Liquid abutment patch and method of using a liquid abutment patch

Abstract

The liquid contact patch (1) has a liquid package (10) and a shell (20). The liquid package (10) stores liquid by being held by a flexible cover (11) with a protrusion (12) and a ruptureable sheet (14). The shell (20) has a top surface (21) and a side wall (25) surrounding the top surface (21). A cylindrical portion (24) hangs down from the center of the top surface (21). By pressing the protrusion (12) of the liquid package (10), the sheet (14) ruptures, and the stored liquid flows out from the cylindrical portion (24).

Description

Technical Field

[0001] This invention relates to liquid abutment patches and methods of using liquid abutment patches. Background Technology

[0002] In recent years, microneedle masks have been known to allow active ingredients to penetrate the skin by applying dissolved microneedles to the skin (see, for example, Patent Document 1).

[0003] However, in mask-type microneedles like those in Patent Document 1, since the microneedles and active ingredients are integrated, a long placement time is required to inject the cosmetic ingredients dissolved in the microneedles into the skin. Furthermore, the types of cosmetic ingredients that can be integrated with the microneedles are limited.

[0004] On the other hand, a technique has been proposed in which a spring, which is an elastic member, is provided in the applicator. When the microneedle is applied to the skin, the force of the spring is transmitted to the microneedle, causing the microneedle to fall into the applicator and come into contact with the skin (see, for example, Patent Document 2).

[0005] In addition, there is a technology in which the patch is adhered to the skin by means of an adhesive part extending from the patch, and the medicine inside the patch is injected by pressing it in with a finger during use (see Patent Document 3).

[0006] In addition, Patent Document 4 proposes the following solution: two sheets, a sheet on the lower surface side and a sheet on the upper surface side, are bonded together, wherein the sheet on the lower surface side is provided with micro protrusions with openings on the contact surface side, and the liquid contained therein is applied by pressing with a finger from above using the micro protrusions.

[0007] Prior art literature

[0008] Patent Document 1: Japanese Patent Application Publication No. 2017-051354

[0009] Patent Document 2: WO2017 / 038499

[0010] Patent Document 3: Japanese Patent No. 4815095

[0011] Patent Document 4: Japanese Patent Application Publication No. 2020-96790 Summary of the Invention

[0012] The problem that the invention aims to solve

[0013] However, when using a spring to raise and lower the microneedle, as in Patent Document 2, the applicator becomes correspondingly larger because a mechanism for raising and lowering is required. Furthermore, in order not to affect the spring, the applicator is formed by pre-coating the surface of the microneedle with a drug or by having the microneedle itself contain a drug, resulting in a low content of active ingredient and the inability to use fresh liquid in the active ingredient.

[0014] On the other hand, if the adhesive part is set as in Patent Document 3, especially when applied to the face, the adhesive part may cause adverse effects on the skin, such as rashes and peeling of the stratum corneum when it is removed.

[0015] Furthermore, in the structure of Patent Document 4, since it is constructed by laminating two sheets together, it is prone to tilting and becomes unstable during use. Additionally, due to the lamination of the sheets, the sides are very thin, making it impossible to grasp the sides from the side while pressing down from above.

[0016] Therefore, in view of the above circumstances, the present invention aims to provide a liquid abutment patch that is small and easy to hold, and can leave fresh liquid active ingredients on the surface or inside the surface of the object by pressing it with a finger to make it abut against the object in a stable state.

[0017] Methods for solving problems

[0018] To address the aforementioned issues, one technical solution of the present invention provides a liquid contact patch having a liquid packaging body and a shell. The liquid packaging body stores liquid by being held in place by a flexible cover with protrusions and a ruptureable sheet. The shell has a top surface and sidewalls surrounding the top surface, and a cylindrical portion hangs down from the center of the top surface. By pressing the protrusions of the liquid packaging body, the sheet ruptures, and the stored liquid flows out from the cylindrical portion.

[0019] The effects of the invention

[0020] According to this technical solution, the liquid contact patch is small and easy to hold. By pressing it with a finger, it can be made to contact the object in a stable state, and fresh liquid active ingredients can be applied to the surface or interior of the object. Attached Figure Description

[0021] Figure 1 This is a cross-sectional view of the liquid contact patch according to the first embodiment of the present invention.

[0022] Figure 2A This is a top perspective view of the liquid contact patch according to the first embodiment.

[0023] Figure 2B yes Figure 2AA bottom-view stereoscopic view of the liquid contact patch.

[0024] Figure 3 This is an exploded perspective view of the liquid contact patch according to the first embodiment.

[0025] Figure 4 This is an enlarged perspective view of the cross-section of the needle plate portion according to the first embodiment.

[0026] Figure 5 This describes the usage process of the liquid contact patch according to the first embodiment.

[0027] Figure 6A yes Figure 5 The diagram illustrating the process of using a liquid contact patch shows the state of gently placing the liquid contact patch onto the object.

[0028] Figure 6B It means Figure 6A A diagram showing the state of the liquid contacting the needle-like protrusions of the patch piercing the object.

[0029] Figure 6C It means Figure 6A The image shows the state in which the liquid is pressed against the protrusion of the patch.

[0030] Figure 6D It means Figure 6A The image shows the state in which the liquid on the patch diffuses onto the surface of the object and enters its interior.

[0031] Figure 6E It means to Figure 6A The image shows the state of the liquid-adhesive patch peeling off from the object.

[0032] Figure 7 This diagram illustrates the application of the liquid-adhesive patch of the present invention to the face.

[0033] Figure 8 This is a cross-sectional view showing the cover of the first structural example engaged with the liquid abutment patch of the first embodiment.

[0034] Figure 9A This is a top perspective view of the liquid contact patch of the first embodiment, which engages with the cover of the first structural example.

[0035] Figure 9B yes Figure 9A A bottom-view stereoscopic view of the liquid contact patch that is attached to the cover.

[0036] Figure 10A This is a diagram illustrating the engagement of the housing of the first embodiment with the cover of the first structural example, and is a top perspective view of the cover of the first structural example.

[0037] Figure 10B Is with Figure 10A A bottom perspective view of the housing of the liquid abutment patch according to the first embodiment of the cover snap-fit.

[0038] Figure 11A This is a top perspective view of the liquid contact patch according to the second embodiment of the present invention.

[0039] Figure 11B yes Figure 11A A bottom-view stereoscopic view of the liquid contact patch.

[0040] Figure 12A This is a diagram illustrating the engagement between the pressing component and the housing according to the second embodiment, and is a top perspective view of the housing.

[0041] Figure 12B Is with Figure 12A A bottom-view perspective view of the pressing component that engages with the housing.

[0042] Figure 13 This is a cross-sectional view showing the cover of the first structural example engaged with the liquid abutment patch of the second embodiment.

[0043] Figure 14 This is a cross-sectional view showing the cover of the second structural example engaging with the liquid abutment patch of a modified example of the second embodiment.

[0044] Figure 15A This is a diagram illustrating the engagement of the housing and pressing member of the liquid contact patch in a modified example of the second embodiment with the cover of the second structural example, and is a top perspective view of the cover of the second structural example.

[0045] Figure 15B Is with Figure 15A A bottom perspective view of the housing and pressing component of the liquid abutment patch, which is a variation of the second embodiment of the cover latch.

[0046] Figure 16 This is a cross-sectional view of the liquid contact patch according to the third embodiment.

[0047] Figure 17 This is a three-dimensional enlarged view of the needle plate portion according to the third embodiment.

[0048] Figure 18 This is the usage process of the liquid contact patch involved in the third embodiment.

[0049] Figure 19A yes Figure 18 The diagram illustrating the process of using a liquid contact patch shows the state of gently placing the liquid contact patch onto the object.

[0050] Figure 19B It means Figure 19AA diagram showing the state of the object being punctured by the hollow needle of the patch when the liquid comes into contact with it.

[0051] Figure 19C It means Figure 19A The image shows the state in which the liquid is pressed against the protrusion of the patch.

[0052] Figure 19D It means Figure 19A The diagram shows the state in which the liquid from the patch enters the object.

[0053] Figure 19E It means to Figure 19A The image shows the state of the liquid-adhesive patch peeling off from the object.

[0054] Figure 20 This is a cross-sectional view of the liquid contact patch according to the fourth embodiment.

[0055] Figure 21 This is a cross-sectional view of the liquid contact patch according to the fifth embodiment.

[0056] Figure 22 This diagram illustrates the state in which the liquid of the liquid contact patch in the fifth embodiment enters the interior of the object.

[0057] Figure 23 This is a cross-sectional view of the liquid contact patch according to the sixth embodiment.

[0058] Figure 24 The figure shows a liquid-absorbing patch with a permeation component installed in the sixth embodiment. Detailed Implementation

[0059] Hereinafter, the embodiments for carrying out the present invention will be described with reference to the accompanying drawings. In the following drawings, the same reference numerals are used to denote the same components, and repeated descriptions are sometimes omitted.

[0060] This invention relates to a liquid-adhesive patch and a method of using the liquid-adhesive patch. The skin-adhesive portion of the liquid-adhesive patch of this invention can be an absorbent material such as needle-like protrusions, hollow needles, or sponge, which are components of the liquid-adhesive patch, or an absorbent material such as cotton prepared separately by the user. Using this adhesive portion, the contents can be applied to the surface of the skin. Furthermore, in the case of a liquid-adhesive patch of this invention with a structure of needle-like protrusions or hollow needles, the contents can also be injected into the interior of the skin.

