel with each other.

15. The sample analyzer according to claim 14, characterized in that, The erythrocyte sedimentation rate (ESR) driving device is configured to immediately stop driving after driving a portion of the blood sample allocated by the sampling and dispensing module into the detection area of ​​the ESR detection pipeline, or after driving the blood sample in the ESR detection pipeline to flow back and forth in the ESR detection pipeline a predetermined number of times, thereby keeping the allocated portion of the blood sample stationary in the detection area of ​​the ESR detection pipeline, so that the ESR optical detection device can detect the red blood cell aggregation rate of the portion of the blood sample in the detection area.

16. The sample analyzer according to claim 14 or 15, characterized in that, The erythrocyte sedimentation rate (ESR) detection pipeline is part of the power delivery pipeline.

17. The sample analyzer according to claim 16, characterized in that, The sampling needle moving device includes a moving part and a driving part for driving the movement of the moving mechanism, and the sampling needle and the erythrocyte sedimentation rate optical detection device are disposed on the moving part.

18. A sample analysis method, characterized in that, The sample analysis method includes: The sampling and distribution module collects a blood sample from a test tube and distributes different blood segments of the collected blood sample to the routine blood test module, the specific protein test module, and the erythrocyte sedimentation rate test module, respectively. The blood routine detection module performs blood routine parameter detection on the assigned blood segments; The specific protein detection module performs specific protein parameter detection on the assigned blood segments; The erythrocyte sedimentation rate (ESR) detection module performs erythrocyte sedimentation rate detection on the assigned blood segments. The routine blood test module, the specific protein detection module, and the ESR detection module perform their respective tests in parallel.

19. The sample analysis method according to claim 18, characterized in that, The steps of the sampling allocation module in allocating the blood sample collected in one transaction include: The sampling allocation module allocates different blood segments of the blood sample collected in one session to the routine blood test module, the specific protein test module, and the erythrocyte sedimentation rate test module in a predetermined order.

20. The sample analysis method according to claim 19, characterized in that, The steps of the sampling allocation module in allocating the blood sample collected in one transaction include: The sampling allocation module first allocates at least a portion of the blood segment of the blood sample collected in one go to the routine blood test module and / or the specific protein test module, and then allocates another portion of the blood segment of the blood sample collected in one go to the erythrocyte sedimentation rate (ESR) test module.

21. The sample analysis method according to claim 20, characterized in that, The steps of the sampling allocation module in allocating the blood sample collected in one transaction include: The sampling allocation module first allocates the first blood segment of the blood sample collected in one go to the specific protein detection module, then allocates the second blood segment of the blood sample collected in one go to the blood routine detection module, and finally allocates the third blood segment of the blood sample collected in one go to the erythrocyte sedimentation rate detection module.

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