Kit and poct blood cell analyzer

Abstract

This application provides a reagent kit and a POCT hematology analyzer. The reagent kit includes: at least two pipette tips and a housing; the at least two pipette tips are used for aspirating liquid, and the at least two pipette tips have different volumes; the housing is provided with at least two pipette tip placement pools for holding the at least two pipette tips. The reagent kit of this application improves sample dispensing accuracy by providing two pipette tips with different volumes, thereby improving the accuracy of the reagent kit's test results.

Description

Technical Field

[0001] This application relates to the field of medical device technology, and in particular to a reagent kit and a POCT blood cell analyzer. Background Technology

[0002] A blood cell analyzer is a commonly used medical testing device. It is an instrument that detects parameters such as the number and proportion of blood cells (red blood cells, white blood cells, and platelets) in the blood. Through blood analysis, it enables functions such as identifying the type of microbial infection in the tested sample, diagnosing and treating anemia, and diagnosing blood diseases. With the advancement of technology and scientific development, the functions of blood cell analyzers have been continuously expanded, their performance has been continuously improved, and their degree of automation has been continuously increased, leading to their widespread application in clinical practice.

[0003] In existing POCT hematology analyzers, samples or reagents are typically added using pipette tips. However, current technology suffers from low accuracy in pipette tip addition, resulting in inaccurate sample testing results from reagent kits. Summary of the Invention

[0004] This application provides a reagent kit and a POCT hematology analyzer to solve the technical problems of low sample addition accuracy of pipette tips and low accuracy of sample detection results of reagent kits in the prior art.

[0005] To solve the above-mentioned technical problems, one technical solution adopted in this application is: to provide a reagent kit, which includes: at least two pipette tips for drawing liquid, wherein the at least two pipette tips have different volumes; and a box body provided with at least two pipette tip placement pools for placing at least two pipette tips.

[0006] Furthermore, at least two straw heads have different lengths and / or inner diameters, and at least two straw head placement pools have different inner diameters, so as to place at least two straw heads respectively.

[0007] Furthermore, each straw head includes: a tube body having a suction port; and a fixing part disposed on the periphery of the tube body for fixing the tube body to the straw head placement pool. The fixing part is located at the end of the tube body away from the suction port, and the fixing part includes at least two steps. The at least two steps are spaced apart toward the side away from the suction port, and the outer diameter of the at least two steps gradually increases toward the direction away from the suction port.

[0008] Furthermore, the inner wall of the straw head is provided with a hydrophobic coating.

[0009] Furthermore, the straw head includes a tube body and a fixing part, the fixing part being fixed to the periphery of the tube body for fixing the tube body to the straw head placement pool, wherein the fixing parts of at least two straw heads have different shapes.

[0010] Furthermore, the box body includes: a first box body with at least two straw head placement pools, the first box body also having a first detection pool position for impedance detection; and a second box body with a second detection pool position for optical detection, the first box body and the second box body being detachably connected.

[0011] Furthermore, at least one slot is provided on one side of the first box, and a protrusion that mates with the slot is provided on one side of the second box.

[0012] Furthermore, a hanging bracket is provided on one side of the first box, and at least two ends of the second box are suspended on the hanging bracket.

[0013] To solve the above-mentioned technical problems, another technical solution adopted in this application is to provide a POCT blood cell analyzer, which includes a pipette and a reagent kit of any of the above embodiments, wherein the end of the pipette is used to cooperate with the pipette tip in the reagent kit to perform pipetting operations.

[0014] Furthermore, the end of the pipette is provided with a pipette tip for attaching a pipette tip, wherein the pipette tip is stepped to accommodate pipette tips of different diameters.

[0015] The beneficial effects of this application are as follows: Unlike existing technologies, the reagent kit of this application includes at least two pipette tips and a housing. The housing is provided with at least two pipette tip placement pools for holding at least two pipette tips. In the reagent kit provided by this application, the pipette tips are used to draw liquid and add samples. The at least two pipette tips have different volumes. This method can improve the sample addition accuracy of the reagent kit, thereby improving the accuracy of sample detection results. Attached Figure Description

[0016] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort, wherein:

[0017] Figure 1 This is a schematic diagram of the structure of one embodiment of the reagent kit provided in this application;

[0018] Figure 2 yes Figure 1 The diagram shows an exploded view of the kit.

[0019] Figure 3 yes Figure 1 A schematic cross-sectional view of the reagent kit shown.

