Agitator, disposable reaction bag, and agitating method

Abstract

Embodiments of the present application relate to a stirring device (10), a disposable reaction bag (60), and a stirring method (80). The stirring device (10) comprises a base (12), a plurality of stirring paddles (14) extending outwardly from the base (12), a bearing (16) disposed on the base (12), a positioning drive (18) disposed on the base (12) and capable of positioning the stirring device (10) and driving the plurality of stirring paddles (14) to rotate around the bearing (16), and a first box body (34) and a second box body (36), the first box body (34) and the second box body (36) together enclosing the base (12), the plurality of stirring paddles (14), the bearing (16), and the positioning drive (18). Embodiments of the present application can help to effectively utilize resources, save time, simplify processes, and the like.

Description

Technical Field

[0001] This invention relates to the field of stirring, and more particularly to stirring apparatus, disposable reaction bags, and stirring methods. Background Technology

[0002] Stirring has a wide range of applications in many industries. For example, pharmaceutical companies require extensive stirring when preparing culture media and buffer solutions in reaction bags. Taking monoclonal antibody production as an example, the entire process involving a 2000-liter culture volume involves more than 20 types of buffer solutions, with a total prepared volume exceeding 20,000 liters, all requiring corresponding stirring.

[0003] Some existing mixing devices cannot be used with existing equipment in pharmaceutical companies, requiring installation, which may result in significant waste of resources, longer processing times, and more complex processes.

[0004] Therefore, improvements are needed. Summary of the Invention

[0005] One object of the present invention is to provide an improved stirring device, a disposable reaction bag, and a stirring method.

[0006] To achieve the above objectives, one aspect of the present invention relates to a stirring device, comprising: a base; a plurality of stirring blades extending outward from the base; a bearing disposed on the base; a positioning drive member disposed on the base, capable of positioning the stirring device and driving the plurality of stirring blades to rotate around the bearing; and a first housing and a second housing, the first housing and the second housing together surrounding the base, the plurality of stirring blades, the bearing and the positioning drive member.

[0007] In some embodiments, the base includes a coupling portion, and the positioning drive includes a magnetic element coupled to the coupling portion.

[0008] In some embodiments, the base includes a plurality of said coupling portions, and the positioning drive includes a plurality of said magnetic elements, the plurality of said magnetic elements being coupled to some or all of the plurality of coupling portions.

[0009] In some embodiments, the base includes a mating portion that can be detachably mated with the plurality of agitators.

[0010] In some embodiments, each of the plurality of stirring paddles includes a mounting portion that mates with the mating portion, and a blade extending from the mounting portion, the blade intersecting the mounting portion at an oblique angle or a right angle.

[0011] In some embodiments, the plurality of impellers includes one or more of the following: oblique blade impeller, backward curved blade impeller, parabolic rounded corner impeller, and right-angle impeller.

[0012] In some embodiments, the stirring device includes a first cover plate and a second cover plate respectively disposed on opposite sides of the base, and the positioning drive member is located between the first cover plate and the second cover plate.

[0013] In some embodiments, the first housing includes a first substrate, and the second housing includes a second substrate opposite to the first substrate, wherein the first substrate and the second substrate each include a plurality of through holes.

[0014] In some embodiments, the first substrate and the second substrate extend parallel to each other along a first direction, and the base, the plurality of stirring paddles, the bearing and the positioning drive are located between the first substrate and the second substrate. After installation, the dimensions of the base, the plurality of stirring paddles, the bearing and the positioning drive in the first direction are smaller than the dimensions of the first substrate and the second substrate in the first direction.

[0015] In some embodiments, the first substrate includes a first connecting portion, the second substrate includes a second connecting portion connected to the first connecting portion, and at least one of the first connecting portion and the second connecting portion is coupled to the bearing.

[0016] In some embodiments, the first housing includes a first peripheral wall extending from the edge of the first substrate toward the second substrate, and the second housing includes a second peripheral wall extending from the edge of the second substrate toward the first substrate.

[0017] In some embodiments, the outer surfaces of the first housing and the second housing comprise a high-friction material.

[0018] Another aspect of the present invention relates to a disposable reaction bag, comprising: a bag body; and a stirring device as described in this application, which can be housed in the bag body without being connected to the bag body.

