Polymer phospholipid nanoparticle mRNA vaccine and method of making same

CN115645517BActive Publication Date: 2026-08-28JIANGSU JICUI ADVANCED POLYMER MATERIAL RES INST CO LTD +1
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Patent Information

Application Number
CN202211101558.X
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-09-09
Publication Date
2026-08-28
Estimated Expiration
2042-09-09

AI Technical Summary

Technical Problem

[0004]但目前mRNA疫苗载体系统在体内发挥疗效的稳定性、传递效率、自身安全性上还存在不足，迄今为止能被大众所接受且完全成熟的mRNA疫苗依旧很少

Benefits of technology

[0031]本发明以脂质体-功能性聚多巴胺纳米粒复合物为mRNA的递送载体兼佐剂，可与mRNA混合缩合形成纳米沉淀，可防止脂质体包裹mRNA过程中出现脂质体融合使其包裹的mRNA丢失和核酸酶对mRNA的降解作用，提高mRNA递送系统的物理和生物学稳定。

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Abstract

The application discloses a kind of polymer phospholipid nanoparticle mRNA vaccine and preparation method thereof, the vaccine with functional polydopamine phospholipid nanoparticle complex as mRNA delivery carrier and adjuvant, the functional polydopamine nanoparticle complex is chitosan modified spherical polydopamine nanoparticle, so that the complex carrier simultaneously has viscosity and biocompatibility.The polymer phospholipid nanoparticle mRNA vaccine prepared in the application uses liposome-functional polydopamine nanoparticle complex as mRNA delivery carrier, can prevent unstable conditions such as liposome fusion, breakage during the process of liposome-wrapped mRNA, improve the physical and biological stability of mRNA delivery system.Moreover, polydopamine nanoparticles can be used as a photothermal conversion agent to enable the vaccine to perform photothermal therapy for anti-tumor treatment.
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Citation Information

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