[0020] Figure 4yes Figure 1 A schematic diagram of the structure of one embodiment of the posterior chamber body in the kit shown;

[0021] Figure 5 yes Figure 1 A schematic diagram of another embodiment of the posterior chamber body in the kit shown;

[0022] Figure 6 This is a schematic diagram of another embodiment of the reagent kit provided in this application;

[0023] Figure 7 yes Figure 6 The diagram shows an exploded view of the kit.

[0024] Figure 8 This is a schematic diagram of another embodiment of the reagent kit provided in this application;

[0025] Figure 9 yes Figure 8 The diagram shows an exploded view of the kit.

[0026] Figure 10 This is a schematic diagram of another embodiment of the reagent kit provided in this application;

[0027] Figure 11 This is a schematic diagram of an embodiment of the pipette and pipette tip in the POCT blood cell analyzer provided in this application. Detailed Implementation

[0028] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of the embodiments. Based on the embodiments of this application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this application.

[0029] It should be noted that if the embodiments of this application involve directional indicators (such as up, down, left, right, front, back, etc.), the directional indicators are only used to explain the relative positional relationship and movement of the components in a certain specific posture (as shown in the figure). If the specific posture changes, the directional indicators will also change accordingly.

[0030] Furthermore, if the embodiments of this application involve descriptions such as "first" or "second," these descriptions are for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, features defined with "first" or "second" may explicitly or implicitly include at least one of those features. Additionally, the technical solutions of various embodiments can be combined with each other, but this must be based on the ability of those skilled in the art to implement them. If the combination of technical solutions is contradictory or impossible to implement, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection claimed in this application.

[0031] In a first embodiment, this application provides a reagent kit, such as... Figures 1-3 As shown, Figure 1 This is a schematic diagram of the structure of one embodiment of the reagent kit provided in this application. Figure 2 yes Figure 1 The diagram shows an exploded view of the kit. Figure 3 yes Figure 1 The diagram shows a cross-sectional view of the kit, which includes: a housing 10, a sealing ring 20, a microporous sheet 30, and a rear chamber body 40.

[0032] Specifically, such as Figure 1 and Figure 2 As shown, the housing 10 includes a pre-pool 101 and a mounting cavity 102 communicating with the pre-pool 101. In this embodiment, the pre-pool 101 is an impedance detection cell, and two sets are provided, respectively for cooperating in the detection of WBC (white blood cells) and RBC (red blood cells). In other embodiments, the pre-pool 101 may also be provided with one or at least three sets, etc., for the detection of red blood cells, white blood cells, or other items, and the specific configuration can be determined according to actual needs.

[0033] like Figure 3 As shown, the sealing ring 20 is disposed within the mounting cavity 102 and located on the side of the mounting cavity 102 closest to the front pool 101. The microporous plate 30 has micropores 31 that allow cells to pass through one by one. The microporous plate 30 is disposed on the side of the sealing ring 20 away from the front pool 101. The rear pool body 40 is located on the side of the microporous plate 30 away from the sealing ring 20. The rear pool body 40 is used to fix the microporous plate 30 and the sealing ring 20 to the housing 10. The rear pool body 40 is engaged with the mounting cavity 102 by snap-fit, threaded fit, interference fit, laser welding, or adhesive bonding.

[0034] In this embodiment, the sealing ring 20, the microporous sheet 30, and the rear chamber body 40 are sequentially disposed within the mounting cavity 102. The microporous sheet 30 and the sealing ring 20 are pressed and fixed onto the box body 10 by the rear chamber body 40. This method ensures a good seal at the inner end of the mounting cavity 102, improving the reliability of the reagent kit and facilitating the processing and assembly of the reagent kit. Here, the inner end of the mounting cavity 102 refers to the end of the mounting cavity 102 closest to the front chamber 101.

[0035] like Figure 3 As shown, the box body 10 includes a through hole 103 connecting the front chamber 101 and the mounting cavity 102. The sealing ring 20 is installed at the through hole 103 and is clearance-fitted with the mounting cavity 102. In this way, the sealing ring 20 will not tilt when it is inserted, which facilitates the installation of the sealing ring 20. Moreover, the liquid in the front chamber 101 will not enter the rear chamber body 40 from the edge of the sealing ring 20, thereby improving the reliability of the reagent kit detection.

