Production device and process of pyrroloquinoline quinone disodium

Abstract

The application discloses a production device and process of pyrroloquinoline quinone disodium, and relates to the technical field of production device. The multifunctional feeding table structure is designed, containers which need to be mixed in the production process are conveniently conveyed to appropriate positions, a surrounding refrigeration output is formed, the influence of heat on the production effect in the stirring reaction process is avoided, the preparation height adjusting structure and the multifunctional matching and adjusting stirring and adsorbing structure are cooperatively designed, the device is convenient to adjust the stirring height according to different production mixing tools, the adaptability in the production process is improved, the multifunctional matching and adjusting stirring and adsorbing structure is arranged, stirring is conveniently completed, the adsorbing plate required according to different production steps can be replaced and applied, the position of the adsorbing plate can be adjusted according to the diameter of different mixing containers, and the application adaptability is further improved.

Description

Technical Field

[0001] This invention relates to the field of manufacturing equipment technology, specifically to a manufacturing equipment and process for disodium pyrroloquinoline quinone. Background Technology

[0002] Disodium pyrroloquinoline quinone is a chemical intermediate. To facilitate the processing of disodium pyrroloquinoline quinone, corresponding production equipment is often required. However, existing production equipment is not convenient to adjust according to different temperatures, nor is it convenient to adjust the height and application size according to different production mixing tools, resulting in inconvenience in use. Therefore, a new solution is needed to address these issues. Summary of the Invention

[0003] The purpose of this invention is to provide a production apparatus and process for disodium pyrroloquinoline quinone to solve the existing problems: the existing production apparatus is not convenient to adjust according to different temperatures, and it is not convenient to adjust the height and application size according to different production mixing tools, resulting in inconvenience in use.

[0004] To achieve the above objectives, the present invention provides the following technical solution: a production device for disodium pyrroloquinoline quinone, comprising a multifunctional feeding platform structure, a preparation height adjustment structure, and a multifunctional blending, stirring, and adsorption structure, wherein the preparation height adjustment structure is fixedly connected to the top of the multifunctional feeding platform structure, and the multifunctional blending, stirring, and adsorption structure is fixedly connected to the bottom of the inner side of the preparation height adjustment structure. The multi-functional feeding platform structure includes a positioning mounting frame, a transmission belt motor, a first transmission belt, a temperature guiding frame, a placement slot, a conductive plate, and a semiconductor cooling plate. The temperature guiding frame is fixedly connected to the top of the positioning mounting frame, and a placement slot is opened on the inner side of the temperature guiding frame. A conductive plate is fixedly connected to one end of the temperature guiding frame, and a semiconductor cooling plate is connected to the end of the conductive plate away from the placement slot through a temperature-conducting adhesive. A first transmission belt is provided on the inner side of the positioning mounting frame, and a transmission belt motor is fixedly connected to one side of the positioning mounting frame through screws. The first transmission belt is connected to the transmission belt motor.

[0005] Preferably, both the placement groove and the conductive plate are made of copper.

[0006] Preferably, the preparation height adjustment structure includes a support positioning frame, a first moving guide module, and a first driven pushing module. The top of the multi-functional feeding table structure is fixedly connected to the support positioning frame, the top of the support positioning frame is fixedly connected to the preparation height adjustment structure, and the first driven pushing modules are fixedly connected to both sides of the first moving guide module.

[0007] Preferably, the first dynamic guide module includes an inner frame, an extended mounting plate, a first motor, a drive gear shaft, a first bevel gear, a first transmission gear ring, a driven gear shaft, and a second bevel gear. The two ends of the inner frame are fixedly connected to the extended mounting plate. The top end of one of the extended mounting plates is fixedly connected to the first motor by screws. The output end of the first motor is fixedly connected to the drive gear shaft. The bottom end of the drive gear shaft is fixedly connected to the first bevel gear. The inner side of the other extended mounting plate is rotatably connected to the driven gear shaft. The bottom end of the driven gear shaft is fixedly connected to the second bevel gear. The inner side of the inner frame is fixedly connected to a core column. The outer side of the core column is rotatably connected to the first transmission gear ring. The two ends of the first transmission gear ring are respectively meshed with the drive gear shaft and the driven gear shaft.