[0061] <First Embodiment>

[0062] use Figures 1 to 6E The liquid-blocking patch according to the first embodiment of the present invention will be described. First, using... Figures 1-3The overall structure of the liquid contact patch 1 according to the first embodiment will be described.

[0063] Figure 1 This is a cross-sectional view of the liquid contact patch 1 according to the first embodiment of the present invention. Figure 2A , Figure 2B This is a perspective view of the liquid-contact patch 1 according to the first embodiment. Figure 2A It is a top-down 3D view. Figure 2B It is a three-dimensional image viewed from below. Figure 3 This is an exploded perspective view of the liquid contact patch 1 according to the first embodiment.

[0064] Reference Figure 1 In this embodiment, the liquid contact patch 1 has a liquid packaging body 10, a housing 20, and a needle plate portion 30.

[0065] Reference Figure 1 , Figure 2A , Figure 2B , Figure 3 The liquid package 10 holds and stores the liquid by a flexible cover 11 with protrusions and a breakable sheet 14. The liquid package 10 is, for example, a blister pack such as a PTP (press-through pack) sheet. The flexible cover 11 is, for example, aluminum, or a material containing a metal or inorganic layer as described below. The breakable sheet 14 is, for example, aluminum, or a material containing a metal or inorganic layer as described below.

[0066] For example, the material constituting the liquid packaging body 10 preferably includes a metal layer or an inorganic layer. The metal of the metal layer is preferably any one of aluminum, iron, gold, silver, titanium, tin, zinc, platinum, ruthenium, palladium, iridium, their alloys, or metal oxides (such as aluminum oxide). "Including a metal layer" can mean that it is entirely composed of metallic materials, or it can include a metallic film formed by vapor deposition of metal onto one side of another material (such as resin). The inorganic layer includes layers containing inorganic substances such as silica gel (silicon oxide).

[0067] The metallic and inorganic layers are air-blocking materials. Additionally, the metallic layer is a light-blocking material. The inorganic layer can be colored to have light-blocking properties, or it can be made transparent without light-blocking properties.

[0068] In this way, by making the flexible cover 11 and the sheet 14 constituting the upper side of the liquid packaging body 10 both made of materials with oxygen barrier and light barrier properties, the liquid contained in the liquid packaging body 10 can be made of materials that are not resistant to oxygen or light.

[0069] For example, the contents contained in the liquid packaging 10 are suitable to contain substances that are easily altered by oxygen and / or light. There are no limitations on the contents; examples include cosmetics containing vitamins (vitamin A, vitamin C, etc.) and their derivatives (e.g., retinol), pharmaceuticals that are easily degraded by oxidation, and food products.

[0070] Furthermore, the upper surface of the flexible cover 11 of the liquid packaging body 10 has a hemispherical protrusion 12 and a flat upper surface (flat portion) 13. Additionally, in this example, as... Figure 3 As shown, an example of the protrusion 12 being semi-circular in cross-section is illustrated, but the protrusion 12 can also be quadrilateral, triangular, or other shapes that bulge upwards in cross-section. Additionally, as... Figure 2A As shown, an example of the protrusion 12 being circular when viewed from above is illustrated, but the protrusion 12 can also be elliptical, rounded polygonal, etc. when viewed from above.

[0071] Furthermore, the sheet of the liquid packaging body 10 of the present invention is prone to breakage even when pressure is applied via a fluid, simply due to the nature of sheet material. Therefore, the sheet 14 is made of sheet material of the aforementioned easily breakable raw materials, such as aluminum foil, and the protrusion 12 and the planar upper surface 13 are made of a multilayer body of aluminum foil and resin.

[0072] The housing 20 of the present invention has a top surface 21, a side wall 25, and a cylindrical portion 24. The cylindrical portion 24 hangs down from the center of the top surface 21. The side wall 25 is connected to the top surface 21 in a manner that surrounds the top surface 21. A flow hole P is formed on the cylindrical portion 24.

[0073] In detail, in this embodiment, a recess 22 is formed in the center of the top surface 21 of the housing 20, and the area around the recess 22 is a flat surface 23. By forming the recess, the protrusion 12 of the liquid packaging body 10 can be pressed into the recess 22. With the recess 22 provided on the top surface 21, the cylindrical portion 24 hangs down from the lowest point in the center of the recess 22. By placing the cylindrical portion 24 at the lowest point of the recess 22, the liquid easily concentrates on the cylindrical portion 24, and the liquid contained in the liquid packaging body 10 can be used up with almost no residue until the end.

[0074] In addition, in this embodiment, a drooping rib 26 is provided to surround the cylindrical portion 24. With the drooping rib 26, the lower end of the drooping rib 26 contacts the upper surface (back side) of the plate 31. The drooping rib 26 is provided to adjust the position of the needle plate portion 30 so that the user can easily hold the liquid abutment patch 1 and position the needle plate portion 30 at the lower periphery of the side wall 25.

[0075] exist Figure 3The diagram shows four hanging ribs 26. An example of eight hanging ribs 26 on the entire housing 20 is illustrated, but the number of hanging ribs 26 can be any number as long as there are two or more.

[0076] Furthermore, the shape of the hanging ribs 26 can also be other shapes, as long as they can define the position of the needle plate portion 30 and provide support. For example, they can be multiple rod-shaped parts starting from below the top surface, or they can be multiple cylindrical shapes such as concentric rings.

[0077] The shell 20 is made of resins such as polypropylene (PP), polyethylene (PE), acrylonitrile-butadiene-styrene (ABS), polybutylene terephthalate (PBS), polyacetal (POM), polyethylene terephthalate (PET), polycarbonate (PC), polyetheretherketone (PEEC), and other thermoplastic resins and biodegradable resins.

[0078] The liquid-holding patch of the present invention is small; for example, the diameter of the top surface 21 of the housing 20 is about 1.0 to 5.0 cm, and the height of the sidewall 25 is about 0.6 to 2.5 cm, more preferably about 0.7 to 2.0 cm. With the sidewall 25 being 0.6 cm or more, the user can grasp the sidewall 25 from the outside. Furthermore, this example shows a generally circular top surface 21, but the top surface 21 can also be elliptical, rectangular, square, polygonal, rounded polygonal, or approximately semi-circular, etc.

[0079] In this embodiment, the lower surface of the sheet 14 of the liquid packaging body 10 and the upper surface of the planar portion 23 of the top surface 21 of the shell 20 are bonded together by heat fusion, ultrasonic welding (stacking), adhesive, etc., thereby fixing the liquid packaging body 10 relative to the shell 20. Alternatively, instead of bonding, as in the second embodiment described later, the liquid packaging body and the shell can be fixed by clamping with the pressing member 40.

[0080] like Figure 2B , Figure 3 As shown, the needle plate portion 30 has an insertion hole 34 formed in the center of the plate 31. The needle plate portion 30 is connected to the housing 20 by inserting the outer periphery of the cylindrical portion 24 of the housing 20 into the insertion hole 34 of the plate 31. The needle provided on the needle plate portion 30 in this embodiment is a needle-shaped protrusion (also called a solid needle). Details of the needle plate portion 30 will be provided below. Figure 4 Please provide an explanation.

[0081] The material of the needle plate portion 30, which includes needle-like protrusions, is preferably a biocompatible material, such as a biodegradable resin like polyglycolic acid, polylactic acid, or polyglycolic acid-polylactic acid copolymer. It can also be a thermoplastic resin such as polypropylene (PP), polyethylene (PE), acrylonitrile-butadiene-styrene (ABS), polybutylene terephthalate (PBS), polyacetal (POM), polyethylene terephthalate (PET), polycarbonate (PC), or polyetheretherketone (PEEC).

[0082] Reference Figure 3 In the housing 20, the cylindrical portion 24 is connected to the needle plate portion 30 at the bottom, so the lower end of the hanging rib portion 26 is set to be shorter than the central cylindrical portion 24.

[0083] Additionally, the lower end of the inner periphery of the side wall 25 of the housing 20 engages with the protrusion (protrusion) of the cover 80, which will be described later, thus forming an inwardly inclined lower end 27. Alternatively, an annular groove may be formed as the engagement shape with the protrusion 84.

[0084] Figure 4 This is an enlarged perspective view of the cross-section of the needle plate portion 30 according to the first embodiment. The needle plate portion 30 has a plate 31, a plurality of needle-shaped protrusions 32, and a lip 33, with an insertion hole 34 formed in the center of the plate 31. Additionally, a puncture amount adjustment rib 35 may be provided on the front end face (lower end face, abutment surface) of the plate 31. Furthermore, in Figure 4 The example shown is that there are multiple needle-shaped protrusions 32 provided on the needle plate portion 30, but in this embodiment, there only needs to be at least one needle-shaped protrusion 32 provided on the needle plate portion 30.

[0085] In the needle plate portion 30, a plurality of needle-like protrusions 32 protrude from the front end face CF of the plate 31. The plurality of needle-like protrusions 32 are so-called fine, solid microneedles, each having a length of approximately 1 μm to 5000 μm, more preferably 5 μm to 3000 μm, and a diameter around the root of each needle-like protrusion 32 ranging from 2 μm to 5000 μm, more preferably 5 μm to 3000 μm. Furthermore, it is preferable that the plurality of needle-like protrusions 32 are spaced apart from each other by approximately 0.1 mm to 10 mm or more.

