抗除草剂基因的产生及其用途
By using base editing technology to target and edit herbicide resistance-related genes in the plant genome, the shortcomings of traditional breeding and transgenic methods have been overcome. This enables the efficient and convenient introduction of multiple herbicide resistances into plants, avoiding the inefficiency and high cost of traditional methods.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- INST OF GENETICS & DEVELOPMENTAL BIOLOGY CHINESE ACAD OF SCI
- Filing Date
- 2018-05-11
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies make it difficult to efficiently and cost-effectively introduce herbicide resistance genes into plants. In particular, traditional breeding methods have a low probability of generating multi-site mutations and may introduce linked undesirable mutations. Transgenic technology can only introduce known genes and cannot meet the diverse needs for herbicide resistance.
Using base editing technology, a fusion protein of nuclease-inactivated Cas9 and deaminase is used to target and edit herbicide resistance-related genes in the plant genome. Herbicide resistance is achieved through C-to-T base substitution, including mutations in genes such as ALS, PsbA, EPSPS, and ACCase.
It enables the efficient and convenient introduction of herbicide resistance into plants, avoiding the inefficiency and high cost of traditional methods. It can create single, double, or multiple mutations in plants in situ, conferring resistance to a variety of herbicides.
Smart Images
Figure SMS_1 
Figure SMS_2 
Figure SMS_3