Ultrasound thrombolytic system

Abstract

The present disclosure relates to the technical field of thrombolytic therapy, and particularly discloses an ultrasonic thrombolytic system, which comprises a control module, a voltage regulation module, N sets of pulse excitation modules, and N sets of signal processing modules. The control module is configured to generate a control signal according to acquired control information and / or transducer information. The voltage regulation module is connected to the control module and configured to adjust an input electrical signal to a target electrical signal according to the control signal. The N sets of pulse excitation modules are connected to the control module and the voltage regulation module and configured to generate a pulse excitation signal according to the target electrical signal and the control signal. The N sets of signal processing modules are connected to the control module and the N sets of pulse excitation modules and configured to realize impedance matching between an output end of the pulse excitation module and an input end of a transducer assembly according to the control signal. The N sets of transducer assemblies are arranged in a treatment catheter and connected to the N sets of signal processing modules respectively, and configured to convert the pulse excitation signal into an ultrasonic signal. By arranging multiple sets of different transducer assemblies in the treatment catheter, the treatment of multiple thrombus regions in the whole body can be simultaneously performed through one-time puncture.

Description

Technical Field

[0001] This invention relates to the field of thrombolysis technology, and in particular to an ultrasonic thrombolysis system. Background Technology

[0002] Current thrombolysis devices are essentially catheters with a set of transducers built into them. The limited length of this set of transducers makes it unsuitable for treating patients with systemic thrombosis in a single puncture. Current thrombolysis systems can only emit ultrasound waves of a single frequency, sound pressure, and intensity. Using thrombolysis devices with fixed frequencies, sound pressures, and intensities results in low efficiency, limiting their application to only a small percentage of patients with varying degrees of thrombosis. However, the severity of thrombosis varies across different areas of a patient's body, requiring targeted treatment. Therefore, current thrombolysis systems cannot simultaneously treat systemic thrombosis with varying degrees of thrombosis in different areas of the body in a single puncture. Summary of the Invention

[0003] Therefore, it is necessary to provide an ultrasonic thrombolysis system to address the problem that existing thrombolysis systems cannot treat systemic thrombotic diseases of different degrees and locations throughout the body in a single puncture.

[0004] An ultrasonic thrombolysis system includes a control module for acquiring control information and / or transducer information, and generating a control signal based on the control information and / or the transducer information; a voltage regulation module connected to the control module for adjusting an input electrical signal to a target electrical signal based on the control signal; N sets of pulse excitation modules connected to the control module and the voltage regulation module respectively, for generating pulse excitation signals based on the target electrical signal and the control signal; wherein N is an integer greater than zero; N sets of signal processing modules connected to the N sets of pulse excitation modules respectively, and also connected to the control module, for processing the pulse excitation signals based on the control signal, and achieving impedance matching between the output terminals of the pulse excitation modules and the input terminals of the transducer components; and a treatment catheter, wherein the treatment catheter is provided with N sets of transducer components, and the N sets of transducer components are respectively connected to the N sets of signal processing modules for converting the pulse excitation signals into ultrasonic signals.

[0005] In one embodiment, the voltage regulation module includes an input circuit connected to a power supply module for acquiring an input electrical signal; a transformer connected to the input circuit for voltage transformation of the input electrical signal; an output circuit connected to the transformer for rectifying the voltage-transformed input electrical signal to acquire the target electrical signal; a voltage sampling circuit connected to the output circuit for sampling the voltage at the output terminal of the output circuit to acquire a sampled electrical signal; and a main control circuit connected to the transformer, the voltage sampling circuit, and the control module for feedback adjustment of the transformer based on the control signal and the sampled electrical signal.

[0006] In one embodiment, the input circuit includes an input terminal, a positive output terminal, and a negative output terminal. The input circuit includes a first capacitor, and the transformer includes a primary winding, a second primary winding, and a third secondary winding. The output circuit includes a first diode, a second diode, a second capacitor, and a third capacitor. A first terminal of the first capacitor is connected to the input terminal of the input circuit, and a second terminal of the first capacitor is grounded. A first terminal of the primary winding is also connected to the input terminal of the input circuit, and a second terminal of the primary winding is connected to the main control circuit. A first terminal of the second primary winding is connected to the positive terminal of the first diode, and a third terminal of the second primary winding is connected to the positive terminal of the first diode. The first diode is connected to the first terminal of the second secondary winding, and the second terminal of the second secondary winding is connected to the negative terminal of the second diode. The negative terminal of the first diode is connected to the first terminal of the second capacitor, and the positive terminal of the second diode is connected to the first terminal of the third capacitor. The second terminal of the second capacitor, the second terminal of the third capacitor, the second terminal of the first secondary winding, and the first terminal of the second secondary winding are all grounded. The negative terminal of the first diode and the first terminal of the second capacitor are both connected to the positive output terminal of the output circuit, and the positive terminal of the second diode and the first terminal of the third capacitor are both connected to the negative output terminal of the output circuit.

[0007] In one embodiment, the voltage sampling circuit includes a first resistor and a second resistor. The main control circuit includes a main control unit, a PWM controller, a first switching transistor, a third resistor, a voltage feedback operational amplifier, and a digital-to-analog converter module. The first end of the first resistor is connected to the positive output terminal of the output circuit, the second end of the first resistor is connected to the first end of the second resistor, and the second end of the second resistor is grounded. The main control unit is connected to the first input terminal of the PWM controller, the digital-to-analog converter module, and the control module. The digital-to-analog converter module is connected to the negative input terminal of the voltage feedback operational amplifier, and the positive input terminal of the voltage feedback operational amplifier is connected to the second end of the first resistor. The output terminal of the voltage feedback operational amplifier is connected to the second input terminal of the PWM controller, the output terminal of the PWM controller is connected to the gate of the first switching transistor, the current detection pin of the PWM controller is connected to the source of the first switching transistor, the drain of the first switching transistor is connected to the second end of the primary winding, the source of the first switching transistor is also connected to the first end of the third resistor, and the second end of the third resistor is grounded.

