An automated integrated processing device for centrifuge tubes

Abstract

This invention relates to an automated integrated processing device for centrifuge tubes, comprising at least two of a mixing mechanism, a temperature control mechanism, and a magnetic bead adsorption mechanism, and a controller. The mixing mechanism includes a support plate and a rotary drive mechanism mounted on the support plate. Centrifuge tubes are placed on the support plate, and the rotary drive mechanism drives the centrifuge tubes to rotate to achieve solution mixing. The temperature control mechanism and the magnetic bead adsorption mechanism are located below the support plate and are used to control the temperature of the solution in the centrifuge tubes and to adsorb magnetic beads in the solution, respectively. The controller is electrically connected to the mixing mechanism, the temperature control mechanism, and the magnetic bead adsorption mechanism, and controls the operation of the mixing mechanism, the temperature control mechanism, and the magnetic bead adsorption mechanism respectively. This integrated processing device can achieve stirring, mixing, temperature control, and adsorption of suspended magnetic beads in one mechanical device, eliminating the need for transfer between different devices and improving experimental efficiency and reliability.

Description

Technical Field

[0001] This invention relates to the field of experimental instruments, and more particularly to an automated integrated processing device for centrifuge tubes. Background Technology

[0002] Currently, in laboratories, centrifuge tubes have diverse processing needs, such as temperature control, solution mixing, and magnetic bead adsorption. This is mainly due to breakthroughs in biological cell processing and nucleic acid processing, which necessitate a variety of equipment to meet the diverse experimental needs of researchers. While laboratories have equipment for centrifuge temperature control, shaking, and magnetic bead levitation, these are not the only options available.

[0003] However, these devices are currently independent, requiring technicians to use different equipment and manually transfer centrifuge tubes between them. This necessitates that technicians memorize the operating methods and procedures of various experimental devices, demanding a high level of experimental expertise. In terms of economy and practicality, these devices not only consume significant experimental funds and manpower, but also pose problems such as space requirements and high maintenance costs. Summary of the Invention

[0004] To address the aforementioned problems, the purpose of this invention is to provide an automated integrated centrifuge tube processing device that can simultaneously perform processes such as mixing, temperature control, and magnetic bead adsorption without requiring switching between different devices, thereby improving the success rate and reliability of experiments and reducing costs.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] An automated integrated processing device for centrifuge tubes includes any combination of a mixing mechanism, a temperature control mechanism, and a magnetic bead adsorption mechanism, as well as a controller. The mixing mechanism includes a support plate and a rotary drive mechanism mounted on the support plate. Centrifuge tubes are inserted into the support plate, and the rotary drive mechanism drives the centrifuge tubes to rotate to achieve solution mixing. The temperature control mechanism and the magnetic bead adsorption mechanism are used to control the temperature of the solution in the centrifuge tubes and to adsorb magnetic beads in the solution, respectively. The controller is electrically connected to the mixing mechanism, the temperature control mechanism, and / or the magnetic bead adsorption mechanism, and controls the operation of the mixing mechanism, the temperature control mechanism, and / or the magnetic bead adsorption mechanism.

[0007] Furthermore, the support plate is provided with several through holes, and the centrifuge tube is inserted into the through holes;

[0008] The rotary drive mechanism includes a drive component, a drive wheel, and several driven wheels. The output end of the drive component is connected to the drive wheel. The drive wheel is connected to the several driven wheels via a transmission connection. Each driven wheel is installed in a through hole. The driven wheel is rotatably connected to the through hole via a bearing. The centrifuge tube is fixedly inserted into the driven wheel.

[0009] Furthermore, the inner diameter of the driven wheel is larger than the diameter of the centrifuge tube body but smaller than the thread diameter of the centrifuge tube opening. The centrifuge tube is inserted into and fixed inside the driven wheel, and the driving component drives the driven wheel to rotate, thereby causing the centrifuge tube to rotate.

[0010] Furthermore, the driving wheel is connected to several driven wheels via a belt, chain, or gear transmission structure, and the driving component is a rotary motor.