[0008] Preferably, the first driven push module includes an extension positioning frame, a linkage shaft, a third bevel gear, a first gear, a second gear, a threaded rod, a first linkage displacement block, a folding push rod, a mounting plate, and an auxiliary positioning frame. One end of the extension mounting plate is fixedly connected to the extension positioning frame. The inner side of the bottom end of the extension positioning frame is rotatably connected to a threaded rod. One end of the threaded rod is fixedly connected to a second gear. The inner side of the extension positioning frame is rotatably connected to the linkage shaft. One end of the linkage shaft is fixedly connected to a third bevel gear. The other end of the linkage shaft is fixedly connected to a first gear. The top end of the first gear is meshed with both the second and third bevel gears. The bottom end of the third bevel gear is meshed with the second gear. The outer side of the threaded rod is threadedly connected to a first linkage displacement block. The first linkage displacement block is slidably connected to the bottom end of the extension positioning frame. The bottom end of the first linkage displacement block is rotatably connected to a folding push rod. The bottom end of the folding push rod is rotatably connected to a mounting plate. The upper surface of the mounting plate is fixedly connected to an auxiliary positioning frame.

[0009] Preferably, the multifunctional blending and adsorption structure includes a stirring output module, a second dynamic guide module, and a second driven push module. The stirring output module includes a second motor, a stirring plate, and stirring blades. The top of the auxiliary positioning frame is fixedly connected to the second motor by screws. The output end of the second motor is fixedly connected to the stirring plate. The stirring plate is rotatably connected to the inner side of the mounting plate. Multiple stirring blades are fixed to the outer side of the stirring plate. The bottom of the mounting plate is provided with the second dynamic guide module, and the four ends of the bottom of the second dynamic guide module are each provided with a second driven push module.

[0010] Preferably, the second motion guide module includes an inner mounting ring, a third motor, an extension positioning plate, a drive shaft, a third gear, a drive pulley, and a second transmission gear ring. The bottom end of the mounting plate is fixedly connected to the inner mounting ring, and the top end of the mounting plate is fixedly connected to the third motor by screws. Four extension positioning plates are fixedly attached to the top end of the inner side of the inner mounting ring. The bottom end of the inner side of the inner mounting ring is movably connected to the second transmission gear ring. The inner side of the extension positioning plate and the drilled hole are connected to the drive shaft. The outer side of the drive shaft is fixedly connected from top to bottom to the third gear and the drive pulley. The output end of the third motor is fixedly connected to one of the drive shafts, and the outer side of the third gear meshes with the second transmission gear ring.

[0011] Preferably, the second driven push module includes a positioning guide frame, a second linkage displacement block, a driven pulley, a second transmission belt, an insertion fitting block, a first fitting hole, a second fitting hole, an adsorption plate, and a pin. The four ends of the lower surface of the inner mounting ring are fixedly connected to the positioning guide frame. The bottom end of the positioning guide frame away from the driving pulley is rotatably connected to the driven pulley. A second transmission belt is sleeved between the driven pulley and the driving pulley. A second linkage displacement block is fixedly connected to the outer side of one side of the second transmission belt. The top end of the second linkage displacement block is slidably connected to the positioning guide frame. A first fitting hole is opened on the inner side of the second linkage displacement block. An insertion fitting block is inserted into the inner side of the second linkage displacement block. An adsorption plate is fixedly connected to the bottom end of the insertion fitting block. A second fitting hole is opened on the inner side of the insertion fitting block. The second fitting hole has the same size as the first fitting hole. Pins are inserted into the inner sides of both the first and second fitting holes. A third gear is fixedly connected to the bottom end of the insertion fitting block.

[0012] Preferably, nuts are threadedly connected to both sides of the pin.

[0013] A process for producing disodium pyrroloquinoline quinone, used for the above-mentioned purposes: S1: Dissolve any one of the culture medium components (NH4)SO4, KH2PO4, MgSO4・7H2O and Na2SO4) in water, place in a fermenter, adjust the pH value, sterilize and disinfect for later use; S2: Under a certain positive pressure, inoculate the raw silk microbial strain or seed culture into the production culture medium, and culture at 30 degrees Celsius. During the fermentation process, add methanol as feed and use ammonia water to control a certain pH value. S3: By adjusting the aeration flow rate and stirring, the dissolved oxygen level is maintained at no less than that of the semiconductor cooling plate throughout the fermentation process. S4: After fermentation is completed, the fermentation tank is transferred to the work station through the multi-functional feeding platform structure. At this time, the corresponding adsorption plate is not installed. The stirring output module of the preparation height adjustment structure is inserted into the fermentation liquid to lower the temperature of the fermentation liquid to below 15 degrees Celsius and continuously maintain stirring and aeration. S5: After cooling, the fermentation broth is centrifuged at high speed or filtered through ceramic membrane microfiltration, and the filtrate is collected. S6: Sequentially perform acid precipitation, primary salting out, salting out resolution, cross-linking chromatography, secondary salting out, and crystallization drying; S7: When adsorption filtration is required in the S process, a height-adjustable structure is used to drive adsorption plates of different materials into the production liquid for adsorption filtration.