[0036] Furthermore, the ratio of the diameter of the microporous plate 30 to the diameter of the through hole 103 is not less than 1.7, and the diameter of the microporous plate 30 is not greater than the inner diameter of the mounting cavity 102. For example, the ratio of the diameter of the microporous plate 30 to the diameter of the through hole 103 is 1.7, 1.75, or 1.8, etc., and the diameter of the microporous plate 30 can be equal to or slightly smaller than the inner diameter of the mounting cavity 102. This method facilitates the rear tank body 40 to press the microporous plate 30, preventing liquid from entering the rear tank body 40 from the edge of the microporous plate 30, and also facilitates the installation of the microporous plate 30, saving assembly time.

[0037] Optionally, the housing 10, sealing ring 20, microporous plate 30, and rear pool body 40 are each independent components. In one specific embodiment, the microporous plate 30 and sealing ring 20 are bonded to the housing 10, and the rear pool body 40 is bonded to the housing 10. In another specific embodiment, the microporous plate 30 and sealing ring 20 are bonded to the rear pool body 40, and the rear pool body 40 is bonded to the housing 10. This reduces assembly difficulty.

[0038] In other embodiments, the sealing ring 20, the microporous plate 30, and the rear pool body 40 can be an integral structural component to reduce the number of assembly parts, reduce assembly difficulty, and save assembly time.

[0039] The housing 10 and / or the rear pool body 40 can be made of plastic. The microporous sheet 30 can be made of plastic or ceramic. Plastic or ceramic sheets are relatively inexpensive and can be used as disposable products, eliminating the need for expensive materials that can be repeatedly washed and reused. The sealing ring 20 can be injection molded using a secondary injection molding process, using a relatively soft plastic material.

[0040] Furthermore, such as Figure 2 and Figure 3As shown, the housing 10 has a front chamber electrode 60 corresponding to the front chamber 101, and the rear chamber body 40 forms a drainage cavity 41 (also called the rear chamber). The front chamber 101 and the drainage cavity 41 are connected through micropores 31. A rear chamber electrode 50 is provided on the rear chamber body 40 extending into the drainage cavity 41. The front chamber electrode 60 and the rear chamber electrode 50 are respectively located on both sides of the microporous sheet 30 at intervals. The outer ends of the front chamber electrode 60 and the rear chamber electrode 50 (i.e., the two ends that are far apart) are used to connect the working voltage, and the inner ends of the front chamber electrode 60 and the rear chamber electrode 50 (i.e., the two ends that are close to each other) are in contact with the sample liquid to be tested. The liquid level of the sample liquid to be tested in the front chamber 101 will be higher than that of the front chamber electrode 60, and the drainage cavity 41 will be filled with the sample liquid to be tested during detection.

[0041] In this embodiment, the axis of the forecell electrode 60 and the axis of the rear cell electrode 50 are approximately on a straight line. Experiments have verified that the detection accuracy is relatively high when the axes of the forecell electrode 60 and the rear cell electrode 50 are coaxial. In other embodiments, the axes of the forecell electrode 60 and the rear cell electrode 50 may not be on the same straight line.

[0042] In the impedance channel, during cell calculation, the liquid in the pre-cell 101 slowly fills the drainage chamber 41 (post-cell) through the microporous sheet 30. The pre-cell electrode 60 and / or the post-cell electrode 50 can be columnar electrodes. However, in this configuration, the liquid column passing through the micropores 31 of the microporous sheet 30 may impact the post-cell electrode 50, causing backflow that impacts the microporous sheet 30. This phenomenon affects signal stability and may also generate M-waves, reducing the reliability of detection.

[0043] To improve the above-mentioned problems, in some embodiments, the inner end face of the rear chamber electrode 50 can be configured as a convex surface. For example, the inner end of the rear chamber electrode 50 can be configured as a hemispherical shape, making the inner end face of the rear chamber electrode 50 a curved surface. In this way, the liquid backflow can be evenly distributed from the center to the surrounding area, so that the backflow will not flow directly to the microporous sheet 30, thereby reducing the phenomenon of cell particle backflow. Here, the inner end face is defined as the end of the rear chamber electrode 50 pointing towards the front chamber 101 when the front chamber 101 is taken as a reference, and the end away from the front chamber 101 is the outer end face.

[0044] Furthermore, the rear pool body 40 is provided with a liquid outlet 44, which is connected to the mounting cavity 102 and is used to discharge gas or liquid from the drainage cavity 41.