[0011] Furthermore, the temperature control mechanism includes a base, a first lifting mechanism mounted on the base, and a temperature control block. The first lifting mechanism drives the temperature control block to rise or fall. When the centrifuge tube needs to be heated, the first lifting mechanism drives the temperature control block to rise. When heating needs to be stopped, the first lifting mechanism drives the temperature control block to fall.

[0012] Furthermore, the first lifting mechanism includes a first driving mechanism and a first bracket. The first driving mechanism drives the first bracket to move up and down, and the temperature control block is disposed on the first bracket.

[0013] Furthermore, the first bracket includes a support frame, a temperature control block seat, and an isolation seat. The support frame is connected to the output end of the first drive mechanism, the temperature control block seat is fixed to the top of the support frame, the isolation seat is placed on the temperature control block seat, and the temperature control block is located on the isolation seat.

[0014] Furthermore, the magnetic bead adsorption mechanism includes a support, a second lifting mechanism mounted on the support, and a magnet. The second lifting mechanism drives the magnet to rise or fall. When magnetic adsorption is required, the second lifting mechanism drives the magnet to rise. When heating needs to be stopped, the second lifting mechanism drives the magnet to fall.

[0015] Furthermore, the second lifting mechanism includes a second driving mechanism and a second support. The output end of the second driving mechanism is connected to the second support. The magnet is mounted on the second support. The second support moves up and down, causing the magnet to move up and down. When magnetic beads need to be attracted, the magnet moves upward. When magnetic beads do not need to be attracted, the magnet moves downward.

[0016] Furthermore, the temperature control mechanism also includes a first guide mechanism, which includes two guide posts and two first sliders. The two first sliders are respectively sleeved on the guide posts on both sides. The two ends of the first bracket are respectively fixedly connected to the first sliders on both sides, and the first sliders slide up and down along the guide posts.

[0017] Furthermore, the support includes two spaced-apart left and right supports, and the magnetic bead adsorption mechanism further includes a second guide mechanism. The second guide mechanism includes two vertical guide rails, which are respectively fixedly installed on the left and right supports. A second slider is fixedly connected to both ends of the second bracket, and the second sliders at both ends are slidably connected to the vertical guide rails on both sides. The second drive mechanism is fixedly installed on the left or right support, and the output end of the second drive mechanism is connected to the second bracket.

[0018] Furthermore, the second drive mechanism includes a drive motor, a lead screw, and a transmission nut. The output end of the second drive motor is connected to the lead screw, the lead screw is parallel to the guide rail, the transmission nut is sleeved on the lead screw, and the transmission nut is connected to the slider on one side.

[0019] Furthermore, the temperature control mechanism also includes a first photoelectric switch, and the magnetic bead adsorption mechanism also includes a second photoelectric switch. The first and second photoelectric switches are respectively used to limit the lifting height of the temperature control block and the magnetic block. The first and second photoelectric switches are respectively fixedly installed on the base and the support.

[0020] Furthermore, the temperature control mechanism also includes a temperature detection mechanism, which is fixedly installed on the base of the temperature control block to detect the temperature of the temperature control block and feed the detection result back to the controller. The controller controls the temperature of the temperature control block according to the detected temperature.

[0021] The present invention has the following advantages due to the adoption of the above technical solutions:

[0022] The automated centrifuge tube processing device includes a mixing mechanism, a temperature control mechanism, and a magnetic bead adsorption mechanism. Therefore, it can realize the functions of stirring and mixing, temperature control and heating, and adsorption of suspended magnetic beads in one mechanical device without the need to transfer between different devices. Only the corresponding functional module needs to be selected as needed, thus improving the efficiency and reliability of the experiment. Attached Figure Description

[0023] Various other advantages and benefits will become apparent to those skilled in the art upon reading the following detailed description of preferred embodiments. The accompanying drawings are for illustrative purposes only and are not intended to limit the invention. Throughout the drawings, the same reference numerals denote the same parts. In the drawings:

[0024] Figure 1 This is a schematic diagram of the structure of an embodiment of an automated integrated processing device;

[0025] Figure 2 yes Figure 1 Schematic diagram of the central temperature control mechanism;

[0026] Figure 3 yes Figure 2 A schematic diagram of the centrifuge tube and the rotary drive mechanism in the diagram;

[0027] Figure 4 yes Figure 2 Top view;

[0028] Figure 5 yes Figure 1 A schematic diagram of the magnetic bead adsorption mechanism in the image;

[0029] Figure 6 Yes, it is a top view of the magnetic bead adsorption mechanism;

[0030] Figure 7 yes Figure 1 Top view. Detailed Implementation

[0031] Exemplary embodiments of the invention will now be described in more detail with reference to the accompanying drawings. While exemplary embodiments of the invention are shown in the drawings, it should be understood that the invention can be implemented in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided to enable a more thorough understanding of the invention and to fully convey the scope of the invention to those skilled in the art.

[0032] This invention provides an automated integrated centrifuge tube processing device, comprising at least two of a mixing mechanism, a temperature control mechanism, and a magnetic bead adsorption mechanism, and a controller. The mixing mechanism includes a support plate and a rotary drive mechanism mounted on the support plate. Centrifuge tubes are placed on the support plate, and the rotary drive mechanism drives the centrifuge tubes to rotate to achieve solution mixing. The temperature control mechanism and the magnetic bead adsorption mechanism are located below the support plate and are respectively used to control the temperature of the solution in the centrifuge tube and to adsorb magnetic beads in the solution after temperature control. The controller is electrically connected to the mixing mechanism, the temperature control mechanism, and the magnetic bead adsorption mechanism, and controls the operation of each mechanism. The automated integrated centrifuge tube processing device includes a mixing mechanism, a temperature control mechanism, and a magnetic bead adsorption mechanism, thus enabling mixing, temperature control, and adsorption of suspended magnetic beads within a single mechanical device. This eliminates the need for transfer between different devices; only the appropriate functional module needs to be selected for operation, thereby improving experimental efficiency and reliability.

[0033] Example 1

[0034] like Figure 1 and Figure 2 As shown, in the operation process of centrifuge tubes, the functions of stirring and mixing reagents, temperature control, and adsorption of suspended magnetic beads are frequently used. Therefore, an automated integrated processing device for centrifuge tubes is provided. The automated integrated processing device for centrifuge tubes includes at least two of the following: a mixing mechanism 1, a temperature control mechanism 3, and a magnetic bead adsorption mechanism 4, and a controller. The mixing mechanism 1 includes a support plate 11 and a rotary drive mechanism mounted on the support plate 11. Centrifuge tubes 2 are placed on the support plate 11, and the rotary drive mechanism drives the centrifuge tubes 2 to rotate to achieve solution mixing. The temperature control mechanism 3 and the magnetic bead adsorption mechanism 4 are located below the support plate 11 and are respectively used to control the temperature of the solution in the centrifuge tubes 2 and to adsorb magnetic beads in the solution after temperature control. The controller is electrically connected to the mixing mechanism 1, the temperature control mechanism 3, and the magnetic bead adsorption mechanism 4, and controls the operation of the mixing mechanism 1, the temperature control mechanism 3, and the magnetic bead adsorption mechanism 4 respectively.

[0035] The automated centrifuge tube processing device includes a mixing mechanism 1, a temperature control mechanism 3, and a magnetic bead adsorption mechanism 4. Therefore, it can realize the functions of stirring and mixing, temperature control and heating, and adsorption of suspended magnetic beads in one mechanical device without the need to transfer between different devices. It is only necessary to select the corresponding functional module to operate as needed, thus improving the efficiency and reliability of the experiment.

[0036] The automated centrifuge tube processing unit adopts a modular design, allowing it to be designed as a standalone device or integrated into other experimental equipment as a functional module. In practical use, the three functional modules can be paired according to different experimental projects; all three modules do not necessarily need to be present in the device simultaneously. For example, if only the rotation and temperature control modules are needed, the magnetic bead adsorption mechanism can be removed without affecting the functionality of other modules, thus meeting economic requirements. As described above, the module combinations can be fine-tuned as needed.