[0014] Compared with the prior art, the beneficial effects of the present invention are: 1. The present invention, through the design of a multi-functional feeding platform structure, facilitates the convenient transportation of containers that need to be mixed during the production process to a suitable position, forming a surrounding cooling output, and avoiding the impact of heat during the stirring reaction on the production effect; 2. The present invention, through the combined design of a height-adjustable structure and a multifunctional mixing and adsorption structure, makes the device easy to adjust the stirring height according to different production mixing tools, thereby improving its adaptability in the production process; 3. The present invention, through its multifunctional mixing and adsorption structure, facilitates mixing, allows for easy replacement of adsorption plates according to the needs of different production steps, and makes it easy to adjust the position of the adsorption plates according to the diameter of different mixing containers, thereby further improving the adaptability of the application. Attached Figure Description

[0015] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0016] Figure 1 This is a schematic diagram of the overall structure of the present invention; Figure 2 This is a top view of the entire invention; Figure 3 This is a partial structural diagram of the multifunctional feeding platform structure of the present invention; Figure 4 A partial structural schematic diagram of the height-adjustable structure prepared according to the present invention; Figure 5 This is a partial structural schematic diagram of the first dynamic guidance module of the present invention; Figure 6This is a partial structural schematic diagram of the first driven derivation module of the present invention; Figure 7 This is a partial structural schematic diagram of the multifunctional blending, stirring, and adsorption structure of the present invention; Figure 8 This is a partial structural schematic diagram of the stirring output module of the present invention; Figure 9 This is a partial structural schematic diagram of the second dynamic guidance module of the present invention; Figure 10 This is a partial structural diagram of the second driven derivation module of the present invention.

[0017] In the diagram: 1. Multifunctional feeding platform structure; 2. Preparation height adjustment structure; 3. Multifunctional mixing and adsorption structure; 4. Positioning support frame; 5. Transmission belt motor; 6. First transmission belt; 7. Temperature guide frame; 8. Placement slot; 9. Conductive plate; 10. Semiconductor cooling plate; 11. Support positioning frame; 12. First dynamic guide module; 13. First driven push module; 14. Internal frame; 15. Extended support plate; 16. First motor; 17. Drive gear shaft; 18. First bevel gear; 19. First transmission gear ring; 20. Driven gear shaft; 21. Second bevel gear; 22. Extended positioning frame; 23. Linkage shaft; 24. Third bevel gear; 25. First gear; 26. Second gear; 27. 1. Threaded rod; 28. First linkage displacement block; 29. ​​Folding push rod; 30. Mounting plate; 31. Auxiliary positioning frame; 32. Stirring output module; 33. Second dynamic guide module; 34. Second motor; 35. Stirring plate; 36. Stirring blade; 37. Internal mounting ring; 38. Third motor; 39. Extended positioning plate; 40. Drive shaft; 41. Second driven push module; 42. Third gear; 43. Drive pulley; 44. Second transmission gear ring; 45. Positioning guide frame; 46. Second linkage displacement block; 47. Driven pulley; 48. Second transmission belt; 49. Insert fitting block; 50. First fitting hole; 51. Second fitting hole; 52. Adsorption plate; 53. Pin; 54. Nut. Detailed Implementation

[0018] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments.