[0045] The distance between the inner end face of the rear chamber electrode 50 and the microporous plate 30 is not less than 5 mm. For example, the distance between the inner end face of the rear chamber electrode 50 and the microporous plate 30 can be set to 5 mm, 6 mm, 7 mm, or 8 mm, etc. By limiting the distance between the microporous plate 30 and the inner end face of the rear chamber electrode 50, the microporous plate 30 is prevented from being too close to the rear chamber electrode 50, so as to provide sufficient buffer distance for the liquid and facilitate the timely discharge of liquid in the drainage chamber 41 from the outlet 44 by negative pressure.

[0046] Furthermore, the inner end of the mounting cavity 102 is connected to the front pool 101 through the through hole 103, and the outer end of the mounting cavity 102 is an open end for receiving the insertion of the rear pool body 40. A positioning part (not shown) may be provided on the end face of the mounting cavity 102, and a mating part (not shown) may be provided on the rear pool body 40. The mating part and the positioning part are connected to each other to position and install the rear pool body 40.

[0047] In one specific embodiment, a positioning protrusion may be provided on the outer end face of the mounting cavity 102 as a positioning part, and a positioning groove adapted to the positioning protrusion may be provided on the rear pool body 40 as a mating part. When the rear pool body 40 is installed, the positioning protrusion and the positioning groove mate to position the rear pool body 40. In this way, the assembly difficulty of the rear pool body 40 can be reduced and the assembly time can be saved.

[0048] In other embodiments, a positioning groove may be provided on the outer end face of the mounting cavity 102 as a positioning part, and a positioning protrusion adapted to the positioning groove may be provided on the rear pool body 40 as a mating part. When the rear pool body 40 is installed, the positioning protrusion and the positioning groove mate to position and install the rear pool body 40. In this way, the assembly difficulty of the rear pool body 40 can be reduced and the assembly time can be saved.

[0049] In summary, the reagent kit of this embodiment has a simple structure, a novel fixation method for the microwell plate 30, is easy to process, has low assembly difficulty, and has high reliability.

[0050] In a second embodiment, this application also provides a reagent kit, such as... Figures 1-5 As shown, Figure 4 yes Figure 1 The diagram shows a structural schematic of one embodiment of the posterior chamber body in the kit. Figure 5 yes Figure 1 The diagram shows another embodiment of the back cell body in the kit. The kit in this embodiment includes an impedance detection cell (not shown in the figure) for impedance detection of the sample to be tested. The impedance detection cell includes a back cell body 40 and a back cell electrode 50. The back cell electrode 50 is embedded in the back cell body 40. The back cell electrode 50 and the back cell body 40 can be integrally injection molded or detachably connected.

[0051] The rear chamber body 40 has a drainage cavity 41. The rear chamber electrode 50 is disposed on the rear chamber body 40 and extends into the drainage cavity 41. The inner end face of the rear chamber electrode 50 is convex. Specifically, the inner end of the rear chamber electrode 50 can be configured as a hemispherical shape, and the inner end face of the rear chamber electrode 50 is the side end face of the rear chamber electrode 50 extending into the drainage cavity 41. For details on the convex structure of the rear chamber electrode 50, please refer to the description of the first embodiment, which will not be repeated here.

[0052] Furthermore, such as Figure 4 As shown, the rear chamber body 40 includes a bottom wall 43 and a side wall 42. The bottom wall 43 connects to the side wall 42 to form a drainage cavity 41. The rear chamber electrode 50 is disposed on the bottom wall 43. A liquid outlet 44 is provided on the side wall 42, which communicates with the drainage cavity 41 and is used to discharge gas or liquid from the drainage cavity 41. Figure 4 In the illustrated embodiment, the bottom wall 43 is a plane, and the plane containing the bottom wall 43 is inclined relative to the side wall 42. The liquid outlet 44 is located at the intersection of the bottom wall 43 and the side wall 42, and is located on the side away from the microporous sheet 30. In this embodiment, the bottom wall 43 is set as an upwardly inclined plane and serves as a drainage surface, allowing the liquid to flow through the microporous sheet 30 to the rear cell electrode 50 and then be guided by the bottom wall 43 to the liquid outlet 44. This facilitates the liquid's outflow from the liquid outlet 44, avoids liquid accumulation, reduces signal disturbance caused by particle vortex near the rear cell electrode 50, and improves the reliability of detection.

