Method for determining the actual concentration of a substrate using a series of self-calibrating biosensors and apparatus for implementing the method

By using sensor combinations of different calibration curves in the biosensor array, self-calibration is achieved, the problem of time drift of glucose sensors is solved, stable blood sugar monitoring is achieved, user operation is reduced, and the service life of the sensor is improved.

CN115768350BActive Publication Date: 2025-08-12UNIVERSITE GRENOBLE ALPES +3
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Patent Information

Application Number
CN202180042565.4
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Priority Date
2020-06-12
Filing Date
2021-06-11
Publication Date
2025-08-12
Estimated Expiration
2041-06-11

AI Technical Summary

Technical Problem

Existing glucose biosensors cannot monitor blood sugar stably for a long time due to time drifting, and require frequent calibration or replacement, resulting in the inability to achieve continuous and stable blood sugar monitoring.

Method used

Multiple biosensors are used to form an array, each sensor has a different calibration curve. By comparing the sensor signal values, the substrate concentration in the medium is determined, and the combination of different catalysts and mediators is used to achieve self-calibration to avoid direct measurement value drift.

Benefits of technology

It realizes long-term stable monitoring of blood sugar concentration without external calibration or replacement, improves the accuracy and reliability of the sensor, and reduces user operation inconvenience.

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Abstract

The present invention relates to a method for determining in a stable manner over a period of time the region in which the actual concentration of a substrate (S1) in a medium lies, the substrate (S1) consisting of any molecule that can undergo a catalytic redox reaction by a catalyst, characterized in that the method comprises the following steps: (a) taking at least one group of at least two biosensors, each group having a calibration curve for a signal induced by an oxidation-reduction reaction, the biosensors in a group having the same initial portion of the calibration curve up to a substrate concentration value (S1), called the separation concentration (SC), the signal measurement of one biosensor in the group differing from that of another biosensor in the group at the separation concentration; when there is more than one group of biosensors, the biosensors in different groups have different calibration curves without the same initial portion; (b) bringing the biosensors into contact with the medium; (c) measuring the signal caused by the oxidation or reduction reaction of each biosensor in one or more groups; and (d) comparing all the signal values generated by all the biosensors and following the method described in the instructions.
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Citation Information

Patent Citations

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