一种单信号激活型TIL细胞的制备方法及应用

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By expressing CD3-CD28 or CD137 fusion proteins on the surface of TIL cells, single-signal activated TIL cells were constructed, which solved the problem of insufficient TIL cell activation in the tumor microenvironment and achieved a highly efficient tumor killing effect.

CN116103244BActive Publication Date: 2026-07-17HEBEI UNIV OF SCI & TECH

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Patent Information

Authority / Receiving Office: CN · China
Patent Type: Patents(China)
Current Assignee / Owner: HEBEI UNIV OF SCI & TECH
Filing Date: 2023-04-12
Publication Date: 2026-07-17

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Abstract

本发明提供了一种将CD3与T细胞共刺激因子受体的胞内激活结构域融合并表达于肿瘤浸润T淋巴细胞或外周血游离肿瘤浸润T淋巴细胞，制备单信号激活型TIL细胞，借助TIL的肿瘤特异识别性，在不需要APC细胞辅助的情况下即可实现对肿瘤的特异识别和杀伤，有效避免了TIL细胞在肿瘤微环境下因缺乏共刺激信号而不能被激活所造成的免疫耐受，可应用于不区分癌种的抗肿瘤治疗中。

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