[0086] In addition, Figure 4 The diagram shows an example where the needle-like protrusion 32 is conical in shape, but it can also be a polygonal pyramidal shape or other needle-like shapes (star-shaped, cross-shaped, etc.). Additionally, it can be an asymmetrical shape starting from the front end. Furthermore, it can be a two-section shape with a base provided below the conical front end. By providing a base portion, puncture difficulties caused by skin deformation can be eliminated. Furthermore, multiple shapes of needle-like protrusions can be mixed within the plate 31.

[0087] Alternatively, the height of the needle-like protrusions 32 can be made uneven. Furthermore, slits, tiny grooves, or irregularities can be provided on the surface of the needle-like protrusions 32. In this case, it can facilitate the penetration of fluid through the skin pores opened by the puncture.

[0088] A lip 33 is formed on the outer edge of the front end face (abutment surface) CF of the plate 31. In this embodiment, the lip 33 serves to stop liquid flow. The height of the lip 33 is, for example, about 5 μm to 3000 μm.

[0089] The height of the lip 33, measured from the front end face CF of the plate 31, is configured to be lower (shorter) than the height of the needle-like protrusion 32.

[0090] In addition, a puncture volume adjustment rib 35 is provided to limit the depth of penetration of the needle-like protrusion 32 into objects such as skin. Furthermore, the height of the puncture volume adjustment rib 35 is configured to be lower than the needle-like protrusion 32, lower than the lip 33, or approximately equal to the height of the lip 33.

[0091] In addition, such as Figure 1 As shown, in this embodiment, the front end face LT of the lip 33 of the needle plate portion 30 is located outside (below) than the end (lower end) ST of the side wall 25 of the housing 20.

[0092] In this embodiment, when the sheet 14 is ruptured by pressing the protrusion 12 of the liquid packaging 10, the liquid contained in the liquid packaging 10 flows out from the downstream end through the flow hole P of the cylindrical portion 24. The liquid diffuses in the space formed between the object such as skin and the front end face CF of the lip 33 and the plate 31, and the liquid enters the interior of the skin through the holes opened by the plurality of needle-like protrusions 32. The user's operation and the flow of the liquid will be described below.

[0093] (Usage flow of the first embodiment)

[0094] Figure 5 This describes the usage process of the liquid contact patch 1 according to the first embodiment. Figures 6A-6E This diagram illustrates the application of the liquid-adhesive patch of the present invention to the face. Figure 5 A flowchart illustrating the usage process. In detail, Figure 6A This diagram shows the state in which the liquid contact patch 1 is gently placed on the object. Figure 6B This diagram illustrates the state of liquid contact with the needle-like protrusion 32 of patch 1, piercing the target object. Figure 6C This diagram shows the state in which the liquid is pressed against the protrusion of patch 1. Figure 6D This diagram illustrates the state in which the liquid abuts against patch 1 diffuses across the surface of the object and penetrates its interior. Figure 6E This diagram shows the state in which the liquid-contact patch 1 is peeled off from the object.

[0095] exist Figure 5 In S11, when the liquid-contact patch 1 is held against the side wall 25 of the housing 20 and gently placed on an object (e.g., skin), the tip of the needle-like protrusion 32 of the needle plate portion 30 contacts the skin (see reference). Figure 6A ).

[0096] In S12, by pressing a portion of the non-convex surface 13 of the liquid packaging body 10, multiple needle-like protrusions 32 pierce the object (see reference). Figure 6B At this time, the lip 33 of the needle plate 30 comes into contact with the skin.

[0097] In S13, by pressing the protrusion 12 of the liquid packaging body 10, the lower sheet 14 breaks, and the liquid stored in the liquid packaging body 10 flows into the cylindrical portion 24 of the shell 20 (see reference). Figure 6C ).

[0098] In S14, by continuing to press the protrusion 12, liquid flows out from the downstream end of the cylinder 24. The liquid diffuses in the space formed between the object and the front end face CF of the lip 33 and the plate 31, and the liquid enters the interior of the object O through the holes opened by each of the plurality of needle-like protrusions 32 (see reference). Figure 6D ).

[0099] An example of the pressing method for liquid contact patch 1 in steps S13 and S14 is shown below. Figure 7 In the liquid-adhesive patch 1 of the present invention, since it does not have the function of adhering to an object, the user needs to press the protrusion 12 of the liquid packaging body 10 and, as needed, grasp the side wall 25 of the housing 20 or press the flat upper surface 13 of the liquid packaging body 10 during S12 to S14, thereby continuously pressing the liquid-adhesive patch 1 onto the object. This pressing period is about 1 second to 30 minutes (more preferably a few seconds to a few minutes).

[0100] In S15, the needle-like protrusion 32 is pulled out of the skin by grasping the side wall 25 of the liquid-contact patch 1's housing 20 and peeling it off the object (see reference). Figure 6E ).

[0101] Here, in the liquid-resistant patch 1, because it has a sidewall 25 of the housing 20 that does not come into contact with the liquid, the user's hands will not be covered with liquid (contents), such as... Figure 6CAs shown, the sidewall 25 can be held to inject liquid into the object. Therefore, compared with a structure that uses only one finger to support the sheet with needles, the state of the patch relative to the object can be maintained in a stable state during the injection waiting time during use, so that the needle protrusions are pressed into the object evenly and do not shift, thus preventing the opening on the skin (object) from being too large.

[0102] Or, such as Figure 7 As shown, even when supported by only one finger during use, in this invention, because the sidewall 25 of the housing 20 of the liquid contact patch 1 has a moderate thickness, the user can grasp the sidewall 25 from the side with one hand for positioning without changing its position, and can press the protrusion 12 of the liquid packaging 10 from above with a finger different from the finger used for positioning. Furthermore, because the sidewall 25 has a moderate thickness and the protrusion 12 of the liquid packaging 10 is made of a flexible material, even if the finger pressing the protrusion 12 tilts or deviates midway, the liquid contact patch 1 will not tilt unstablely, maintaining the state where the needle plate portion 30 is evenly pressed onto the object.

[0103] Therefore, in this embodiment, for the small liquid contact patch 1, by having the user hold the side wall of the housing and maintain its position, or by holding the side wall and pressing it with their fingers to bring it into contact with the object, the liquid effective for the object diffuses towards the object from the inside of the lip 33 and penetrates into the inside of the object through the hole opened by the needle-like protrusion 32, which is a solid needle. Thus, the effective ingredients of the liquid can penetrate in a stable state from both the outside and inside of the object's surface. For example, by pressing the small and easy-to-hold liquid contact patch 1 with a finger to bring it into contact with the skin, fresh liquid beauty ingredients can be applied to the skin and into the skin.

[0104] At this time, as Figure 6D As shown, due to the narrow gap between the object and the lower surface of the plate 31 of the needle plate portion 30, the liquid permeates the entire area surrounded by the lip 33. Specifically, even if liquid initially accumulates below the surface in the space surrounded by the skin and lip 33, it quickly diffuses upwards when the space is filled with liquid. Thus, by utilizing the lip 33 to prevent leakage from the gap, the active ingredient can be retained on the surface and inside the object. Therefore, even relative to the object, such as… Figure 7 In cases of puncture from the side or from below, the small and easy-to-hold liquid contact patch 1 can be pressed with a finger to bring it into contact with the object, thereby applying fresh liquid active ingredients to the surface and interior of the object.

[0105] (Example 1 of the lid's structure)

[0106] Next, using Figures 8 to 10B The cap covering the needle-like protrusions 32 relative to the liquid-contact patch 1 will be described. First, using... Figure 8 The cover 80 of the first structural example will be described.

[0107] Figure 8 This is a cross-sectional view of the cover 80 of the first structural example, in which the liquid-resistant patch 1 of the first embodiment is engaged. Figure 9A , Figure 9B This is an explanatory diagram of the liquid-contact patch 1 of the first embodiment, which engages with the cover 80 of the first structural example. Figure 9A It is a top-down 3D view. Figure 9B It is a three-dimensional image viewed from below.

[0108] The liquid-contact patch 1 can engage with the cover 80 covering the needle plate portion 30. The housing 20 contacts the cover 80, and in the engaged state, the needle plate portion 30 and the cover 80 are not in contact. Since the needle-like protrusions 32 of the needle plate portion 30 are thin and short, in the standby state, non-contact protection by the cover 80 prevents deformation of the needle-like protrusions 32 during transport.

[0109] Furthermore, in this structure, the length (height) of the side wall 82 of the cover 80 is longer than the length (height) of the side wall 25 of the housing 20. Therefore, in the engaged state of the cover 80, the upper end UT of the side wall 82 of the cover 80 and the lower surface rib 28 (see reference) provided on the lower surface of the planar portion 23 of the top surface 21 of the housing 20 Figure 10B The bottom surface 81 of the cover 80 does not come into contact with the needle plate portion 30, even if it is subjected to forces from above or below before use, such as during transport.

[0110] The cover 80 of this structure has a bottom surface 81 and a side wall 82. The side wall 82 is connected to the bottom surface 81. In this structure, the side wall 82 of the cover 80 is configured to be between the inner surface IF of the side wall 25 of the housing 20 and the outer edge OE of the plate 31 of the needle plate portion 30. That is, the cover 80 of this structural example is a cover with an internal locking structure.

