A medicinal dressing fixation bandage and its preparation method

Abstract

This application relates to the field of medical dressing technology, specifically disclosing a medicated dressing fixation band and its preparation method. The medicated dressing fixation band of this application consists of an adhesive layer and a fixation band; one end of the fixation band is connected and fixed to the side of the adhesive layer; the adhesive layer, from bottom to top, includes a waterproof and breathable layer, a sterile cotton pad layer, and a dressing bag; the dressing bag is made of a composite membrane; the composite membrane includes a permeable membrane and an antibacterial membrane; the medicated dressing fixation band of this application can accelerate drug penetration and has a high antibacterial rate. The medicated dressing fixation band of this application can be used to prepare medicated plasters for treating arthritis. By filling the dressing bag with a drug prepared from raw materials such as *Saussurea involucrata*, dried ginger, *Scorpion*, frankincense, myrrh, borneol, and ethanol, the resulting medicated plaster has a significant therapeutic effect on arthritis.

Description

Technical Field

[0001] This application relates to the field of medical dressing technology, and more specifically, to a medicated dressing fixation bandage and its preparation method. Background Technology

[0002] Intravenous injection is a common treatment method, but due to individual differences, some patients may experience swelling and pain in the subcutaneous tissue due to medication entering the surrounding tissues at the injection site, drug exudation or extravasation, or factors such as movement at the injection site or fragile blood vessels. In addition to swelling, the wound may also develop lumps and inflammation. Clinically, from the perspective of efficacy and cost-effectiveness, self-adhesive medical dressings applied to the affected area can effectively treat trauma, eliminate bruising, reduce swelling and pain, demonstrating significant efficacy. Moreover, self-adhesive medical dressings can be directly applied without the need for fixation bandages, making them convenient and favored by most medical professionals and patients.

[0003] Currently, the drug components in self-adhesive medical dressings generally penetrate the skin through diffusion, resulting in a slow treatment process. Prolonged application to the affected area can lead to skin rashes and poor antibacterial effects. Therefore, there is an urgent need to develop a medicated dressing fixation bandage and its preparation method to solve the problems of poor drug penetration and low antibacterial rate of existing medicated dressing fixation bandages, and effectively alleviate patients' pain. Summary of the Invention

[0004] To address the issues of poor drug penetration and low antibacterial rate in existing medicated dressing fixation strips, this application provides a medicated dressing fixation strip and its preparation method.

[0005] In a first aspect, this application provides a medicinal dressing fixation bandage, which adopts the following technical solution:

[0006] A medicinal dressing fixation bandage is composed of an adhesive layer and a fixation band; one end of the fixation bandage is connected and fixed to the side of the adhesive layer; the adhesive layer includes, from bottom to top, a waterproof and breathable layer, a sterile cotton pad layer, and a dressing bag.

[0007] The dressing bag is made of a composite membrane; the composite membrane includes a permeable membrane and an antibacterial membrane.

[0008] The permeation membrane comprises the following raw materials in parts by weight: 25-30 parts polylactic acid, 10-20 parts polycaprolactone, 4-8 parts carbon nanotubes, 2-6 parts bamboo charcoal powder, 2-4 parts β-cyclodextrin, 1-4 parts trioctyl phosphate, 2-3 parts silicone powder, 6-8 parts polyethyleneimine, 100-200 parts water, and 120-160 parts ethyl acetate.

[0009] By adopting the above technical solution, the medicated dressing fixation tape of this application consists of an attachment layer and a fixation tape. The attachment layer includes a waterproof and breathable layer, a sterile cotton pad layer, and a dressing bag. The structure is simple and the design is reasonable. It can not only achieve direct drug application and antibacterial effect on the wound, but also ensure close contact with the body to prevent the wound from being infected by the outside world. The overall effect is excellent and the application is convenient and effective.

[0010] In addition, the dressing bag is made of a composite membrane, which includes a permeable membrane and an antibacterial membrane. The permeable membrane is made of raw materials such as polylactic acid, polycaprolactone, carbon nanotubes, bamboo charcoal powder, β-cyclodextrin, trioctyl phosphate, silicone powder, and polyethyleneimine. The resulting permeable membrane is a high-performance microporous membrane that can improve drug permeation and thus solve the problem of slow drug penetration.

[0011] Preferably, the permeation membrane is prepared by the following method:

[0012] S11. Polylactic acid, polycaprolactone, carbon nanotubes, bamboo charcoal powder, β-cyclodextrin, trioctyl phosphate, and silicone powder are added to ethyl acetate and dissolved completely to obtain a mixture. The mixture is then allowed to stand to remove bubbles and cast into a film to obtain a substrate film.

[0013] S12. The substrate membrane obtained in step S11 is subjected to biaxial stretching to obtain a microporous membrane.

[0014] S13. Mix polyethyleneimine with water, add the microporous membrane obtained in step S12 for amination, remove, dry, and obtain a permeable membrane.

[0015] Preferably, the specific operation of the biaxial stretching is as follows: the base film is first stretched longitudinally at a stretching ratio of 1-5 times and a temperature of 70-90℃, and then stretched transversely at a stretching ratio of 1-5 times and a temperature of 80-100℃.

[0016] By adopting the above technical solution, this application uses polylactic acid and polycaprolactone as the main materials, both of which are good biodegradable materials and have sustained-release function. Carbon nanotubes, bamboo charcoal powder, and β-cyclodextrin are also added, giving the permeate membrane a rich microporous structure. Additionally, trioctyl phosphate and silicone powder are added to improve the mechanical properties of the permeate membrane. After the mixture is cast into a film using a casting process, it undergoes biaxial stretching to obtain a microporous membrane. Subsequently, the microporous membrane is amination, resulting in a large number of active groups on the surface of the microporous membrane, which facilitates the chemical bonding between the permeate membrane and the antibacterial membrane. In the process of preparing the permeate membrane, this application controls various process parameters, effectively improving the overall performance of the permeate membrane.

