Ultrasound ablation system

Abstract

The present disclosure relates to the field of ablation technology, and particularly discloses an ultrasonic ablation system, which comprises a temperature monitoring module for monitoring temperature information of a target region; a control module for generating an ablation signal or an adjusting signal according to control information and a first control signal or a second control signal; a voltage regulating module for adjusting an input electrical signal to a target electrical signal according to the ablation signal or the adjusting signal; N groups of pulse excitation modules for generating pulse excitation signals according to the target electrical signal and the ablation signal or the adjusting signal; N groups of signal processing modules for realizing impedance matching between output ends of the pulse excitation modules and input ends of a transducer assembly according to control signals; and N groups of piezoelectric crystal assemblies arranged in a treatment catheter and connected with the N groups of signal processing modules respectively, for converting the pulse excitation signals into ultrasonic signals, wherein the N groups of piezoelectric crystal assemblies respectively emit ultrasonic energy along different directions. The piezoelectric crystal assemblies of multiple groups emitting ultrasonic energy in different directions can simultaneously realize multi-directional ultrasonic ablation.

Description

Technical Field

[0001] This invention relates to the field of ultrasonic ablation technology, and in particular to an ultrasonic ablation system. Background Technology

[0002] Based on the different ablation energy, there are currently at least five types of ablation methods: radiofrequency, ultrasound, microwave, cryoablation, and chemical ablation. Ultrasound is a mechanical wave, and its biological effects include mechanical, cavitation, and thermal effects; the principle of ultrasound ablation lies in utilizing the thermal effect of ultrasound. Currently, ultrasound ablation systems are mainly divided into catheter-based intravascular ultrasound ablation systems and extracorporeal high-intensity focused ultrasound (HIFU) ablation systems. The former mainly includes the Paradise system and the TIVUS system, while the latter mainly includes the Kona system and the Model-JC HIFU tumor treatment system. In the Paradise system, a ring transducer is used, which cannot selectively ablate a specific area, but can only ablate circumferentially, and is also prone to causing excessive temperature rise of the ultrasound components. Excessive temperature rise can cause certain harm to the human body; for example, in blood vessels, it may cause blood clotting or thrombosis, failing to meet the precision and safety requirements of ultrasound ablation treatment. Summary of the Invention

[0003] Therefore, it is necessary to provide an ultrasonic ablation system to address the issue that existing ultrasonic ablation devices cannot meet the requirements for precision and safety in ultrasonic ablation treatment.

[0004] An ultrasonic ablation system includes a temperature monitoring module for monitoring temperature information of a target area, generating a first control signal when the temperature information meets a first preset condition, or generating a second control signal when the temperature information meets a second preset condition; a control module connected to the temperature monitoring module for acquiring control information, including piezoelectric crystal information, and for generating an ablation signal based on the control information and the first control signal, or generating an adjustment signal based on the control information and the second control signal; a voltage regulation module connected to the control module for adjusting an input electrical signal to a target electrical signal based on the ablation signal or the adjustment signal; and N pulse excitation modules connected to the control module and the voltage regulation module respectively, for adjusting the input electrical signal to a target electrical signal based on the ablation signal or the adjustment signal. The target electrical signal is converted into a pulse excitation signal; where N is an integer greater than zero; N sets of signal processing modules are respectively connected to the N sets of pulse excitation modules and are also connected to the control module, used to process the pulse excitation signal according to the ablation signal or the adjustment signal, and to achieve impedance matching between the output terminal of the pulse excitation module and the input terminal of the piezoelectric crystal assembly; the control module is also used to control the conduction or cutoff between the N sets of pulse excitation modules and the N sets of signal processing modules; the treatment catheter is provided with N sets of piezoelectric crystal assemblies, the N sets of piezoelectric crystal assemblies are respectively connected to the N sets of signal processing modules, used to convert the pulse excitation signal into an ultrasonic signal, and the N sets of piezoelectric crystal assemblies are also used to emit ultrasonic energy to the outside of the treatment catheter.

[0005] In one embodiment, N sets of the piezoelectric crystal assemblies are circumferentially distributed around the axis of the treatment catheter within the treatment catheter.

[0006] In one embodiment, the voltage regulation module includes an input circuit with an input terminal, a positive output terminal, and a negative output terminal. The input terminal is connected to a power supply module for acquiring an input electrical signal. The input circuit includes a first capacitor. A transformer is connected to the input circuit for voltage transformation of the input electrical signal. The transformer includes a primary winding, a second primary winding, and a second secondary winding. An output circuit is connected to the transformer for rectifying the voltage-transformed input electrical signal to acquire the target electrical signal. The output circuit includes a first diode, a second diode, a second capacitor, and a third capacitor. The first terminal of the first capacitor is connected to the input terminal of the input circuit, and the second terminal of the first capacitor is grounded. The first terminal of the primary winding is also connected to the input circuit. The input terminals are connected; the first end of the first primary winding is connected to the positive terminal of the first diode, the second end of the first primary winding is connected to the first end of the second secondary winding, and the second end of the second secondary winding is connected to the negative terminal of the second diode; the negative terminal of the first diode is connected to the first terminal of the second capacitor, and the positive terminal of the second diode is connected to the first terminal of the third capacitor; the second terminal of the second capacitor, the second terminal of the third capacitor, the second terminal of the first primary winding, and the first terminal of the second secondary winding are all grounded; the negative terminal of the first diode and the first terminal of the second capacitor are both connected to the positive output terminal of the output circuit, and the positive terminal of the second diode and the first terminal of the third capacitor are both connected to the negative output terminal of the output circuit.

[0007] In one embodiment, the voltage regulation module further includes a voltage sampling circuit connected to the output circuit for sampling the voltage at the positive output terminal of the output circuit to obtain a sampled electrical signal; the voltage sampling circuit includes a first resistor and a second resistor; a main control circuit is connected to the transformer, the voltage sampling circuit, and the control module respectively, for feedback adjustment of the transformer based on the ablation signal and the sampled electrical signal, or for feedback adjustment of the transformer based on the adjustment signal and the sampled electrical signal; the main control circuit includes a main control unit, a PWM controller, a first switching transistor, a third resistor, a voltage feedback operational amplifier, and a digital-to-analog converter module; the first end of the first resistor is connected to the positive output terminal of the output circuit, and the second end of the first resistor is connected to the second resistor. The first terminal is connected, and the second terminal of the second resistor is grounded; the main control unit is connected to the first input terminal of the PWM controller, the digital-to-analog converter module, and the control module respectively; the digital-to-analog converter module is connected to the negative input terminal of the voltage feedback operational amplifier, and the positive input terminal of the voltage feedback operational amplifier is connected to the second terminal of the first resistor; the output terminal of the voltage feedback operational amplifier is connected to the second input terminal of the PWM controller, the output terminal of the PWM controller is connected to the gate of the first switching transistor, the current detection pin of the PWM controller is connected to the source of the first switching transistor, the drain of the first switching transistor is connected to the second terminal of the primary winding, the source of the first switching transistor is also connected to the first terminal of the third resistor, and the second terminal of the third resistor is grounded.

[0008] In one embodiment, the pulse excitation module includes a driver chip, a second switch, a third switch, a third diode, and a fourth diode. The driver chip is connected to the source of the second switch, the source of the third switch, and the control module. The drain of the second switch is connected to the positive output terminal of the voltage regulation module. The gate of the third switch is connected to the negative output terminal of the voltage regulation module. The gate of the second switch is connected to the anode of the third diode. The drain of the third switch is connected to the cathode of the fourth diode. The cathode of the third diode and the anode of the fourth diode are connected to the output terminal of the pulse excitation module.

[0009] In one embodiment, the signal processing module includes a switching unit and M sets of impedance matching units, where M is an integer greater than zero; the pulse excitation module is connected to the M sets of impedance matching units, the M sets of impedance matching units are connected to the piezoelectric crystal assembly through the switching unit, the switching unit is also connected to the control module, and the switching unit is used to conduct the connection path between any one of the M sets of impedance matching units and the piezoelectric crystal assembly according to the ablation signal or the adjustment signal.