[0019] In some embodiments, the stirring device is located at the bottom of the bag body during operation.

[0020] Another aspect of the present invention relates to a stirring method, which includes the following steps: adding the material to be stirred into a disposable reaction bag placed on a workbench; and placing the material to be stirred into a stirring device as described in this application, so that the stirring device settles in the material to be stirred, is positioned relative to the workbench, and is driven by the workbench to stir the material to be stirred.

[0021] In some embodiments, when the stirring device settles in the stirred material, the positioning drive is attracted by the magnetic actuator of the worktable to be positioned relative to the magnetic actuator, and is driven by the magnetic actuator to drive the plurality of stirring paddles to rotate.

[0022] In some embodiments, after the stirring device is positioned relative to the worktable, the first box and the second box are attached to the disposable reaction bag and do not rotate, while the plurality of stirring paddles can rotate.

[0023] Where technical conditions permit, the technical solutions of the various embodiments in this application can be combined in any way.

[0024] The present application will be further described below with reference to the accompanying drawings. The same or similar reference numerals may be used in the drawings to refer to the same or similar devices, elements, devices, shapes, structures, methods, and steps in different embodiments. Descriptions of the same or similar devices, elements, devices, shapes, structures, methods, steps, features, and effects in different embodiments, as well as descriptions of devices, elements, devices, shapes, structures, methods, steps, features, and effects that are the same or similar to those in the prior art, may also be omitted. Attached Figure Description

[0025] Figure 1 This is an explosion diagram of a stirring device according to some embodiments of the present invention;

[0026] Figure 2 yes Figure 1 A partial explosion diagram of the mixing device;

[0027] Figure 3 This is a perspective view of a stirring impeller according to other embodiments of the present invention;

[0028] Figure 4 yes Figure 1 A partial assembly diagram of the stirring device;

[0029] Figure 5 for Figure 4 A perspective view of the second housing of the stirring device;

[0030] Figure 6 yes Figure 1 A perspective view of the assembly of the internal stirring device;

[0031] Figure 7 This is a schematic diagram illustrating a single-use reaction bag in use, according to another aspect of an embodiment of the present invention.

[0032] Figure 8 This is a schematic flowchart of a stirring method according to another aspect of an embodiment of the present invention;

[0033] Figure 9 for Figure 7 Another schematic diagram showing the usage status of the disposable reaction bag;

[0034] Figure 10 yes Figure 7Partial cross-sectional view of the mixing device and worktable;

[0035] Figure 11 This is a graph showing the test data of the stirring efficiency of the stirring device according to an embodiment of the present invention. Detailed Implementation

[0036] Figure 1 This is an explosion diagram of a stirring device according to some embodiments of the present invention. Figure 1 As shown, one aspect of the present invention relates to a stirring device 10, which includes: a base 12; a plurality of stirring paddles 14 extending outward from the base 12; a bearing 16 disposed on the base 12; a positioning drive member 18 disposed on the base 12, which can position the stirring device 10 and drive the plurality of stirring paddles 14 to rotate around the bearing 16; and a first housing 34 and a second housing 36, the first housing 34 and the second housing 36 together surrounding the base 12, the plurality of stirring paddles 14, the bearing 16 and the positioning drive member 18.

[0037] The terms “first,” “second,” and similar terms used in this application are not intended to indicate priority, importance, or chronological order. They are primarily used to distinguish the elements, devices, shapes, structures, etc., they modify and should not be construed as limiting the scope of protection unless otherwise stated.

[0038] The embodiments of this application can help to effectively utilize resources, save time, and simplify processes.

[0039] For example, compared to the stirring device 10 described in this embodiment of the invention, if a traditional upper stirring device is used, it cannot be used in conjunction with the readily available lower stirring equipment typically found in pharmaceutical companies, resulting in significant resource waste. The upper stirring device is an additional, independent hardware investment, including costly components such as rods, stirring paddles, upper stirring motors, and upper stirring control systems. Using the upper stirring device requires installing the stirring paddle and rod from outside the reaction bag, which is time-consuming. The upper stirring device is typically made of stainless steel; generally, a stainless steel stirring paddle for a 100-liter or larger reaction bag weighs over 10 kilograms. During installation, the stirring paddle must be suspended and aligned with the central shaft of the stirring paddle in the center of the reaction bag without damaging the plastic film, typically requiring 2-3 people to complete the operation, which is inconvenient. Furthermore, the stainless steel upper stirring device is designed for reuse; after each solution preparation and stirring, it must be cleaned and inspected before preparing the next buffer solution to avoid cross-contamination between solutions. This contradicts the characteristics of quick and flexible process applications, such as disposable reaction bags, and also causes great trouble to the work efficiency of the solution preparation station. Moreover, the cleaning of stainless steel blades and the quality inspection after cleaning involve the superposition of costs in terms of time, water, reagents, and personnel.