[0017] Preferably, the composite membrane comprises the following raw materials in parts by weight: 20-30 parts chitosan, 4-8 parts aloe vera extract, 1-2 parts calendula oil, 200-400 parts citric acid solution, 20-30 parts dispersion, 30-40 parts permeable membrane, and 100-200 parts treatment solution.

[0018] Preferably, the composite membrane is prepared by the following method:

[0019] S21. Chitosan is dissolved in a 5 wt% citric acid solution, and aloe vera extract and calendula oil are added to obtain an electrospinning solution.

[0020] S22. Using electrospinning process, with a permeable membrane as the receiving plate, and applying atomized dispersion liquid during the spinning process, the electrospinning liquid obtained in step S21 forms an antibacterial membrane on the surface of the permeable membrane, thus obtaining a permeable membrane with an antibacterial membrane on the surface.

[0021] S23. The permeable membrane with an antibacterial film on its surface obtained in step S22 is immersed in the treatment solution, ultrasonically treated for a period of time, then removed and dried to obtain a composite membrane.

[0022] Preferably, the electrospinning process parameters are as follows: electrospinning liquid feed rate is 20-60 mL / min; spinning voltage is 10-30 kV; wire splicing distance is 26-30 cm; receiving plate temperature is 40-60 °C; and atomization speed is 10-50 mL / min.

[0023] Preferably, the conditions for the ultrasonic treatment are: ultrasonic frequency of 30-40KHz, temperature of 65-75℃, and time of 1-2h.

[0024] Preferably, the treatment solution is obtained by mixing glutaraldehyde, sodium borohydride and water in a mass ratio of 3-6:4-9:50.

[0025] By adopting the above technical solution, the antibacterial membrane of this application uses chitosan as the main material and adds aloe vera extract and calendula oil, which improves the antibacterial effect of the membrane and also has anti-inflammatory effects. Using an electrospinning process, a fine-pore structure is formed on the surface of the permeable membrane. Simultaneously, an atomized dispersion is applied during the spinning process, ensuring a uniform distribution of electret on the surface of the antibacterial membrane, further improving its antibacterial performance. It also accelerates the fluidity of skin lipids, facilitating transdermal drug delivery and enhancing the therapeutic effect. Furthermore, after the permeable membrane covered with the antibacterial membrane is soaked in a treatment solution, a cross-linking reaction occurs between the antibacterial membrane and the permeable membrane, forming a more structurally stable composite membrane. In the preparation of the composite membrane, this application controls each process parameter within a certain range, further optimizing the overall performance of the composite membrane.

[0026] Preferably, the dispersion is prepared by the following method:

[0027] By weight, 6-10 parts of nano-hydroxyapatite, 4-8 parts of nano-silica, and 0.5-1 parts of sophorolipid are added to 20-30 parts of water, dispersed evenly, and then treated with plasma to obtain a dispersion.

[0028] By adopting the above technical solution, this application uses nano-hydroxyapatite and nano-silica as electrets, dispersed by sophorolipids, and treated with plasma to form a dispersion with excellent biocompatibility and bioactivity. The nano-hydroxyapatite and nano-silica work synergistically to not only improve the antibacterial rate of the antibacterial film, but also facilitate drug absorption.

[0029] Secondly, this application provides a method for preparing a pharmaceutical dressing fixation bandage, which adopts the following technical solution:

[0030] A method for preparing a medicinal dressing fixation bandage includes the following steps:

[0031] S1. Cut the composite membrane into two pieces of equal size, with the antibacterial membrane as the outer layer and the permeable membrane as the inner layer, align and sew them together to form a dressing bag;

[0032] S2. Adhere the dressing bag, sterile cotton pad, and waterproof and breathable layer obtained in step S1 in sequence to form an adhesive layer;

[0033] S3. Adhere and fix the fixing tape to the upper and lower ends of the left and right sides of the adhesive layer obtained in step S2 to obtain the medicinal dressing fixing tape.

[0034] By adopting the above technical solution, the preparation method of the pharmaceutical dressing fixation tape of this application is simple in steps, low in cost, and suitable for industrial production. The obtained pharmaceutical dressing fixation tape has better overall performance and has broad market prospects.

[0035] Thirdly, this application provides an application of a medical dressing fixation bandage, employing the following technical solution:

[0036] An application of a medicinal dressing fixation tape, wherein the prepared medicinal dressing fixation tape is used to prepare a plaster for treating arthritis.

[0037] Preferably, the medicated plaster for treating arthritis is prepared by the following method:

[0038] The medicine is placed into the dressing bag of the medicated dressing fixing strap, sewn closed, sterilized by Co60 irradiation, and then placed into a composite aluminum bag to obtain a plaster for treating arthritis.

[0039] Preferably, the drug is prepared by the following method:

[0040] Mix 3-4 parts of Artemisia argyi, 1-2 parts of dried ginger, 2-3 parts of Scorpion, 0.5-1.5 parts of frankincense, 1-2 parts of myrrh, and 0.1-0.8 parts of borneol according to the weight ratio, grind them to obtain powder; then disperse the powder in 10-15 parts of ethanol to obtain the drug.

[0041] By adopting the above technical solution, the medicated dressing fixation bandage of this application can be used to prepare medicated plasters for treating arthritis. The medicine for treating arthritis is prepared by using Saussurea involucrata, dried ginger, Scorpion, frankincense, myrrh, borneol, and ethanol as raw materials. The medicine is put into a dressing bag and sterilized to obtain the medicated plaster for treating arthritis. The medicated plaster of this application has a significant therapeutic effect on arthritis.