[0008] In one embodiment, the pulse excitation module includes a driver chip, a second switch, a third switch, a third diode, and a fourth diode. The driver chip is connected to the source of the second switch, the source of the third switch, and the control module. The drain of the second switch is connected to the positive output terminal of the voltage regulation module. The gate of the third switch is connected to the negative output terminal of the voltage regulation module. The gate of the second switch is connected to the anode of the third diode. The drain of the third switch is connected to the cathode of the fourth diode. The cathode of the third diode and the anode of the fourth diode are connected to the output terminal of the pulse excitation module.

[0009] In one embodiment, the signal processing module includes a switching unit and M groups of impedance matching units, where M is an integer greater than zero; the pulse excitation module is connected to the M groups of impedance matching units, the M groups of impedance matching units are connected to the transducer assembly through the switching unit, the switching module is also connected to the control module, and the switching unit is used to conduct the connection path between any one of the M groups of impedance matching units and the transducer assembly according to the control signal.

[0010] In one embodiment, when M is 2, the switching unit is a double-pole double-throw switch, which includes a first stationary terminal, a second stationary terminal, a first moving terminal, a second moving terminal, a third moving terminal, and a fourth moving terminal. One set of impedance matching units includes a first inductor, a fourth capacitor, and a fifth capacitor, and another set of impedance matching units includes a second inductor, a sixth capacitor, and a seventh capacitor. The first terminal of the first inductor is connected to the output terminal of the pulse excitation module and the second moving terminal, respectively. The second terminal of the first inductor is connected to the first terminal of the fifth capacitor. The second terminal of the fifth capacitor is connected to the first stationary terminal, the third moving terminal, and the first terminal of the second inductor, respectively. The second terminal of the second inductor is connected to the first terminal of the sixth capacitor. The second terminal of the sixth capacitor is connected to the transducer assembly and the second stationary terminal, respectively. The first terminal of the fourth capacitor is connected to the first moving terminal, and the second terminal of the fourth capacitor is grounded. The first terminal of the seventh capacitor is connected to the fourth moving terminal, and the second terminal of the seventh capacitor is grounded.

[0011] In one embodiment, the treatment catheter further includes a thermocouple, and the ultrasonic thrombolysis system further includes a temperature acquisition circuit. The temperature acquisition circuit is connected to the thermocouple and the control module respectively, and is used to acquire the temperature information of the thermocouple. The control module is also used to monitor the temperature information and generate an alarm signal when the temperature information is greater than a preset threshold.

[0012] In one embodiment, the ultrasonic thrombolysis system further includes a human-machine interaction module connected to the control module for acquiring control information.

[0013] In one embodiment, the ultrasonic thrombolysis system further includes a display module connected to the control module for displaying the control information and / or the temperature information.

[0014] The aforementioned ultrasonic thrombolysis system incorporates multiple sets of different transducer assemblies within the treatment catheter. Based on acquired control information and / or transducer information, the control module adaptively adjusts the voltage amplitude output by the voltage regulation module and the pulse frequency output by the pulse excitation module by generating control signals, thereby enabling the transducer assemblies to output corresponding ultrasonic signals. By incorporating multiple sets of different transducer assemblies within the treatment catheter, treatment of multiple thrombus-affected areas throughout the body can be performed simultaneously with a single puncture. Targeted treatment of different areas can be achieved using transducer assemblies of varying sizes, effectively improving the flexibility and efficiency of the ultrasonic thrombolysis system. Attached Figure Description

[0015] To more clearly illustrate the technical solutions in the embodiments of this specification or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this specification. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0016] Figure 1 This is a schematic diagram of the ultrasonic thrombolysis system in one embodiment of the present disclosure;

[0017] Figure 2 This is a circuit connection diagram of the voltage regulation module in one embodiment of the present disclosure;

[0018] Figure 3 This is a circuit connection diagram of multiple pulse excitation modules in one embodiment of the present disclosure;

[0019] Figure 4 This is a schematic diagram of the circuit connection of multiple signal processing modules in one embodiment of the present disclosure;

[0020] Figure 5 This is a schematic diagram of the circuit connection of multiple transducer assemblies in one embodiment of the present disclosure;

[0021] Figure 6 This is a schematic diagram of the ultrasonic thrombolysis system in another embodiment of the present disclosure. Detailed Implementation

[0022] To facilitate understanding of the present invention, a more complete description will be given below with reference to the accompanying drawings. Preferred embodiments of the invention are shown in the drawings. However, the invention can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to provide a thorough and complete understanding of the disclosure of the invention.

[0023] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0024] Existing thrombolysis devices typically consist of a catheter with a set of transducers built-in, making them unsuitable for treating patients with systemic thrombosis in a single puncture. This disclosure provides an ultrasonic thrombolysis system that, by incorporating multiple sets of transducer assemblies of different specifications within the treatment catheter, enables simultaneous targeted treatment of different areas of the body in patients with systemic thrombosis, improving the flexibility and efficiency of its application.

[0025] Figure 1 This is a schematic diagram of the structure of an ultrasonic thrombolysis system in one embodiment of the present disclosure. In one embodiment, the ultrasonic thrombolysis system may include a control module 100, a voltage regulation module 200, N sets of pulse excitation modules 300, N sets of signal processing modules 400, and N sets of transducer assemblies 500 disposed within a treatment catheter. Here, N is an integer greater than zero, and the N sets of transducer assemblies 500 disposed within the treatment catheter can be of the same or different specifications; for example, the specification may refer to the center frequency.

[0026] The control module 100 can acquire control information and / or transducer information through various methods. The control module 100 can pre-store control information and / or transducer information corresponding to different operating modes, or acquire this information through human-computer interaction or by inputting information directly. The control information can be parameters related to the transducer assembly when it is in the target treatment area, including the target transducer's emission frequency, voltage amplitude, and emission energy duty cycle. The control module 100 can generate corresponding control signals based on the control information and use these signals to control the outputs of the voltage regulation module 200, pulse excitation module 300, and signal processing module 400, so that the transducer assembly 500 outputs corresponding ultrasound signals. The transducer information can include the transducer's center frequency, the temperature information of the transducer's treatment area, etc. The temperature information of the transducer's treatment area can be obtained by measuring with a thermocouple element.