[0111] Therefore, as Figure 8 As shown, in the liquid-contact patch 1 of the first embodiment, a gap is left between the inner side surface of the side wall 25 of the housing 20 and the outer edge of the plate 31 of the needle plate portion 30. That is, in this structure, the outer diameter of the plate 31 is set such that the inner diameter of the side wall 82 of the cover 80 is less than the inner diameter of the side wall 25 of the housing 20. Furthermore, as... Figure 8 As shown, the side wall 82 of the cover 80 can also be configured such that the lower part is thicker than the upper part, and the outer diameter of the lower part of the side wall 82 of the cover 80 does not overlap with the side wall 25 of the housing 20 in the locked state. The outer diameter of the lower part of the side wall 82 of the cover 80 can also be located slightly outside the inner diameter of the side wall 25 of the housing 20.

[0112] Next, using Figures 8 to 10B The engagement between the cover 80 and the liquid contact patch 1 is explained. Figure 10A , Figure 10B This is a diagram illustrating the engagement of the housing 20 of the liquid contact patch 1 in the first embodiment with the cover 80 in the first structural example. Figure 10A It is a top-down 3D view of the Geely 80. Figure 10B This is a bottom-view perspective view of the shell 20.

[0113] like Figure 10A As shown, a protrusion 84 is provided on the outer surface of the side wall 82 of the cover 80. Furthermore, on the outer surface of the side wall 82, the upper part is thinner than the lower part, forming a step 83 at the boundary, and the protrusion 84 is provided to cover the step 83. This protrusion 84 connects with... Figure 10B The inner inclined lower end 27 of the side wall 25 of the housing 20 shown is engaged, and the cover 80 will not fall off, thus maintaining the engaged state between the cover 80 and the housing 20.

[0114] The cover 80 and the housing 20 are fitted together to ensure airtightness. In addition, to improve the airtightness of the cover 80 and the housing 20, they can also be pressed together around the entire circumference, or they can be fitted together by providing protrusions 84 around the entire circumference.

[0115] Alternatively, although not shown in the figure, a positioning pin (protrusion) can be provided at the center of the bottom of the cap as another structural feature. In this case, the positioning pin is embedded inside the insertion hole 34 of the needle plate portion 30 and inside the flow hole P of the cylinder portion 24. As a result, the position of the cap 80 relative to the housing 20 at the center of the bottom surface 81 is restricted, so even if a force is applied from the side, the cap 80 and the housing 20 can be maintained in an engaged state. In addition, the positioning pin is provided to make the engagement state more reliable, so it is not necessary and can be provided as such depending on the shape of the liquid contact patch. Figure 8 That's how you set it up.

[0116] <Second Implementation>

[0117] Next, using Figures 11A to 12B The liquid contact patch according to the second embodiment will be described. Figure 11A , Figure 11B This is an explanatory diagram of the liquid contact patch 2 according to the second embodiment of the present invention. Figure 11A This is a top-view 3D view of liquid contact patch 2. Figure 11B This is a bottom perspective view of the liquid contact patch 2. In this embodiment, the same symbols are used to label structures identical to those in the first embodiment, and descriptions are omitted.

[0118] In the liquid contact patch 2 of this embodiment, the difference from the structure of the first embodiment is that a pressing member 40 is provided.

[0119] like Figure 11A As shown, the pressing member 40 is configured to cover the periphery of the outer edge of the liquid packaging body 10 from above and to cover the side wall of the housing 20A. In the liquid contact patch 2 of this embodiment, the shape of the housing 20A is also slightly different from that of the housing 20 so that the pressing member 40 can be installed.

[0120] Figure 12A , Figure 12B This diagram illustrates the engagement between the pressing member 40 and the housing 20A according to the second embodiment. Figure 12A This is a top-view perspective view of the casing 20A containing the liquid packaging body 10. Figure 12B This is a bottom-view perspective view of the pressing component 40.

[0121] like Figure 11A , Figure 11B and Figure 12A As shown, the housing 20A according to this embodiment has a lower outer peripheral ring 29 extending outward from the lower end of the side wall 25A. Additionally, as... Figure 12A As shown, a threaded protrusion 251 is provided on the outer peripheral surface of the side wall 25A.

[0122] On the other hand, the pressing member 40 has an upper ring 41 and an outer peripheral wall 42. Additionally, as... Figure 12B As shown, a pressing protrusion 43 that hangs downward is provided on the lower surface of the upper ring 41, and a threaded protrusion 44 is provided on the inner side of the outer peripheral wall 42.

[0123] The pressing component 40, like the housing 20 (20A), is made of thermoplastic resins such as polypropylene (PP), polyethylene (PE), acrylonitrile-butadiene-styrene (ABS), polybutylene terephthalate (PBS), polyacetal (POM), polyethylene terephthalate (PET), polycarbonate (PC), and polyetheretherketone (PEEC), as well as biodegradable resins.

[0124] In this embodiment, the pressing member 40 is mounted relative to the housing 20A by engaging the threaded protrusion 251 of the side wall 25A of the housing 20A with the threaded protrusion 44 of the pressing member 40.

[0125] At this point, as will be described later Figure 13As shown, the pressing member 40 clamps the outer periphery of the liquid packaging body 10 together with the outer periphery of the housing 20A, and the pressing member 40 is mounted on the housing 20A. At this time, the pressing protrusion 43 on the lower surface of the upper side of the pressing member 40 presses the upper surface 13 of the liquid packaging body 10 from above. Therefore, in this embodiment, the sheet 14 on the lower surface side of the liquid packaging body 10 does not need to be bonded to the flat portion 23 around the recess 22 of the top surface 21 of the housing 20A, and the liquid packaging body 10 can be fixed by being pressed by the pressing member 40 when it is placed on the top surface 21.

[0126] In addition, to improve sealing, an annular gasket can be placed between the liquid packaging body 10 and the top surface 21.

[0127] Furthermore, as described above, in the housing 20A according to this embodiment, since the lower outer peripheral ring 29 extends from the lower end of the side wall 25A, therefore... Figure 11B As shown, a lower outer peripheral ring 29 exists at the lowest end of the housing 20A. Therefore, when the liquid contact patch 2 is pressed into the object, even if the area around the needle plate portion 30 pressed into the object such as skin expands, it is the lower outer peripheral ring 29 that contacts the object within the housing 20A.

[0128] Furthermore, in the above description, as part of the second embodiment for installing the pressing member 40, a structure in which a lower outer peripheral ring 29 is provided on the housing 20A was described. However, in the liquid contact patch 1 of the first embodiment where the pressing member 40 is not installed, a lower outer peripheral ring 29 may also be provided on the housing 20.

[0129] (Interlocking with the cover of the first structural example)

[0130] The liquid-contact patch 2 of the second embodiment can also engage with the cover 80 of the first structural example. Figure 13 This is a cross-sectional view of the cover of the first structural example that is engaged with the liquid-blocking patch 2 of the second embodiment. Figure 13 The structure of the cover 80 and the structure of the inner side wall 25A of the shell 20A are similar to those of the inner side wall 25A of the shell 20A. Figure 8 same.

[0131] Compared to this embodiment, when installing the cover 80 with the internal hanging structure, the above-described Figure 8 Similarly, it is installed by embedding the side wall 82 of the cover 80 into the inside of the side wall 25A of the housing 20A.

[0132] Thus, in this embodiment, when the cover 80 is engaged with the liquid-contact patch 2, the cover 80 is in contact with the housing 20A, and the needle plate portion 30 is not in contact with the cover 80A. The cover 80 is protected in a non-contact manner, which can prevent the deformation of the needle-shaped protrusion 32 during transportation.

[0133] Here, in Figure 8 and Figure 13 In the description, the cover 80 is an inner hanging structure in which the inner side of the cover 80 is embedded in the side wall 25 (25A) of the housing 20 (20A). However, the cover that can engage with the liquid contact patch 1 (2) can also be an outer hanging structure that covers the side wall of the housing from the outside.

[0134] (Interlocking with the cover of the second structural example)

[0135] Next, using Figures 14-15B The engagement between the cap and the liquid contact patch in the second structural example will be explained. Figure 14 This is a cross-sectional view showing the liquid-blocking patch 2B engaging with the cover 80B of the second structural example, as described in the modified example of the second embodiment. The differences from the first structural example will be explained below.

[0136] In the second structural example, the cover 80B has a side wall 82B that covers the outer side of the side wall 25A of the housing 20A. That is, in this structure, the inner diameter of the side wall 82B of the cover 80B is set to be greater than the inner diameter of the side wall 25A of the housing 20A. In other words, the cover 80B of this structural example is an externally attached cover.

[0137] Furthermore, in the cover 80B of this structure, multiple upward-protruding upright ribs 85 are provided around the outer edge of the bottom surface 81B. Moreover, in the engaged state of the cover 30B, as... Figure 14 As shown, the raised rib 85 contacts the lower outer peripheral ring 29 of the housing 20A. According to this structure, when the cover 80B is engaged, the bottom surface 81B of the cover 80B remains in contact with the needle plate portion 30A. Furthermore, even when subjected to pressure from above or below while the cover is engaged, such as during transport or before use, the lower outer peripheral ring 29 of the housing 20A abuts against the raised rib 85 of the cover 80B, ensuring that the bottom surface 81B of the cover 80B remains in contact with the needle plate portion 30A.