[0042] In summary, this application has the following beneficial effects:

[0043] 1. The pharmaceutical dressing fixation tape of this application consists of an adhesive layer and a fixation tape; the adhesive layer includes, from bottom to top, a waterproof and breathable layer, a sterile cotton pad, and a dressing bag; the dressing bag is made of a composite membrane; the composite membrane includes a permeable membrane and an antibacterial membrane, and the permeable membrane and the antibacterial membrane are connected by chemical bonds; the pharmaceutical dressing fixation tape of this application can not only improve the penetration of drugs, but also has excellent antibacterial properties.

[0044] 2. The preparation method of the medicated dressing fixation bandage of this application is simple, low in cost, and suitable for industrial production; at the same time, the medicated dressing fixation bandage obtained by this application can be used to prepare medicated plasters for treating arthritis, and the medicated plasters have a significant therapeutic effect on arthritis. Detailed Implementation

[0045] The present application will be further described in detail below with reference to the embodiments.

[0046] Preparation Examples 1-5 and Comparative Preparation Examples 1-5 provide permeable membranes and their preparation methods.

[0047] Preparation Example 1

[0048] The permeable membrane comprises the following raw materials: 250g polylactic acid, 100g polycaprolactone, 40g carbon nanotubes, 20g bamboo charcoal powder, 20g β-cyclodextrin, 10g trioctyl phosphate, 20g silicone powder, 60g polyethyleneimine, 1000g water, and 1200g ethyl acetate.

[0049] The permeable membrane is prepared by the following method:

[0050] S11. Polylactic acid, polycaprolactone, carbon nanotubes, bamboo charcoal powder, β-cyclodextrin, trioctyl phosphate, and silicone powder are added to ethyl acetate and dissolved at 50°C and a rotation speed of 800 r / min for 25 min to obtain a mixture. Then, the mixture is allowed to stand for degassing for 10 min, and then cast into a film. The casting machine has a traction speed of 3 m / min and a forming thickness of 10 μm to obtain a base film.

[0051] S12. The substrate membrane obtained in step S11 is first stretched longitudinally at a stretching ratio of 1 and a temperature of 70°C, and then stretched laterally at a stretching ratio of 1 and a temperature of 80°C to obtain a microporous membrane.

[0052] S13. Mix polyethyleneimine with water and add the microporous membrane obtained in step S12. Amination is carried out at 60°C for 2 hours. The mixture is then removed and dried at 80°C for 30 minutes to obtain a permeable membrane.

[0053] Preparation Example 2

[0054] The permeable membrane comprises the following raw materials: 260g polylactic acid, 120g polycaprolactone, 50g carbon nanotubes, 30g bamboo charcoal powder, 25g β-cyclodextrin, 1.5g trioctyl phosphate, 22g silicone powder, 65g polyethyleneimine, 1250g water, and 1300g ethyl acetate.

[0055] The permeable membrane is prepared by the following method:

[0056] S11. Polylactic acid, polycaprolactone, carbon nanotubes, bamboo charcoal powder, β-cyclodextrin, trioctyl phosphate, and silicone powder are added to ethyl acetate and dissolved at 52°C and a rotation speed of 800 r / min for 26 min to obtain a mixture. The mixture is then allowed to stand for 12 min to degas, and then cast into a film. The casting machine has a traction speed of 4 m / min and a forming thickness of 15 μm to obtain a base film.

[0057] S12. The substrate membrane obtained in step S11 is first stretched longitudinally at a stretching ratio of 2 and a temperature of 75°C, and then stretched laterally at a stretching ratio of 2 and a temperature of 85°C to obtain a microporous membrane.

[0058] S13. Mix polyethyleneimine with water and add the microporous membrane obtained in step S12. Amination is carried out at 65°C for 1.8 hours. The mixture is then removed and dried at 80°C for 35 minutes to obtain a permeable membrane.

[0059] Preparation Example 3

[0060] The permeable membrane comprises the following raw materials: 280g polylactic acid, 150g polycaprolactone, 60g carbon nanotubes, 40g bamboo charcoal powder, 30g β-cyclodextrin, 20g trioctyl phosphate, 25g silicone powder, 70g polyethyleneimine, 1500g water, and 1400g ethyl acetate.

[0061] The permeable membrane is prepared by the following method:

[0062] S11. Polylactic acid, polycaprolactone, carbon nanotubes, bamboo charcoal powder, β-cyclodextrin, trioctyl phosphate, and silicone powder are added to ethyl acetate and dissolved at 55°C and a rotation speed of 800 r / min for 28 min to obtain a mixture. Then, the mixture is allowed to stand for degassing for 15 min, and then cast into a film with a casting machine traction speed of 5 m / min and a forming thickness of 20 μm to obtain a base film.

[0063] S12. The substrate membrane obtained in step S11 is first stretched longitudinally at a stretching ratio of 3 times and a temperature of 80°C, and then stretched laterally at a stretching ratio of 3 times and a temperature of 90°C to obtain a microporous membrane.

[0064] S13. Mix polyethyleneimine with water and add the microporous membrane obtained in step S12. Amination is carried out at 70°C for 1.5 hours. The mixture is then removed and dried at 80°C for 40 minutes to obtain a permeable membrane.

[0065] Preparation Example 4

[0066] The permeable membrane comprises the following raw materials: 290g polylactic acid, 180g polycaprolactone, 70g carbon nanotubes, 50g bamboo charcoal powder, 35g β-cyclodextrin, 30g trioctyl phosphate, 28g silicone powder, 75g polyethyleneimine, 1750g water, and 1500g ethyl acetate.

[0067] The permeable membrane is prepared by the following method:

[0068] S11. Polylactic acid, polycaprolactone, carbon nanotubes, bamboo charcoal powder, β-cyclodextrin, trioctyl phosphate, and silicone powder are added to ethyl acetate and dissolved at 58°C and a rotation speed of 800 r / min for 28 min to obtain a mixture. The mixture is then allowed to stand for degassing for 18 min, and then cast into a film. The casting machine has a traction speed of 6 / min and a forming thickness of 30 μm to obtain a base film.