[0053] In addition, the outlet 44 is located at the intersection of the side wall 42 and the bottom wall 43. Thus, the end of the slope formed by the bottom wall 43 is close to the outlet 44. When the liquid in the drainage cavity 41 finishes to be drained through the bottom wall 43, it will flow directly out of the outlet 44, further reducing the liquid retention.

[0054] In another embodiment, such as Figure 5 As shown, in this embodiment, the bottom wall 43 also serves as a drainage surface to drain the liquid in the drainage cavity 41. Specifically, from the position where the rear pool electrode 50 is provided on the bottom wall 43 to the edge of the bottom wall 43, the distance from the bottom wall 43 to the microporous plate 30 gradually decreases. That is, the bottom wall 43 can be shaped like a funnel to drain the liquid in the drainage cavity 41.

[0055] Furthermore, such as Figure 5 As shown, the outlet 44 is located at the intersection of the bottom wall 43 and the side wall 42, that is, the outlet 44 can be set close to the bottom wall 43. In this way, when the liquid in the rear pool finishes flowing through the bottom wall 43, it will flow directly out of the outlet 44, reducing the liquid retention.

[0056] Furthermore, the maximum distance between the inner end face of the rear electrode 50 and the bottom wall 43 is less than 0.5 mm. The distance by which the inner end face of the rear electrode 50 protrudes from the inner surface of the bottom wall 43 is small, reducing the phenomenon of liquid jamming in the rear electrode 50.

[0057] Furthermore, the distance between the inner end face of the rear pool electrode 50 and the microporous plate 30 is not less than 5mm, so as to avoid the microporous plate 30 being too close to the rear pool electrode 50, so as to provide sufficient buffer distance for the liquid and facilitate the negative pressure to timely discharge the liquid in the drainage cavity 41 from the liquid outlet 44.

[0058] Optionally, the rear electrode 50 is located at the center of the bottom wall 43, and the rear electrode 50 is coaxially arranged with the drainage cavity 41. This facilitates the demolding operation after the mold is formed.

[0059] In the above embodiments, the structure of the impedance detection cell is novel. The inner end face of the rear cell electrode 50 is set as a convex surface, and the bottom wall 43 of the rear cell body 40 forms a flow guide surface to guide the liquid to the outlet 44. This structural improvement facilitates the liquid to flow out from the outlet hole and can reduce the influence of signal disturbance caused by particle backlash and swirl, thereby improving the sample detection accuracy and the accuracy of the detection results.

[0060] In a third embodiment, this application also provides a reagent kit; please refer to [link to kit]. Figure 6 and Figure 7 As shown, Figure 6 This is a schematic diagram of another embodiment of the reagent kit provided in this application. Figure 7 yes Figure 6 The diagram shown is an exploded view of the kit. The kit includes a box 10, which includes a first box 11 and a second box 12. The first box 11 and the second box 12 are detachably connected.

[0061] The first housing 11 is provided with a first detection cell position for electrical impedance detection, and the second housing 12 is provided with a second detection cell position for optical detection. In this embodiment, the first detection cell position can be used for WBC and RBC detection, and the second detection cell position can be used for the detection of specific proteins. In other embodiments, the second detection cell can also be used in conjunction with other biochemical detection, immunoassay, etc.

[0062] In this embodiment, the first box 11 and the second box 12 are detachably connected. This facilitates the storage and transportation of the box 10. In other embodiments, the first box 11 and the second box 12 can also be integrally formed to improve the reliability of the connection between the first box 11 and the second box 12.

[0063] exist Figure 6 and Figure 7In the illustrated embodiment, at least one slot 111 is provided on one side of the first housing 11, and a protrusion 121 that mates with the slot 111 is provided on one side of the second housing 12. The slot 111 and the protrusion 121 engage to attach the second housing 12 to the first housing 11. This method simplifies the connection structure between the first housing 11 and the second housing 12, and simplifies the assembly and disassembly process. Preferably, the number of slots 111 and protrusions 121 can be multiple to make the connection between the second housing 12 and the first housing 11 more secure.

[0064] Furthermore, the side of the card slot 111 away from the first box 11 is designed as a constricted opening, that is, the area of ​​the opening on the side of the card slot 111 away from the first box 11 is smaller than the area of ​​the bottom wall of the card slot 111 near the first box 11. In this way, the second box 12 can be effectively prevented from falling off the first box 11.