[0138] Furthermore, in this structural example, in the pressing member 40B of the liquid-contact patch 2B, the outer peripheral wall 42B has a structure that extends outward and upward. Therefore, in the engaged state, when viewed from above, the upper end of the side wall 82B of the cover 80B is hidden through the shape of the upper ring 41B of the pressing member 40B, making the upper end of the cover 80B an inconspicuous structure. Therefore, for example, during transportation, it is possible to prevent the upper end of the side wall 82B of the cover 80B from getting stuck and falling off.

[0139] in addition, Figure 14 The needle plate portion 30 shown illustrates its use with... Figure 13The example shown is approximately the same as the needle plate portion 30, but in the liquid contact patch 2B that can engage with the cap 80B of the second structural example, the outer diameter of the needle plate portion 30 can be set to be larger than the outer diameter of the needle plate portion 30 in the liquid contact patch 2 that engages with the cap 80 of the first structural example. Specifically, since the engaging cap 80B is an external structure, in the engaged state, the side wall 82B is located further outward than the side wall 25B of the housing 20A, so there can be almost no gap between the side wall 25A of the housing 20A and the plate 31 of the needle plate portion 30. Therefore, the outer diameter of the plate 31 of the needle plate portion 30 can be increased within the range where it does not contact the side wall 25A of the housing 20. For example, to avoid wasting space, in the liquid contact patch that engages with the externally attached cap 80B, there can be a structure where the side wall 25A of the housing 20A and the plate 31 of the needle plate portion 30 are close together without leaving a gap.

[0140] Figure 15A , Figure 15B This is a diagram illustrating the engagement between the housing 20A of the liquid-contact patch 2B and the pressing member 40B of the modified embodiment 2, and the cover 80B of the second structural example.

[0141] Figure 15A This is a top perspective view of the cover 80B of the second structural example. Figure 15B This is a bottom-view perspective view of the housing 20A and the pressing component 40B.

[0142] like Figure 15A and Figure 14 As shown, in the cover 80B of this structural example, a plurality of raised ribs 85 are provided around the outer edge of the upper surface of the bottom surface 81B. Furthermore, an inclined step portion 86 with a thickness greater on the lower side than on the upper side is provided on the inner peripheral surface of the side wall 82, and a protruding protrusion 87 is provided on a portion of the inclined step portion 86.

[0143] On the other hand, such as Figure 15B As shown, on the side of the liquid contact patch 2B, the outer edge of the lower outer peripheral ring 29 of the housing 20B is located slightly outside the outer peripheral surface of the outer peripheral wall 42B of the pressing member 40B, and the boundary portion of it forms a step S on the outer peripheral surface of the liquid contact patch 2B.

[0144] In this structure, when the cap 80B is engaged with the liquid contact patch 2B, the pressing limit is defined by the contact between the lower outer peripheral ring 29 of the housing 20B and the upright rib 85, and the cap 80B is prevented from falling off by the embedded protrusion 87 at the step S portion of the boundary between the housing 20A and the pressing member 40B.

[0145] In addition, Figure 15AThe example shown has eight upright ribs 85 (four of which are not shown), but it is sufficient to have two or more upright ribs 85 to ensure that they are not tilted in order to specify the pressing position. In addition, there are three protrusions 87 (one of which is not shown), but it is sufficient to have two or more protrusions so that one side does not float.

[0146] Thus, in this structure, when the cover 80B is engaged with the patch 2B in the liquid contact state, the housing 20B contacts the cover 80B, and the needle plate portion 30 is not in contact with the cover 80B. The cover 80B protects the needle plate portion 30 in a non-contact manner, which can prevent the deformation of the needle protrusion 32 during transportation.

[0147] In addition, Figures 14-15B In this paper, an example is described in which the cover 80B of the second structure example of the external structure is engaged with the liquid abutment patch 2B of the modified example of the second embodiment. However, it is also possible to engage the cover 80B of the second structure example of the external structure with respect to the liquid abutment patch 1 of the first embodiment, which does not have a pressing member.

[0148] <Third Implementation>

[0149] Next, using Figure 16 , Figure 17 The liquid contact patch according to the third embodiment of the present invention will be described. Figure 16 This is a cross-sectional view of the liquid contact patch 3 according to the third embodiment of the present invention. The differences from the first embodiment will be described below only.

[0150] In this embodiment, the shapes of the liquid packaging body 10 and the shell 20 of the liquid contact patch 3 are the same as in the first embodiment, but the functions and structures of the needle plate portion α and the needle plate portion 30 are different. In the first and second embodiments described above, the needles provided are solid needles, and the contents do not pass through the inside of the needle. However, in this embodiment, the needles provided on the needle plate portion α are hollow needles, and the contents pass through the inside of the needle.

[0151] like Figure 16 As shown, the needle plate portion α involved in this embodiment is an assembly (component) formed by combining two parts, having a support plate portion 50 and an abutment plate portion 60. Figure 17 This is a three-dimensional enlarged view of the cross-section of the needle plate portion α according to the third embodiment. (Refer to...) Figure 16 , Figure 17 The details of the needle plate portion α will be explained.

[0152] In this embodiment, the support plate portion 50 of the needle plate portion α has a circular flat upstream side plate 51 and an outer edge rim (flange) 52 hanging down from the outer edge of the upstream side plate 51. An insert hole 53 that runs vertically through the center of the upstream side plate 51 is formed.

[0153] Additionally, the abutment plate portion 60 has a downstream side plate 61 and a plurality of hollow needles 62 protruding to the lower side of the downstream side plate 61. An independent flow path 63 is formed on the downstream side plate 61, which is connected to the upper end (upstream end) of the hollow needles 62 and extends vertically through the downstream side plate 61.

[0154] The plurality of hollow needles 62 are so-called micro-hollow type microneedles, each hollow needle 62 having a length of about 1 μm to 5000 μm, more preferably about 5 μm to 3000 μm, and the diameter of the periphery of the root of the needle-like protrusion 112 being in the range of 2 μm to 5000 μm, more preferably in the range of 5 μm to 3000 μm. In addition, it is preferable that the plurality of hollow needles 62 are spaced apart from each other by about 0.1 mm to 10 mm or more.

[0155] Furthermore, an inner circumferential ...

[0156] By mounting the upper surface of the outer peripheral thin-walled portion 64 of the abutment plate portion 60 relative to the lower end face of the inner peripheral rim 54 of the support plate portion 50, the lower surface (downstream surface) of the upstream side plate 51 and the upper surface (upstream surface) of the downstream side plate 61 are separated by a predetermined interval, and the support plate portion 50 and the abutment plate portion 60 are joined facing each other. Through this joining, the predetermined interval space sandwiched between the lower surface of the upstream side plate 51 and the upper surface of the downstream side plate 61 becomes the liquid storage portion SP.

[0157] In the liquid contact patch 3 of this embodiment, for Figure 16 When the protrusion 12 of the liquid packaging body 10 is pressed, the sheet 14 breaks and the liquid flows out. It passes through the flow path P in the center of the cylindrical part 24 embedded in the embedding hole 53 of the shell 20, diffuses to the liquid storage part SP on the upper surface of the downstream side plate 61, and then reaches the hollow needle 62 through the independent flow path 63. Then, the target object is injected from the hollow needle 62.

[0158] Furthermore, after assembling the needle plate portion α, the cylindrical portion 24 of the housing 20 is inserted into the through hole 53 in the center of the support plate portion 50, and the upper surface of the upstream side plate 51 is joined with the lower end of the hanging rib 26, thereby mounting the needle plate portion α onto the housing 20. In addition to sealing the housing 20 by inserting the cylindrical portion 24 of the housing 20 into the insertion hole 53, the needle plate portion α can also be mounted onto the housing 20 by means of adhesive bonding, ultrasonic welding, O-rings, etc.

[0159] Thus, in the needle plate portion α of this embodiment, the downstream abutment plate portion 60 does not have a vertically penetrating flow path at a position different from the needle. Therefore, the liquid as the contents will not diffuse to the surface of the skin, but will be directly injected into the inner side of the skin from the needle hole at the front end of the hollow needle 62. When using the hollow needle 62, since it can be directly and effectively injected and penetrated into the interior of the skin from the needle hole at the front end, the influence of gravity can be ignored.

[0160] Therefore, although the edge portion does not need to function as a stopper, a lip similar to the lip 33 in the first embodiment can be provided on the lower side of the outer edge of the abutment plate portion 60, for example, to prevent excessive needle insertion. In this case, the height of the lip is configured to be lower than the height of the hollow needle 62. By contacting the skin with the lower end of the lip, the injection volume from the hollow needle 62 increases, and as a result, even if the portion that leaks onto the skin surface diffuses on the surface, the contents can remain on the skin surface.

[0161] In addition, in this structural example, an example of liquid movement through the liquid storage part SP in the gap space between the upstream side plate 51 and the downstream side plate 61 was described. However, in order to move the liquid from the center to the outside more effectively, the part of the shortest path from the center to the through hole can also be used as the flow path, and a strip-shaped recess can be formed on the rear side (upper surface) of the downstream side plate 61.

[0162] In addition, Figure 16 , Figure 17 In the previous example, an example of a needle plate portion α using a hollow needle 62 was described, which is achieved by combining two plate portions 50 and 60 into an assembly structure. However, the needle plate portion α can also be achieved by integrating the functions of the plate portions 50 and 60 into a single component (an integrated needle plate portion). In this case, the integrated needle plate portion is a frame-shaped component with internal space, top, bottom, and sides. A fitting hole is formed in the center of the upper surface, and multiple independent flow paths with hollow needles are formed on the lower surface.