[0069] S12. The substrate membrane obtained in step S11 is first stretched longitudinally at a stretching ratio of 4 times and a temperature of 85°C, and then stretched laterally at a stretching ratio of 4 times and a temperature of 95°C to obtain a microporous membrane.

[0070] S13. Mix polyethyleneimine with water and add the microporous membrane obtained in step S12. Amination is carried out at 75°C for 1.2 hours. The mixture is then removed and dried at 80°C for 45 minutes to obtain a permeable membrane.

[0071] Preparation Example 5

[0072] The permeable membrane comprises the following raw materials: 300g polylactic acid, 200g polycaprolactone, 80g carbon nanotubes, 60g bamboo charcoal powder, 40g β-cyclodextrin, 40g trioctyl phosphate, 30g silicone powder, 80g polyethyleneimine, 2000g water, and 1600g ethyl acetate.

[0073] The permeable membrane is prepared by the following method:

[0074] S11. Polylactic acid, polycaprolactone, carbon nanotubes, bamboo charcoal powder, β-cyclodextrin, trioctyl phosphate, and silicone powder are added to ethyl acetate and dissolved at 60°C and 800 r / min for 30 min to obtain a mixture. The mixture is then allowed to stand for 20 min to degas, and then cast into a film. The casting machine has a traction speed of 7 m / min and a forming thickness of 40 μm to obtain a base film.

[0075] S12. The substrate membrane obtained in step S11 is first stretched longitudinally at a stretching ratio of 5 times and a temperature of 90°C, and then stretched laterally at a stretching ratio of 5 times and a temperature of 100°C to obtain a microporous membrane.

[0076] S13. Mix polyethyleneimine with water and add the microporous membrane obtained in step S12. Amination is carried out at 80°C for 1 hour. The membrane is then removed and dried at 80°C for 50 minutes to obtain a permeable membrane.

[0077] Comparative Preparation Example 1

[0078] Compared with Preparation Example 1, the only difference is that no carbon nanotubes are added.

[0079] Comparative Preparation Example 2

[0080] Preparation Example 2 is the same as Preparation Example 1, except that bamboo charcoal powder is not added.

[0081] Comparative preparation example 3

[0082] Preparation Example 3 is the same as Preparation Example 1, except that β-cyclodextrin is not added.

[0083] Comparative preparation example 4

[0084] In comparison with preparation example 4, the only difference from preparation example 1 is that the substrate membrane was longitudinally stretched at a stretch ratio of 2 times and a temperature of 75°C to obtain a microporous membrane.

[0085] Comparative preparation example 5

[0086] Comparative preparation example 5 is the same as preparation example 1, except that the substrate membrane is stretched laterally at a stretch ratio of 2 times and a temperature of 85°C to obtain a microporous membrane.

[0087] Preparations 6-10 and comparative preparations 6 and 7 provide methods for preparing dispersions.

[0088] Preparation Example 6

[0089] 60g of nano-hydroxyapatite, 40g of nano-silica, and 5g of sophorolipid were added to 200g of water and dispersed evenly. Then, the mixture was treated with plasma hydrogen at 40℃ for 30min to obtain a dispersion.

[0090] Preparation Example 7

[0091] 70g of nano-hydroxyapatite, 50g of nano-silica, and 6g of sophorolipid were added to 220g of water and dispersed evenly. Then, the mixture was treated with plasma hydrogen at 45℃ for 25min to obtain a dispersion.

[0092] Preparation Example 8

[0093] 80g of nano-hydroxyapatite, 60g of nano-silica, and 7g of sophorolipid were added to 250g of water and dispersed evenly. Then, the mixture was treated with plasma hydrogen at 50℃ for 20min to obtain a dispersion.

[0094] Preparation Example 9

[0095] 90g of nano-hydroxyapatite, 70g of nano-silica, and 8g of sophorolipid were added to 280g of water and dispersed evenly. Then, the mixture was treated with plasma hydrogen at a temperature of 40-60℃ for 15 minutes to obtain a dispersion.

[0096] Preparation Example 10

[0097] 100g of nano-hydroxyapatite, 80g of nano-silica, and 10g of sophorolipid were added to 300g of water and dispersed evenly. Then, the mixture was treated with plasma hydrogen at 60℃ for 10min to obtain a dispersion.

[0098] Comparative preparation example 6

[0099] Comparative preparation example 6 is the same as preparation example 1, except that nano-hydroxyapatite of equal mass is used instead of nano-silica.

[0100] Comparative preparation example 7

[0101] Comparative preparation example 7 is the same as preparation example 1, except that nano-hydroxyapatite is replaced with an equal mass of nano-silica.

[0102] Preparation Examples 11-15 and Comparative Preparation Examples 8-16 provide composite membranes and their preparation methods.

[0103] Preparation Example 11

[0104] The composite membrane comprises the following raw materials: 200g chitosan, 40g aloe vera extract, 10g calendula oil, 2000g citric acid solution, 200g dispersion, 300g permeable membrane, and 1000g treatment solution.

[0105] The dispersion was prepared in Preparation Example 6; the permeation membrane was prepared in Preparation Example 1; and the treatment solution was prepared by mixing glutaraldehyde, sodium borohydride and water in a mass ratio of 3:4:50.

[0106] The composite membrane is prepared by the following method:

[0107] S21. Dissolve chitosan in a 5 wt% citric acid solution, add aloe vera extract and calendula oil, and stir at 1100 r / min for 50 min to obtain an electrospinning solution.

[0108] S22. Using electrospinning process, with a permeable membrane as the receiving plate, and applying atomized dispersion during the spinning process, an antibacterial membrane is formed on the surface of the permeable membrane, resulting in a permeable membrane with an antibacterial membrane on the surface.