[0040] On the other hand, the stirring device 10 described in this embodiment of the invention can be used with, for example, the bottom stirring equipment of a pharmaceutical company, without the need for installation, thereby effectively utilizing resources, significantly reducing costs, reducing time consumption, and simplifying related processes.

[0041] Specifically, as detailed below, the stirring device 10 does not need to be installed outside the reaction bag, nor does it need to be assembled or connected to the reaction bag by welding or other means. When the stirring device 10 is located in the reaction bag above the lower stirring device, the positioning drive 18 can cooperate with the lower stirring device to position the stirring device 10 relative to the lower stirring device and be driven by the lower stirring device to rotate the plurality of stirring paddles 14 to stir the material in the reaction bag, which is convenient, fast, efficient and time-saving.

[0042] The stirring device 10 is ready to use immediately, saving process operation time and providing a highly efficient application solution. The first housing 34 and the second housing 36 can protect the base 12, the plurality of stirring paddles 14, the bearing 16, and the positioning drive component 18. In particular, they can protect the plurality of stirring paddles 14 from damage during the insertion process, which is conducive to the complete insertion and smooth landing of the stirring device 10. The first housing 34 and the second housing 36 can also help avoid friction between the plurality of stirring paddles 14 and the reaction bag during rotation, thus preventing the generation of unwanted debris and other impurities.

[0043] The stirring device 10 can be packaged independently of the reaction bag and used in batches, offering high flexibility. The stirring device 10 can be sterilized to achieve a high degree of cleanliness and good safety.

[0044] In some embodiments, the stirring device 10 can be used only once, eliminating the need to clean, wash, and inspect the stirring device 10 after each material is stirred to avoid cross-contamination between materials before stirring the next material. This makes the process quick and flexible, greatly improving the work efficiency of tasks such as liquid preparation, and also saving significant costs in terms of time, water, reagents, and personnel.

[0045] The base 12 can be approximately cylindrical.

[0046] Unless otherwise specified, “several” in this document may mean 1, 2 or more, for example, the number of the stirring paddles 14 may be equal to 6 as shown in the figure, less than 6 or more than 6.

[0047] The plurality of agitators 14 may be distributed along the outer circumferential edge of the base 12. Each of the plurality of agitators 14 may protrude beyond the outer circumferential edge of the base 12.

[0048] In this embodiment of the invention, unless otherwise specifically indicated, the numerical value may include errors such as measurement error, precision error, and measurement error, for example, an error within the range of ±5%. For example, 100 may include a value within the range of 100 × (1 ± 5%), that is, a value within the interval of 95 to 105.

[0049] The bearing 16 may be located in the middle of the base 12, for example, housed in a receiving hole 13 in the center of the base 12. The bearing 16 may be made of materials such as ceramic or plastic.

[0050] As described later, the positioning drive component 18 can be positioned relative to the lower stirring device without direct contact with it, and driven by the lower stirring device to rotate the plurality of stirring paddles 14. The positioning drive component 18 and the base 12 can be separately formed and assembled together.

[0051] In some embodiments, the base 12 includes a coupling portion 20, and the positioning drive 18 includes a magnetic element 22 coupled to the coupling portion 20.

[0052] The magnetic component 22 can be mounted to the base 12 through the connecting part 20. The positioning drive component 18 can be positioned by the magnetic component 22 and driven to rotate the plurality of stirring paddles 14.

[0053] The magnetic component 22 may include a magnetic material. The magnetic component 22 may be made of a magnetic material. The magnetic component 22 may be a magnet or a lodestone. The magnetic component 22 may be a cylinder with a height and diameter less than or equal to that of the base 12.