[0027] Meanwhile, since there are a large number of transducer groups installed in the treatment catheter, and the frequency of each transducer may vary during actual operation, the control module 100 can also comprehensively consider the control signal and transducer information to adaptively generate corresponding control signals to adjust the voltage amplitude and pulse frequency in order to ensure that the transducer is at the optimal operating frequency.

[0028] The voltage regulating module 200 is connected to the control module 100 to obtain the control signal generated by the control module 100. The voltage regulating module 200 can also be connected to the power supply module to obtain the input electrical signal. Based on the control signal, the voltage regulating module 200 can adjust the input electrical signal to the target electrical signal. The power supply module can be a dedicated ultrasonic power supply, and the target electrical signal can be the emission voltage amplitude required by the thrombolysis system.

[0029] In some other embodiments, the power supply module may also be connected to the control module 100, the pulse excitation module 300, and the signal processing module 400 respectively, to provide the electrical energy required for the operation of the above-mentioned functional modules. The control module 100 may also control the ultrasonic power supply to provide input electrical signals to the voltage regulation module 200.

[0030] Because the treatment catheter contains N transducer assemblies 500, during treatment, these N transducer assemblies 500 may be used simultaneously to treat thrombi in different areas. Since different transducer assemblies 500 may require different emission frequencies during treatment, the ultrasonic thrombolysis system of this disclosure includes N pulse excitation modules 300 to adaptively provide corresponding pulse excitation signals to the N transducer assemblies 500. Each of the N pulse excitation modules 300 is connected to both the control module 100 and the voltage regulation module 200. Each of the N pulse excitation modules 300 can convert the target electrical signal according to the control signal to generate the required pulse excitation signal.

[0031] Similarly, by setting up N sets of signal processing modules 400, the N sets of signal processing modules 400 can adaptively process the N sets of pulse excitation signals. Signal processing can include filtering, amplification, and other methods. Furthermore, the N sets of signal processing modules 400 can also be used to achieve impedance matching between the output terminals of the N sets of pulse excitation modules 300 and the input terminals of the N sets of transducer assemblies 500.

[0032] By placing N transducer assemblies 500 within the treatment catheter, each of the N transducer assemblies 500 is connected to an N signal processing module 400. The transducer assemblies 500 convert pulse excitation signals into ultrasonic signals. The relevant parameters of the ultrasonic signals can include ultrasonic power and sound field intensity. Different transducer assemblies can generate ultrasonic waves with different center frequencies, sound pressures, and pressures. Utilizing ultrasonic waves with different center frequencies, sound pressures, and pressures allows for more targeted treatment of thrombosis in different areas of a patient with systemic thrombosis.

[0033] The aforementioned ultrasonic thrombolysis system, by embedding multiple transducer assemblies of different specifications within a single treatment catheter, allows for more targeted treatment of different areas of a patient with systemic thrombosis through a single puncture. The control module 100 acquires control information and generates control signals based on this information. The voltage regulation module 200 adaptively adjusts the amplitude voltage of the ultrasonic pulse power supply according to the control signals issued by the control module 100, adjusting the input electrical signal of the ultrasonic pulse power supply to the target electrical signal. The N-group pulse excitation module 300, based on the control signals, can excite N groups of transmission channels, generating N groups of pulse excitation signals. The pulse excitation module 300 supplies voltage to multiple pulse excitation channels through the voltage regulation module 200. The N-group signal processing module 400, based on the control signals, can process the pulse excitation signals, achieving adaptive selection of signal transmission, filtering, and impedance matching between each channel and different transducer assemblies 500. The N-group signal processing module 400 is correspondingly matched and connected to the radio frequency signal transmission channels of the N-group pulse excitation module 300. The treatment catheter, which has N sets of transducer assemblies 500, is connected to the corresponding matching channel of the N sets of signal processing modules 400.

[0034] Using the control signals generated by the control module 100, the voltage regulation module 200, pulse excitation module 300, and signal processing module 400 can adaptively turn multiple sets of transmission channels on and off to match different transducer components 500, adaptively adjust the transmission frequency, voltage amplitude, and energy regulation, thereby achieving adaptive adjustment of the ultrasonic power and sound field intensity output of each transducer component to achieve the best therapeutic effect and improve the flexibility and efficiency of the ultrasonic thrombolysis system in clinical applications.

[0035] In one embodiment, the voltage regulation module 200 may include an input circuit 210, a transformer 220, an output circuit 230, a voltage sampling circuit 240, and a main control circuit 250. The input terminal of the input circuit 210 may be connected to a power supply module to acquire input electrical signals. The power supply module may be a dedicated ultrasonic power supply.

[0036] Transformer 220 utilizes the principle of electromagnetic induction to change AC voltage. In some embodiments of this disclosure, transformer 220 can step up or step down the input electrical signal; that is, transformer 220 can be a step-up transformer or a step-down transformer. The turns ratio of the transformer 220's coils is equal to the voltage ratio. When the primary coil has fewer turns than the secondary coil, the transformer is a step-up transformer, capable of raising a low voltage to a high voltage. The voltage transformation effect of transformer 220 can be changed by adjusting the number of turns in the primary and secondary coils.

[0037] The output circuit 230 is connected to the transformer 220 and can be used to rectify the input electrical signal after voltage transformation to obtain the target electrical signal. The output circuit 230 can provide the pulse excitation module 300 with symmetrical positive and negative voltages HV+ and HV-.

[0038] The voltage sampling circuit 240 is connected to the output circuit 230, and can sample the voltage at the output terminal of the output circuit 230 to obtain the sampled electrical signal, thereby realizing voltage monitoring of the output circuit 230. The main control module 250 is connected to the voltage sampling circuit 240, and the voltage sampling module 240 can transmit the sampled electrical signal to the main control circuit 250 in real time.