[0109] The electrospinning liquid feeding rate was 20 mL / min; the spinning voltage was 10 kV; the wire splicing distance was 26 cm; the receiving plate temperature was 40 ℃; and the atomization rate was 10 mL / min.

[0110] S23. The permeable membrane with an antibacterial film on its surface obtained in step S22 is immersed in a treatment solution and treated with an ultrasonic frequency of 30KHz and a temperature of 65℃ for 1 hour. After treatment, it is taken out and dried at 80℃ for 2 hours to form a composite membrane.

[0111] Preparation Example 12

[0112] The composite membrane comprises the following raw materials: 220g chitosan, 50g aloe vera extract, 12g calendula oil, 2500g citric acid solution, 220g dispersion, 320g permeable membrane, and 1200g treatment solution.

[0113] The dispersion was prepared in Preparation Example 7; the permeation membrane was prepared in Preparation Example 2; and the treatment solution was prepared by mixing glutaraldehyde, sodium borohydride and water in a mass ratio of 4:5:50.

[0114] The composite membrane is prepared by the following method:

[0115] S21. Dissolve chitosan in a 5 wt% citric acid solution, add aloe vera extract and calendula oil, and stir at 1200 r / min for 45 min to obtain an electrospinning solution.

[0116] S22. Using electrospinning process, with a permeable membrane as the receiving plate, and applying atomized dispersion during the spinning process, an antibacterial membrane is formed on the surface of the permeable membrane, resulting in a permeable membrane with an antibacterial membrane on the surface.

[0117] The electrospinning liquid feed rate was 3 mL / min; the spinning voltage was 15 kV; the wire splicing distance was 27 cm; the receiving plate temperature was 45 ℃; and the atomization rate was 20 mL / min.

[0118] S23. The permeable membrane with an antibacterial film on its surface obtained in step S22 is immersed in a treatment solution and treated with an ultrasonic frequency of 32KHz and a temperature of 68℃ for 1.8h. After treatment, it is taken out and dried at 82℃ for 1.8h to form a composite membrane.

[0119] Preparation Example 13

[0120] The composite membrane comprises the following raw materials: 250g chitosan, 60g aloe vera extract, 15g calendula oil, 3000g citric acid solution, 250g dispersion, 350g permeable membrane, and 1500g treatment solution.

[0121] The dispersion was prepared in Preparation Example 8; the permeation membrane was prepared in Preparation Example 3; and the treatment solution was prepared by mixing glutaraldehyde, sodium borohydride and water in a mass ratio of 4.5:7:50.

[0122] The composite membrane is prepared by the following method:

[0123] S21. Dissolve chitosan in a 5 wt% citric acid solution, add aloe vera extract and calendula oil, and stir at 1300 r / min for 40 min to obtain an electrospinning solution.

[0124] S22. Using electrospinning process, with a permeable membrane as the receiving plate, and applying atomized dispersion during the spinning process, an antibacterial membrane is formed on the surface of the permeable membrane, resulting in a permeable membrane with an antibacterial membrane on the surface.

[0125] The electrospinning liquid feed rate was 40 mL / min; the spinning voltage was 20 kV; the wire splicing distance was 28 cm; the receiving plate temperature was 50 ℃; and the atomization rate was 30 mL / min.

[0126] S23. The permeable membrane with an antibacterial film on its surface obtained in step S22 is immersed in a treatment solution and treated for 1.5 hours at an ultrasonic frequency of 38KHz and a temperature of 70℃. After treatment, it is taken out and dried at 85℃ for 1.5 hours to form a composite membrane.

[0127] Preparation Example 14

[0128] The composite membrane comprises the following raw materials: 280g chitosan, 70g aloe vera extract, 18g calendula oil, 3500g citric acid solution, 280g dispersion, 380g permeable membrane, and 1800g treatment solution.

[0129] The dispersion was prepared in Preparation Example 9; the permeation membrane was prepared in Preparation Example 4; and the treatment solution was prepared by mixing glutaraldehyde, sodium borohydride and water in a mass ratio of 5:8:50.

[0130] The composite membrane is prepared by the following method:

[0131] S21. Dissolve chitosan in a 5 wt% citric acid solution, add aloe vera extract and calendula oil, and stir at 1400 r / min for 35 min to obtain an electrospinning solution.

[0132] S22. Using electrospinning process, with a permeable membrane as the receiving plate, and applying atomized dispersion during the spinning process, an antibacterial membrane is formed on the surface of the permeable membrane, resulting in a permeable membrane with an antibacterial membrane on the surface.

[0133] The electrospinning liquid feed rate was 50 mL / min; the spinning voltage was 25 kV; the wire splicing distance was 29 cm; the receiving plate temperature was 55 ℃; and the atomization rate was 40 mL / min.

[0134] S23. The permeable membrane with an antibacterial film on its surface obtained in step S22 is immersed in a treatment solution and treated with an ultrasonic frequency of 38KHz and a temperature of 72℃ for 1.2h. After treatment, it is taken out and dried at 88℃ for 1.2h to form a composite membrane.

[0135] Preparation Example 15

[0136] The composite membrane comprises the following raw materials: 300g chitosan, 80g aloe vera extract, 20g calendula oil, 4000g citric acid solution, 300g dispersion, 400g permeable membrane, and 2000g treatment solution.

[0137] The dispersion was prepared in Preparation Example 10; the permeation membrane was prepared in Preparation Example 5; and the treatment solution was prepared by mixing glutaraldehyde, sodium borohydride and water in a mass ratio of 6:9:50.

[0138] The composite membrane is prepared by the following method:

[0139] S21. Dissolve chitosan in a 5 wt% citric acid solution, add aloe vera extract and calendula oil, and stir at 1500 r / min for 30 min to obtain an electrospinning solution.