[0010] In one embodiment, when M is 3, the switching unit is a three-pole three-throw switch, which includes a first fixed terminal, a second fixed terminal, a third fixed terminal, a first moving terminal, a second moving terminal, a third moving terminal, a fourth moving terminal, a fifth moving terminal, and a sixth moving terminal. The first group of impedance matching units includes a first inductor, a fourth capacitor, and a fifth capacitor. The second group of impedance matching units includes a second inductor, a sixth capacitor, and a seventh capacitor. The third group of impedance matching units includes a third inductor, an eighth capacitor, and a ninth capacitor. The first terminal of the first inductor is connected to the output terminal of the pulse excitation module and the second moving terminal, respectively. The second terminal of the first inductor is connected to the first terminal of the fourth capacitor, and the second terminal of the fourth capacitor is connected to the first fixed terminal. The moving terminal, the fourth moving terminal, and the first terminal of the second inductor are connected together. The second terminal of the second inductor is connected to the first terminal of the fifth capacitor. The second terminal of the fifth capacitor is connected to the second stationary terminal, the sixth moving terminal, and the first terminal of the third inductor. The second terminal of the third inductor is connected to the first terminal of the sixth capacitor. The second terminal of the sixth capacitor is connected to the piezoelectric crystal assembly and the third stationary terminal. The first terminal of the seventh capacitor is connected to the first moving terminal. The second terminal of the seventh capacitor is grounded. The first terminal of the eighth capacitor is connected to the third moving terminal. The second terminal of the eighth capacitor is grounded. The first terminal of the ninth capacitor is connected to the fifth moving terminal. The second terminal of the ninth capacitor is grounded.

[0011] In one embodiment, the treatment catheter further includes a thermocouple, and the temperature monitoring module includes a temperature acquisition circuit, which is connected to both the thermocouple and the control module to acquire temperature information from the thermocouple. The temperature monitoring module is also used to generate an alarm signal when the temperature information exceeds a preset threshold.

[0012] In one embodiment, the ultrasonic ablation system further includes a human-computer interaction module connected to the control module, and the control module obtains control information through the human-computer interaction module.

[0013] In one embodiment, the ultrasonic ablation system further includes a display module connected to the control module for displaying the control information and / or the temperature information.

[0014] The aforementioned ultrasonic ablation system incorporates multiple sets of piezoelectric crystal assemblies within the treatment catheter. These assemblies emit ultrasonic energy in different directions, enabling simultaneous ultrasonic ablation in various orientations. When only one set of piezoelectric crystal assemblies is used, targeted ablation can be achieved. A temperature monitoring module monitors the temperature of the target area and generates different control signals based on varying temperature readings. A control module generates ablation or adjustment signals based on the acquired control information and signals. The ablation signal controls the voltage regulation module to output a corresponding voltage amplitude and the pulse excitation module to output a corresponding pulse frequency, enabling the piezoelectric crystal assemblies to output appropriate ultrasonic signals. The adjustment signal adaptively adjusts the voltage amplitude of the voltage regulation module and the pulse frequency of the pulse excitation module. By utilizing multiple sets of piezoelectric crystal assemblies emitting ultrasonic energy in different directions, simultaneous multi-directional ultrasonic ablation can be achieved. Furthermore, the system adaptively adjusts the operating state of the piezoelectric crystals based on temperature information, preventing excessive temperature rise and ensuring optimal treatment efficacy. This significantly improves the safety and efficiency of the ultrasonic ablation system. Attached Figure Description

[0015] To more clearly illustrate the technical solutions in the embodiments of this specification or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this specification. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0016] Figure 1 This is a schematic diagram of the structure of an ultrasonic ablation system in one embodiment of the present disclosure; Figure 2 This is a schematic diagram of the radial cross-section of the treatment catheter in one embodiment of the present disclosure; Figure 3 This is a circuit connection diagram of the voltage regulation module in one embodiment of the present disclosure; Figure 4 This is a circuit connection diagram of multiple pulse excitation modules in one embodiment of the present disclosure; Figure 5 This is a schematic diagram of the circuit connection of multiple signal processing modules in one embodiment of the present disclosure; Figure 6 This is a schematic diagram of the circuit connection of multiple piezoelectric crystal components in one embodiment of the present disclosure; Figure 7 This is a schematic diagram of the structure of an ultrasonic ablation system in another embodiment of the present disclosure. Detailed Implementation

[0017] To facilitate understanding of the present invention, a more complete description will be given below with reference to the accompanying drawings. Preferred embodiments of the invention are shown in the drawings. However, the invention can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to provide a thorough and complete understanding of the disclosure of the invention.

[0018] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0019] Existing ablation devices are basically catheters with a single piezoelectric crystal embedded in them, requiring multiple rotations of the piezoelectric crystal to ablate peripheral nerve tissue. The ultrasonic ablation system disclosed in this invention can effectively improve the safety and efficiency of the application.

[0020] Figure 1 This is a schematic diagram of the ultrasonic ablation system in one embodiment of the present disclosure. In one embodiment, the ultrasonic ablation system may include a temperature monitoring module 100, a control module 200, a voltage regulation module 300, N sets of pulse excitation modules 400, N sets of signal processing modules 500, and N sets of piezoelectric crystal assemblies 600 disposed within the treatment catheter. Wherein, N is an integer greater than zero, and N sets can be understood as N units; examples include: N=1, using one set of piezoelectric crystal assemblies to achieve targeted ablation of the area to be ablated; N=2, using two sets of piezoelectric crystal assemblies, which can be arranged back-to-back or in other circumferential arrangements, the specific arrangement depending on the treatment site and area; N=3, 4, 5, 6, etc., using N sets of piezoelectric crystal assemblies, which can be distributed circumferentially around the axis of the treatment catheter, and the distribution can be equidistant or non-equidistant; N is not limited to the listed number, and other arrangements are still equivalent to the structure of this solution.

[0021] The N sets of piezoelectric crystal components 600 installed in the treatment catheter can be of the same or different specifications. For example, the specification can refer to the center frequency.

[0022] Since the piezoelectric crystal assembly 600 utilizes the thermal energy generated by ultrasonic signals to thermally ablate specific nerves or solid tissues, when multiple piezoelectric crystal assemblies 600 are installed within the treatment catheter, heat accumulation may cause the temperature of the treatment area to exceed the target treatment temperature, posing a safety hazard. The temperature monitoring module 100 can be used to monitor the temperature information of the target area. The target area can be the treatment area corresponding to the piezoelectric crystal assembly 600, or the area where the piezoelectric crystal assembly 600 is installed. By monitoring the temperature using the temperature monitoring module 100, adjustments can be made promptly when the temperature is too high, preventing excessive temperature rise from affecting the treatment effect and preventing sustained high temperatures from causing damage to the human body, thus ensuring the safety of the system.

[0023] The temperature monitoring module 100 can be pre-set with preset conditions for performing different actions based on different temperatures. A first control signal is generated when the temperature information meets a first preset condition, or a second control signal is generated when the temperature information meets a second preset condition. These preset conditions can be adaptively adjusted according to different application scenarios.

[0024] In this embodiment, the first preset condition can be that the temperature information is less than a set temperature, and correspondingly, the first control signal can be an ablation command. For example, before the ultrasound ablation system performs the ablation action on the target treatment area, the temperature monitoring module 100 determines whether the temperature of the target treatment area is less than the set temperature. When the temperature information is less than the set temperature, the temperature monitoring module 100 generates a first control signal, which can be used to instruct the control module 200 to execute the ablation command.