[0163] In this structure, when liquid flows from the cylindrical portion 24 into the interior of the integrated needle plate by pressing the protrusion 12, the liquid can flow from the flow path P in the center of the fitting hole to multiple hollow needles inside the integrated needle plate, and the liquid is injected into the object from the multiple hollow needles that enter the object.

[0164] Below, using Figures 18-19E The usage process and flow of contents of the liquid contact patch 3 in this embodiment will be explained. Figure 18 This describes the usage process of the liquid contact patch 3 according to the third embodiment. Figures 19A-19E yes Figure 18 The usage process is illustrated in the diagram. Figure 19A This diagram shows the state in which the liquid contact patch 3 is gently placed on the object. Figure 19B This diagram illustrates the state of the object being pierced by the hollow needle 62 of the liquid contact patch 3. Figure 19C This diagram shows the state in which the liquid is pressed against the protrusion of patch 3. Figure 19D This diagram illustrates the state of liquid entering the object through the contact patch 3. Figure 19E This diagram shows the state in which the liquid-contact patch 3 is peeled off from the object.

[0165] In S31, when the side wall 25 of the housing 20 of the liquid contact patch 3 is held and the liquid contact patch 3 is gently placed on the object, the front end of the hollow needle 62 of the contact plate portion 60 of the needle plate portion α contacts the object (see reference). Figure 19A ).

[0166] In S32, the hollow needle 62 punctures the target object (see reference) by pressing the upper surface 13 of the liquid packaging body 10. Figure 19B ).

[0167] In S33, by pressing the protrusion 12 of the liquid packaging body 10, the lower sheet 14 breaks, and the stored liquid flows into the flow path P of the cylinder 24 (see reference). Figure 19C ).

[0168] In S34, liquid flows from flow path P into the gap space within the needle plate section α, and from the liquid storage section SP flows through multiple independent flow paths 63 to multiple hollow needles 62. Liquid is injected into the interior of the object through the front end of the hollow needle 62 that enters the object (see reference). Figure 19D ).

[0169] In S35, the hollow needle 62 is pulled out of the object by grasping the liquid-contact patch 3 and peeling it off (see reference). Figure 19E ).

[0170] Therefore, in this embodiment, for the small liquid contact patch 3, by having the user hold the side wall 25 of the housing 20 and maintain its position, or by holding the side wall 25 and pressing it with their fingers to bring it into contact with the object, the liquid effective for the object permeates from the hollow needle inserted into the object to the inside of the object. Thus, in this embodiment, by pressing the small and easily held liquid contact patch 3 with a finger to bring it into contact with the object (e.g., skin), a stable state is maintained while allowing the active ingredients of fresh liquid to permeate from the hole opened by the needle to the inside of the object. Therefore, the active ingredients can penetrate to the inside of the object.

[0171] <Fourth Implementation>

[0172] Figure 20 This is a cross-sectional view of the liquid contact patch according to the fourth embodiment. In the liquid contact patch 4 according to this embodiment, which has a needle plate portion α with a hollow needle, a pressing member 40 is provided in the same manner as in the second embodiment.

[0173] Figure 20 The structure of the needle plate portion α of the liquid contact patch 4 in the fourth embodiment shown is the same as described above. Figure 16 , Figure 17 The structure of the third embodiment shown is the same as that of the second embodiment, with the shell 20A, liquid packaging body 10 and pressing member 40 having the same structure.

[0174] Additionally, although not illustrated, but as Figures 8 to 10B As shown, the liquid-holding patches 3 and 4 of the third and fourth embodiments can also engage with the inner-hanging type cap 80 involved in the first structural example. The cap engagement method is the same as described above.

[0175] (A variation of the fourth embodiment)

[0176] Although not shown, the external cap 80B of the second structural example can also be engaged with the liquid-resistant patch according to the modification of the fourth embodiment. In this case, in the liquid-resistant patch according to the modification, in order to prevent the cap 80B from falling off, the pressing member 40 on the upper side of the liquid-resistant patch having the needle plate portion α can be configured as described above. Figure 14 The pressing component 40B is shown.

[0177] <Fifth Implementation>

[0178] Next, using Figure 21 , Figure 22 The liquid contact patch 5 according to the fifth embodiment of the present invention will be described. Figure 21 This is a cross-sectional view of the liquid contact patch 5 according to the fifth embodiment. Figure 22This diagram illustrates the state in which the liquid in the liquid-contact patch of the fifth embodiment enters the interior of the object.

[0179] like Figure 21 As shown, the needle plate portion β in this embodiment is an assembly (component) formed by combining two parts, having a support plate portion 50 and a plate portion 600 with a base. The support plate portion 50 has the same structure as in the third embodiment.

[0180] like Figure 21 , Figure 22 As shown, in this embodiment, one or more pedestal portions 66 are provided on the plate portion 600 with pedestals, protruding from one side (downstream surface) F1 of the downstream side plate 65, which is the main body of the plate. The diameter of the front end surface CF2 of the upper base surface of the pedestal portion 66, which is in the shape of a frustum of a cone, i.e., the front end diameter, is, for example, 100 μm to 1500 μm, and is particularly preferably 300 μm to 600 μm.

[0181] Furthermore, one or more tiny needle-like protrusions 67 protruding from the downstream end face, i.e. the front end face CF2, of the multiple pedestal portions 66 are respectively provided, and a lip 68 formed on the outer edge of the front end face CF2 of the pedestal portion 66.

[0182] The needle-like protrusions 67 in this embodiment are so-called fine microneedles. The length of each needle-like protrusion 67 is about 1 μm to 5000 μm, more preferably about 5 μm to 3000 μm, and the diameter of the periphery of the root of the needle-like protrusion 67 is in the range of 2 μm to 5000 μm, more preferably in the range of 5 μm to 3000 μm. In addition, the spacing (c) between the apexes of the plurality of needle-like protrusions 67 is, for example, 1 mm to 10 mm, more preferably about 2 mm to 5 mm.

[0183] Furthermore, the height of the lip 68 is shorter than or equal to the length of the needle-like protrusion 67, for example, about 1 μm to 5000 μm, more preferably about 5 μm to 3000 μm. Additionally, the thickness of the lip 68 is about 0.05 mm to 3 mm.

[0184] Furthermore, the combined height (a+b) of the base portion 66 and the needle-like protrusions 67 is 600 μm to 5000 μm. Additionally, the ratio of the combined height (a) of the base portion 66 and the needle-like protrusions 67 to the spacing (c) of the needle-like protrusions 67 ((a+b) / c) is preferably 0.1 or more and 2.8 or less.

[0185] Furthermore, on the downstream side plate 65 and multiple base portions 66 of the plate portion 600 with base, an injection hole 69 is formed that extends vertically from the other side surface (upstream surface) F2 of the downstream side plate 65 to the front end surface, i.e., the abutment surface CF2 of the base portion 66.

[0186] In addition, in the plate portion 600 with a base, a thin-walled outer peripheral portion 64, which extends outward from the lower surface and is thinner on the upper surface, is provided on the outer edge of the downstream side plate 65, similar to the third embodiment.

[0187] Since the support plate portion 50 in this embodiment is the same as that in the third embodiment, by mounting the upper surface of the outer peripheral thin-walled portion 64 of the plate portion 600 with the platform onto the outer edge rim 52 hanging from the outer edge of the support plate portion 50, the lower surface (downstream surface) of the upstream side plate 51 and the upper surface (upstream surface) of the downstream side plate 65 can be separated by a predetermined interval, allowing the support plate portion 50 and the plate portion 600 with the platform to be joined facing each other. Through this joining, the predetermined interval space sandwiched between the lower surface of the upstream side plate 51 and the upper surface of the downstream side plate 65 becomes the liquid storage portion SP.

[0188] In this embodiment, by pressing the protrusion 12 of the liquid packaging body 10, the lower sheet 14 breaks, and the stored liquid flows into the flow path P of the cylinder 24. Then, as... Figure 22 As shown, the liquid diffuses from the flow path P into the gap space on the upper surface of the downstream side plate 65 in the needle plate section β, where it is stored as liquid, and then enters multiple injection holes 69.

[0189] Furthermore, in this embodiment, the liquid diffuses onto the object on the contact surface CF2 of the base portion 66 and on the inner circumferential side of the lip portion 68, while simultaneously penetrating into the inner side of the object O through the hole opened by the needle-like protrusion 67. Therefore, the effective components of the liquid can penetrate from both the outer and inner sides of the object O.

[0190] In this embodiment, the liquid diffuses in the region on the inner periphery of the lips 68 of the plurality of base portions 66, and also forms a liquid accumulation on the front end side of the base portion 66. Therefore, for example, when the liquid abutment patch 5 is large and the area of ​​the downstream side plate 65 is large, the liquid can be applied in a point-like and precise manner when it is desired to apply the active ingredient.

[0191] In addition, in this embodiment, such as Figure 22 As shown, through the step difference between the pedestal portion 66 and the surface F1 of the downstream side plate 65, the lip 68 connected to the pedestal portion 66 presses against the object such as skin within a narrow range, causing the needle-like protrusion 67 to pierce. Therefore, when the surface of the object O is uneven or the object O is soft, the needle-like protrusion 67 can easily pierce the object O, and can more reliably deliver liquid from both the outside and the inside.