[0065] Furthermore, the cross-sectional shape of the slot 111 along the first plane can be trapezoidal, wherein the first plane is a plane perpendicular to the thickness direction of the first box 11. This method makes the connection part between the first box 11 and the second box 12 have a regular shape, which facilitates the processing of the box 10.

[0066] In another embodiment, such as Figure 8 and Figure 9 As shown, Figure 8 This is a schematic diagram of another embodiment of the reagent kit provided in this application. Figure 9 yes Figure 8 The exploded view of the reagent kit shown shows that, specifically, a hanger 112 is provided on one side of the first box 11, and the edge of the second box 12 is suspended on the hanger 112.

[0067] Specifically, such as Figure 9 As shown, the hanger 112 has a hanging hole 1120 formed around it, and the second box 12 is inserted into the hanging hole 1120. The outer edge of the second box 12 is supported on the hanger 112. This method can make the force on the second box 12 more even and can make the second box 12 more stably fixed on the hanger 112.

[0068] Furthermore, the cross-sectional shape of the hanging hole 1120 can be rectangular, circular, trapezoidal, triangular, or irregular. The shape of the hanging hole 1120 can be adapted to the shape of the second box 12. For example, when the second box 12 is rectangular, the shape of the hanging hole 1120 is also set to rectangular.

[0069] In other embodiments, at least two ends of the second box 12 are suspended from the edges of the bracket 112 for support. This simplifies the structure of the box 10 and facilitates production. For example, the bracket 112 can directly include two or three support rods to support the edges of the two or three ends of the second box 12, thus saving material costs.

[0070] Furthermore, such as Figure 7 and Figure 8 As shown, the first detection cell position may include a pre-cell 101, which can be configured in two sets for use in conjunction with white blood cell detection and red blood cell detection, respectively. The first detection cell position may also include at least one pipette tip placement cell 113, a diluent cell 114, a hemolysin cell 115, and a sample container 116. The pipette tip placement cell is used to hold pipette tips 60, the diluent cell 114 is used to encapsulate the diluent, and the hemolysin cell 115 is used to encapsulate the hemolysin. The first detection cell position may also include a sample dilution cell 117 for sample dilution. The multiple cells are arranged in a straight line. This arrangement facilitates shorter movement of the pipetting device during automated detection, where the pipetting device is used to transfer and mix the liquids in each cell.

[0071] To ensure the light transmittance of the material, the first housing 11 can be made of transparent PP (Polypropylene). In other embodiments, the forepool 101 may also be provided with a light transmittance detection window (not shown) for optical detection. The light transmittance and smoothness of the light transmittance detection window can be the same as or higher than other parts of the forepool 101.

[0072] Furthermore, the second detection chamber includes several placement holes 123 for placing an optical detection cup assembly (not shown) for optical detection. The placement holes 123 may include first placement holes 121 and second placement holes 122 spaced apart. The optical detection cup assembly includes an optical measuring cup (not shown) and a reagent cup (not shown). The optical measuring cup can be used for the detection of specific proteins and can be made of transparent PC (Polycarbonate). The reagent cup is used to store reagents. The first placement hole 121 can be used to place the optical measuring cup, and the second placement hole 122 can be used to place the detection cup.

[0073] The first placement hole 121 and the second placement hole 122 have different shapes. For example, the first placement hole 121 can be circular and the second placement hole 122 can be rectangular to distinguish them.

[0074] Optionally, the second detection pool position can be used to place two or more sets of optical detection cup assemblies, that is, the number of the first placement hole 121 and the second placement hole 122 can both be two or more sets, for the detection of different items.

[0075] The kit body 10 of the above embodiment is detachable, and the assembly and disassembly process is simple and convenient for transportation.

[0076] In a fourth embodiment, this application also provides a reagent kit; please refer to [link to kit]. Figure 10 As shown, Figure 10 This is a schematic diagram of another embodiment of the reagent kit provided in this application. The reagent kit of this embodiment includes a housing 10 and at least two pipette tips 60. The housing 10 is provided with at least two pipette tip placement basins for placing the at least two pipette tips 60. The pipette tips 60 are used to be mounted on a pipette for pipetting operations.