[0025] In this embodiment, the second preset condition can be that the temperature information is greater than the safe temperature, and correspondingly, the second control signal can be an adjustment command or a sleep command. For example, during the ablation process performed by the ultrasonic ablation system, when the temperature monitoring module 100 determines that the temperature of the target treatment area is greater than the preset safe temperature based on the real-time monitored temperature information, the temperature monitoring module 100 generates a second control signal, which can be used to instruct the control module 200 to execute an adjustment command or a sleep command.

[0026] In some other embodiments, the temperature monitoring module 100 can also make judgments based on temperature and other information, for example, it can also make different indications based on the temperature magnitude, ultrasonic energy magnitude and / or the duration of ultrasonic ablation.

[0027] The control module 200 is connected to the temperature monitoring module 100 and can acquire the first or second control signal generated by the temperature monitoring module 100. The control module 200 can also acquire control information in various ways. For example, the control module 200 can pre-store control information corresponding to different operating modes or different control signals, or it can acquire control information input by the user through human-machine interaction, or it can acquire control information stored in the cloud through wireless / wired communication.

[0028] The control information may include piezoelectric crystal information, which can be the set operating parameters of the piezoelectric crystal assembly 600, including the emission frequency, voltage amplitude, and emission energy duty cycle of the target piezoelectric crystal. The control module 200 can generate a corresponding ablation signal based on the control information and the first control signal, or generate an adjustment signal based on the control information and the second control signal. The ablation signal can be used to control the voltage regulation module 300, pulse excitation module 400, and signal processing module 500 to output the emission frequency, voltage amplitude, and emission energy duty cycle required for the piezoelectric crystal assembly 600 to operate, so that the piezoelectric crystal assembly 600 can output target ultrasonic energy along the target direction. The adjustment signal can be used to adjust the emission frequency, voltage amplitude, and emission energy duty cycle output by the voltage regulation module 300, pulse excitation module 400, and signal processing module 500.

[0029] Because there are a large number of piezoelectric crystal components 600 installed within the treatment catheter, and the actual operating frequency of each piezoelectric crystal component 600 may differ from the standard operating frequency during actual operation, the piezoelectric crystal information can also serve as the real-time operating parameters of the piezoelectric crystal component 600, including the center frequency of the piezoelectric crystal component 600 and the temperature information at the treatment site. The control module 200 can also comprehensively consider the control information and the actual operating parameters of the piezoelectric crystal component 600, and adaptively generate adjustment signals to adjust the voltage amplitude and pulse frequency to ensure that the piezoelectric crystal component 600 is at its optimal operating frequency.

[0030] The voltage regulating module 300 is connected to the control module 200 and can acquire the ablation signal or adjustment signal generated by the control module 200. The voltage regulating module 300 can also be connected to the power supply module to acquire the input electrical signal. The power supply module can be a dedicated ultrasound power supply. The voltage regulating module 300 can adjust the input electrical signal to the target electrical signal based on the ablation signal, or it can increase or decrease the target electrical signal based on the adjustment signal. The target electrical signal can be the emission voltage amplitude required by the ablation system.

[0031] In some other embodiments, the power supply module may also be connected to the control module 200, the pulse excitation module 400, and the signal processing module 500, respectively, to provide the electrical energy required for the operation of the aforementioned functional modules. The control module 200 may also control the power supply module to provide input electrical signals to the voltage regulation module 300.

[0032] Since the treatment catheter contains N sets of piezoelectric crystal assemblies 600, and different piezoelectric crystal assemblies 600 may require different emission frequencies during treatment, the ultrasonic ablation system of this disclosure includes N sets of pulse excitation modules 400. These N sets of pulse excitation modules 400 adaptively provide corresponding pulse excitation signals to the N sets of piezoelectric crystal assemblies 600. Each of the N sets of pulse excitation modules 400 is connected to both the control module 200 and the voltage regulation module 300. Each set of pulse excitation modules 400 can convert the target electrical signal according to the ablation signal or the adjustment signal to generate the corresponding pulse excitation signal required for the piezoelectric crystal assembly 600 to operate.

[0033] Similarly, by setting up N sets of signal processing modules 500, the N sets of signal processing modules 500 can adaptively process the N sets of pulse excitation signals. Signal processing can include filtering, amplification, and other methods. Furthermore, the N sets of signal processing modules 500 can also be used to achieve impedance matching between the output terminals of the N sets of pulse excitation modules 400 and the input terminals of the N sets of piezoelectric crystal components 600.

[0034] The control module 200 can also use adjustment signals to control the conduction or deactivation between the N groups of pulse excitation modules 400 and the N groups of signal processing modules 500. Before the ultrasound ablation system performs ablation, if only a portion of the piezoelectric crystals needs to treat the treatment area in the corresponding direction, the connection between the corresponding pulse excitation module 400 and the signal processing module 500 can be made to provide pulse excitation signals to only a portion of the piezoelectric crystals, thereby selectively activating a portion of the piezoelectric crystal assembly 600. In this way, the remaining piezoelectric crystals will not cause unnecessary tissue damage to areas that are not lesions during treatment.

[0035] When the ultrasonic ablation system performs ablation, if the treatment area corresponding to the designated piezoelectric crystal has been treated, or if the temperature of the treatment area corresponding to the piezoelectric crystal rises too quickly, the pulse excitation signal to the designated piezoelectric crystal can be stopped by disconnecting the connection between the corresponding pulse excitation module 400 and the signal processing module 500. This will cause the designated piezoelectric crystal to enter a dormant state, end its treatment action, or reduce the temperature of the treatment area.

[0036] By placing N sets of piezoelectric crystal assemblies 600 within the treatment catheter, each set connected to an N-set signal processing module 500, the piezoelectric crystal assemblies 600 can convert pulse excitation signals into ultrasonic signals. During treatment, the N sets of piezoelectric crystal assemblies 600 can simultaneously ablate tissue in different directions outside the treatment catheter. The relevant parameters of the ultrasonic signal can include ultrasonic power and sound field intensity. Different piezoelectric crystal assemblies 600 can generate ultrasonic waves with different center frequencies, sound pressures, and pressures, and each piezoelectric crystal assembly 600 has a different signal emission direction and emission range.

[0037] In the aforementioned ultrasonic ablation system, the temperature monitoring module 100 monitors the temperature information of the target area and outputs different control signals based on the temperature information. When the temperature is lower than the set temperature, the temperature monitoring module 100 outputs a first control signal, and the control module 200 generates an ablation signal based on the control information and the first control signal. The voltage regulation module 300 adaptively adjusts the input electrical signal to the target electrical signal based on the ablation signal. The N-group pulse excitation module 400 performs excitation control of N groups of transmission channels based on the ablation signal, generating corresponding pulse excitation signals. The pulse excitation module 400 supplies voltage to multiple pulse excitation channels through the voltage regulation module 300.

[0038] The N-group signal processing modules 500 are matched and connected to the radio frequency signal transmission channels of the N-group pulse excitation modules 400. Based on the ablation signal, the N-group signal processing modules 500 can process the pulse excitation signal to achieve adaptive selection of signal transmission, filtering, and impedance matching between themselves and the N-group piezoelectric crystal components 600 or a subset of the piezoelectric crystal components 600. Treatment catheters containing the N-group piezoelectric crystal components 600 are connected to the matched channels of the N-group signal processing modules 500. By embedding multiple piezoelectric crystal components 600 of different specifications and emission directions within a single treatment catheter, simultaneous treatment of different angle treatment areas can be achieved during treatment. Furthermore, ultrasound waves with different center frequencies, sound pressures, and pressures can be emitted to lesions at different angles for more targeted treatment.

[0039] When the temperature exceeds the safe temperature, the temperature monitoring module 100 outputs a second control signal. The control module 200 generates an adjustment signal based on the control information and the second control signal. The voltage regulation module 300 adaptively adjusts the magnitude of the target electrical signal based on the adjustment signal. The control module 200 can also use the adjustment signal to control the switching on or off of the N pulse excitation modules 400 and the N signal processing modules 500. The adjustment signal can be used to adjust the ultrasonic energy output by the piezoelectric crystal assembly 600, or to put a designated piezoelectric crystal assembly 600 into a dormant state, thereby achieving the purpose of adjusting the temperature of the treatment area.