[0054] In some embodiments, the base 12 includes a plurality of the connecting portions 20, and the positioning drive 18 includes a plurality of the magnetic elements 22, the plurality of magnetic elements 22 being coupled to some or all of the plurality of connecting portions 20.

[0055] The specific number of magnetic components 22 and / or the corresponding joints 20 can be selected as needed so that the stirring device 10 can be matched with different specifications of lower stirring equipment to meet the corresponding magnetic requirements.

[0056] The plurality of coupling portions 20 may be arranged around the bearing 16. Each coupling portion 20 may be spaced apart from adjacent coupling portions 20. Each coupling portion 20 may be a receiving hole. One coupling portion 20 may accommodate one magnetic element 22. When the magnetic element 22 is accommodated in the coupling portion 20, the magnetic element 22 may not extend beyond the base 12 and may be located inside the base 12.

[0057] The number of the connecting parts 20 can be less than 8, equal to 8, or greater than 8. For example, the number of the connecting parts 20 can be 6 as shown in the figure. The number of the magnetic components 22 can be less than or equal to the number of the connecting parts 20. For example, the number of the magnetic components 22 can be 6 as shown in the figure.

[0058] The base 12 can be assembled with the plurality of stirring paddles 14 after being formed separately.

[0059] Figure 2 yes Figure 1 A partial explosion diagram of the stirring device. Please refer to [link / reference]. Figure 2 In some embodiments, the base 12 includes a mating part 24 that can be detachably mated with the plurality of stirring paddles 14.

[0060] The plurality of stirring blades 14 can be assembled and disassembled with the base 12 by engaging and disengaging the mating parts 24. Different types of stirring blades 14, such as inclined blades and straight blades, can be engaged with the mating parts 24 to provide different turbulence modes, such as different fluid disturbance methods in liquid-liquid mixing or solid-liquid mixing, depending on the needs or the materials being stirred. Therefore, different stirring devices 10 with different stirring blades 14 can be flexibly selected according to specific process requirements.

[0061] In some embodiments, each of the plurality of stirring paddles 14 includes a mounting portion 26 that mates with the mating portion 24, and a blade 28 extending from the mounting portion 26, the blade 28 intersecting the mounting portion 26 at an oblique angle or a right angle.

[0062] The mating portion 24 can correspond in shape, structure, and size to the mounting portion 26 for mating. The mating portion 24 can be a recessed groove extending inward from the outer edge of the base 12 between adjacent mating portions 20; that is, the outer edge of the base 12 on the outer side of each mating portion 20 protrudes outward relative to the mating portion 24. The mounting portion 26 can be a block that fits into the mating portion 24. When the mounting portion 26 is fitted into the mating portion 24, the outer edge of the mounting portion 26 can be approximately flush with the exposed edge of the adjacent base 12, together forming a generally smooth cylindrical outer surface.

[0063] The blade 28 may be plate-shaped. The blade 28 may extend from the middle of the outer surface of the mounting portion 26 in a direction away from the bearing 16. When the blade 28 intersects the mounting portion 26 at an oblique angle, the included angle between the blade 28 and the mounting portion 26 may be greater than or less than 90 degrees.

[0064] Figure 3 This is a perspective view of a stirring impeller according to other embodiments of the present invention. Figure 3 As shown, when the blade 28 intersects the mounting portion 26 at a right angle, the blade 28 and the mounting portion 26 are approximately perpendicular.

[0065] In some embodiments, the plurality of impellers 14 include one or more of the following: oblique blade impeller, backward curved blade impeller, parabolic rounded corner impeller, and right-angle impeller.

[0066] In this way, it is possible to flexibly select different stirring devices 10 with different stirring paddles 14 according to specific process needs, so as to provide different turbulence modes, different fluid disturbance methods, etc., and to put the stirring device 10 into operation as needed to solve complex stirring requirements, with high flexibility.

[0067] Please continue reading Figure 2 In some embodiments, the stirring device 10 includes a first cover plate 30 and a second cover plate 32 respectively disposed on opposite sides of the base 12, and the positioning drive member 18 is located between the first cover plate 30 and the second cover plate 32.

[0068] The first cover plate 30 and the second cover plate 32 can cover the positioning drive member 18 together with the base 12, prevent the stirred material from contacting the positioning drive member 18, and protect the positioning drive member 18.