[0140] S22. Using electrospinning process, with a permeable membrane as the receiving plate, and applying atomized dispersion during the spinning process, an antibacterial membrane is formed on the surface of the permeable membrane, resulting in a permeable membrane with an antibacterial membrane on the surface.

[0141] The electrospinning liquid feed rate was 60 mL / min; the spinning voltage was 30 kV; the wire splicing distance was 30 cm; the receiving plate temperature was 60 ℃; and the atomization rate was 50 mL / min.

[0142] S23. The permeable membrane with an antibacterial film on its surface obtained in step S22 is immersed in a treatment solution and treated with an ultrasonic frequency of 40KHz and a temperature of 75℃ for 1 hour. After treatment, it is taken out and dried at 90℃ for 1 hour to form a composite membrane.

[0143] Comparative Preparation Example 8

[0144] Comparative preparation example 8 is the same as preparation example 11, except that the permeation membrane was prepared by comparative preparation example 1.

[0145] Comparative preparation example 9

[0146] Comparative preparation example 9 is the same as preparation example 11, except that the permeation membrane was prepared by comparative preparation example 2.

[0147] Comparative Preparation Example 10

[0148] Comparative preparation example 10 is the same as preparation example 11, except that the permeation membrane was prepared by comparative preparation example 3.

[0149] Comparative Preparation Example 11

[0150] Comparative Preparation Example 11 is the same as Preparation Example 11, except that the permeation membrane was prepared by Comparative Preparation Example 4.

[0151] Comparative preparation example 12

[0152] Comparative preparation example 12 is the same as preparation example 11, except that the permeation membrane was prepared by comparative preparation example 5.

[0153] Comparative preparation example 13

[0154] Comparative preparation example 13 is the same as preparation example 11, except that the dispersion was prepared by comparative preparation example 6.

[0155] Comparative preparation example 14

[0156] Comparative preparation example 14 is the same as preparation example 11, except that the dispersion was prepared by comparative preparation example 7.

[0157] Comparative preparation example 15

[0158] Preparation Example 15 is the same as Preparation Example 11, except that no aloe vera extract is added.

[0159] Comparative Preparation Example 16

[0160] Preparation Example 16 is the same as Preparation Example 11, except that calendula oil is not added.

[0161] Examples 1-5 provide a medicinal dressing fixation bandage and its preparation method.

[0162] Example 1

[0163] A medicinal dressing fixing band consists of an adhesive layer and a fixing band, with one end of the fixing band connected and fixed to the side of the adhesive layer; the adhesive layer includes, from bottom to top, a waterproof and breathable layer, a sterile cotton pad layer, and a dressing bag.

[0164] The dressing bag is made of a composite film; the composite film is made of preparation example 11; the waterproof and breathable layer is a polyurethane layer; the fixing strap is a hook and loop adhesive structure.

[0165] A method for preparing a medicinal dressing fixation bandage includes the following steps:

[0166] S1. Cut the composite membrane into two pieces of equal size, 40mm×50mm. With the antibacterial membrane as the outer layer and the permeable membrane as the inner layer, align and sew them together to form a dressing bag.

[0167] S2. The dressing bag, sterile cotton pad, and waterproof and breathable layer obtained in step S1 are bonded together in sequence using silicone adhesive to form an adhesive layer.

[0168] S3. Adhere and fix the fixing tape to the upper and lower ends of the left and right sides of the adhesive layer obtained in step S2 to obtain the medicinal dressing fixing tape.

[0169] Example 2

[0170] A medicinal dressing fixing band consists of an adhesive layer and a fixing band, with one end of the fixing band connected and fixed to the side of the adhesive layer; the adhesive layer includes, from bottom to top, a waterproof and breathable layer, a sterile cotton pad layer, and a dressing bag.

[0171] The dressing bag is made of a composite film; the composite film is made of preparation example 12; the waterproof and breathable layer is a polyurethane layer; the fixing strap is a Velcro adhesive structure.

[0172] A method for preparing a medicinal dressing fixation bandage includes the following steps:

[0173] S1. Cut the composite membrane into two pieces of equal size, 40mm×50mm. With the antibacterial membrane as the outer layer and the permeable membrane as the inner layer, align and sew them together to form a dressing bag.

[0174] S2. The dressing bag, sterile cotton pad, and waterproof and breathable layer obtained in step S1 are bonded together in sequence using silicone adhesive to form an adhesive layer.

[0175] S3. Adhere and fix the fixing tape to the upper and lower ends of the left and right sides of the adhesive layer obtained in step S2 to obtain the medicinal dressing fixing tape.

[0176] Example 3

[0177] A medicinal dressing fixing band consists of an adhesive layer and a fixing band, with one end of the fixing band connected and fixed to the side of the adhesive layer; the adhesive layer includes, from bottom to top, a waterproof and breathable layer, a sterile cotton pad layer, and a dressing bag.

[0178] The dressing bag is made of a composite film; the composite film is prepared in Preparation Example 13; the waterproof and breathable layer is a polyurethane layer; the fixing strap is a Velcro adhesive structure.

[0179] A method for preparing a medicinal dressing fixation bandage includes the following steps:

[0180] S1. Cut the composite membrane into two pieces of equal size, 40mm×50mm. With the antibacterial membrane as the outer layer and the permeable membrane as the inner layer, align and sew them together to form a dressing bag.

[0181] S2. The dressing bag, sterile cotton pad, and waterproof and breathable layer obtained in step S1 are bonded together in sequence using silicone adhesive to form an adhesive layer.

[0182] S3. Adhere and fix the fixing tape to the upper and lower ends of the left and right sides of the adhesive layer obtained in step S2 to obtain the medicinal dressing fixing tape.