[0040] The temperature monitoring module 100 monitors temperature information, and the control module 200 generates ablation or adjustment signals. This allows the voltage regulation module 300, pulse excitation module 400, and signal processing module 500 to adaptively open and close multiple transmission channels to match different piezoelectric crystal components 600. They also adaptively adjust the transmission frequency, voltage amplitude, and energy, thereby adaptively adjusting the ultrasonic power and sound field intensity output of each piezoelectric crystal component 600. This regulates the energy of thermal ablation to achieve the best therapeutic effect, improving the flexibility and efficiency of the ultrasonic ablation system in clinical applications. When performing ablation using this ultrasonic ablation system, there is no need to rotate the piezoelectric crystal components 600. The output direction and energy magnitude of each piezoelectric crystal component 600 can be selectively adjusted according to the location of the lesion and the severity of the condition, adapting to a wider range of application scenarios.

[0041] Figure 2 This is a schematic radial cross-sectional view of a treatment catheter in one embodiment of the present disclosure. In one embodiment, N sets of piezoelectric crystal assemblies 600 are circumferentially distributed around the axis of the treatment catheter within the treatment catheter. That is, the N sets of piezoelectric crystal assemblies 600 can form a regular prism with N sides, and the axis of the regular prism coincides with the axis of the treatment catheter. The sides of the regular prism may or may not contact the inner wall of the treatment catheter.

[0042] Figure 2 The diagram shows the radial cross-section of the treatment catheter when N is 3. The N piezoelectric crystal components 600 form a regular triangular prism. Each of the three piezoelectric crystal components 600 can emit ultrasonic energy in different directions, and any one component can cover a 120° emission angle. If all three components work simultaneously, they can cover the entire circumferential treatment area of ​​the treatment catheter. In practical applications, the value of N can be changed according to the needs of different application scenarios to adapt to different treatment plans.

[0043] Figure 3 This is a circuit connection diagram of a voltage regulating module in one embodiment of the present disclosure. In one embodiment, the voltage regulating module 300 may include an input circuit 310, a transformer 320, and an output circuit 330.

[0044] The input terminal of the input circuit 310 can be connected to the power supply module to acquire the input electrical signal. The power supply module can be a dedicated ultrasound power supply, and the control module 200 is connected to this dedicated ultrasound power supply. The control module 200 can provide the input electrical signal Vin to the ultrasound ablation system using the dedicated ultrasound power supply.

[0045] The input circuit 310 may include an input terminal, a positive output terminal, and a negative output terminal. The input electrical signal connected to the input terminal is Vin, the voltage output from the positive output terminal is HV+, and the voltage output from the negative output terminal is HV-. The input circuit 310 may also include a first capacitor C1. The first terminal of the first capacitor C1 is connected to the input terminal of the input circuit 310, and the ultrasonic power supply can provide the input electrical signal Vin to the voltage regulation module 300 through the input terminal of the input circuit 310. The second terminal of the first capacitor C1 is grounded. The first capacitor C1 is an energy storage capacitor that can store the input electrical signal Vin.

[0046] Transformer 320 is connected to input circuit 310 and can be used to transform the voltage of input electrical signals. Transformer 320 utilizes the principle of electromagnetic induction to change AC voltage. In some embodiments of this disclosure, transformer 320 can either step up or step down the input electrical signal; that is, transformer 320 can be a step-up transformer or a step-down transformer. The turns ratio of the transformer 320's coils is equal to the voltage ratio. When the primary coil has fewer turns than the secondary coil, the transformer is a step-up transformer, capable of raising a low voltage to a high voltage. The voltage transformation effect of transformer 320 can be changed by adjusting the number of turns in the primary and secondary coils.

[0047] Transformer 320 may include a primary winding N1, a first secondary winding N2, and a second secondary winding N3. The first end of the primary winding N1 is also connected to the input terminal of the input circuit 310, and the second end of the primary winding N1 is connected to the main control circuit 350. The first end of the first secondary winding N2 is connected to the anode of the first diode D1. The second end of the first secondary winding N2 is connected in series with the first end of the second secondary winding N3 and then grounded. The second end of the second secondary winding N3 is connected to the cathode of the second diode D2. An iron core (or magnetic core) may also be included between the primary winding N1 and the first secondary windings N2 and N3, with the primary winding N1 wound around one side of the iron core, and the first secondary windings N2 and N3 wound around the other side of the iron core, respectively.

[0048] When the input electrical signal Vin is transmitted to the primary winding N1, the primary winding N1 can store the energy of the input circuit 310. Simultaneously, an induced electromotive force (EMF) will be generated across the primary winding N2 and the secondary winding N3. When the number of turns in the primary winding N2 and the secondary winding N3 is greater than the number of turns in the primary winding N1, the induced EMF in the primary winding N2 and the secondary winding N3 will be greater than the voltage on the primary winding N1, thereby boosting the input electrical signal Vin and releasing energy to the output circuit 330.

[0049] The first diode D1 and the second diode D2 are rectifier diodes for output voltages HV+ and HV-, respectively. The anode of the first diode D1 is connected in series with the primary winding N2 of the transformer 320, and the cathode of the second diode D2 is connected in series with the secondary winding N3 of the transformer 320. The first terminal of the second capacitor C2 is connected to the second terminal of the first diode D1 and then to the positive output terminal of the output circuit 330. The second terminal of the second capacitor C2 is connected in series with the first terminal of the third capacitor C3 and then to ground. The second terminal of the third capacitor C3 is connected to the anode of the second diode D2 and then to the negative output terminal of the output circuit 330.

[0050] The output circuit 330 is connected to the transformer 320 and can be used to rectify the input electrical signal after voltage transformation to obtain the target electrical signal. The output circuit 330 can provide symmetrical positive and negative voltages HV+ and HV- to the pulse excitation module 400. The output circuit 330 may include a first diode D1, a second diode D2, a second capacitor C2, and a third capacitor C3.

[0051] The output circuit 330 can be a rectifier circuit used to convert AC power into DC power. In some embodiments of this disclosure, the unidirectional conduction properties of the first diode D1 and the second diode D2 are used to convert the AC voltages HV+ and HV- output from the transformer 320 into unidirectional pulsating DC power.

[0052] Since the positive terminal of the first diode D1 is connected in series with the first primary winding N2, when the AC voltage output across the first primary winding N2 is in its positive half-cycle, the first diode D1 conducts, and the positive half-cycle voltage output from the first primary winding N2 charges the second capacitor C2; conversely, when the AC voltage output across the first primary winding N2 is in its negative half-cycle, the first diode D1 is cut off, and the second capacitor C2 stops charging. Similarly, since the negative terminal of the second diode D2 is connected in series with the second primary winding N3, when the AC voltage output across the second primary winding N3 is in its negative half-cycle, the second diode D2 conducts, and the negative half-cycle voltage output from the second primary winding N3 charges the third capacitor C3; conversely, when the AC voltage output across the second primary winding N3 is in its positive half-cycle, the second diode D2 is cut off, and the third capacitor C3 stops charging.

[0053] That is, the second capacitor C2 and the third capacitor C3 store voltages HV+ and HV- with opposite polarities, respectively, and serve as the output of the rectifier circuit. The voltages HV+ and HV- after rectification are a mixed voltage containing both DC and AC voltages, which can be transmitted to the pulse excitation module 400 through the positive and negative output terminals, respectively, to provide a stable target electrical signal to the pulse excitation module 400.

[0054] In one embodiment, the voltage regulation module 300 may further include a voltage sampling circuit 340 and a main control circuit 350.