[0069] The first cover plate 30 and the second cover plate 32 may each be generally circular plates. The first cover plate 30 and the second cover plate 32 may correspond to or be the same as the side surface of the adjacent base 12 in shape and size, so as to cover the side surface. The outer edges of the first cover plate 30 and the second cover plate 32 may include notches 33 corresponding to the mating part 24, so that the installation and removal of the plurality of stirring paddles 14 are not interfered with by the first cover plate 30 and the second cover plate 32.

[0070] Figure 4 yes Figure 1 A partial assembly diagram of the stirring device. Please refer to [link / reference]. Figure 4 After the base 12, the plurality of stirring paddles 14, the bearing 16, the positioning drive component 18, the first cover plate 30 and the second cover plate 32 are installed, only the paddle blades 28 protrude relatively, and the rest are combined into a hollow cylinder.

[0071] The first box 34 and the second box 36 can be symmetrical to each other so that the plurality of stirring paddles 14 remain stable during stirring.

[0072] In some embodiments, the first housing 34 includes a first substrate 38, and the second housing 36 includes a second substrate 40 opposite to the first substrate 38. The first substrate 38 and the second substrate 40 each include a plurality of through holes 42.

[0073] The first substrate 38 and the second substrate 40 may be generally circular. The first substrate 38 and the second substrate 40 may surround the base 12, the plurality of stirring paddles 14, the bearing 16, and the positioning drive member 18 in a direction that does not interfere with the rotation of the plurality of stirring paddles 14. The first substrate 38 and the second substrate 40 may be adjacent to the first cover plate 30 and the second cover plate 32, respectively.

[0074] The first housing 34 and the second housing 36 can communicate with each other through the plurality of through holes 42. The plurality of through holes 42 can be arranged around the outer edges of the first substrate 38 and the second substrate 40, corresponding to the positions of the plurality of stirring paddles 14.

[0075] In some embodiments, the first substrate 38 and the second substrate 40 extend parallel to each other along a first direction X. The base 12, the plurality of stirring paddles 14, the bearing 16 and the positioning drive 18 are located between the first substrate 38 and the second substrate 40. After installation, the dimensions of the base 12, the plurality of stirring paddles 14, the bearing 16 and the positioning drive 18 in the first direction X are smaller than the dimensions of the first substrate 38 and the second substrate 40 in the first direction X.

[0076] After installation, the plurality of stirring paddles 14 can not exceed the outer edges of the first substrate 38 and the second substrate 40, can rotate between the first substrate 38 and the second substrate 40, are protected by the first substrate 38 and the second substrate 40, and are not easily damaged.

[0077] Figure 5 for Figure 4 A perspective view of the second housing of the stirring device. Please refer to [reference needed]. Figure 5 In some embodiments, the first substrate 38 includes a first connecting portion 44, and the second substrate 40 includes a second connecting portion 46 connected to the first connecting portion 44. At least one of the first connecting portion 44 and the second connecting portion 46 is coupled to the bearing 16.

[0078] The middle portion of the first substrate 38 and the second substrate 40 may be a solid portion surrounded by the plurality of through holes 42. The first connecting portion 44 and the second connecting portion 46 may protrude from the inner surface of the middle portion of the first substrate 38 and the second substrate 40. The first connecting portion 44 and the second connecting portion 46 may protrude and engage with each other to connect the first substrate 38 and the second substrate 40, and thereby connect the first housing 34 and the second housing 36.

[0079] Please refer to the above. Figure 2 The bearing 16, the first cover plate 30, and the second cover plate 32 may be provided with a first through hole 17, a second through hole 31, and a third through hole 35 at positions corresponding to the first connecting part 44 and the second connecting part 46, respectively, so that at least one of the first connecting part 44 and the second connecting part 46 passes through the first cover plate 30 and the second cover plate 32, protrudes into the bearing 16, and is tightly pressed and engaged with the first through hole 17 to combine with the bearing 16, thereby ensuring the integrity and symmetry of the stirring device 10.

[0080] In some embodiments, the first housing 34 includes a first peripheral wall 48 extending from the edge of the first substrate 38 toward the second substrate 40, and the second housing 36 includes a second peripheral wall 50 extending from the edge of the second substrate 40 toward the first substrate 38.