[0039] The main control module 250 is also connected to the transformer 220 and the control module 100. Based on the control signal and the sampled electrical signal collected by the voltage sampling module 240, it can determine whether the electrical signal output by the output circuit 230 meets the control requirements. When the electrical signal output by the output circuit 230 does not meet the control requirements, the main control module 250 can control the energy storage and release of the transformer 220, thereby controlling the amplitude and stabilizing the output voltages HV+ and HV- of the output circuit 230, and outputting a more accurate target electrical signal. In some other embodiments, the main control module 250 can also be connected to the pulse excitation module 300, using the main control module 250 to control the frequency and duty cycle of the pulse excitation module 300 output.

[0040] The voltage regulating module 200 in the above-mentioned ultrasonic thrombolysis system can adaptively adjust the amplitude of the output electrical signal according to the control signal. By sampling the voltage at the output terminal, it can also realize internal adaptive feedback regulation, which can ensure that the voltage regulating module 200 can output stably and provide a stable and accurate target electrical signal to the pulse excitation module 300.

[0041] Figure 2 This is a circuit connection diagram of the voltage regulation module in one embodiment of the present disclosure. In one embodiment, the input circuit 210 may include an input terminal, a positive output terminal, and a negative output terminal. The input electrical signal connected to the input terminal is Vin, the voltage output from the positive output terminal is HV+, and the voltage output from the negative output terminal is HV-. The input circuit 210 may also include a first capacitor C1, the transformer 220 may include a primary winding N1, a second primary winding N2, and a second secondary winding N3, and the output circuit 230 may include a first diode D1, a second diode D2, a second capacitor C2, and a third capacitor C3.

[0042] The first terminal of the first capacitor C1 is connected to the input terminal of the input circuit 210. The ultrasonic power supply can provide an input electrical signal Vin to the voltage regulation module 200 through the input terminal of the input circuit 210. The second terminal of the first capacitor C1 is grounded. The first capacitor C1 is an energy storage capacitor that can store the input electrical signal Vin.

[0043] The first end of the primary winding N1 is also connected to the input terminal of the input circuit 210, and the second end of the primary winding N1 is connected to the main control circuit 250. The first end of the first primary winding N2 is connected to the positive terminal of the first diode D1, the second end of the first primary winding N2 is connected in series with the first end of the second secondary winding N3 and then grounded, and the second end of the second secondary winding N3 is connected to the negative terminal of the second diode D2. An iron core (or magnetic core) may also be included between the primary winding N1 and the first and second secondary windings N2 and N3, with the primary winding N1 wound around the iron core on both sides.

[0044] When the input electrical signal Vin is transmitted to the primary winding N1, the primary winding N1 can store the energy of the input circuit 210. Simultaneously, an induced electromotive force (EMF) will be generated across the primary winding N2 and the secondary winding N3. When the number of turns in the primary winding N2 and the secondary winding N3 is greater than the number of turns in the primary winding N1, the induced EMF in the primary winding N2 and the secondary winding N3 will be greater than the voltage on the primary winding N1, thereby boosting the input electrical signal Vin and releasing energy to the output circuit 230.

[0045] The first diode D1 and the second diode D2 are rectifier diodes for output voltages HV+ and HV-, respectively. The anode of the first diode D1 is connected in series with the primary winding N2 of the transformer 220, and the cathode of the second diode D2 is connected in series with the secondary winding N3 of the transformer 220. The first terminal of the second capacitor C2 is connected to the second terminal of the first diode D1 and then to the positive output terminal of the output circuit 230. The second terminal of the second capacitor C2 is connected in series with the first terminal of the third capacitor C3 and then to ground. The second terminal of the third capacitor C3 is connected to the anode of the second diode D2 and then to the negative output terminal of the output circuit 230.

[0046] The output circuit 230 can be a rectifier circuit used to convert AC power into DC power. In some embodiments of this disclosure, the unidirectional conduction properties of the first diode D1 and the second diode D2 are used to convert the AC voltages HV+ and HV- output from the transformer 220 into unidirectional pulsating DC power.

[0047] Since the positive terminal of the first diode D1 is connected in series with the first primary winding N2, when the AC voltage output across the first primary winding N2 is in its positive half-cycle, the first diode D1 conducts, and the positive half-cycle voltage output from the first primary winding N2 charges the second capacitor C2; conversely, when the AC voltage output across the first primary winding N2 is in its negative half-cycle, the first diode D1 is cut off, and the second capacitor C2 stops charging. Similarly, since the negative terminal of the second diode D2 is connected in series with the second primary winding N3, when the AC voltage output across the second primary winding N3 is in its negative half-cycle, the second diode D2 conducts, and the negative half-cycle voltage output from the second primary winding N3 charges the third capacitor C3; conversely, when the AC voltage output across the second primary winding N3 is in its positive half-cycle, the second diode D2 is cut off, and the third capacitor C3 stops charging.

[0048] That is, the second capacitor C2 and the third capacitor C3 store voltages HV+ and HV- with opposite polarities, respectively, and serve as the output of the rectifier circuit. The voltages HV+ and HV- after rectification are a mixed voltage containing both DC and AC voltages, which can be transmitted to the pulse excitation module 300 through the positive and negative output terminals, respectively, to provide a stable target electrical signal to the pulse excitation module 300.

[0049] In one embodiment, the voltage sampling circuit 240 may include a first resistor R1 and a second resistor R2, and the main control circuit 250 may include a main control unit 251, a PWM controller 252, a digital-to-analog converter module 253, a first switching transistor Q1, a third resistor R3, and a voltage feedback operational amplifier U1.

[0050] The first end of the first resistor R1 is connected to the positive output terminal of the output circuit 230. The second end of the first resistor R1 and the first end of the second resistor R2 are connected in series and then connected to the positive input terminal of the voltage feedback operational amplifier U1. The second end of the second resistor R2 is grounded. In some embodiments of this disclosure, the voltage sampling circuit 240 formed by the first resistor R1 and the second resistor R2 can sample the output voltage HV+ at the positive output terminal of the output circuit 230 and transmit the sampled electrical signal VFB (Voltage Feedback) to the voltage feedback operational amplifier U1.