[0077] Each pipette tip 60 has a certain volume. During pipetting, the sample solution or reagent solution will remain in the pipette tip 60. In this embodiment, at least two pipette tips 60 have different volumes. For example, the kit can be equipped with two pipette tips 60, and these two pipette tips 60 have different volumes. In actual use, different sample solutions or reagent solutions can use pipette tips 60 with different volumes. For example, when 10 μL needs to be pipetted, to ensure pipetting accuracy, a pipette tip 60 with a capacity of 10 μL to 20 μL can be selected for pipetting. In this way, the sample loading accuracy can be improved, thereby improving the accuracy of the sample detection results.

[0078] Furthermore, such as Figure 10 As shown, the straw head 60 includes a tube body 61 and a fixing part 62. The fixing part 62 is fixed to the periphery of the tube body 61. The tube body 61 has a suction port 63 for sucking / spitting out liquid. The fixing part 62 is located on the side of the tube body 61 away from the suction port 63, and is used to fix the tube body 61 in the straw head placement pool 113. The fixing part 62 of straw heads 60 with different volumes has different shapes to distinguish the straw heads 60 and prevent incorrect selection. In other embodiments, the fixing part 62 of straw heads 60 with different volumes can also have the same shape to facilitate the production of the straw heads 60.

[0079] The inner diameters of the straw head placement pools 113 on the box body 10 can be the same or different. For example, to facilitate differentiation, at least two straw head placement pools 113 may have different inner diameters to accommodate different straw heads 60. Specifically, straw heads 60 with larger volumes can be inserted into straw head placement pools 113 with larger inner diameters, and straw heads 60 with smaller volumes can be inserted into straw head placement pools 113 with smaller inner diameters.

[0080] To accommodate straw tip holders 113 with different inner diameters, the fixing portion 62 of the straw tip 60 can be stepped. Specifically, the fixing portion 62 of the straw tip 60 includes at least two steps, which are parallel and spaced apart on the side away from the suction port 63, and the outer diameter of the at least two steps gradually increases in the direction away from the suction port 63. By setting the fixing portion 62 with steps of different sizes, the straw tip 60 can accommodate straw tip holders 113 with different inner diameters. This allows the insertion of the straw tip 60 to be unrestricted by the inner diameter of the straw tip holder 113, thereby facilitating the placement and removal of the straw tip 60.

[0081] When the straw head 60 is placed in the straw head placement pool 113, the tube body 61 is inserted into the straw head placement pool 113, and the straw head 60 can be supported on the surface of the box body 10 by the fixing part 62.

[0082] Furthermore, a recessed platform 1131 can be provided at the opening of the straw head placement pool 113. When the straw head 60 is placed in the straw head placement pool 113, the fixing part 62 can be supported on the recessed platform 1131 to support the straw head 60.

[0083] Optionally, straw heads 60 with different volumes may also have different lengths and / or diameters to facilitate differentiation between different straw heads 60. For example, straw heads 60 with smaller volumes may also have smaller lengths / diameters to facilitate identification of different straw heads 60.

[0084] Furthermore, a hydrophobic coating can be provided on the inner wall of the pipette tip 60 to prevent liquid from adhering to the pipette tip 60 and improve the sample dispensing accuracy of the pipette tip 60.

[0085] Furthermore, the straw head 60 may be marked with an electronic tag, QR code, or barcode to record relevant parameters of the straw head 60.

[0086] The kit described in the above embodiments can improve the accuracy of sample loading, thereby improving the accuracy of sample detection results.

[0087] The structures of the reagent kits in the first, second, third, and fourth embodiments described above can be combined with each other. For example, the structure of the box 10 in the fourth embodiment may not be integrally formed, such as... Figures 6-9 In the embodiment shown, the box 10 may include a first box 11 and a second box 12. The first box 11 and the second box 12 are detachably connected. For details, please refer to the accompanying drawings and related text descriptions of the above embodiments, which will not be repeated here.

[0088] Fifthly, this application also provides a POCT (point-of-care testing) blood cell analyzer. Please refer to [link to relevant documentation]. Figure 11 The diagram shown is a schematic representation of an embodiment of the pipette and pipette tip in a POCT hematology analyzer provided in this application. The POCT hematology analyzer includes a pipette 70, the end of which is used to cooperate with the pipette tip 60 of the above embodiment for pipetting operations.

