mass fraction compression
By performing multi-stage encoding on nucleic acid sequence data, the quality score sequence is converted from 8 bits to 2 or 1.6 bits. Combined with a compression engine, the problem of low compression efficiency of genome sequencing data is solved, achieving faster compression speed and higher compression ratio.
CN115668384BActive Publication Date: 2026-07-03ILLUMINA INC
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- ILLUMINA INC
- Filing Date
- 2021-11-05
- Publication Date
- 2026-07-03
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Figure CN115668384B_ABST
Abstract
This invention discloses a method, system, and computer program for compressing nucleic acid sequence data. The method may include: obtaining nucleic acid sequence data representing: (i) read sequences, and (ii) multiple quality fractions; determining whether the read sequence includes at least one N base; based on the determination that the read sequence does not include at least one N base, generating a first encoded dataset using a first encoding process that encodes each quality fraction of the read sequence using a number to the base (x-1), where x is an integer representing the number of different quality fractions used by a nucleic acid sequencing device; and encoding the first encoded dataset using a second encoding process to compress the data to be compressed.
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