[0019] Example 1: This embodiment discloses a production apparatus for disodium pyrroloquinoline quinone; Please see Figure 1 - Figure 2A production device for disodium pyrroloquinoline quinone includes a multi-functional feeding platform structure 1, a preparation height adjustment structure 2, and a multi-functional blending, stirring, and adsorption structure 3. The top of the multi-functional feeding platform structure 1 is fixedly connected to the preparation height adjustment structure 2, and the bottom of the inner side of the preparation height adjustment structure 2 is fixedly connected to the multi-functional blending, stirring, and adsorption structure 3. The multi-functional feeding platform structure 1 is used to transport production mixing tools of different sizes to the appropriate position and facilitate their cooling and temperature maintenance. A height-adjustable structure 2 is prepared to adjust the height of the multifunctional blending and stirring adsorption structure 3. The multi-functional mixing and adsorption structure 3 is used for mixing while being equipped with adsorption plates of different materials, and the adsorption position can be easily adjusted according to the width of the production mixing equipment. Example 2: This embodiment further discloses the specific structure of the multi-functional feeding table structure 1 based on the above embodiment 1; Please see Figure 3 The multi-functional feeding platform structure 1 includes a positioning mounting frame 4, a transmission belt motor 5, a first transmission belt 6, a temperature guide frame 7, a placement groove 8, a conductive plate 9, and a semiconductor cooling plate 10. The top of the positioning mounting frame 4 is fixedly connected to the temperature guide frame 7. The inner side of the temperature guide frame 7 is provided with a placement groove 8. One end of the temperature guide frame 7 is fixedly connected to the conductive plate 9. The end of the conductive plate 9 away from the placement groove 8 is connected to the semiconductor cooling plate 10 through a temperature-conducting adhesive. The inner side of the positioning mounting frame 4 is provided with a first transmission belt 6. One side of the positioning mounting frame 4 is fixedly connected to the transmission belt motor 5 by screws. The first transmission belt 6 is connected to the transmission belt motor 5. Both the placement slot 8 and the conduction plate 9 are made of copper. The first transmission belt 6 is driven by the transmission belt motor 5 to complete the transmission, and the production mixing tool is transported into the inner side of the placement tank 8. This allows the production mixing tool to be energized with the control semiconductor cooling plate 10 to form a cooling effect. The temperature output of the outer side of the production mixing tool is completed by the cooperation of the conduction plate 9 and the placement tank 8, so as to avoid the temperature of the production mixing tool being too high. Example 3: This embodiment further discloses the specific structure for preparing the height adjustment structure 2 based on the above embodiment 2; Please see Figure 4 - Figure 6 The height adjustment structure 2 includes a support positioning frame 11, a first dynamic guide module 12 and a first driven push module 13. The top of the multi-functional feeding platform structure 1 is fixedly connected to the support positioning frame 11, and the top of the support positioning frame 11 is fixedly connected to the height adjustment structure 2. The first driven push module 13 is fixedly connected to both sides of the first dynamic guide module 12. The first dynamic guide module 12 includes an inner frame 14, an extended mounting plate 15, a first motor 16, a drive gear shaft 17, a first bevel gear 18, a first transmission gear ring 19, a driven gear shaft 20, and a second bevel gear 21. The two ends of the inner frame 14 are fixedly connected to the extended mounting plate 15. The top end of one of the extended mounting plates 15 is fixedly connected to the first motor 16 by screws. The output end of the first motor 16 is fixedly connected to the drive gear shaft 17. The bottom end of the drive gear shaft 17 is fixedly connected to the first bevel gear 18. The inner side of the other extended mounting plate 15 is rotatably connected to the driven gear shaft 20. The bottom end of the driven gear shaft 20 is fixedly connected to the second bevel gear 21. The inner side of the inner frame 14 is fixedly connected to a core column. The outer side of the core column is rotatably connected to the first transmission gear ring 19. The two ends of the first transmission gear ring 19 are respectively meshed with the drive gear shaft 17 and the driven gear shaft 20. The first driven push module 13 includes an extension positioning frame 22, a linkage shaft 23, a third bevel gear 24, a first gear 25, a second gear 26, a threaded rod 27, a first linkage displacement block 28, a retractable push rod 29, a mounting plate 30, and an auxiliary positioning frame 31. One end of the extension mounting plate 15 is fixedly connected to the extension positioning frame 22. The inner side of the bottom end of the extension positioning frame 22 is rotatably connected to the threaded rod 27. One end of the threaded rod 27 is fixedly connected to the second gear 26. The inner side of the extension positioning frame 22 is rotatably connected to the linkage shaft 23. One end of the linkage shaft 23 is fixedly connected to the third bevel gear 24. The other end of the linkage shaft 23 is fixedly connected to the first gear 25. The top of the first gear 25 is meshed with the second bevel gear 21 and the first bevel gear 18. The bottom end of the third bevel gear 24 is meshed with the second gear 26. The outer side of the threaded rod 27 is threadedly connected to the first linkage displacement block 28. The first linkage displacement block 28 is slidably connected to the bottom end of the extension positioning frame 22. The bottom end of the first linkage displacement block 28 is rotatably connected to the folding push rod 29. The bottom end of the folding push rod 29 is rotatably connected to the mounting plate 30. The upper surface of the mounting plate 30 is fixedly connected to the auxiliary positioning frame 31. It should be emphasized that the threaded rods 27 at both ends have the same thread direction; The first motor 16 drives the drive gear shaft 17 to rotate. The drive gear shaft 17 meshes with the first transmission gear ring 19, causing the first transmission gear ring 19 to rotate around a central axis. The first transmission gear ring 19 then