[0192] Furthermore, hollow needles have the following disadvantage: if not all needles pierce the target, liquid may be expelled from needles that have not been pierced due to poor injection resistance. However, in this embodiment, the lip 68 is in contact with the target regardless of whether the needle protrusion 67 pierces it, thus applying injection pressure (resistance) uniformly to all the front portions, i.e., the area on the inner circumference of the lip 68. Therefore, it has the advantage of effectively improving injection performance.

[0193] In addition, in this structure, in order to make the liquid move from the center of the main surface to the outside more effectively in the gap space between the downstream side plate 65 and the upstream side plate 51, the part of the shortest path of the liquid flowing from the center to the multiple injection holes 69 can be used as the flow path, and a strip-shaped recess is formed on the surface F2 on the other side of the downstream side plate 65.

[0194] Alternatively, multiple needle-like protrusions or multiple injection holes can be provided on a single base portion 66. In this case, in each base portion 66, the liquid squeezed out from the multiple injection holes can diffuse onto the object O on the contact surface CF2 of the base portion 66, inside the lip 68, and also penetrate into the inside of the object O through the holes opened by the multiple needle-like protrusions 67.

[0195] Additionally, although not shown, the liquid-holding patch 5 according to the fifth embodiment can also be used as follows: Figures 8 to 10B As shown, the first structural example involves an inner-mounted cover 80. The method of engaging the cover is the same as described above.

[0196] Alternatively, although not shown, as a variation of the liquid contact patch 5 in the fifth embodiment, a pressing member 40 may be provided in the housing, as in the second and fourth embodiments.

[0197] In this case, although not shown, the cap 80B of the external type according to the second structural example can also be engaged with the modified liquid-resistant patch 5 according to the fifth embodiment. In this case, in order to prevent the cap 80B from falling off in the modified liquid-resistant patch, the pressing member 40 on the upper side of the liquid-resistant patch having the needle plate portion β can be configured as described above. Figure 14 The pressing component 40B is shown.

[0198] <Sixth Implementation>

[0199] Next, using Figure 23 The liquid contact patch 6 according to the sixth embodiment of the present invention will be described. Figure 23 This is a cross-sectional view of the liquid contact patch 6 according to the sixth embodiment.

[0200] The liquid contact patch 6 of this embodiment does not have the needle plate portion 30 (α, β) with needles that abut against the target object, which is a component of the embodiment described above. Instead, it has a mounting plate portion 70 capable of mounting a certain permeation component. Apart from this, the structure of the housing 20 and the liquid packaging body 10 is the same as in the first embodiment.

[0201] The mounting plate portion 70 has a structure similar to the support plate portion 50 described above, having a circular flat plate 71 and an outer edge rim 72 hanging down from the outer edge of the plate 71, with an insert hole 73 forming in the center of the plate 71 that runs vertically through it.

[0202] Regarding the mounting plate portion 70 with such a structure, the mounting plate portion 70 is mounted on the housing 20 by inserting the cylindrical portion 24 of the housing 20 into the central through hole, i.e., the insertion hole 73, and by engaging the upper surface of the plate 71 with the lower end of the hanging rib portion 26.

[0203] For example, in this embodiment, the user prepares a permeation component made of commercially available materials such as sponges (puffs), cotton, or non-woven fabrics that allow liquid to pass through slowly, and embeds the permeation component into the mounting plate 70 for use.

[0204] Figure 24 The figure shows the liquid-blocking patch 6 according to the fifth embodiment, on which the permeation member 90 is installed. In such a way... Figure 24 In the installed configuration shown, the permeation component 90 is located at the bottom. Therefore, when the liquid abutting patch 6 with the permeation component 90 installed is placed... Figure 7 When pressed onto objects such as skin, the penetrating component 90 comes into contact with the skin.

[0205] The installed permeation component 90 is, for example, a sponge. Because the permeation component 90 allows the liquid to pass through slowly, the liquid flowing in from the flow path P of the cylindrical portion 24 of the housing 20 embedded in the insertion hole 73 of the mounting plate portion 70 diffuses throughout the permeation component 90 and reaches the target object through the permeation component 90.

[0206] For example, when the target object is skin, in this embodiment, the small and easy-to-hold liquid contact patch 6, combined with other penetration components, is pressed against the skin with a finger, allowing fresh liquid beauty ingredients to remain on the skin. Furthermore, by pressing the penetration component 90 firmly against the skin, the liquid with beauty effects is penetrated into the skin. Therefore, it is possible to apply pressure while allowing beauty ingredients to penetrate the skin.

[0207] Furthermore, in the first to fifth embodiments described above, the structure was explained in which the needle of the needle plate portion is located at the bottom and thus engages with the cover to protect the needle. However, in this embodiment, since there is no needle plate portion and no object to be protected, the cover may not be provided during the circulation stage, or the cover may be provided.

[0208] In addition, Figure 23 , Figure 24 In the liquid contact patch 6 shown, the structure in which the permeation component 90 can be installed via the mounting plate 70 has been described. However, it is also possible to install the permeation component directly by embedding it into the cylindrical portion 24 of the housing 20 without providing a mounting plate.

[0209] In addition, Figure 23 , Figure 24 In the liquid abutment patch 6 shown, an example of the upper housing 20 and liquid packaging body 10 having the same structure as in the first embodiment has been described. However, in a liquid abutment patch that can install a permeation component, a pressing component 40 or 40B may also be provided on the upper part, adopting the same structure as in the second embodiment or a variation thereof.

[0210] (Example 1 of a variation of a liquid packaging)

[0211] In the liquid packaging body 10 of the present invention described above, the material allows for destruction with relatively light force. However, in order to destroy the sheet 14 with even lighter force, protrusions can be provided on the inner surface of the protrusion 12 of the liquid packaging body 10, at the center of the recess 22 of the shell 20, or at multiple locations. When provided on the shell 20, it can be integrally provided during the molding of the shell 20.

[0212] (Modified Example 2 of Liquid Packaging)

[0213] It can replace sheet 14, in Figure 1 The upper surface of the hole P is integrally formed with the housing 20 to form a thin-walled portion. The cap is opened by hydraulic pressure when pressing the protrusion 12 of the liquid packaging 10, or by pressing the cap 80 deeper relative to the positioning pin (not shown) at the center of the bottom of the cap 80 to open it before applying it to the skin. In this case, since the reagent is filled between the recess 22 of the housing 20 and the sheet 14, the housing material is preferably made of COP (cyclic olefin polymer) for preservation stability. In this structure, since the thin-walled portion is formed integrally, it is not necessary to attach the sheet 14.

[0214] (Contents)

[0215] In the above embodiments of the present invention, the contents (liquid substances) used in the liquid contact patch were described using cosmetic substances as an example, but the contents may also be selected from cell suspensions, gel materials, therapeutic substances, and diagnostic substances.

[0216] As cosmetic substances, this includes general cosmetic substances that may be contained in cosmetic compositions, as well as cosmetic substances used in cosmetic medicine. General cosmetic substances include, for example, ascorbic acid or its derivatives, tranexamic acid, arbutin, 4-MSK (potassium 4-methoxysalicylate) for whitening purposes, and retinol, niacinamide, hyaluronic acid or its derivatives for anti-wrinkle purposes, but are not limited to these.

[0217] In addition to general cosmetic substances that may be contained in cosmetic compositions, injectable cosmetic substances may also include fat cells as fillers, hyaluronic acid, or botulinum toxin (Botox, Btx) used in wrinkle treatment, but are not limited to these.

[0218] Therapeutic substances may include, but are not limited to, antibiotics, anesthetics, analgesics, vaccines, and antibodies.

[0219] In addition, the liquid contact patch of the present invention can be used to inject cells in suspension or in liquid medium into test subjects.

[0220] Additionally, the cell suspension contained within the liquid contact patch can be mixed with developmental factors. Alternatively, the cell suspension can contain a gel-like structure. This gel-like structure preferably represents a mixture of extracellular matrix proteins that mimic the extracellular environment of other different tissues, and more preferably a gel-like structure such as hyaluronic acid.

[0221] Furthermore, in the above description, human skin was used as an example of the object on which the liquid is applied using the liquid contact patch of the present invention. However, the object can also be applied to animal skin, the stem, trunk, or leaf surface of a plant, etc. Alternatively, the object can also be skin, organs, or other tissues taken from a test subject or a test animal.

[0222] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific embodiments involved, and various modifications and alterations can be made within the scope of the spirit of the embodiments of the present invention as described in the claims.

[0223] This international application claims priority based on Japanese Patent Application No. 2020-166214, filed on September 30, 2020, the entire contents of which are incorporated herein by reference.