[0051] The negative input terminal of the voltage feedback operational amplifier U1 is connected to the digital-to-analog converter module 253 (DAC). The main control unit 251 is connected to the first input terminal of the PWM controller 252, the DAC module 253, and the control module 100. The output terminal of the voltage feedback operational amplifier U1 is connected to the second input terminal of the PWM controller 252, the output terminal of the PWM controller 252 is connected to the gate of the first switching transistor Q1, and the current detection pin ISENSE of the PWM controller 252 is connected to the source of the first switching transistor Q1. The drain of the first switching transistor Q1 is connected to the second terminal of the primary winding N1, and the source of the first switching transistor Q1 is also connected to the first terminal of the third resistor R3, the second terminal of the third resistor R3 is grounded.

[0052] When the ultrasonic thrombolysis system needs to adjust the target electrical signal output by the voltage regulation module 200, the control module 100 can transmit a corresponding control signal to the main control unit 251. The main control unit 251, based on the control signal generated by the control module 100, can send a digital voltage regulation signal to the digital-to-analog converter module 253. The digital-to-analog converter module 253 can generate a voltage regulation reference signal based on the digital voltage regulation signal and transmit it to the negative input terminal of the voltage feedback operational amplifier U1. The sampling electrical signal VFB from the voltage sampling circuit 240 is transmitted to the positive input terminal of the voltage feedback operational amplifier U1, i.e., the differential signal input pin.

[0053] The voltage feedback operational amplifier U1 generates an enable control signal based on the voltage reference signal and the sampled electrical signal VFB. The enable control signal output by the voltage feedback operational amplifier U1 is transmitted to the second input terminal of the PWM controller 252, which can be either a signal feedback pin or a compensation pin. The enable control signal can be used to control the enable switch of the PWM controller 252, thereby controlling the PWM controller 252 to send a PWM signal. The PWM signal sent by the PWM controller 252 can be used to control the first switching transistor Q1 to turn on or off.

[0054] The main control circuit 250 is connected to the primary winding N1 of the transformer 220 via the first switching transistor Q1. It can change the on / off state of the first switching transistor Q1 to control the energy storage and release of the transformer 220. When the first switching transistor Q1 is on, the input voltage Vin charges the primary winding N1; when the first switching transistor Q1 is off, the transformer 220 releases energy to the output circuit 230 through the primary winding N2. Therefore, the main control circuit 250, based on the control signal and the output status of the output circuit 230, controls the energy storage and release of the transformer 220 to digitally regulate the output voltages HV+ and HV-, thereby achieving precise control and stable output of the amplitudes of the output voltages HV+ and HV-.

[0055] In some embodiments, the main control circuit 250 can also be connected to the pulse excitation module 300 to adjust the frequency and duty cycle of the pulse excitation module 300 according to the control signal output by the control module 100, so as to achieve the effect of adaptively adjusting the acoustic power output of each transducer assembly.

[0056] Figure 3 This is a circuit connection diagram of multiple pulse excitation modules in one embodiment of the present disclosure. Figure 3 The illustration shows an embodiment with N=4, that is, four sets of pulse excitation modules 300 configured in the ultrasonic thrombolysis system. In practical applications, other numbers of pulse excitation modules 300 can be set according to the application requirements of different scenarios. Figure 3 HV+ and HV- in the middle are respectively with Figure 2 The HV+ and HV- are connected. In one embodiment, the circuit structures of the four pulse excitation modules 300 can all be the same, but the performance parameters of each component in each pulse excitation module can be different. Each pulse excitation module 300 can include a driver chip 310, a second switch Q2, a third switch Q3, a third diode D3, and a fourth diode D4.

[0057] The driver chip 310 is connected to the gate of the second switch Q2, the gate of the third switch Q3, and the control module 100. In some embodiments, the driver chip 310 can also be connected to the main control unit 251 in the voltage regulation module 200. The drain of the second switch Q2 is connected to the positive output terminal of the voltage regulation module 200, and the source of the third switch Q3 is connected to the negative output terminal of the voltage regulation module 200. The source of the second switch Q2 is connected to the anode of the third diode D3, and the drain of the third switch Q3 is connected to the cathode of the fourth diode D4. The connection point between the cathode of the third diode D3 and the anode of the fourth diode D4 can be used as the output terminal OUT1 of the pulse excitation module 300.

[0058] The driver chip 310 can generate S1-Sn (n is a positive integer) positive and negative pulses according to the control signal issued by the control module 100. The width, interval time, amplitude and other parameters of each pulse can be adaptively adjusted according to the control signal. By adjusting the pulse width, a pulse excitation signal adapted to different frequency transducer components 500 can be output. The pulse forming section composed of the second switch Q2, the third switch Q3, the third diode D3 and the fourth diode D4 combines the S1-Sn positive and negative pulses and outputs the pulse excitation signal. The target electrical signal output by the voltage regulating module 200 can realize the voltage power supply of N pulse excitation channels. The N-group pulse excitation module 300 can realize the excitation control of N transmission channels. By using the N-group pulse excitation module 300 to adaptively realize N transmission channels, different voltage amplitudes and pulse excitation signals can be matched with different transducer components 500, improving the efficiency and universality of the ultrasonic thrombolysis system in practical applications.

[0059] In one embodiment, the signal processing module 400 may include a switching unit 410 and M sets of impedance matching units 420, where M is an integer greater than zero. The pulse excitation module 300 is connected to the M sets of impedance matching units 420, which are connected to the transducer assembly 500 via the switching unit 410. The switching module 410 may also be connected to a control module 100, which can control the switching unit 410 to establish a connection path between any one set of impedance matching units 420 and the transducer assembly 500.

[0060] The performance parameters of the components within the M-group impedance matching unit 420 can differ. Different impedance matching units 420 can be used to achieve impedance matching between transducer assemblies of different specifications and the pulse excitation module 300. The switching unit 410 can select and activate the appropriate impedance matching unit 420 and the transducer assembly 500 according to the control signal, thereby achieving filtering and impedance matching between each channel and different transducer assemblies 500. The pulse excitation signal output by the pulse excitation module 300, after being filtered and impedance matched by the impedance matching unit 420, can be transmitted to the transducer assembly 500 to excite the piezoelectric ceramic of the transducer assembly 500.

