周期蛋白PER2及其基因在抑制Tau及磷酸化Tau蛋白聚集、提升认知功能中的应用
By knocking out the PER2 gene in mice, reducing PER2 protein expression, inhibiting the aggregation of Tau and phosphorylated Tau proteins, and improving cognitive function in P301L mice, the interaction between PER2 and Alzheimer's disease was resolved, providing a new approach to treating Alzheimer's disease.
CN115785246BActive Publication Date: 2026-07-17INST OF ENVIRONMENTAL MEDICINE & OCCUPATIONAL MEDICINE ACAD OF MILITARY MEDICINE ACAD OF MILITARY SCI
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- INST OF ENVIRONMENTAL MEDICINE & OCCUPATIONAL MEDICINE ACAD OF MILITARY MEDICINE ACAD OF MILITARY SCI
- Filing Date
- 2022-11-04
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Current research has not revealed the interaction between cyclin PER2 and neurodegenerative diseases such as Alzheimer's disease, and the accumulation of Tau and phosphorylated Tau proteins leads to cognitive decline.
Method used
By knocking out the PER2 gene in mice, the expression level of PER2 protein or gene is reduced, inhibiting the aggregation and spread of Tau and phosphorylated Tau protein, thereby improving cognitive function.
Benefits of technology
It significantly inhibits the aggregation of Tau and phosphorylated Tau proteins and enhances the cognitive function of P301L mice, providing a new approach for the treatment of neurodegenerative diseases such as Alzheimer's disease.
✦ Generated by Eureka AI based on patent content.
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Figure CN115785246B_ABST
Abstract
本发明涉及基因编辑技术领域，特别是涉及周期蛋白PER2及其基因在抑制Tau及磷酸化Tau蛋白聚集、提升认知功能中的应用。本发明通过利用PER2基因敲除小鼠与P301L小鼠进行杂交，并经过逐代繁育得到PER2‑ / ‑x P301L双转基因小鼠，并通过与P301L小鼠比较Tau蛋白、磷酸化Tau的表达量，确定了周期蛋白PER2或PER2基因具有调控Tau蛋白和 / 或磷酸化Tau蛋白的聚集的作用，通过敲除小鼠的PER2基因可以抑制Tau蛋白及磷酸化Tau蛋白聚集。另外，敲除小鼠的PER2基因可以提升P301L小鼠的认知功能，为研制治疗阿尔茨海默病等神经退行性疾病的药物提供了一种新的思路。
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