drives the driven gear shaft 20 to rotate. The drive gear shaft 17 and the driven gear shaft 20 respectively drive the first bevel gear 18 and the second bevel gear 21 to rotate. The meshing of the first bevel gear 18 with the first gear 25 and the meshing of the second bevel gear 21 with the first gear 25 causes the first gear 25 to drive the linkage shaft 23 to rotate. The linkage shaft 23 then drives the third bevel gear 24 to rotate. The meshing of the third bevel gear 24 and the second gear 26 causes the second gear 26 to rotate under the drive of the third bevel gear 24. The second gear 26 drives the threaded rod 27 to rotate. The threaded connection between the threaded rod 27 and the first linkage displacement block 28 causes the first linkage displacement block 28 to obtain torque. The sliding connection between the first linkage displacement block 28 and the extension positioning frame 22 limits the torque at the first linkage displacement block 28 to form a sliding displacement. The displacement of the first linkage displacement block 28 drives the folding push rod 29 to complete the angle adjustment. The angle adjustment of the folding push rod 29 completes the descent of the electric mounting plate 30. Example 4: This embodiment further discloses the specific structure of the multifunctional blending and stirring adsorption structure 3 based on the above embodiment 3; Please see Figure 7 - Figure 10 The multifunctional blending and adsorption structure 3 includes a stirring output module 32, a second dynamic guide module 33, and a second driven push module 41. The stirring output module 32 includes a second motor 34, a stirring plate 35, and stirring blades 36. The top of the auxiliary positioning frame 31 is fixedly connected to the second motor 34 by screws. The output end of the second motor 34 is fixedly connected to the stirring plate 35. The stirring plate 35 is rotatably connected to the inner side of the mounting plate 30. Multiple stirring blades 36 are fixed on the outer side of the stirring plate 35. The bottom end of the mounting plate 30 is provided with the second dynamic guide module 33. The four ends of the bottom end of the second dynamic guide module 33 are all provided with the second driven push module 41. The second drive module 33 includes an internal mounting ring 37, a third motor 38, an extension positioning plate 39, a drive shaft 40, a third gear 42, a drive pulley 43, and a second drive gear ring 44. The bottom end of the mounting plate 30 is fixedly connected to the internal mounting ring 37, and the top end of the mounting plate 30 is fixedly connected to the third motor 38 by screws. Four extension positioning plates 39 are fixedly attached to the top end of the inner side of the internal mounting ring 37, and the bottom end of the inner side of the internal mounting ring 37 is movably connected to the second drive gear ring 44. The inner side of the extension positioning plate 39 and the drilled hole are connected to the drive shaft 40. The outer side of the drive shaft 40 is fixedly connected to the third gear 42 and the drive pulley 43 from top to bottom. The output end of the third motor 38 is fixedly connected to one of the drive shafts 40, and the outer side of the third gear 42 is meshed with the second drive gear ring 44. The second driven guide module 41 includes a positioning guide frame 45, a second linkage displacement block 46, a driven pulley 47, a second transmission belt 48, an insertion fitting block 49, a first fitting hole 50, a second fitting hole 51, an adsorption plate 52, and a pin 53. The positioning guide frame 45 is fixedly connected to all four ends of the lower surface of the mounting ring 37. The driven pulley 47 is rotatably connected to the bottom end of the positioning guide frame 45 away from the driving pulley 43. A second transmission belt 48 is sleeved between the driven pulley 47 and the driving pulley 43. A second transmission belt 48 is fixedly connected to the outer side of one side of the second transmission belt 48. The top of the second linkage displacement block 46 is slidably connected to the positioning guide frame 45. The inner side of the second linkage displacement block 46 is provided with a first fitting hole 50. An insertion fitting block 49 is inserted into the inner side of the second linkage displacement block 46. An adsorption plate 52 is fixedly connected to the bottom end of the insertion fitting block 49. The inner side of the insertion fitting block 49 is provided with a second fitting hole 51. The second fitting hole 51 is the same size as the first fitting hole 50. Pins 53 are inserted into the inner side of both the first fitting hole 50 and the inner side of the second fitting hole 51. A third gear 42 is fixedly connected to the bottom end of the insertion fitting block 49. Depending on the mixture, different adsorption plates 52 with different adsorption materials are used. During the assembly of the adsorption plates 52, the insertion fitting block 49 is inserted into the inner side of the second linkage displacement block 46, so that the second fitting hole 51 corresponds to the first fitting hole 50. At this time, the pin 53 is inserted into the inner side of the first fitting hole 50 and the second fitting hole 51. Then, the pin 53 is locked on both sides with the nut 54, thereby completing the stable assembly of the adsorption plate 52. After the production mixing tool enters the designated position, the third motor 38 is controlled to drive the transmission shaft 40 to rotate. The transmission shaft 40 drives the third gear 42 and the drive pulley 43 to rotate synchronously. The meshing of the third gear 42 with the second transmission gear ring 44 enables the second transmission gear to rotate synchronously. The moving gear ring 44 distributes the torque to the remaining third gear 42, which drives the driving pulley 43 to rotate synchronously. The second transmission belt 48 transmits the displacement power generated during the rotation of the driving pulley 43 to the second linkage displacement block 46, so that the second linkage displacement block 46 completes displacement under the auxiliary guidance of the positioning guide frame 45, thereby driving the adjustment of the position of the adsorption plate 52. Under the derivation of the preparation of the height adjustment structure 2, the adsorption plate 52 and the stirring blade 36 are inserted into the inside of the production mixing tool. At this time, the second motor 34 drives the stirring plate 35 to rotate, so that the stirring plate 35 drives the stirring blade 36 to mix and stir the liquid inside the production mixing tool.