[0061] The aforementioned ultrasonic thrombolysis system incorporates multiple transducer assemblies 500 of varying specifications within the treatment catheter. The control module 100 generates control signals based on acquired control information and / or transducer information. These control signals enable the voltage regulation module 200 to adaptively output the target electrical signal, and the pulse excitation module 300 to output a suitable pulse excitation signal and adaptively activate or deactivate different transmission channels. The control signals can also adaptively switch appropriate impedance matching units 420 to match different transducer assemblies 500, thereby coordinating with the transducer assemblies to generate the target ultrasonic signal. Therefore, the ultrasonic thrombolysis system provided in this disclosure can achieve more targeted treatment of different areas of a patient with systemic thrombosis simultaneously, exhibiting excellent flexibility and efficiency.

[0062] Figure 4 This is a circuit connection diagram of multiple signal processing modules in one embodiment of the present disclosure. Figure 4 The illustration shows an embodiment where N=4 and M=2, i.e., four signal processing modules 400 are configured in the ultrasonic thrombolysis system. In practical applications, other numbers of signal processing modules 400 can be set according to the application requirements of different scenarios. Figure 4 OUT1, OUT2, OUT3, and OUT4 are respectively with Figure 3 OUT1, OUT2, OUT3, and OUT4 are connected together, and THV1, THV2, THV3, and THV4 are connection ports used to drive the four sets of transducer assemblies 500. Figure 5 This is a schematic diagram of the circuit connection of multiple transducer assemblies in one embodiment of this disclosure. The four transducer assemblies 500 are designated as transducer assembly one through transducer assembly four. The connection ports THV1, THV2, THV3, and THV4 of the four transducer assemblies 500 are all integrated into the catheter plug, and the four transducer assemblies 500 can also be grounded through the catheter plug. A catheter ID information identification module can also be provided on the catheter plug. The control module 100 can also use the catheter ID information identification module to identify the identity information of the treatment catheter to obtain information and parameters related to the treatment catheter, such as the transmission frequency, transmission voltage amplitude, and transmission energy duty cycle of the treatment catheter.

[0063] In one embodiment, the circuit structures of the four signal processing modules 400 can all be identical, while the specific performance parameters of each component in each signal processing module 400 can be different. When the value of M is 2, the switching unit 410 can be a double-pole double-throw switch S1. The double-pole double-throw switch S1 may include a first fixed terminal 1, a second fixed terminal 2, a first moving terminal 3, a second moving terminal 4, a third moving terminal 5, and a fourth moving terminal 6. The first impedance matching unit 420 may include a first inductor L1, a fourth capacitor C4, and a fifth capacitor C5. The second impedance matching unit 420 may include a second inductor L2, a sixth capacitor C6, and a seventh capacitor C7.

[0064] The first terminal of the first inductor L1 is connected to the output terminal OUT1 and the second moving terminal 4 of the pulse excitation module 300. The second terminal of the first inductor L2 is connected to the first terminal of the fifth capacitor C5. The second terminal of the fifth capacitor C5 is connected to the first stationary terminal 1, the third moving terminal 5, and the first terminal of the second inductor L2. The second terminal of the second inductor L2 is connected to the first terminal of the sixth capacitor C6. The second terminal of the sixth capacitor C6 is connected to the connection port THV1 of the transducer assembly and the second stationary terminal 2. The first terminal of the fourth capacitor C4 is connected to the first moving terminal 3, and the second terminal of the fourth capacitor C4 is grounded. The first terminal of the seventh capacitor C7 is connected to the fourth moving terminal 6, and the second terminal of the seventh capacitor C7 is grounded.

[0065] When the first stationary terminal 1 is connected to the first moving terminal 3, and the second stationary terminal 2 is connected to the third moving terminal 5, the second inductor L2 and the sixth capacitor C6 will be short-circuited. Therefore, the pulse excitation signal output by the pulse excitation module 300 will be impedance matched with the transducer assembly 500 through the impedance matching unit 420 composed of the first inductor L1 and the fifth capacitor C5. At the same time, the seventh capacitor C7 can be used to filter the pulse excitation signal. The filtered and impedance-matched pulse excitation signal is transmitted to the transducer assembly 500, which can excite the piezoelectric ceramic of the transducer assembly 500 to work and adjust the output of the ultrasonic signal of the transducer assembly 500.

[0066] When the first stationary terminal 1 is connected to the second moving terminal 4 and the second stationary terminal 2 is connected to the fourth moving terminal 6, the first inductor L1 and the fifth capacitor C5 will be short-circuited. Therefore, the pulse excitation signal output by the pulse excitation module 300 will be impedance matched with the transducer assembly 500 through the impedance matching unit 420 composed of the second inductor L2 and the sixth capacitor C6. At the same time, the fourth capacitor C4 can be used to filter the pulse excitation signal. The filtered and impedance-matched pulse excitation signal is transmitted to the transducer assembly 500, which can excite the piezoelectric ceramic of the transducer assembly 500 to work and adjust the output of the ultrasonic signal of the transducer assembly 500.

[0067] The switching unit 410 may also include a switching control unit, such as Figure 4The switch control unit is connected to the control module 100 and can change the continuity between the stationary and moving terminals according to the control signals output by the control module 100. The switch control unit can adaptively connect the first stationary terminal 1 to the first moving terminal 3 and the second stationary terminal 2 to the third moving terminal 5, or connect the first stationary terminal 1 to the second moving terminal 4 and the second stationary terminal 2 to the fourth moving terminal 6, according to the control signals. The basis for the adaptive control of the connection between different ports by the switch control unit can be the impedance determined by the number of transducer assemblies 500, for example, the impedance of 6 transducer assemblies 500 is 8 ohms, and the impedance of 8 transducer assemblies 500 is 10 ohms, etc.