[0089] Specifically, the end of the pipette 70 is provided with a pipette tip 71, which is used to attach to the pipette head 60. The pipette head 60 has a certain volume, and during the pipetting operation, the sample solution or reagent solution will remain in the pipette head 60 and will not enter the interior of the pipette 70. After completing the aspiration, transfer, and dispensing operations, when it is necessary to change the sample solution or reagent solution, the used pipette head 60 can be discarded and the unused pipette head 60 can be reinstalled, so that the new sample solution or reagent solution can be pipetted without contaminating the pipette 70. Therefore, there is no need to clean the pipette 70 after each use, which eliminates the need for complicated cleaning components and cleaning processes and improves detection efficiency.

[0090] Furthermore, the tip 71 at the end of the pipette 70 is stepped to accommodate pipette tips 60 of different diameters. In this way, different diameter pipette tips 60 can be connected with a single tip 71, simplifying the pipetting process and saving material costs.

[0091] This application also provides a POCT (point-of-care testing) hematology analyzer, which includes the reagent kit of any of the foregoing embodiments and a test socket that works with the reagent kit. This POCT hematology analyzer is used for blood sample analysis. For the specific structure of the reagent kit, please refer to the accompanying drawings and related textual descriptions of the foregoing embodiments; further details will not be repeated here.

[0092] The above are merely embodiments of this application and do not limit the patent scope of this application. Any equivalent structural or procedural transformations made using the content of this application's specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this application.

Claims

1. A reagent kit, characterized in that, The kit includes: At least two straw tips for drawing liquid, wherein the at least two straw tips have different volumes; The box body is provided with at least two straw head placement pools for placing the at least two straw heads; The kit includes a first housing with at least two pipette tip placement chambers. The first housing also includes a first detection chamber for impedance detection, comprising a front chamber. The kit further includes a sealing ring, a microporous sheet, and a rear chamber body. The sealing ring, the microporous sheet, and the rear chamber body are sequentially disposed within an mounting cavity communicating with the front chamber. The rear chamber body includes a bottom wall and a side wall, the bottom wall connecting to the side wall to form a drainage cavity. A rear chamber electrode extending into the drainage cavity is disposed on the rear chamber body. The rear cell electrode is disposed on the bottom wall, and a liquid outlet is disposed on the side wall. The liquid outlet communicates with the drainage cavity and is used to discharge gas or liquid from the drainage cavity. The bottom wall is a plane, and the plane on which the bottom wall is located is inclined relative to the side wall. The liquid outlet is disposed at the intersection of the bottom wall and the side wall and is located on the side away from the microporous sheet. The inner end face of the rear cell electrode is a convex surface. The bottom wall of the rear cell body forms a drainage surface for guiding the liquid in the drainage cavity to the liquid outlet disposed on the side wall of the rear cell body.

2. The reagent kit according to claim 1, characterized in that, The at least two straw heads have different lengths and / or inner diameters, and the at least two straw head placement pools have different inner diameters, so as to place the at least two straw heads respectively.

3. The reagent kit according to claim 2, characterized in that, Each of the straw heads includes: The tube body has a suction port; A fixing part is provided on the periphery of the tube body for fixing the tube body to the straw head placement pool. The fixing part is located at the end of the tube body away from the suction port. The fixing part includes at least two steps, which are spaced apart on the side away from the suction port, and the outer diameter of the at least two steps gradually increases in the direction away from the suction port.

4. The reagent kit according to claim 1, characterized in that, The inner wall of the straw head is provided with a hydrophobic coating.

5. The reagent kit according to claim 1, characterized in that, The straw head includes a tube body and a fixing part. The fixing part is fixed to the periphery of the tube body and is used to fix the tube body to the straw head placement pool. The fixing parts of the at least two straw heads have different shapes.

6. The reagent kit according to claim 1, characterized in that, The housing also includes: The second housing has a second detection pool position for optical detection, and the first housing and the second housing are detachably connected.

7. The reagent kit according to claim 6, characterized in that, The first box body has at least one slot on one side, and the second box body has a protrusion on one side that engages with the slot.

8. The reagent kit according to claim 6, characterized in that, A hanging bracket is provided on one side of the first box, and at least two ends of the second box are suspended on the hanging bracket.

9. A POCT blood cell analyzer, characterized in that, The POCT hematology analyzer includes a pipette and a kit according to any one of claims 1-8, wherein the tip of the pipette is used to engage with a pipette tip in the kit for pipetting operations.

10. The POCT blood cell analyzer according to claim 9, characterized in that, The pipette is provided with a tip at its end for attaching to the pipette tip. The tip is stepped to accommodate pipette tips of different diameters.

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