[0020] Example 5: Based on the above Examples 1-4, a production process for disodium pyrroloquinoline quinone is provided: S1: Dissolve or suspend any one of the culture medium components (NH4)SO4, KH2PO4, MgSO4・7H2O and Na2SO4) in water, place it in a fermenter, adjust the pH value, sterilize and disinfect for later use. S2: Under a certain positive pressure, inoculate the raw silk microbial strain or seed culture into the production culture medium, and culture at 30 degrees Celsius. During the fermentation process, add methanol as feed and use ammonia water to control a certain pH value. S3: By adjusting the aeration flow rate and stirring, the dissolved oxygen level is maintained at no less than 10% of the semiconductor cooling plate throughout the fermentation process; S4: After fermentation is completed, the fermentation tank is transferred to the work station through the multi-functional feeding platform structure 1. At this time, the corresponding adsorption plate 52 is not installed. The stirring output module 32 is inserted into the fermentation liquid in conjunction with the preparation height adjustment structure 2 to reduce the temperature of the fermentation liquid to below 15 degrees Celsius and continuously maintain stirring and aeration. S5: After cooling, the fermentation broth is centrifuged at high speed or filtered through ceramic membrane microfiltration, and the filtrate is collected. S6: Sequentially perform acid precipitation, primary salting out, salting out resolution, cross-linking chromatography, secondary salting out, and crystallization drying; S7: When adsorption filtration is required in process S6, the height adjustment structure 2 is used to drive the adsorption plates 52 of different materials into the production liquid for adsorption filtration.