[0037] Combination Figure 2 and Figure 4 As shown, the support plate 11 has several through holes, and the centrifuge tube 2 is inserted into the through holes. The through holes can be designed to include two rows, with the centrifuge tube 2 inserted into the through holes and extending to the bottom of the support plate 11.

[0038] The rotary drive mechanism includes a drive component 12, a drive wheel 13, and several driven wheels 14. The output end of the drive component 12 is connected to the drive wheel 13. The drive wheel 13 is connected to the several driven wheels 14 in a transmission manner. Each through hole corresponds to one driven wheel 14. The driven wheel 14 is rotatably connected to the through hole through a bearing. The inner diameter of the driven wheel 14 is larger than the diameter of the centrifuge tube 2 body and smaller than the diameter of the thread at the opening of the centrifuge tube 2. The centrifuge tube 2 is inserted into the driven wheel 14. The drive component 12 drives the driven wheel 14 to rotate, thereby causing the centrifuge tube 2 to rotate.

[0039] The inner diameter of the driven wheel 14 is larger than the diameter of the centrifuge tube 2 body but smaller than the diameter of the thread at the opening of the centrifuge tube 2. This allows the centrifuge tube 2 to be secured at the lower part of the threaded portion, preventing it from falling out. The driven wheel 14 rotates with the centrifuge tube 2 due to gravity and the friction between the wall of the centrifuge tube 2 and the inner wall of the driven wheel 14.

[0040] The driving wheel 13 is connected to several driven wheels 14 via belt drive, and the driving component 12 is a rotary motor.

[0041] It should be noted that the transmission method between the driving wheel 13 and the driven wheel 14 in this invention is not limited to belt drive, but can also be chain drive or transmission through the meshing of teeth.

[0042] The added reagents and samples need to be thoroughly stirred. Stirring is achieved by rotating the centrifuge tube in both directions and inserting the pipette tip into the liquid to act as a stirring rod. Depending on the experiment, parameters such as rotation time, motor speed, and rotation frequency can be selected in advance to enhance the applicability of the stirring function.

[0043] The temperature control mechanism 3 includes a base 32, a first drive mechanism 31 mounted on the base 32, a first bracket 33, and a plurality of temperature control blocks 34 mounted on the first bracket 33. The first drive mechanism 31 drives the first bracket 33 to move up and down. The temperature control blocks 34 are disposed on the first bracket 33. The up and down movement of the first bracket 33 drives the temperature control blocks 34 to move up and down. The temperature control blocks 34 move upward to control the temperature of the centrifuge tube 2, and move downward to stop temperature control.

[0044] The first bracket 33 includes a support frame 36, a temperature control block seat 35, and an isolation seat 37. The support frame 36 is connected to the output end of the first drive mechanism 31. The temperature control block seat 35 is fixed on the top of the support frame 36. The isolation seat 37 is placed on the temperature control block seat 35, and the temperature control block 34 is located on the isolation seat 37.

[0045] The temperature control block 34 and the isolation seat 37 are both multiple, and the multiple temperature control blocks 34 and the isolation seat 37 are in one-to-one correspondence, or the multiple temperature control blocks 34 may share a single isolation seat 37.

[0046] The first driving mechanism includes a first driving motor, a first lead screw, a first transmission nut, and a first guide mechanism. The first driving motor is fixedly mounted on the base 32, and the output end of the first driving motor is connected to the first lead screw. The first transmission nut is sleeved on the first lead screw. The first bracket 33 is fixedly connected to the first transmission nut. The two ends of the first bracket 33 are slidably connected to the first guide mechanism through a first slider. The first guide mechanism includes two spaced guide rods fixedly mounted on the base, and the first slider slides up and down along the guide rods.

[0047] It should be noted that the first drive mechanism can also be replaced by a rotary cylinder or rotary hydraulic cylinder, which are common in the art.