[0081] The first peripheral wall 48 and the second peripheral wall 50 can protect the outer edges of the plurality of stirring paddles 14 away from the center of the base 12. The first peripheral wall 48 and the second peripheral wall 50 can be relatively close to the plurality of through holes 42.

[0082] Figure 6 yes Figure 1 A perspective view of the assembly of the internal stirring device. Please refer to [reference needed]. Figure 6The first peripheral wall 48 and the second peripheral wall 50 abut against each other. The first cover plate 30, the base 12, and the second cover plate 32 are stacked sequentially between the first substrate 38 and the second substrate 40. The sum of the heights of the first peripheral wall 48 and the second peripheral wall 50 in the direction perpendicular to the first direction X can be greater than or equal to the sum of the heights of the first cover plate 30, the base 12, and the second cover plate 32 in the direction perpendicular to the first direction X. The base 12, the plurality of stirring paddles 14, the bearing 16, and the positioning drive member 18 are housed inside the first housing 34 and the second housing 36.

[0083] In some embodiments, the outer surfaces of the first housing 34 and the second housing 36 comprise a high-friction material.

[0084] Examples of the high-friction materials include, but are not limited to, silicone.

[0085] The stirring device 10 can stir within the reaction bag. The reaction bag can be a regular liquid storage bag or a disposable reaction bag.

[0086] Figure 7 This is a schematic diagram illustrating a usage state of a disposable reaction bag according to another aspect of an embodiment of the present invention. Figure 7 As shown, another aspect of the present invention relates to a disposable reaction bag 60, which includes: a bag body 62; and a stirring device 10 as described in this application, which can be housed within the bag body 62 without being connected to the bag body 62.

[0087] The disposable reaction bag 60 can be used once when preparing culture media, buffer solutions, etc. The bag body 62 can be made of a flexible material such as plastic film.

[0088] The disposable reaction bag 60 can be open or closed. When the disposable reaction bag 60 is closed, the stirring device 10 can be pre-placed inside the bag body 62 during the manufacturing of the disposable reaction bag 60.

[0089] The stirring device 10 and the disposable reaction bag 60 can be used once, eliminating the need for batch cleaning and validation during preparation, which is convenient and simple. Before stirring, the stirring device 10 and the disposable reaction bag 60 can be sterilized to achieve a sterile state, resulting in a low risk of introducing microorganisms and high safety. This method is suitable for both high-risk materials and highly clean operations, as well as for the preparation of commonly used excipients with general control, such as buffer solution preparation.

[0090] The stirring device 10 can be placed inside the bag body 62 without needing to be connected or assembled to the bag body 62 by welding or other means. The stirring device 10 can be placed inside the bag body 62 before or after the material to be stirred is added to the bag body 62. When the stirring device 10 is placed inside the bag body 62 before the material to be stirred is added, the stirring device 10 can be sterilized together with the disposable reaction bag 60, making it suitable for use in the biopharmaceutical field.

[0091] In some embodiments, the stirring device 10 is located at the bottom 64 of the bag body 62 when it is in operation.

[0092] The stirring device 10 can be attached to the bottom 64 by the friction between the outer surfaces of the first box 34 and the second box 36 and the bag body 62, and stirs and works when the plurality of stirring paddles 14 rotate.

[0093] Figure 8 This is a schematic flowchart of a stirring method according to another aspect of the present invention. Figure 9 for Figure 7 Another schematic diagram showing the usage of the disposable reaction bag. Please refer to [link / reference]. Figure 8 , 9 Another aspect of the present invention relates to a stirring method 80, which includes the following steps: 82, adding the material to be stirred 84 to a disposable reaction bag 60 placed on a workbench 86; and 90, placing the material to be stirred 84 into a stirring device 10 as described in this application, so that the stirring device 10 settles in the material to be stirred 84, is positioned relative to the workbench 86, and is driven by the workbench 86 to stir the material to be stirred 84.

[0094] The material being stirred 84 may include solids, liquids, etc. The workbench 86 may be, for example, a bottom stirring device used in pharmaceutical manufacturing. The workbench 86 can support the disposable reaction bag 60 via the tank bottom plate 87, and cooperates with the positioning drive 18 to position the stirring device 10 and drive the plurality of stirring paddles 14 to rotate.