[0183] Example 4

[0184] A medicinal dressing fixing band consists of an adhesive layer and a fixing band, with one end of the fixing band connected and fixed to the side of the adhesive layer; the adhesive layer includes, from bottom to top, a waterproof and breathable layer, a sterile cotton pad layer, and a dressing bag.

[0185] The dressing bag is made of a composite film; the composite film is prepared in Example 14; the waterproof and breathable layer is a polyurethane layer; the fixing strap is a Velcro adhesive structure.

[0186] A method for preparing a medicinal dressing fixation bandage includes the following steps:

[0187] S1. Cut the composite membrane into two pieces of equal size, 40mm×50mm. With the antibacterial membrane as the outer layer and the permeable membrane as the inner layer, align and sew them together to form a dressing bag.

[0188] S2. The dressing bag, sterile cotton pad, and waterproof and breathable layer obtained in step S1 are bonded together in sequence using silicone adhesive to form an adhesive layer.

[0189] S3. Adhere and fix the fixing tape to the upper and lower ends of the left and right sides of the adhesive layer obtained in step S2 to obtain the medicinal dressing fixing tape.

[0190] Example 5

[0191] A medicinal dressing fixing band consists of an adhesive layer and a fixing band, with one end of the fixing band connected and fixed to the side of the adhesive layer; the adhesive layer includes, from bottom to top, a waterproof and breathable layer, a sterile cotton pad layer, and a dressing bag.

[0192] The dressing bag is made of a composite film; the composite film is made of preparation example 15; the waterproof and breathable layer is a polyurethane layer; the fixing strap is a Velcro adhesive structure.

[0193] A method for preparing a medicinal dressing fixation bandage includes the following steps:

[0194] S1. Cut the composite membrane into two pieces of equal size, 40mm×50mm. With the antibacterial membrane as the outer layer and the permeable membrane as the inner layer, align and sew them together to form a dressing bag.

[0195] S2. The dressing bag, sterile cotton pad, and waterproof and breathable layer obtained in step S1 are bonded together in sequence using silicone adhesive to form an adhesive layer.

[0196] S3. Adhere and fix the fixing tape to the upper and lower ends of the left and right sides of the adhesive layer obtained in step S2 to obtain the medicinal dressing fixing tape.

[0197] An application example provides an application of a medicinal dressing fixation bandage.

[0198] Application examples

[0199] A medicinal dressing fixation bandage is used in the preparation of medicated plasters for treating arthritis, and is prepared by the following method:

[0200] Step 1: Mix 35mg of Artemisia argyi, 15mg of dried ginger, 25mg of snow scorpion, 15mg of frankincense, 15mg of myrrh, and 5mg of borneol, then grind them into powder; subsequently, disperse the powder in 100mg of ethanol to obtain the drug.

[0201] Step 2: Put 50mg of the drug into the dressing bag of the medicated dressing fixation strap, sew it closed, sterilize it by Co60 irradiation, put it into a composite aluminum bag, and obtain the medicated plaster for treating arthritis.

[0202] The medicated dressing bag was prepared according to Example 1.

[0203] To verify the performance of the pharmaceutical dressing fixation bandage provided in this application, the applicant has set up comparative examples 1-9, wherein: Comparative Example 1

[0204] Comparative Example 1 is the same as Example 1, except that the composite membrane was prepared by Comparative Preparation Example 8.

[0205] Comparative Example 2

[0206] Comparative Example 2 is the same as Example 1, except that the composite membrane was prepared by Comparative Preparation Example 9.

[0207] Comparative Example 3

[0208] Comparative Example 3 is the same as Example 1, except that the composite membrane was prepared by Comparative Preparation Example 10.

[0209] Comparative Example 4

[0210] Comparative Example 4 is the same as Example 1, except that the composite membrane was prepared by Comparative Preparation Example 11.

[0211] Comparative Example 5

[0212] Comparative Example 5 is the same as Example 1, except that the composite membrane was prepared by Comparative Preparation Example 12.

[0213] Comparative Example 6

[0214] Comparative Example 6 is the same as Example 1, except that the composite membrane was prepared by Comparative Preparation Example 13.

[0215] Comparative Example 7

[0216] Comparative Example 7 is the same as Example 1, except that the composite membrane was prepared by Comparative Preparation Example 14.

[0217] Comparative Example 8

[0218] Comparative Example 8 is the same as Example 1, except that the composite membrane was prepared by Comparative Preparation Example 15.

[0219] Comparative Example 9

[0220] Comparative Example 9 is the same as Example 1, except that the composite membrane was prepared by Comparative Preparation Example 16.

[0221] The properties of the medicinal dressing fixation bandages prepared in Examples 1-5 and Comparative Examples 1-9 of this application were tested respectively, and the following results parameters were obtained, as shown in Table 1.

[0222] Antibacterial rate: The antibacterial properties of the medicated dressing fixation tape were tested using the "oscillation method (GB / T 20944.3)" described in Part 3 of "Evaluation of Antibacterial Properties of Textiles". The bacteria used for testing were Escherichia coli and Staphylococcus aureus. The process was repeated three times, and the average value was taken as the antibacterial rate.

[0223] Water flux: refers to the volume of deionized water passing through a unit area membrane per unit time, measured in L / m². 2 •h(LMH); Add 20mL of deionized water to the dressing bag, seal it, and calculate the water flux. The water flux characterizes the permeability of the medicated dressing fixation tape.

[0224] Table 1:

[0225]

[0226]

[0227] As shown in Table 1 above, the overall quality of the pharmaceutical dressing fixation tapes prepared in Examples 1-5 of this application is far superior to that of the pharmaceutical dressing fixation tapes prepared in Comparative Examples 1-9. The pharmaceutical dressing fixation tapes prepared in Examples 1-5 have significant antibacterial rates and high water flux, and have broad market prospects.

