猫传染性鼻结膜炎和猫传染性鼻气管炎二联冻干卵黄抗体以及制备方法与应用
By preparing bivalent lyophilized egg yolk antibodies against feline infectious rhinoconjunctivitis and feline infectious rhinotracheitis, the problem of the lack of effective treatment methods in existing technologies has been solved, achieving a highly efficient and stable immune protection effect, which is in line with animal welfare and cost-effectiveness.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- CHANGCHUN SR BIOLOGICAL TECH
- Filing Date
- 2022-09-27
- Publication Date
- 2026-07-17
AI Technical Summary
There is a lack of effective drugs for treating feline infectious rhinoconjunctivitis and feline infectious rhinotracheitis in the current technology, and existing vaccines cannot provide complete protection. Traditional vaccines can only reduce clinical morbidity and viral shedding, and there is a lack of specific antibody treatment products.
By immunizing laying hens with feline calicivirus and feline herpesvirus, bivalent lyophilized egg yolk antibodies against feline infectious rhinoconjunctivitis and feline infectious rhinotracheitis were prepared. Laying hens were immunized with inactivated vaccines prepared from FCV CC3 strain and FHV CP2 strain. High-titer egg yolk antibodies were extracted and lyophilized using acid dilution, ammonium sulfate purification and ultrafiltration concentration methods.
The prepared bivalent lyophilized egg yolk antibody has high titers, with a feline calicivirus neutralizing antibody titer of no less than 1:2048 and a feline herpesvirus neutralizing antibody titer of no less than 1:512. It provides effective immune protection, is fast-acting, has no drug resistance, complies with animal welfare, has good stability, and is low in cost.
Smart Images
Figure CN115611979B_ABST