[0068] In some embodiments of this disclosure, the connection between the first stationary terminal 1 and the first moving terminal 3, and the second stationary terminal 2 and the third moving terminal 5, can be in a normally closed state, that is, the first set of impedance matching units 420 and the transducer assembly 500 are in a state of long-term connection. When the switch control unit determines that it is necessary to open the connection path between the second set of impedance matching units 420 and the transducer assembly 500 according to the control signal, the switch control unit controls the double-pole double-throw switch to disconnect the connection between the first stationary terminal 1 and the first moving terminal 3, and the second stationary terminal 2 and the third moving terminal 5, and to make the connection between the first stationary terminal 1 and the second moving terminal 4, and the second stationary terminal 2 and the fourth moving terminal 6, thereby realizing the switching of the connection between different impedance matching units 420 and the transducer assembly 500.

[0069] Figure 6 The diagram below illustrates the structure of an ultrasonic thrombolysis system according to another embodiment of this disclosure. In one embodiment, the treatment catheter may further include a thermocouple 600, and the ultrasonic thrombolysis system may further include a temperature acquisition circuit 700. The temperature acquisition circuit 700 is connected to both the thermocouple 600 and the control module 100, and is used to acquire temperature information from the thermocouple and transmit the temperature information to the control module 100. The control module 100 may also monitor the temperature information and generate an alarm signal when the temperature exceeds a preset threshold.

[0070] The transducer assembly 500 generates heat during operation. In the ultrasonic thrombolysis system provided in this disclosure, multiple transducer assemblies 500 are connected together. As heat accumulates, the temperature of the treatment area may become excessively high, posing a safety hazard. By using a thermocouple 600 and a temperature acquisition circuit 700 to monitor the temperature of the treatment area, adjustments can be made promptly when the temperature becomes too high, preventing sustained high temperatures from causing harm to the human body and ensuring the safety of the system.

[0071] Thermocouples can directly measure the temperature of the treatment area and convert the temperature signal into a thermoelectric potential signal. The temperature acquisition circuit 700 can convert the thermoelectric potential signal into temperature information of the treatment area. The control module 100 can monitor the temperature information and determine that the temperature of the treatment area is too high when the temperature information exceeds a preset threshold, generating an alarm signal. In some embodiments of this disclosure, the alarm signal can be used to instruct the system to perform an operation to reduce the temperature of the treatment area. This can be achieved through physical cooling, such as circulating cooling water into the treatment area, or by reducing or shutting down the transducer output, such as shutting down some transducer components, switching the power output, or instructing to lower the frequency of the ultrasonic signal output by the transducer. For example, when the control module 100 determines that the accumulated heat exceeds 40°C based on the temperature signal acquired by the temperature acquisition circuit 700, the control module 100 will output an alarm signal, and the system will cut off the power output based on the alarm signal.

[0072] In one embodiment, the ultrasonic thrombolysis system may further include a PC (Personal Computer). The PC system may include a human-machine interface (HMI) module connected to the control module. The HMI module may be a touchscreen input unit and / or a button control unit. Control information, such as the ultrasonic thrombolysis system's transmission frequency, transmission voltage amplitude, and transmission energy duty cycle, is input to the HMI module via touchscreen or button input. The HMI module can communicate with the control module 100 via USB serial port and / or CAN bus communication, and transmit control information to the control module 100.

[0073] In one embodiment, the ultrasonic thrombolysis system may further include a display module. The display module can be connected to the control module 100 and can be used to display control information and / or temperature information. The display module can display the input control signals, and the user can verify the information displayed on the display module to prevent errors in the input information. After the temperature acquisition circuit 700 collects the temperature information of the transducer assembly 500 in the treatment area through the thermocouple 600 and feeds it back to the control module 100, the display module can also display the temperature information. The user can adjust the input control information based on the temperature information, or take other measures to address safety hazards caused by temperature rise. The display module allows for simpler and more intuitive display of various information to the user, simplifying operation and optimizing the user experience.

[0074] In the description of this specification, references to terms such as "some embodiments," "other embodiments," and "ideal embodiments" indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. In this specification, the illustrative descriptions of the above terms do not necessarily refer to the same embodiments or examples.

[0075] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0076] The embodiments described above are merely illustrative of several implementations of the present invention, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these all fall within the protection scope of the present invention. Therefore, the protection scope of this invention patent should be determined by the appended claims.

Claims

1. An ultrasonic thrombolysis system, characterized in that, include: The system includes a control module, a voltage regulation module, N sets of pulse excitation modules, N sets of signal processing modules, and a treatment catheter. The treatment catheter contains N sets of transducer assemblies, where N is a positive integer, and at least two sets of transducer assemblies have different specifications, including a center frequency. A control module is used to acquire control information and / or transducer information, and generate control signals based on the control information and / or transducer information; the transducer information includes the center frequency of the transducer assembly and / or the temperature information of the treatment area where the transducer assembly is working. A voltage regulating module, connected to the control module, is used to adjust the input electrical signal to the target electrical signal according to the control signal; N sets of pulse excitation modules are connected to the control module and the voltage regulation module respectively, and are used to generate pulse excitation signals according to the target electrical signal and the control signal; and the frequency of the pulse excitation signals output by the N sets of pulse excitation modules is independently adjustable under the control of the control module. N signal processing modules are connected to the N pulse excitation modules respectively, and also to the control module. Each signal processing module includes a switching unit and M impedance matching units, where M is an integer greater than or equal to 2. The performance parameters of each component in the M impedance matching units are different. The pulse excitation module is connected to the M impedance matching units, and the M impedance matching units are connected to the transducer assembly through the switching unit. The switching unit is also connected to the control module. The switching unit is used to open the connection path between any one of the M impedance matching units and the transducer assembly according to the control signal, so as to achieve impedance matching between the output terminal of the pulse excitation module and the input terminal of the transducer assembly; and to filter the pulse excitation signal. The N groups of transducer assemblies are respectively connected to the N groups of signal processing modules, and are used to convert the pulse excitation signal into an ultrasonic signal; The treatment catheter also includes a thermocouple, and the ultrasonic thrombolysis system also includes a temperature acquisition circuit. The temperature acquisition circuit is connected to the thermocouple and the control module respectively, and is used to acquire the temperature information of the thermocouple. The control module is also used to monitor the temperature information and generate an alarm signal when the temperature information is greater than a preset threshold.