[0048] The temperature control block 34 is located directly below the centrifuge tube 2, and its internal shape fits perfectly with the bottom shape of the centrifuge tube 2, ensuring full contact. Its upper part extends below the centrifuge tube 2. The temperature control block 34 sits on a temperature control block base 35, which is connected to the first lead screw via the first bracket 33, etc. When performing temperature control, the temperature is controlled by the temperature control block's contact with the bottom of the centrifuge tube. However, since there are multiple rows of centrifuge tubes, the position of the side wall between the temperature control block 34 and the centrifuge tube 2 can be raised; the height can be adjusted according to the experimental project. The temperature control block 34 is moved up and down by the first drive motor: when temperature control is needed, the temperature control block 34 is first controlled to the desired temperature according to the preset temperature, and then the temperature control block 34 is moved up to the bottom of the centrifuge tube, lifting the centrifuge tube 2 from the driven wheel 14 to ensure full contact; when temperature control is not needed, the temperature control block is removed from the position of the centrifuge tube 2 and moved down below the bottom of the centrifuge tube 2. When temperature control is required on the side wall of centrifuge tube 2, in order to achieve rapid temperature control and improve efficiency, the bottle body is slowly rotated by a rotary motor to ensure that the side wall of the bottle body makes uniform contact with the temperature control block 34. This requires the cooperation of the rotation module and the temperature control module.

[0049] The temperature control mechanism 3 also includes a first photoelectric switch 38 mounted on the base 32. The first photoelectric switch 38 is used to limit the lifting height of the temperature control block 34. The first photoelectric switch 38 is fixedly mounted on the base 32 and the support to prevent the centrifuge tube from being lifted too high and colliding with other modules. The first drive motor has a self-locking function, which can protect the parts and prevent collisions in the event of a sudden power failure.

[0050] The temperature control mechanism 3 also includes a temperature detection mechanism 39, which is fixedly installed on the temperature control block base 35 to detect the temperature control temperature of the temperature control block 34 and send the detected temperature to the controller. The controller controls the temperature control temperature of the temperature control block 34 according to the detected temperature.

[0051] like Figure 5 , Figure 6 and Figure 7 As shown, the magnetic bead adsorption mechanism 4 includes a support 41, a second drive mechanism 42 mounted on the support 41, a second bracket 43, and a plurality of magnets 44 mounted on the second bracket 43. The input end of the second drive mechanism 42 is connected to the second bracket 43 and is used to drive the second bracket 43 to move up and down. The magnets 44 are mounted on the second bracket 43. The up and down movement of the second bracket 43 drives the magnets 44 to move up and down. When magnetic adsorption is needed, the magnets 44 move upward to adsorb the magnetic beads in the centrifuge tube 2 to one side of the centrifuge tube 2 wall. When magnetic adsorption is not needed, the magnets 44 move downward.

[0052] The magnet 44 is crescent-shaped, so it can attract the magnetic beads to one side of the centrifuge tube 2 wall.

[0053] The support 41 includes two spaced-apart left supports 411 and right supports 412. Each of the left and right supports 411 and 412 is equipped with a vertical guide rail. Slider 46 is fixedly connected to both ends of the second bracket 43, and the sliders 46 at both ends are slidably connected to the guide rails on both sides. The second drive mechanism 42 is fixedly mounted on either the left or right support 411, and its output end is connected to the second bracket 43. The support plate 11 is fixedly mounted on the left and right supports 411 and 412.

[0054] The second drive mechanism 42 includes a drive motor, a lead screw, and a transmission nut. The output end of the second drive motor is connected to the lead screw, which is parallel to the guide rail. The transmission nut is sleeved on the lead screw, with one end connected to the slider on one side and the other end connected to one end of the second bracket 43 via a first connector 46. The other end of the second bracket 43 is connected to the slide rail 45 on the other side.