[0055] The voltage sampling circuit 340 is connected to the output circuit 330, and can sample the voltage at the output terminal of the output circuit 330 to obtain the sampled electrical signal, thereby realizing voltage monitoring of the output circuit 330. The main control module 350 is connected to the voltage sampling circuit 340, and the voltage sampling module 340 can transmit the sampled electrical signal to the main control circuit 350 in real time.

[0056] The main control module 350 is also connected to the transformer 320 and the control module 200. Based on the ablation signal and the sampled electrical signal collected by the voltage sampling module 340, it can determine whether the electrical signal output by the output circuit 330 meets the control requirements. When the electrical signal output by the output circuit 330 does not meet the control requirements, the main control module 350 can control the energy storage and release of the transformer 320, thereby controlling the amplitude and stabilizing the output voltages HV+ and HV- of the output circuit 330, and outputting a more accurate target electrical signal. In some other embodiments, the main control module 350 can also be connected to the pulse excitation module 400, using the main control module 350 to control the frequency and duty cycle of the pulse excitation module 400 output.

[0057] In addition, when the main control module 350 determines that the electrical signal output by the output circuit 330 needs to be adjusted based on the adjustment signal, the main control module 350 can adaptively adjust the amplitude of the output voltage HV+ and HV- of the output circuit 330 and stabilize the output by controlling the energy storage and release of the transformer 320 based on the sampled electrical signal collected by the voltage sampling module 340, until the output voltage HV+ and HV- of the output circuit 330 are adjusted to the corresponding amplitude.

[0058] The voltage sampling module 340 may include a first resistor R1 and a second resistor R2, and the main control circuit 350 may include a main control unit 351, a PWM controller 352, a digital-to-analog conversion module 353, a first switching transistor Q1, a third resistor R3, and a voltage feedback operational amplifier U1.

[0059] The first end of the first resistor R1 is connected to the positive output terminal of the output circuit 230. The second end of the first resistor R1 and the first end of the second resistor R2 are connected in series and then connected to the positive input terminal of the voltage feedback operational amplifier U1. The second end of the second resistor R2 is grounded. In some embodiments of this disclosure, the voltage sampling module 340, which consists of the first resistor R1 and the second resistor R2, can sample the output voltage HV+ at the positive output terminal of the output circuit 230 and transmit the sampled electrical signal VFB (Voltage Feedback) to the voltage feedback operational amplifier U1.

[0060] The negative input terminal of the voltage feedback operational amplifier U1 is connected to the digital-to-analog converter module 353 (DAC). The main control unit 351 is connected to the first input terminal of the PWM controller 352, the DAC module 353, and the control module 200. The output terminal of the voltage feedback operational amplifier U1 is connected to the second input terminal of the PWM controller 352. The output terminal of the PWM controller 352 is connected to the gate of the first switching transistor Q1. The current detection pin ISENSE of the PWM controller 352 is connected to the source of the first switching transistor Q1. The drain of the first switching transistor Q1 is connected to the second terminal of the primary winding N1. The source of the first switching transistor Q1 is also connected to the first terminal of the third resistor R3, and the second terminal of the third resistor R3 is grounded.

[0061] When the ultrasonic ablation system adjusts the target electrical signal output by the voltage regulation module 300 according to the adjustment signal, the main control unit 351 can send a digital voltage regulation signal to the digital-to-analog converter module 353 based on the adjustment signal generated by the control module 200. The digital-to-analog converter module 353 can generate a voltage regulation reference signal based on the digital voltage regulation signal and transmit it to the negative input terminal of the voltage feedback operational amplifier U1. The sampling electrical signal VFB of the voltage sampling module 340 is transmitted to the positive input terminal of the voltage feedback operational amplifier U1, i.e., the differential signal input pin.

[0062] The voltage feedback operational amplifier U1 generates an enable control signal based on the voltage reference signal and the sampled electrical signal VFB. The enable control signal output by the voltage feedback operational amplifier U1 is sent to the second input terminal of the PWM controller 352, which can be either a signal feedback pin or a compensation pin. The enable control signal can be used to control the enable switch of the PWM controller 352, thereby controlling the PWM controller 352 to send a PWM signal. The PWM signal sent by the PWM controller 352 can be used to control the first switching transistor Q1 to turn on or off.

[0063] The main control circuit 350 is connected to the primary winding N1 of the transformer 220 via the first switching transistor Q1. It can change the on / off state of the first switching transistor Q1 to control the energy storage and release of the transformer 220. When the first switching transistor Q1 is on, the input voltage Vin charges the primary winding N1; when the first switching transistor Q1 is off, the transformer 220 releases energy to the output circuit 230 through the primary winding N2. Therefore, the main control circuit 350, based on the control signal and the output status of the output circuit 230, controls the energy storage and release of the transformer 220 to digitally regulate the output voltages HV+ and HV-, thereby achieving precise control and stable output of the amplitudes of the output voltages HV+ and HV-.

[0064] In some embodiments, the main control circuit 350 can also be connected to the pulse excitation module 400 to adjust the frequency and duty cycle of the pulse excitation module 400 according to the ablation signal or adjustment signal output by the control module 200, so as to achieve the effect of adaptively adjusting the acoustic power output of each group of piezoelectric crystal components 600.

[0065] The aforementioned ultrasonic ablation system utilizes a voltage regulation module 300 to adaptively adjust the amplitude of the output electrical signal based on the ablation signal or adjustment signal. By sampling the voltage at the output terminal, internal adaptive feedback regulation can also be achieved, ensuring that the voltage regulation module 300 can output stably and provide a stable and accurate target electrical signal to the pulse excitation module 400.

[0066] Figure 4 This is a circuit connection diagram of multiple pulse excitation modules in one embodiment of the present disclosure. Figure 4 The illustration shows an embodiment where N is 4, i.e., four pulse excitation modules 400 are configured in the ultrasonic ablation system. In practical applications, other numbers of pulse excitation modules 400 can be set according to the application requirements of different scenarios. Figure 4 HV+ and HV- in the middle are respectively with Figure 3 The HV+ and HV- are connected. In one embodiment, the circuit structures of the four pulse excitation modules 400 can all be the same, but the performance parameters of each component in each pulse excitation module 400 can be different. Each pulse excitation module 400 can include a driver chip 410, a second switch Q2, a third switch Q3, a third diode D3, and a fourth diode D4.

[0067] The driver chip 410 is connected to the gate of the second switch Q2, the gate of the third switch Q3, and the control module 200. In some embodiments, the driver chip 410 can also be connected to the main control unit 251 in the voltage regulation module 300. The drain of the second switch Q2 is connected to the positive output terminal of the voltage regulation module 300, and the source of the third switch Q3 is connected to the negative output terminal of the voltage regulation module 300. The source of the second switch Q2 is connected to the anode of the third diode D3, and the drain of the third switch Q3 is connected to the cathode of the fourth diode D4. The connection point between the cathode of the third diode D3 and the anode of the fourth diode D4 can be used as the output terminal OUT1 of the pulse excitation module 400.

[0068] The driver chip 410 can generate S1-Sn (n is a positive integer) positive and negative pulses according to the control signal issued by the control module 200. The width, interval time, amplitude and other parameters of each pulse can be adaptively adjusted according to the control signal. By adjusting the pulse width, a pulse excitation signal adapted to different frequency piezoelectric crystal components 600 can be output. The pulse forming section composed of the second switch Q2, the third switch Q3, the third diode D3 and the fourth diode D4 combines the waveforms of the S1-Sn positive and negative pulses and outputs the pulse excitation signal. The target electrical signal output by the voltage regulating module 300 can realize the voltage power supply of N sets of pulse excitation channels. The N sets of pulse excitation modules 400 can realize the excitation control of N sets of transmission channels. By using the N sets of pulse excitation modules 400 to adaptively realize N sets of transmission channels, different voltage amplitudes and pulse excitation signals can be matched with different piezoelectric crystal components 600, improving the efficiency and universality of the ultrasonic ablation system in practical applications.