2. The ultrasonic thrombolysis system according to claim 1, characterized in that, The voltage regulating module includes: An input circuit, the input terminal of which is connected to the power supply module, is used to acquire input electrical signals; A transformer, connected to the input circuit, is used to perform voltage transformation on the input electrical signal; An output circuit, connected to the transformer, is used to rectify the input electrical signal after voltage transformation to obtain the target electrical signal; A voltage sampling circuit, connected to the output circuit, is used to sample the voltage at the output terminal of the output circuit to obtain a sampled electrical signal; The main control circuit is connected to the transformer, the voltage sampling circuit, and the control module, respectively, and is used to perform feedback adjustment on the transformer based on the control signal and the sampled electrical signal.

3. The ultrasonic thrombolysis system according to claim 2, characterized in that, The input circuit includes an input terminal, a positive output terminal, and a negative output terminal. The input circuit includes a first capacitor. The transformer includes a primary winding, a first secondary winding, and a second secondary winding. The output circuit includes a first diode, a second diode, a second capacitor, and a third capacitor. The first terminal of the first capacitor is connected to the input terminal of the input circuit, and the second terminal of the first capacitor is grounded; the first terminal of the primary winding is also connected to the input terminal of the input circuit, and the second terminal of the primary winding is connected to the main control circuit; the first terminal of the first primary winding is connected to the anode of the first diode, the second terminal of the first primary winding is connected to the first terminal of the second secondary winding, and the second terminal of the second secondary winding is connected to the cathode of the second diode; the cathode of the first diode is connected to the first terminal of the second capacitor, and the anode of the second diode is connected to the first terminal of the third capacitor; the second terminals of the second capacitor, the third capacitor, the first primary winding, and the second secondary winding are all grounded. The cathode of the first diode and the first terminal of the second capacitor are both connected to the positive output terminal of the output circuit, and the anode of the second diode and the first terminal of the third capacitor are both connected to the negative output terminal of the output circuit.

4. The ultrasonic thrombolysis system according to claim 3, characterized in that, The voltage sampling circuit includes a first resistor and a second resistor, and the main control circuit includes a main control unit, a PWM controller, a first switching transistor, a third resistor, a voltage feedback operational amplifier, and a digital-to-analog converter module. The first end of the first resistor is connected to the positive output terminal of the output circuit, the second end of the first resistor is connected to the first end of the second resistor, and the second end of the second resistor is grounded. The main control unit is connected to the first input terminal of the PWM controller, the digital-to-analog converter module, and the control module, respectively. The digital-to-analog converter module is connected to the negative input terminal of the voltage feedback operational amplifier, and the positive input terminal of the voltage feedback operational amplifier is connected to the second terminal of the first resistor. The output terminal of the voltage feedback operational amplifier is connected to the second input terminal of the PWM controller. The output terminal of the PWM controller is connected to the gate of the first switching transistor. The current detection pin of the PWM controller is connected to the source of the first switching transistor. The drain of the first switching transistor is connected to the second terminal of the primary winding. The source of the first switching transistor is also connected to the first terminal of the third resistor. The second terminal of the third resistor is grounded.

5. The ultrasonic thrombolysis system according to claim 1 or 2, characterized in that, The pulse excitation module includes a driver chip, a second switch, a third switch, a third diode, and a fourth diode. The driving chip is connected to the gate of the second switch, the gate of the third switch, and the control module. The drain of the second switch is connected to the positive output terminal of the voltage regulation module. The source of the third switch is connected to the negative output terminal of the voltage regulation module. The source of the second switch is connected to the positive terminal of the third diode. The drain of the third switch is connected to the negative terminal of the fourth diode. The negative terminals of the third diode and the positive terminals of the fourth diode are connected to the output terminal of the pulse excitation module.

6. The ultrasonic thrombolysis system according to claim 1, characterized in that, The treatment catheter also includes a catheter plug, and the connection ports of the N sets of transducer components are all integrated into the catheter plug; the catheter plug is provided with a catheter ID information identification module, and the control module is also used to identify the identity information of the treatment catheter using the catheter ID information identification module to obtain parameters related to the treatment catheter, the parameters including at least one of the transmission frequency, transmission voltage amplitude and transmission energy duty cycle of the treatment catheter.

7. The ultrasonic thrombolysis system according to claim 1, characterized in that, When M is 2, the switching unit is a double-pole double-throw switch, which includes a first fixed terminal, a second fixed terminal, a first moving terminal, a second moving terminal, a third moving terminal, and a fourth moving terminal. One set of impedance matching units includes a first inductor, a fourth capacitor, and a fifth capacitor, while the other set of impedance matching units includes a second inductor, a sixth capacitor, and a seventh capacitor. The first end of the first inductor is connected to the output end of the pulse excitation module and the second moving end, respectively. The second end of the first inductor is connected to the first end of the fifth capacitor. The second end of the fifth capacitor is connected to the first stationary end, the third moving end, and the first end of the second inductor, respectively. The second end of the second inductor is connected to the first end of the sixth capacitor. The second end of the sixth capacitor is connected to the transducer assembly and the second stationary end, respectively. The first end of the fourth capacitor is connected to the first moving end, and the second end of the fourth capacitor is grounded. The first end of the seventh capacitor is connected to the fourth moving end, and the second end of the seventh capacitor is grounded.

8. The ultrasonic thrombolysis system according to claim 1, characterized in that, The control module is also used to control the ultrasonic thrombolysis system to perform an operation to reduce the temperature of the treatment area according to the alarm signal. The operation includes at least one of the following: cutting off the power output of the voltage regulating module, turning off part of the transducer assembly, switching the power output of the voltage regulating module, and reducing the frequency of the ultrasonic signal output by the transducer assembly.

9. The ultrasonic thrombolysis system according to claim 1, characterized in that, The ultrasonic thrombolysis system also includes a human-machine interaction module, which is connected to the control module and used to acquire control information.

10. The ultrasonic thrombolysis system according to claim 1, characterized in that, The ultrasonic thrombolysis system also includes a display module connected to the control module for displaying the control information and / or the temperature information.

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