[0095] Figure 10 yes Figure 7 A partial sectional view of the mixing device and worktable. Please refer to [reference needed]. Figure 10 In some embodiments, when the stirring device 10 settles in the stirred material 84, the positioning drive 18 is attracted by the magnetic drive 92 of the worktable 86 to be positioned relative to the magnetic drive 92, and is driven by the magnetic drive 92 to drive the plurality of stirring paddles 14 to rotate.

[0096] After the stirring device 10 is placed into the stirred object 84, the stirring device 10 sinks into the stirred object 84 under the action of gravity. The positioning drive 18 and the magnetic actuator 92 attract each other, and the stirring device 10 is positioned above the magnetic actuator 92 and inside the mounting port 85 of the worktable 86.

[0097] The magnetic actuator 92 may include a magnetic element 93 corresponding to the magnetic element 22. The magnetic element 93 may include a magnetic material. The magnetic element 93 may be made of a magnetic material. The magnetic element 93 may be a magnet or a lodestone.

[0098] The magnetic actuator 92 can be connected in sequence to the servo motor reducer 95 and the servo motor 97 so that the positioning drive 18 can be rotated under the drive of the servo motor 97, and the plurality of stirring paddles 14 are rotated together to stir the stirred object 84.

[0099] Please continue reading Figure 7 In some embodiments, after the stirring device 10 is positioned relative to the workbench 86, the first box 34 and the second box 36 are attached to the disposable reaction bag 60 and do not rotate, while the plurality of stirring paddles 14 can rotate.

[0100] Within the mounting port 85, the positioning drive 18, which is coupled to the base 12, is driven by the magnetic drive 92 of the worktable 86, causing the plurality of stirring paddles 14, which are coupled to the base 12, to rotate and stir the stirred object 84. The first box 34 and the second box 36, which are in contact with the disposable reaction bag 60, adhere to the disposable reaction bag 60 by the friction between their outer surfaces and the disposable reaction bag 60. The first connecting part 44 and the second connecting part 46 engage with the first through hole 17 of the bearing 16. The first box 34 and the second box 36 do not rotate.

[0101] After stirring is completed, the stirred material 84 can be stored, used, or sent to the next process point. The disposable reaction bag 60 and the stirring device 10 can be disposed of or discarded after the stirred material 84 leaves.

[0102] Figure 11 This is a graph showing the test data of the stirring efficiency of the stirring device according to an embodiment of the present invention. In one embodiment, four... Figure 6 The stirring device 10 shown is used to add four portions of the mixture, each 20 liters in size, to the mixture. The mixture is stirred at speeds of 100 rpm, 200 rpm, 300 rpm, and 400 rpm. The solubility efficiency of a 500 mM NaCl model solute is tested using a conductivity meter. The solubility values ​​obtained at different time points are shown below. Figure 11 .like Figure 11 As shown, with the help of the stirring device 10 at different speeds, the corresponding stirred objects can be efficiently dissolved and prepared into salt solutions within 6 minutes.

[0103] The various specific embodiments described above and shown in the accompanying drawings are for illustrative purposes only and do not represent the entirety of the invention. Any modifications made by those skilled in the art within the scope of the basic technical concept of this invention are within the protection scope of this invention.

Claims

1. A stirring device (10) for a disposable reaction bag, characterized in that, include: The base (12) includes a plurality of joints (20); Several stirring paddles (14) extend outward from the base (12); A bearing (16) is located in the middle of the base (12), and the plurality of joints (20) are arranged around the bearing (16); A positioning drive (18) is disposed on the base (12). The positioning drive (18) includes a plurality of magnetic elements (22) coupled to the plurality of coupling portions (20). The positioning drive (18) is capable of positioning the stirring device (10) and driving the plurality of stirring paddles (14) to rotate around the bearing (16); and A first box (34) and a second box (36) are symmetrical to each other. The first box (34) includes a first substrate (38), and the second box (36) includes a second substrate (40) opposite to the first substrate (38). The first substrate (38) includes a first connecting portion (44), and the second substrate (40) includes a second connecting portion (46) connected to the first connecting portion (44). At least one of the first connecting portion (44) and the second connecting portion (46) is combined with the bearing (16). The first box (34) and the second box (36) together surround the base (12), the plurality of stirring paddles (14), the bearing (16), and the positioning drive (18). When the stirring device (10) is working, the material to be stirred (84) is added into a disposable reaction bag (60) placed on the workbench (86), and the stirring device (10) is put into the material to be stirred (84) so ​​that the stirring device (10) settles in the material to be stirred (84) under the action of gravity, is positioned relative to the workbench (86), and is driven by the workbench (86) to stir the material to be stirred (84).