[0021] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or essential characteristics. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

Claims

1. A production apparatus for disodium pyrroloquinoline quinone, characterized in that: It includes a multi-functional feeding platform structure (1), a preparation height adjustment structure (2) and a multi-functional mixing and adsorption structure (3). The top of the multi-functional feeding platform structure (1) is fixedly connected to the preparation height adjustment structure (2), and the bottom of the inner side of the preparation height adjustment structure (2) is fixedly connected to the multi-functional mixing and adsorption structure (3). The multi-functional feeding platform structure (1) includes a positioning mounting frame (4), a transmission belt motor (5), a first transmission belt (6), a temperature guide frame (7), a placement slot (8), a conductive plate (9), and a semiconductor cooling plate (10). The top of the positioning mounting frame (4) is fixedly connected to the temperature guide frame (7). The inner side of the temperature guide frame (7) is provided with a placement slot (8). One end of the temperature guide frame (7) is fixedly connected to the conductive plate (9). The end of the conductive plate (9) away from the placement slot (8) is connected to the semiconductor cooling plate (10) through a temperature-conducting adhesive. The inner side of the positioning mounting frame (4) is provided with a first transmission belt (6). One side of the positioning mounting frame (4) is fixedly connected to the transmission belt motor (5) by screws. The first transmission belt (6) is connected to the transmission belt motor (5). The multifunctional blending and adsorption structure (3) includes a stirring output module (32), a second dynamic guide module (33), and a second driven push module (41). The stirring output module (32) includes a second motor (34), a stirring plate (35), and stirring blades (36). The top of the auxiliary positioning frame (31) is fixedly connected to the second motor (34) by screws. The output end of the second motor (34) is fixedly connected to the stirring plate (35). The stirring plate (35) is rotatably connected to the inner side of the mounting plate (30). Multiple stirring blades (36) are fixed on the outer side of the stirring plate (35). The bottom end of the mounting plate (30) is provided with the second dynamic guide module (33). The four ends of the bottom end of the second dynamic guide module (33) are all provided with the second driven push module (41). The second driven push module (41) includes a positioning guide frame (45), a second linkage displacement block (46), a driven pulley (47), a second transmission belt (48), an insertion fitting block (49), a first fitting hole (50), a second fitting hole (51), an adsorption plate (52), and a pin (53). The four ends of the lower surface of the inner mounting ring (37) are fixedly connected to the positioning guide frame (45). The bottom end of the positioning guide frame (45) away from the driving pulley (43) is rotatably connected to the driven pulley (47). The driven pulley (47) and the driving pulley (43) are sleeved with a second transmission belt (48). The outer side of the second transmission belt (48) is fixedly connected to the second linkage displacement block (46). The top of the second linkage displacement block (46) is slidably connected to the positioning guide frame (45). The inner side of the second linkage displacement block (46) is provided with a first fitting hole (50). An insertion fitting block (49) is inserted into the inner side of the second linkage displacement block (46). An adsorption plate (52) is fixedly connected to the bottom end of the insertion fitting block (49). The inner side of the insertion fitting block (49) is provided with a second fitting hole (51). The second fitting hole (51) is the same size as the first fitting hole (50). Pins (53) are inserted into the inner side of the first fitting hole (50) and the inner side of the second fitting hole (51). A third gear (42) is fixedly connected to the bottom end of the insertion fitting block (49).

2. The production apparatus for disodium pyrroloquinoline quinone according to claim 1, characterized in that: The placement groove (8) and the conductive plate (9) are both made of copper.

3. The production apparatus for disodium pyrroloquinoline quinone according to claim 1, characterized in that: The preparation height adjustment structure (2) includes a support positioning frame (11), a first dynamic guide module (12) and a first driven push module (13). The top of the multi-functional feeding platform structure (1) is fixedly connected to the support positioning frame (11), the top of the support positioning frame (11) is fixedly connected to the preparation height adjustment structure (2), and the first driven push module (13) is fixedly connected to both sides of the first dynamic guide module (12).

4. The production apparatus for disodium pyrroloquinoline quinone according to claim 3, characterized in that: The first drive module (12) includes an inner frame (14), an extension mounting plate (15), a first motor (16), a drive gear shaft (17), a first bevel gear (18), a first transmission gear ring (19), a driven gear shaft (20), and a second bevel gear (21). The two ends of the inner frame (14) are fixedly connected to the extension mounting plate (15). The top end of the extension mounting plate (15) at one end is fixedly connected to the first motor (16) by screws. The output end of the first motor (16) is fixedly connected to the drive gear shaft. (17) The bottom end of the drive gear shaft (17) is fixedly connected to a first bevel gear (18), and the inner side of the other extended mounting plate (15) is rotatably connected to a driven gear shaft (20). The bottom end of the driven gear shaft (20) is fixedly connected to a second bevel gear (21). The inner side of the inner frame (14) is fixedly connected to a core column, and the outer side of the core column is rotatably connected to a first transmission gear ring (19). The two ends of the first transmission gear ring (19) are respectively meshed with the drive gear shaft (17) and the driven gear shaft (20).