[0228] As can be seen from Example 1 and Comparative Examples 1-3, the composite membrane in Example 1 was prepared by Preparation Example 11, and the permeation membrane was prepared by Preparation Example 1. The raw materials of the permeation membrane include carbon nanotubes, bamboo charcoal powder, and β-cyclodextrin. Compared with Comparative Examples 1-3, the pharmaceutical dressing fixation tape prepared by Example 1 has excellent antibacterial and permeation properties.

[0229] As can be seen from Example 1 and Comparative Examples 4 and 5, the composite membrane in Example 1 was prepared by Preparation Example 11, and the permeation membrane was prepared by Preparation Example 1. During the preparation process, biaxial stretching was performed. Compared with Comparative Examples 4 and 5, the water flux of the pharmaceutical dressing fixation tape prepared by Example 1 is higher, which can accelerate the permeation speed of the drug.

[0230] As can be seen from Example 1 and Comparative Examples 6 and 7, the composite membrane in Example 1 was prepared by Preparation Example 11, and the dispersion was prepared by Preparation Example 6. The dispersion contains nano-hydroxyapatite and nano-silica. Compared with Comparative Examples 6 and 7, the pharmaceutical dressing fixation tape prepared by Example 1 has better permeability, which is beneficial to accelerating the diffusion and penetration of the drug.

[0231] As can be seen from Example 1 and Comparative Examples 8 and 9, the composite film in Example 1 was prepared by Preparation Example 11. Compared with Comparative Examples 8 and 9, the antibacterial rate of the pharmaceutical dressing fixation tape prepared by Example 1 is higher and it has excellent antibacterial function.

[0232] This specific embodiment is merely an explanation of this application and is not intended to limit it. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they fall within the scope of the claims of this application.

Claims

1. A medicinal dressing fixation bandage, characterized in that, It consists of an adhesive layer and a fixing strap; one end of the fixing strap is connected and fixed to the side of the adhesive layer; the adhesive layer includes, from bottom to top, a waterproof and breathable layer, a sterile cotton pad layer, and a dressing bag; The dressing bag is made of a composite membrane; the composite membrane includes a permeable membrane and an antibacterial membrane; the antibacterial membrane is the outer layer and the permeable membrane is the inner layer. The permeable membrane includes the following raw materials in parts by weight: 25-30 parts of polylactic acid, 10-20 parts of polycaprolactone, 4-8 parts of carbon nanotubes, 2-6 parts of bamboo charcoal powder, 2-4 parts of β-cyclodextrin, 1-4 parts of trioctyl phosphate, 2-3 parts of silicone powder, 6-8 parts of polyethyleneimine, 100-200 parts of water, and 120-160 parts of ethyl acetate.

2. The medicinal dressing fixation bandage according to claim 1, characterized in that, The permeable membrane is prepared by the following method: S11. Polylactic acid, polycaprolactone, carbon nanotubes, bamboo charcoal powder, β-cyclodextrin, trioctyl phosphate, and silicone powder are added to ethyl acetate and dissolved completely to obtain a mixture. The mixture is then allowed to stand to remove bubbles and cast into a film to obtain a substrate film. S12. The substrate membrane obtained in step S11 is subjected to biaxial stretching to obtain a microporous membrane. S13. Mix polyethyleneimine with water, add the microporous membrane obtained in step S12 for amination, remove, dry, and obtain a permeable membrane.

3. The medicinal dressing fixation bandage according to claim 2, characterized in that, The specific operation of the biaxial stretching is as follows: the base film is first stretched longitudinally at a stretching ratio of 1-5 times and a temperature of 70-90℃, and then stretched transversely at a stretching ratio of 1-5 times and a temperature of 80-100℃.

4. The medicinal dressing fixation bandage according to claim 1, characterized in that, The composite membrane comprises the following raw materials in parts by weight: 20-30 parts chitosan, 4-8 parts aloe vera extract, 1-2 parts calendula oil, 200-400 parts citric acid solution, 20-30 parts dispersion, 30-40 parts permeable membrane, and 100-200 parts treatment solution.

5. The medicinal dressing fixation bandage according to claim 4, characterized in that, The composite membrane is prepared by the following method: S21. Chitosan is dissolved in a 5 wt% citric acid solution, and aloe vera extract and calendula oil are added to obtain an electrospinning solution. S22. Using electrospinning process, with a permeable membrane as the receiving plate, and applying atomized dispersion liquid during the spinning process, the electrospinning liquid obtained in step S21 forms an antibacterial membrane on the surface of the permeable membrane, thus obtaining a permeable membrane with an antibacterial membrane on the surface. S23. The permeable membrane with an antibacterial film on its surface obtained in step S22 is immersed in the treatment solution, ultrasonically treated for a period of time, then removed and dried to obtain a composite membrane.

6. The medicinal dressing fixation bandage according to claim 4, characterized in that, The treatment solution is obtained by mixing glutaraldehyde, sodium borohydride and water in a mass ratio of 3-6:4-9:

50.

7. The medicinal dressing fixation bandage according to claim 4, characterized in that, The dispersion is prepared by the following method: By weight, 6-10 parts of nano-hydroxyapatite, 4-8 parts of nano-silica, and 0.5-1 parts of sophorolipid are added to 20-30 parts of water, dispersed evenly, and then treated with plasma to obtain a dispersion.

8. A method for preparing a medicinal dressing fixation bandage according to any one of claims 1-7, characterized in that, Includes the following steps: S1. Cut the composite membrane into two pieces of equal size, with the antibacterial membrane as the outer layer and the permeable membrane as the inner layer, align and sew them together to form a dressing bag; S2. Adhere the dressing bag, sterile cotton pad, and waterproof and breathable layer obtained in step S1 in sequence to form an adhesive layer; S3. Adhere and fix the fixing tape to the upper and lower ends of the left and right sides of the adhesive layer obtained in step S2 to obtain the medicinal dressing fixing tape.

Images