[0055] The magnetic bead adsorption mechanism 4 operates by moving the magnets 44 up and down. Its function is to adsorb suspended magnetic beads onto one side of the centrifuge tube 2 wall, facilitating reagent removal by the pipette tip. The magnets 44 of the magnetic bead adsorption mechanism 4 are distributed on the outside of two rows of centrifuge tubes 2, forming a crescent shape that surrounds the centrifuge tubes 2. Adsorption of suspended magnetic beads is primarily achieved by the lead screw motor of the magnetic bead adsorption mechanism 4 driving the magnets 44 to move. Because the magnets 44 are located on the outside of the centrifuge tubes 2, the magnetic beads are adsorbed onto one side of the tube. Different adsorption times are set depending on the size of the magnetic beads added to the centrifuge tubes 2 to achieve the required adsorption level. To expedite adsorption and reduce adsorption time, the magnets 44 can be moved up and down slowly, while the rotation module controls the centrifuge tubes 2 to rotate slowly, allowing magnetic beads farther from the magnets 44 to be adsorbed.

[0056] The magnetic bead adsorption mechanism 4 also includes a second photoelectric switch 47, which limits the lifting height of the magnet 44. The second photoelectric switch 47 is fixedly mounted on the support 41. The photoelectric switch limits the movement range of the magnet to prevent collisions. After adsorption is complete, the nozzle picks up the reagent, leaving the magnetic bead for subsequent operations.

[0057] The controller can perform status detection and motion control functions for modules such as rotation, temperature control, and magnetic attraction. The mixing mechanism, temperature control mechanism, and magnetic bead attraction mechanism communicate with the controller (computer, industrial computer, etc.) via USB or other interfaces. The controller, through the communication interface and main control board, can perform calibration, debugging, status detection, motion control, and motion flow editing for each functional module of the device. Simultaneously, the edited device motion flow can be downloaded to the main control board.

[0058] In the initial stage of the test run, the temperature control mechanism 3 and the magnetic bead adsorption mechanism 4 are initially positioned at the bottom, approximately 30-50 mm from the lower end of the centrifuge tube 2. A photoelectric switch limits the lower limit position. The centrifuge tube containing reagents is placed into the driven wheel. After the pipette tip of the upper pipetting module adds the lysis solution, suspended magnetic beads, etc., to the centrifuge tube 2, the drive component 12 begins to move, driving the belt via the drive wheel 13, which in turn rotates the driven wheel 14. During this process, the drive component 12 rotates repeatedly in both directions to increase the stirring speed; the pipette tip is inserted into the liquid to perform blowing and suction actions. After waiting for the predetermined time for the process to complete, the next step of the operation can proceed.

[0059] Once the various liquids and magnetic beads in the reagent are thoroughly mixed, temperature control can begin. At this point, the drive unit 12 stops rotating, and the pipette tip exits the centrifuge tube 2. The temperature control motor starts driving, using the support frame 36 to push the temperature control block seat 35 and the temperature control block 34 upwards until the centrifuge tube 2 is raised a certain distance. The temperature control block isolation seat 37 serves as insulation, preventing heat transfer downwards and wasting heat. With the temperature control block 34 raised, only one side of the centrifuge tube is temperature-controlled, resulting in uneven temperature distribution. In this case, the rotation module is needed: first, lower the temperature control block 34 to a position that does not obstruct rotation; then, after the tube has rotated a certain angle, raise the temperature control block 34 to the controlled position and continue temperature control for a period of time. This process is repeated until the predetermined temperature is reached. The predetermined temperature can be input in advance. Once the predetermined temperature is reached, the temperature controller cuts off the power to the temperature control block, stopping temperature control. At this point, the temperature control block 34 detaches from the bottom of the centrifuge tube 2 and moves back to its initial position, ensuring the temperature-controlled reagent quickly returns to room temperature.

[0060] After protein lysis, the suspended magnetic beads need to be adsorbed onto the side wall of centrifuge tube 2. The second drive mechanism 42 drives the second support 43, which in turn moves the magnet 44 upwards to the reagent position in centrifuge tube 2. Then, the second drive mechanism 42 moves slowly up and down, while the drive component 12 slowly rotates the centrifuge tube 2, coordinating with the up-and-down movement of the magnet 44 to cleanly adsorb the suspended magnetic beads that are far from the magnet 44. A photoelectric switch limits the magnet's range of motion to prevent collisions. After adsorption is complete, the pipette tip aspirates the reagent, leaving the magnetic beads for subsequent operations.

