A process for the preparation of N-terminal alkenyl amides from aromatic aldehydes and amides

Abstract

The application discloses a method for preparing N-terminal alkenyl amide from aromatic aldehyde and amide, which comprises the following steps: under the action of a base, aromatic aldehyde and amide or cyclic amide are subjected to one-pot reaction in an atmospheric atmosphere and dimethyl sulfoxide solvent, and N-terminal alkenyl amide compound is obtained. The N-terminal alkenyl amide compound obtained by the method is derived from the aldehyde raw material, but has one more double bond carbon atom than the original aldehyde raw material. In the reaction process, the carbon-oxygen double bond of the raw material aromatic aldehyde is converted into a carbon-carbon double bond, and the hydrogen atom on the carbonyl carbon of the aromatic aldehyde is replaced by the nitrogen atom in the amide or cyclic amide molecule. The method has the advantages of wide and easy raw material source, green environmental protection, low price and simple operation, and is favorable for industrialized production.

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