Application of Bacillus subtilis JZXJ-7 in the preparation of preparations for alleviating Vibrio parahaemolyticus infection

By using the preparation prepared by Bacillus subtilis JZXJ-7, the problem of drug-resistant bacterial production and intestinal flora imbalance in the treatment of food poisoning of Vibrio parahemolyticus was solved, and effective relief of Vibrio parahemolyticus infection and stable remodeling of intestinal microecology was achieved.

CN116115649BActive Publication Date: 2025-03-28BOHAI UNIV
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Patent Information

Application Number
CN202310059691.1
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-01-14
Publication Date
2025-03-28
Estimated Expiration
2043-01-14

AI Technical Summary

Technical Problem

The prior art has side effects such as drug-resistant bacteria production, renal function abnormalities and intestinal flora imbalance in the treatment of food poisoning of Vibrio parahaemolyticus, and Bacillus subtilis has insufficient research on preventing pathogenic infection.

Method used

Bacillus subtilis JZXJ-7 was used to prepare preparations to alleviate Vibrio parahaemolytic infection, which highly inhibited Vp growth by secreting bacterin and gastric acid resistance, and reshaped microbial stability by adjusting the structure of the intestinal microbial community.

Benefits of technology

Bacillus subtilis JZXJ-7 can effectively resist Vibrio parahemolytic infection, improve colon pathological damage, inhibit intestinal physiological dysfunction caused by infection, and alleviate intestinal flora disorders by increasing beneficial bacterial groups such as Akman, Bifidobacteria and Clostridium.

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Abstract

The present invention relates to the field of biomedicine technology, and specifically discloses the application of Bacillus subtilis JZXJ-7 in the preparation of a preparation for alleviating Vibrio parahaemolyticus infection. Based on a study of a mouse model infected with Vibrio parahaemolyticus, it was found that Bacillus subtilis JZXJ-7 increased the diversity of intestinal microorganisms in mice, enriched beneficial bacteria such as Akkermansia, Bifidobacterium and Clostridium, reshaped the stability of intestinal microecology, effectively resisted weight loss, increased disease activity index and colonization of intestinal pathogens caused by Vibrio parahaemolyticus infection, and could alleviate colon damage caused by Vp infection and maintain intestinal physiological function. The preparation is expected to become a new strategy for preventing Vibrio parahaemolyticus food poisoning and reducing the abuse of antibiotics, and has good application prospects.
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