[0069] In one embodiment, the signal processing module 500 may include a switching unit 510 and M sets of impedance matching units 520, where M is an integer greater than zero. The pulse excitation module 400 is connected to the M sets of impedance matching units 520, which are connected to the piezoelectric crystal assembly 600 via the switching unit 510. The switching unit 510 may also be connected to a control module 200, which can control the switching unit 510 to establish a connection path between any one set of impedance matching units 520 and the piezoelectric crystal assembly 600.

[0070] The performance parameters of the components within the M-group impedance matching unit 520 can differ. Different impedance matching units 520 can be used to achieve impedance matching between piezoelectric crystal assemblies of different specifications and the pulse excitation module 400. The switching unit 510 can select and activate the appropriate impedance matching unit 520 and connect it to the piezoelectric crystal assembly 600 according to the control signal, thereby achieving filtering and impedance matching between each channel and different piezoelectric crystal assemblies 600. The pulse excitation signal output by the pulse excitation module 400, after being filtered and impedance matched by the impedance matching unit 520, can be transmitted to the piezoelectric crystal assembly 600 to excite it to operate.

[0071] The aforementioned ultrasonic ablation system incorporates multiple sets of piezoelectric crystal assemblies 600 of different specifications within the treatment catheter. The control module 200 generates ablation signals or adjustment signals based on control information and either a first or second control signal. The ablation signals enable the voltage regulation module 300 to adaptively output the target electrical signal, and the pulse excitation module 400 to output a suitable pulse excitation signal and adaptively activate or deactivate different transmission channels. The adjustment signals allow the voltage regulation module 300 to adaptively adjust the magnitude of the target electrical signal, adjust the pulse excitation signal output by the pulse excitation module 400, and adaptively activate or deactivate different transmission channels. Furthermore, based on the ablation signals or adjustment signals, the appropriate impedance matching unit 520 can be adaptively switched to match different piezoelectric crystal assemblies 600, thereby coordinating with the piezoelectric crystal assemblies 600 to generate the target ultrasonic energy.

[0072] As can be seen, the ultrasonic ablation system provided in this disclosure can adaptively adjust the ultrasonic energy output of the piezoelectric crystal assembly 600 according to the lesion condition around the treatment catheter, and use different piezoelectric crystal assemblies 600 to emit ultrasonic energy to lesions in different directions, so as to achieve a more targeted treatment effect by performing treatment in multiple directions and angles at the same time, which has great flexibility and efficiency.

[0073] Figure 5 This is a circuit connection diagram of multiple signal processing modules in one embodiment of the present disclosure. Figure 5 The illustration shows an example where N=4 and M=3, which is a schematic diagram of an ultrasonic ablation system configured with four signal processing modules 500. In practical applications, other numbers of signal processing modules 500 can be set according to the application requirements of different scenarios. Figure 5 OUT1, OUT2, OUT3, and OUT4 are respectively with Figure 4 OUT1, OUT2, OUT3, and OUT4 are connected together, and THV1, THV2, THV3, and THV4 are connection ports used to drive the four sets of piezoelectric crystal components 600.

[0074] Figure 6This is a schematic diagram of the circuit connection of multiple piezoelectric crystal components in one embodiment of this disclosure. The four piezoelectric crystal components 600 are designated as piezoelectric crystal component one to piezoelectric crystal component four. The connection ports THV1, THV2, THV3, and THV4 of the four piezoelectric crystal components 600 are integrated into an adapter unit, which is connected to the signal processing module 500. The signal processing module 500 includes four impedance matching circuits, designated as impedance matching circuit 1 to impedance matching circuit 4. The adapter unit can be a catheter plug for a treatment catheter, and the four piezoelectric crystal components 600 can also be grounded and / or connected to the control module 200 through the adapter unit. The control module 200 can be an MCU (Microcontroller Unit).

[0075] The adapter unit can also be equipped with a catheter ID information recognition module. The control module 200 can also use the catheter ID information recognition module to identify the identity information of the treatment catheter in order to obtain information and parameters related to the treatment catheter, such as the transmission frequency, transmission voltage amplitude and transmission energy duty cycle of the treatment catheter.

[0076] In one embodiment, the circuit structures of the four signal processing modules 500 can all be identical, while the specific performance parameters of each component in each signal processing module 500 can be different. When the value of M is 3, the switching unit 510 can be a three-pole three-throw switch S1. The three-pole three-throw switch S1 can include a first fixed terminal 1, a second fixed terminal 2, a third fixed terminal 3, a first moving terminal 4, a second moving terminal 5, a third moving terminal 6, a fourth moving terminal 7, a fifth moving terminal 8, and a sixth moving terminal 9. The first impedance matching unit 520 can include a first inductor L1, a fourth capacitor C4, and a seventh capacitor C7. The second impedance matching unit 520 can include a second inductor L2, a fifth capacitor C5, and an eighth capacitor C8. The third impedance matching unit 520 can include a third inductor L3, a sixth capacitor C6, and a ninth capacitor C9.

[0077] The first terminal of the first inductor L1 is connected to the output terminal OUT1 and the second moving terminal 5 of the pulse excitation module 400. The second terminal of the first inductor L1 is connected to the first terminal of the fourth capacitor C4. The second terminal of the fourth capacitor C4 is connected to the first stationary terminal 1, the fourth moving terminal 7, and the first terminal of the second inductor L2. The second terminal of the second inductor L2 is connected to the first terminal of the fifth capacitor C5. The second terminal of the fifth capacitor C5 is connected to the second stationary terminal 2, the sixth moving terminal 9, and the first terminal of the third inductor L3. The second terminal of the third inductor L3 is connected to the first terminal of the sixth capacitor C6. The second terminal of the sixth capacitor C6 is connected to the connection port THV1 of the piezoelectric crystal assembly and the third stationary terminal 3.

[0078] The first terminal of the seventh capacitor C7 is connected to the first moving terminal 4, and the second terminal of the seventh capacitor C7 is grounded. The first terminal of the eighth capacitor C8 is connected to the third moving terminal 6, and the second terminal of the eighth capacitor C8 is grounded. The first terminal of the ninth capacitor C9 is connected to the fifth moving terminal 8, and the second terminal of the ninth capacitor C9 is grounded.

[0079] When the first stationary terminal 1 is connected to the first moving terminal 4, the second stationary terminal 2 is connected to the fourth moving terminal 7, and the third stationary terminal 3 is connected to the sixth moving terminal 9, the second inductor L2, the fifth capacitor C5, the third inductor L3, and the sixth capacitor C6 will be short-circuited. Therefore, the pulse excitation signal output by the pulse excitation module 400 will be impedance matched with the piezoelectric crystal assembly 600 through the impedance matching unit 520 composed of the first inductor L1 and the fourth capacitor C4. At the same time, the seventh capacitor C7 can be used to filter the pulse excitation signal. The filtered and impedance-matched pulse excitation signal is transmitted to the piezoelectric crystal assembly 600, which can excite the piezoelectric crystal assembly 600 to work and adjust the output of the ultrasonic signal of the piezoelectric crystal assembly 600.

[0080] When the first stationary terminal 1 is connected to the second moving terminal 5, the second stationary terminal 2 is connected to the third moving terminal 6, and the third stationary terminal 3 is connected to the sixth moving terminal 9, the first inductor L1, the fourth capacitor C4, the third inductor L3, and the sixth capacitor C6 will be short-circuited. Therefore, the pulse excitation signal output by the pulse excitation module 400 will be impedance matched with the piezoelectric crystal assembly 600 through the impedance matching unit 520 composed of the second inductor L2 and the fifth capacitor C5. At the same time, the eighth capacitor C8 can be used to filter the pulse excitation signal. The filtered and impedance-matched pulse excitation signal is transmitted to the piezoelectric crystal assembly 600, which can excite the piezoelectric ceramic of the piezoelectric crystal assembly 600 to work and adjust the output of the ultrasonic signal of the piezoelectric crystal assembly 600.