5. The production apparatus for disodium pyrroloquinoline quinone according to claim 4, characterized in that: The first driven push module (13) includes an extension positioning frame (22), a linkage shaft (23), a third bevel gear (24), a first gear (25), a second gear (26), a threaded rod (27), a first linkage displacement block (28), a folding push rod (29), a mounting plate (30), and an auxiliary positioning frame (31). One end of the extension mounting plate (15) is fixedly connected to the extension positioning frame (22). The inner side of the bottom end of the extension positioning frame (22) is rotatably connected to the threaded rod (27). One end of the threaded rod (27) is fixedly connected to the second gear (26). The inner side of the extension positioning frame (22) is rotatably connected to the linkage shaft (23). One end of the linkage shaft (23) is fixedly connected to the third bevel gear (24). The other end of the linkage shaft (23) is fixedly connected to a first gear (25). The top end of the first gear (25) is meshed with the second bevel gear (21) and the first bevel gear (18). The bottom end of the third bevel gear (24) is meshed with the second gear (26). The outer side of the threaded rod (27) is connected to a first linkage displacement block (28) by a thread. The first linkage displacement block (28) is slidably connected to the bottom end of the extension positioning frame (22). The bottom end of the first linkage displacement block (28) is rotatably connected to a folding push rod (29). The bottom end of the folding push rod (29) is rotatably connected to a mounting plate (30). The upper surface of the mounting plate (30) is fixedly connected to an auxiliary positioning frame (31).

6. The production apparatus for disodium pyrroloquinoline quinone according to claim 5, characterized in that: The second dynamic guide module (33) includes an inner mounting ring (37), a third motor (38), an extension positioning plate (39), a transmission shaft (40), a third gear (42), a drive pulley (43), and a second transmission gear ring (44). The bottom end of the mounting plate (30) is fixedly connected to the inner mounting ring (37), and the top end of the mounting plate (30) is fixedly connected to the third motor (38) by screws. The top end of the inner side of the inner mounting ring (37) is fixedly connected to four extension positioning plates (39). The bottom end of the inner side of the inner mounting ring (37) is movably connected to the second transmission gear ring (44). The inner side of the extension positioning plate (39) is rotatably connected to the transmission shaft (40). The outer side of the transmission shaft (40) is fixedly connected from top to bottom to the third gear (42) and the drive pulley (43). The output end of the third motor (38) is fixedly connected to one of the transmission shafts (40), and the outer side of the third gear (42) is meshed with the second transmission gear ring (44).

7. The production apparatus for disodium pyrroloquinoline quinone according to claim 1, characterized in that: Nuts (54) are threadedly connected to both sides of the pin (53).

8. A process for producing disodium pyrroloquinoline quinone, used in the production apparatus for disodium pyrroloquinoline quinone as described in any one of claims 1-7, characterized in that: S1: Dissolve any one of the culture medium components (NH4)2SO4, KH2PO4, MgSO4・7H2O and Na2SO4 in water, place in a fermenter, adjust the pH value, sterilize and disinfect for later use; S2: Under a certain positive pressure, inoculate the raw silk microbial strain or seed culture into the production culture medium, and culture at 30 degrees Celsius. During the fermentation process, add methanol as feed and use ammonia water to control a certain pH value. S3: Adjust the aeration flow and stirring to maintain dissolved oxygen at no less than 10% throughout the fermentation process; S4: After fermentation is completed, the fermentation tank is transferred to the work station through the multi-functional feeding platform structure (1). At this time, the corresponding adsorption plate (52) is not installed. The stirring output module (32) is inserted into the fermentation liquid in conjunction with the preparation height adjustment structure (2) to reduce the temperature of the fermentation liquid to below 15 degrees Celsius and to continuously maintain stirring and ventilation. S5: After cooling, the fermentation broth is centrifuged at high speed or filtered through ceramic membrane microfiltration, and the filtrate is collected. S6: Sequentially perform acid precipitation, primary salting out, salting out resolution, cross-linking chromatography, secondary salting out, and crystallization drying; S7: When adsorption filtration is required in the S6 process, a height adjustment structure (2) is used to drive adsorption plates (52) of different materials into the production liquid for adsorption filtration application.

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