一种PPI多肽抑制剂及其应用
By targeting the Keap1-Nrf2 complex with a PPI peptide inhibitor, the Nrf2-Keap1 dimer is disrupted and Nrf2 is activated, thus solving the skin aging problem caused by ultraviolet radiation and achieving effective antioxidant and anti-photoaging effects.
CN115947784BActive Publication Date: 2026-07-17GERMPLASM INNOVATION GRAND SCIENCE CENTER OF WESTERN CHINA (CHONGQING) SCIENCE CITY
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- GERMPLASM INNOVATION GRAND SCIENCE CENTER OF WESTERN CHINA (CHONGQING) SCIENCE CITY
- Filing Date
- 2023-01-10
- Publication Date
- 2026-07-17
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Figure CN115947784B_ABST
Abstract
本发明公开了一种PPI多肽抑制剂及其应用，属于分子生物学和医药技术领域，所述PPI多肽抑制剂含有ETGE活性基序，所述PPI多肽抑制剂的C端酰胺化，所述PPI多肽抑制剂的氨基酸序列为：GDGETGEKY或GDAETGELL或GDKETGEWL，在4～64μM的浓度处理下，能消除紫外线诱导对细胞产生的损伤，极大保护了细胞免受光毒性，可用于制备抗光老化产品或药物抵御紫外线辐射。
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