[0081] When the first stationary terminal 1 is connected to the second moving terminal 5, the second stationary terminal 2 is connected to the fourth moving terminal 7, and the third stationary terminal 3 is connected to the fifth moving terminal 8, the first inductor L1, the fourth capacitor C4, the second inductor L2, and the fifth capacitor C5 will be short-circuited. Therefore, the pulse excitation signal output by the pulse excitation module 400 will be impedance matched with the piezoelectric crystal assembly 600 through the impedance matching unit 520 composed of the third inductor L3 and the sixth capacitor C6. At the same time, the ninth capacitor C9 can be used to filter the pulse excitation signal. The filtered and impedance-matched pulse excitation signal is transmitted to the piezoelectric crystal assembly 600, which can excite the piezoelectric ceramic of the piezoelectric crystal assembly 600 to work and adjust the output of the ultrasonic signal of the piezoelectric crystal assembly 600.

[0082] The switching unit 510 may also include a switching control unit, such as Figure 5The switch control unit is connected to the control module 200 and can change the continuity between the stationary and moving terminals according to the control signals output by the control module 200. The switch control unit can adaptively connect the first stationary terminal 1 to the first moving terminal 4, the second stationary terminal 2 to the fourth moving terminal 7, and the third stationary terminal 3 to the sixth moving terminal 9, or connect the first stationary terminal 1 to the second moving terminal 5, the second stationary terminal 2 to the third moving terminal 6, and the third stationary terminal 3 to the sixth moving terminal 9, or connect the first stationary terminal 1 to the second moving terminal 5, the second stationary terminal 2 to the fourth moving terminal 7, and the third stationary terminal 3 to the fifth moving terminal 8. The basis for the adaptive control of the connection between different ports by the switch control unit can be the impedance determined by the number of piezoelectric crystal components 600, for example, the impedance of 6 sets of piezoelectric crystal components 600 is 8 ohms, and the impedance of 8 sets of piezoelectric crystal components 600 is 10 ohms, etc.

[0083] In some embodiments of this disclosure, the connections between the first stationary terminal 1 and the first moving terminal 4, the second stationary terminal 2 and the fourth moving terminal 7, and the third stationary terminal 3 and the sixth moving terminal 9 can be normally closed, meaning that the first set of impedance matching units 520 and the piezoelectric crystal assembly 600 are in a state of long-term connection. When the switch control unit determines, based on the ablation signal or adjustment signal, that it is necessary to open the connection path between the second set of impedance matching units 520 and the piezoelectric crystal assembly 600, the switch control unit controls the three-pole three-throw switch to disconnect the connection between the first stationary terminal 1 and the first moving terminal 4, and the second stationary terminal 2 and the fourth moving terminal 7, and to connect the first stationary terminal 1 and the second moving terminal 5, and the second stationary terminal 2 and the third moving terminal 6, thereby achieving the switching of the connection between the second set of impedance matching units 520 and the piezoelectric crystal assembly 600.

[0084] When the switch control unit determines that it is necessary to connect the third impedance matching unit 520 and the piezoelectric crystal assembly 600 based on the ablation signal or adjustment signal, the switch control unit controls the three-pole three-throw switch to disconnect the connection between the second stationary terminal 2 and the third moving terminal 6, and the third stationary terminal 3 and the sixth moving terminal 9, and to connect the second stationary terminal 1 and the fourth moving terminal 7, and the third stationary terminal 3 and the fifth moving terminal 8, thereby realizing the switching of the connection between the third impedance matching unit 520 and the piezoelectric crystal assembly 600.

[0085] Figure 7This is a schematic diagram of the ultrasonic ablation system in another embodiment of the present disclosure. In one embodiment, the treatment catheter may further include a thermocouple 700, and the temperature monitoring module 100 may include a temperature acquisition circuit 110, which is connected to both the thermocouple 700 and the control module 200. The temperature acquisition circuit 110 can be used to acquire the temperature information of the thermocouple and transmit the temperature information to the control module 200. The temperature monitoring module 100 can also generate an alarm signal when the temperature exceeds a preset threshold. By setting the thermocouple 700 and the temperature acquisition circuit 110 to monitor the temperature of the treatment area, adjustments can be made in a timely manner when the temperature is too high, preventing continuous high temperatures from causing damage to the human body and ensuring the safety of the system.

[0086] Thermocouples can directly measure the temperature of the treatment area and convert the temperature signal into a thermoelectric potential signal. Temperature acquisition circuit 110 can convert the thermoelectric potential signal into temperature information of the treatment area. Control module 200 can monitor the temperature information and determine that the temperature of the treatment area is too high when the temperature information exceeds a preset threshold, generating an alarm signal. In some embodiments of this disclosure, the alarm signal is an audible and visual alarm, which is triggered by sound or an indicator light. The alarm signal can also be an operation signal used to instruct the system to reduce the temperature of the treatment area. This can be achieved through physical cooling, such as circulating cooling water to the treatment area, or by reducing or shutting down the piezoelectric crystal output, such as shutting down part of the piezoelectric crystal assembly, switching the power output, or instructing to lower the frequency of the ultrasonic signal output by the piezoelectric crystal. For example, when control module 200 determines that the accumulated heat exceeds 40°C based on the temperature signal acquired by temperature acquisition circuit 110, temperature monitoring module 100 outputs an alarm signal, and the system can cut off the power output based on the alarm signal.

[0087] In one embodiment, the ultrasonic ablation system may further include a PC (Personal Computer). The PC system may include a human-machine interface (HMI) module connected to the control module 200. The HMI module may be a touchscreen input unit and / or a button control unit. Control information, such as the ultrasonic ablation system's emission frequency, emission voltage amplitude, and emission energy duty cycle, is input into the HMI module via touchscreen or button input. The HMI module can communicate with the control module 200 via USB serial port and / or CAN bus, transmitting control information to the control module 200.

[0088] In one embodiment, the ultrasound ablation system may further include a display module. The display module can be connected to the control module 200 and can be used to display control information and / or temperature information. The display module can display the input control signals, and the user can verify the information displayed on the display module to prevent errors in the input information. After the temperature acquisition circuit 110 collects the temperature information of the piezoelectric crystal assembly 600 in the treatment area through the thermocouple 700 and feeds it back to the control module 200, the display module can also display the temperature information. The user can adjust the input control information based on the temperature information, or take other measures to address safety hazards caused by temperature increases. The display module allows for simpler and more intuitive display of various information to the user, simplifying operation and optimizing the user experience.

[0089] In the description of this specification, references to terms such as "some embodiments," "other embodiments," and "ideal embodiments" indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. In this specification, the illustrative descriptions of the above terms do not necessarily refer to the same embodiments or examples.

[0090] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0091] The embodiments described above are merely illustrative of several implementations of the present invention, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these all fall within the protection scope of the present invention. Therefore, the protection scope of this invention patent should be determined by the appended claims.

