一种基于核酸纳米结构的基因递送系统及其制备方法和应用
The gene delivery system, which utilizes the self-assembly of nucleic acid nanostructures and modification with lipid molecules, solves the delivery efficiency and safety issues of existing vectors, achieving highly efficient targeted delivery and low-toxicity gene therapy effects.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
- Filing Date
- 2022-12-22
- Publication Date
- 2026-07-17
AI Technical Summary
Existing gene delivery vectors, such as viral vectors, have limited delivery efficiency and pose risks of immune reactions, while non-viral vectors, such as polymers, liposomes, and inorganic nanoparticles, have systemic toxicity and immunogenicity, which limits their widespread application. Furthermore, nucleic acid delivery strategies are difficult to achieve precise loading and targeted delivery.
A gene delivery system formed by the self-assembly of nucleic acid nanostructures through complementary base pairing, combined with lipid molecule modification, achieves targeted delivery of double-stranded nucleic acids, improving delivery efficiency and reducing the risk of immune response.
It achieves efficient targeted delivery of double-stranded nucleic acids, improves gene expression, has good biocompatibility and low toxicity, and is suitable for various biological disease models.
Smart Images
Figure CN115927480B_ABST