2. The stirring device (10) for a disposable reaction bag as described in claim 1, characterized in that, The plurality of magnetic elements (22) are coupled to some or all of the plurality of coupling portions (20).

3. The stirring device (10) for a disposable reaction bag as described in any one of claims 1-2, characterized in that, The base (12) includes a mating part (24) which can be detachably mated with the plurality of stirring paddles (14).

4. The stirring device (10) for a disposable reaction bag as described in claim 3, characterized in that, Each of the plurality of stirring paddles (14) includes a mounting portion (26) that mates with the mating portion (24), and a blade (28) extending from the mounting portion (26), the blade (28) intersecting the mounting portion (26) at an oblique angle or at a right angle.

5. The stirring device (10) for a disposable reaction bag as described in claim 3, characterized in that, The plurality of impellers (14) include one or more of the following: oblique blade impeller, backward curved blade impeller, parabolic rounded corner impeller, and right angle impeller.

6. The stirring device (10) for a disposable reaction bag as described in claim 1, characterized in that, It includes a first cover plate (30) and a second cover plate (32) respectively disposed on opposite sides of the base (12), and the positioning drive member (18) is located between the first cover plate (30) and the second cover plate (32).

7. The stirring device (10) for a disposable reaction bag as described in claim 1, characterized in that, The first substrate (38) and the second substrate (40) each include a plurality of through holes (42).

8. The stirring device (10) for a disposable reaction bag as described in claim 1, characterized in that, The first substrate (38) and the second substrate (40) extend parallel to each other along a first direction. The base (12), the plurality of stirring paddles (14), the bearing (16) and the positioning drive (18) are located between the first substrate (38) and the second substrate (40). After installation, the dimensions of the base (12), the plurality of stirring paddles (14), the bearing (16) and the positioning drive (18) in the first direction are smaller than the dimensions of the first substrate (38) and the second substrate (40) in the first direction.

9. The stirring device (10) for a disposable reaction bag as described in claim 1, characterized in that, The first housing (34) includes a first peripheral wall (48) extending from the edge of the first substrate (38) toward the second substrate (40), and the second housing (36) includes a second peripheral wall (50) extending from the edge of the second substrate (40) toward the first substrate (38).

10. The stirring device (10) for a disposable reaction bag as described in claim 1, characterized in that, The outer surfaces of the first box (34) and the second box (36) are made of a high-friction material.

11. A disposable reaction bag (60), characterized in that, include: Bag body (62); as well as The stirring device (10) for a disposable reaction bag as described in any one of claims 1-10 is capable of being housed within the bag body (62) without being connected to the bag body (62).

12. The disposable reaction bag (60) as described in claim 11, characterized in that, The stirring device (10) is located at the bottom (64) of the bag body (62) when it is in operation.

13. A stirring method, characterized in that, Includes the following steps: Add the mixture to be stirred (84) into a disposable reaction bag (60) placed on the workbench (86); and Add to the mixture (84) The stirring device (10) for a disposable reaction bag as described in any one of claims 1-10, such that the stirring device (10) settles in the material to be stirred (84), is positioned relative to the worktable (86), and is driven by the worktable (86) to stir the material to be stirred (84).

14. The stirring method as described in claim 13, characterized in that, When the stirring device (10) settles in the material to be stirred (84), the positioning drive (18) is attracted by the magnetic drive (90) of the worktable (86) to be positioned relative to the magnetic drive (90), and is driven by the magnetic drive (90) to drive the plurality of stirring paddles (14) to rotate.

15. The stirring method as described in claim 13, characterized in that, After the stirring device (10) is positioned relative to the workbench (86), the first box (34) and the second box (36) are attached to the disposable reaction bag (60) and do not rotate, while the plurality of stirring paddles (14) can rotate.

Images