Claims

1. An ultrasonic ablation system, characterized in that, include: A temperature monitoring module is used to monitor the temperature information of a target area, and generates a first control signal when the temperature information meets a first preset condition, or generates a second control signal when the temperature information meets a second preset condition; the first preset condition is that the temperature information is less than a set temperature, and the second preset condition is that the temperature information is greater than a safe temperature; A control module, connected to the temperature monitoring module, is used to acquire control information, including piezoelectric crystal information, and is also used to generate an ablation signal based on the control information and the first control signal, or to generate an adjustment signal based on the control information and the second control signal. A voltage regulating module, connected to the control module, is used to adjust the input electrical signal to the target electrical signal according to the ablation signal or the adjustment signal; N sets of pulse excitation modules are connected to the control module and the voltage regulation module respectively, and are used to convert the target electrical signal into a pulse excitation signal according to the ablation signal or the adjustment signal; where N is an integer greater than zero; N signal processing modules are connected to the N pulse excitation modules respectively, and are also connected to the control module. They are used to process the pulse excitation signal according to the ablation signal or the adjustment signal, and to achieve impedance matching between the output terminal of the pulse excitation module and the input terminal of the piezoelectric crystal assembly. The control module is also used to control the conduction or cutoff between the N pulse excitation modules and the N signal processing modules. A treatment catheter is provided with N sets of piezoelectric crystal components. The N sets of piezoelectric crystal components are respectively connected to the N sets of signal processing modules to convert the pulse excitation signal into an ultrasonic signal. The N sets of piezoelectric crystal components are also used to emit ultrasonic energy to the outside of the treatment catheter. The ablation signal is used to control the voltage regulation module, the N sets of pulse excitation modules and the N sets of signal processing modules to output the emission frequency, voltage amplitude and emission energy duty cycle required for the operation of the N sets of piezoelectric crystal components; the adjustment signal is used to adjust the emission frequency, voltage amplitude and emission energy duty cycle output by the voltage regulation module, the N sets of pulse excitation modules and the N sets of signal processing modules.

2. The ultrasonic ablation system according to claim 1, characterized in that, The N groups of piezoelectric crystal assemblies are circumferentially distributed around the axis of the treatment catheter within the treatment catheter.

3. The ultrasonic ablation system according to claim 1 or 2, characterized in that, The voltage regulating module includes: The input circuit includes an input terminal, a positive output terminal, and a negative output terminal. The input terminal is connected to the power supply module and is used to acquire an input electrical signal. The input circuit includes a first capacitor. A transformer, connected to the input circuit, is used to transform the voltage of the input electrical signal; the transformer includes a primary winding, a first-stage winding, and a second-stage winding; An output circuit, connected to the transformer, is used to rectify the input electrical signal after voltage transformation to obtain the target electrical signal. The output circuit includes a first diode, a second diode, a second capacitor, and a third capacitor. The first terminal of the first capacitor is connected to the input terminal of the input circuit, and the second terminal of the first capacitor is grounded. The first terminal of the primary winding is also connected to the input terminal of the input circuit. The first terminal of the first primary winding is connected to the anode of the first diode, the second terminal of the first primary winding is connected to the first terminal of the second secondary winding, and the second terminal of the second secondary winding is connected to the cathode of the second diode. The cathode of the first diode is connected to the first terminal of the second capacitor, and the anode of the second diode is connected to the first terminal of the third capacitor. The second terminals of the second capacitor, the third capacitor, the first primary winding, and the second secondary winding are all grounded. The cathode of the first diode and the first terminal of the second capacitor are both connected to the positive output terminal of the output circuit, and the anode of the second diode and the first terminal of the third capacitor are both connected to the negative output terminal of the output circuit.

4. The ultrasonic ablation system according to claim 3, characterized in that, The voltage regulating module also includes: A voltage sampling circuit, connected to the output circuit, is used to sample the voltage at the positive output terminal of the output circuit to obtain a sampled electrical signal; the voltage sampling circuit includes a first resistor and a second resistor; The main control circuit is connected to the transformer, the voltage sampling circuit, and the control module, respectively, and is used to perform feedback adjustment on the transformer based on the ablation signal and the sampling electrical signal, or to perform feedback adjustment on the transformer based on the adjustment signal and the sampling electrical signal; the main control circuit includes a main control unit, a PWM controller, a first switching transistor, a third resistor, a voltage feedback operational amplifier, and a digital-to-analog converter module; The first end of the first resistor is connected to the positive output terminal of the output circuit, the second end of the first resistor is connected to the first end of the second resistor, and the second end of the second resistor is grounded. The main control unit is connected to the first input terminal of the PWM controller, the digital-to-analog converter module, and the control module, respectively. The digital-to-analog converter module is connected to the negative input terminal of the voltage feedback operational amplifier, and the positive input terminal of the voltage feedback operational amplifier is connected to the second terminal of the first resistor. The output terminal of the voltage feedback operational amplifier is connected to the second input terminal of the PWM controller. The output terminal of the PWM controller is connected to the gate of the first switching transistor. The current detection pin of the PWM controller is connected to the source of the first switching transistor. The drain of the first switching transistor is connected to the second terminal of the primary winding. The source of the first switching transistor is also connected to the first terminal of the third resistor. The second terminal of the third resistor is grounded.

5. The ultrasonic ablation system according to claim 1 or 2, characterized in that, The pulse excitation module includes a driver chip, a second switch, a third switch, a third diode, and a fourth diode. The driving chip is connected to the gate of the second switch, the gate of the third switch, and the control module. The drain of the second switch is connected to the positive output terminal of the voltage regulation module. The source of the third switch is connected to the negative output terminal of the voltage regulation module. The source of the second switch is connected to the positive terminal of the third diode. The drain of the third switch is connected to the negative terminal of the fourth diode. The negative terminals of the third diode and the positive terminals of the fourth diode are connected to the output terminal of the pulse excitation module.

6. The ultrasonic ablation system according to claim 1, characterized in that, The signal processing module includes a switching unit and M sets of impedance matching units, where M is an integer greater than zero. The pulse excitation module is connected to the M sets of impedance matching units. The M sets of impedance matching units are connected to the piezoelectric crystal assembly through the switching unit. The switching unit is also connected to the control module. The switching unit is used to connect any one of the M sets of impedance matching units to the piezoelectric crystal assembly according to the ablation signal or the adjustment signal.

7. The ultrasonic ablation system according to claim 6, characterized in that, When M is 3, the switching unit is a three-pole three-throw switch, which includes a first fixed terminal, a second fixed terminal, a third fixed terminal, a first moving terminal, a second moving terminal, a third moving terminal, a fourth moving terminal, a fifth moving terminal, and a sixth moving terminal. The first group of impedance matching units includes a first inductor, a fourth capacitor, and a fifth capacitor; the second group of impedance matching units includes a second inductor, a sixth capacitor, and a seventh capacitor; and the third group of impedance matching units includes a third inductor, an eighth capacitor, and a ninth capacitor. The first terminal of the first inductor is connected to the output terminal of the pulse excitation module and the second moving terminal, respectively. The second terminal of the first inductor is connected to the first terminal of the fourth capacitor. The second terminal of the fourth capacitor is connected to the first stationary terminal, the fourth moving terminal, and the first terminal of the second inductor, respectively. The second terminal of the second inductor is connected to the first terminal of the fifth capacitor. The second terminal of the fifth capacitor is connected to the second stationary terminal, the sixth moving terminal, and the first terminal of the third inductor, respectively. The second terminal of the third inductor is connected to the first terminal of the sixth capacitor. The second terminal of the sixth capacitor is connected to the piezoelectric crystal assembly and the third stationary terminal, respectively. The first terminal of the seventh capacitor is connected to the first moving terminal, and the second terminal of the seventh capacitor is grounded. The first terminal of the eighth capacitor is connected to the third moving terminal, and the second terminal of the eighth capacitor is grounded. The first terminal of the ninth capacitor is connected to the fifth moving terminal, and the second terminal of the ninth capacitor is grounded.

8. The ultrasonic ablation system according to claim 1, characterized in that, The treatment catheter also includes a thermocouple, and the temperature monitoring module includes a temperature acquisition circuit, which is connected to the thermocouple and the control module respectively, for acquiring the temperature information of the thermocouple; The temperature monitoring module is also used to generate an alarm signal when the temperature information is greater than a preset threshold.

9. The ultrasonic ablation system according to claim 1, characterized in that, The ultrasonic ablation system also includes a human-computer interaction module connected to the control module, through which the control module obtains control information.

10. The ultrasonic ablation system according to claim 8, characterized in that, The ultrasonic ablation system also includes a display module connected to the control module for displaying the control information and / or the temperature information.

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