[0224] Explanation of reference numerals in the attached figures

[0225] 1, 2, 3, 4, 5 Liquid contact patches

[0226] 10. Liquid Packaging (PTP)

[0227] 11 Flexible shield

[0228] 12 convex parts

[0229] 13. Upper surface of the plane (planar part)

[0230] 14 sheets

[0231] 20, 20A housing

[0232] 21 Top surface

[0233] 22 concavities

[0234] 23 Planar section

[0235] 25 sidewalls

[0236] 26. Lower ribs

[0237] 29 Lower peripheral ring

[0238] 30-needle plate (solid)

[0239] 31 boards

[0240] 32 needle-like protrusions

[0241] 33 Lips

[0242] 34 Embedded Holes

[0243] 40, 40B Pressing Components

[0244] 41, 41B upper ring

[0245] 42, 42B peripheral wall

[0246] 50 Support Plate Section

[0247] 51 Upstream side plate

[0248] 53 Embedded Holes

[0249] 60 Abutment Plate Section

[0250] 61 Downstream side plate

[0251] 62 hollow needles

[0252] 63 independent flow paths

[0253] 600 plate with base

[0254] 65 Downstream side plate

[0255] 66 pedestal parts

[0256] 67 needle-like protrusions

[0257] 68 Lips

[0258] 69 injection holes

[0259] 70 Mounting Plate Section

[0260] 73 Embedded Holes

[0261] 80, 80B cover

[0262] 81, 81B bottom surface

[0263] 82, 82B cover sidewalls

[0264] 90% Permeable Components (Sponge)

[0265] α and β needle plate

[0266] CF front-end

[0267] LT lip front face

[0268] P flow hole

[0269] The upper end of the side wall of the UT cover

[0270] The face on the F1 side (downstream face)

[0271] The other side of F2 (upstream side)

[0272] The front end surface of the CF2 pedestal

Claims

1. A liquid contact patch comprising a liquid packaging body and a shell, The liquid packaging body stores the liquid by clamping it with a flexible cover with protrusions and a tearable sheet. The housing has a top surface and sidewalls surrounding the top surface, with a cylindrical portion hanging down from the center of the top surface. By pressing the protrusion of the liquid packaging body, the sheet breaks, and the stored liquid flows out from the cylindrical portion. The liquid contact patch includes a needle plate portion that is connected to the cylindrical portion of the housing. The needle plate portion has an upstream side plate and a downstream side plate. An insert hole extending along the thickness direction is formed in the upstream side plate, and the cylindrical portion of the housing is inserted into the insert hole. The downstream side plate is provided with a plurality of hollow needles protruding from the downstream end face, forming an independent flow path that extends along the thickness direction and communicates with the upstream ends of the plurality of hollow needles. The upstream and downstream side plates are arranged opposite each other with a gap, forming a gap space between the downstream surface of the upstream side plate and the upstream surface of the downstream side plate. When liquid is pressed by the protrusion and flows into the cylindrical portion embedded in the embedded hole, the gap space becomes a liquid storage portion. The liquid flows to the multiple hollow needles through the multiple independent flow paths and enters the interior of the object through the multiple hollow needles.

2. The liquid abutment patch according to claim 1, The height of the sidewall of the housing is 0.6~2.5cm.

3. The liquid abutment patch according to claim 1, A recess is formed on the top surface of the housing, the protrusion of the liquid packaging body can be pressed into the recess, and the cylindrical portion hangs down from the recess.

4. The liquid abutment patch according to claim 2, A recess is formed on the top surface of the housing, the protrusion of the liquid packaging body can be pressed into the recess, and the cylindrical portion hangs down from the recess.

5. The liquid abutment patch according to claim 1, The housing has drooping ribs that hang down from the lower surface of the top surface. The lower end of the drooping rib contacts the upper surface of the needle plate.

6. The liquid abutment patch according to claim 2, The housing has drooping ribs that hang down from the lower surface of the top surface. The lower end of the drooping rib contacts the upper surface of the needle plate.

7. The liquid contact patch according to any one of claims 1 to 6, comprising a pressing member, The pressing component covers the outer periphery of the liquid packaging body from above and covers at least a portion of the sidewall of the housing. The pressing component clamps the outer periphery of the liquid packaging body together with the outer periphery of the upper surface of the shell, and engages with the side wall of the shell.

8. The liquid abutment patch according to claim 1, The liquid-contact patch can engage with the cover covering the needle plate portion. The cover has a sidewall and a bottom surface connected to the sidewall. The sidewall of the cover enters between the sidewall of the housing and the outer edge of the needle plate portion. The needle plate portion is in contact with the cover through the housing, and when the cover is engaged, the needle plate portion is not in contact with the cover.

9. The liquid abutment patch according to claim 2, The liquid-contact patch can engage with the cover covering the needle plate portion. The cover has a sidewall and a bottom surface connected to the sidewall. The sidewall of the cover enters between the sidewall of the housing and the outer edge of the needle plate portion. The needle plate portion is in contact with the cover through the housing, and when the cover is engaged, the needle plate portion is not in contact with the cover.

10. The liquid abutment patch according to claim 1, The liquid-contact patch can engage with the cover covering the needle plate portion. The cover has a sidewall and a bottom surface connected to the sidewall. The sidewall of the cover covers the outer sidewall of the housing. The needle plate portion is in contact with the cover through the housing, and when the cover is engaged, the needle plate portion is not in contact with the cover.

11. The liquid abutment patch according to claim 2, The liquid-contact patch can engage with the cover covering the needle plate portion. The cover has a sidewall and a bottom surface connected to the sidewall. The sidewall of the cover covers the outer sidewall of the housing. The needle plate portion is in contact with the cover through the housing, and when the cover is engaged, the needle plate portion is not in contact with the cover.

12. The liquid contact patch according to any one of claims 1-6 and 8-11, The flexible cover of the liquid packaging body has a metal layer or an inorganic vapor-deposited layer.

13. The liquid abutment patch according to claim 7, The flexible cover of the liquid packaging body has a metal layer or an inorganic vapor-deposited layer.

14. A liquid contact patch comprising a liquid packaging body and a shell, The liquid packaging body stores the liquid by clamping it with a flexible cover with protrusions and a tearable sheet. The housing has a top surface and sidewalls surrounding the top surface, with a cylindrical portion hanging down from the center of the top surface. By pressing the protrusion of the liquid packaging body, the sheet breaks, and the stored liquid flows out from the cylindrical portion. The liquid contact patch includes a needle plate portion that is connected to the cylindrical portion of the housing. The needle plate portion has an upstream side plate and a downstream side plate. An insert hole extending along the thickness direction is formed in the upstream side plate, and the cylindrical portion of the housing is inserted into the insert hole. The downstream side plate is provided with multiple pedestal portions protruding from the downstream surface. Each of the plurality of pedestal portions is provided with a tiny needle-like protrusion protruding from the front end face of the pedestal portion and a lip formed on the outer edge of the front end face. An injection hole is formed that extends from the upstream surface of the downstream side plate along the thickness direction to the front end surface of the plurality of pedestals.

15. The liquid abutment patch according to claim 14, The height of the sidewall of the housing is 0.6~2.5cm.

16. The liquid abutment patch according to claim 14, A recess is formed on the top surface of the housing, the protrusion of the liquid packaging body can be pressed into the recess, and the cylindrical portion hangs down from the recess.

17. The liquid abutment patch according to claim 15, A recess is formed on the top surface of the housing, the protrusion of the liquid packaging body can be pressed into the recess, and the cylindrical portion hangs down from the recess.

18. The liquid abutment patch according to claim 14, The housing has drooping ribs that hang down from the lower surface of the top surface. The lower end of the drooping rib contacts the upper surface of the needle plate.

19. The liquid abutment patch according to claim 15, The housing has drooping ribs that hang down from the lower surface of the top surface. The lower end of the drooping rib contacts the upper surface of the needle plate.

20. The liquid contact patch according to any one of claims 14 to 19, comprising a pressing member, The pressing component covers the outer periphery of the liquid packaging body from above and covers at least a portion of the sidewall of the housing. The pressing component clamps the outer periphery of the liquid packaging body together with the outer periphery of the upper surface of the shell, and engages with the side wall of the shell.

21. The liquid abutment patch according to claim 14, The liquid-contact patch can engage with the cover covering the needle plate portion. The cover has a sidewall and a bottom surface connected to the sidewall. The sidewall of the cover enters between the sidewall of the housing and the outer edge of the needle plate portion. The needle plate portion is in contact with the cover through the housing, and when the cover is engaged, the needle plate portion is not in contact with the cover.

22. The liquid abutment patch according to claim 15, The liquid-contact patch can engage with the cover covering the needle plate portion. The cover has a sidewall and a bottom surface connected to the sidewall. The sidewall of the cover enters between the sidewall of the housing and the outer edge of the needle plate portion. The needle plate portion is in contact with the cover through the housing, and when the cover is engaged, the needle plate portion is not in contact with the cover.

23. The liquid abutment patch according to claim 14, The liquid-contact patch can engage with the cover covering the needle plate portion. The cover has a sidewall and a bottom surface connected to the sidewall. The sidewall of the cover covers the outer sidewall of the housing. The needle plate portion is in contact with the cover through the housing, and when the cover is engaged, the needle plate portion is not in contact with the cover.

24. The liquid abutment patch according to claim 15, The liquid-contact patch can engage with the cover covering the needle plate portion. The cover has a sidewall and a bottom surface connected to the sidewall. The sidewall of the cover covers the outer sidewall of the housing. The needle plate portion is in contact with the cover through the housing, and when the cover is engaged, the needle plate portion is not in contact with the cover.

25. The liquid contact patch according to any one of claims 14-19 and 21-24, The flexible cover of the liquid packaging body has a metal layer or an inorganic vapor-deposited layer.

26. The liquid abutment patch according to claim 20, The flexible cover of the liquid packaging body has a metal layer or an inorganic vapor-deposited layer.

Images