[0061] All of the above operations can be preset, allowing you to select the corresponding experimental procedure and follow the pre-defined operations and times for each procedure. This eliminates the need for manual operation, reduces reliance on personnel, and improves efficiency.

[0062] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. An automated integrated processing device for centrifuge tubes, characterized in that, The system includes a mixing mechanism, a temperature control mechanism, a magnetic bead adsorption mechanism, and a controller. The mixing mechanism includes a support plate and a rotary drive mechanism mounted on the support plate. Centrifuge tubes are inserted into the support plate, and the rotary drive mechanism drives the centrifuge tubes to rotate to achieve solution mixing. The temperature control mechanism and the magnetic bead adsorption mechanism are located below the support plate and are used to control the temperature of the solution in the centrifuge tubes and to adsorb magnetic beads in the solution, respectively. The controller is electrically connected to the mixing mechanism, the temperature control mechanism, and / or the magnetic bead adsorption mechanism, and controls the operation of the mixing mechanism, the temperature control mechanism, and / or the magnetic bead adsorption mechanism. The temperature control mechanism includes a base, a first lifting mechanism mounted on the base, and a temperature control block. The first lifting mechanism drives the temperature control block to rise or fall. When it is necessary to control the temperature of the centrifuge tube, the first lifting mechanism drives the temperature control block to rise. When it is necessary to stop temperature control, the first lifting mechanism drives the temperature control block to fall. The magnetic bead adsorption mechanism includes a support, a second lifting mechanism mounted on the support, and magnets. The magnets are distributed on the outside of the two rows of centrifuge tubes, and are crescent-shaped, encircling the centrifuge tubes. The second lifting mechanism drives the magnets to rise or fall. When magnetic bead adsorption is needed, the second lifting mechanism drives the magnets to rise. When magnetic bead adsorption needs to be stopped, the second lifting mechanism drives the magnets to fall. The second lifting mechanism includes a second driving mechanism and a second bracket. The output end of the second driving mechanism is connected to the second bracket. The magnet is mounted on the second bracket. The second bracket moves up and down, causing the magnet to move up and down. When magnetic adsorption is needed, the magnet moves upward; when magnetic adsorption is not needed, the magnet moves downward. Furthermore, the support plate is provided with several through holes, and the centrifuge tube is inserted into the through holes; The rotary drive mechanism includes a drive component, a drive wheel, and several driven wheels. The output end of the drive component is connected to the drive wheel. The drive wheel is connected to the several driven wheels via a transmission connection. Each driven wheel is installed in a through hole. The driven wheel is rotatably connected to the through hole via a bearing. The centrifuge tube is fixedly inserted into the driven wheel.

2. The automated integrated processing device for centrifuge tubes according to claim 1, characterized in that, The inner diameter of the driven wheel is larger than the diameter of the centrifuge tube body but smaller than the thread diameter of the centrifuge tube opening. The centrifuge tube is inserted into and fixed in the driven wheel. The driving component drives the driven wheel to rotate, thereby causing the centrifuge tube to rotate.

3. The automated integrated processing device for centrifuge tubes according to claim 1, characterized in that, The driving wheel and several driven wheels are connected by a belt, chain or gear transmission structure, and the driving component is a rotary motor.

4. The automated integrated processing device for centrifuge tubes according to claim 1, characterized in that, The first lifting mechanism includes a first driving mechanism and a first support. The first driving mechanism drives the first support to move up and down, and the temperature control block is disposed on the first support.

5. The automated integrated processing device for centrifuge tubes according to claim 4, characterized in that, The first bracket includes a support frame, a temperature control block seat, and an isolation seat. The support frame is connected to the output end of the first drive mechanism. The temperature control block seat is fixed to the top of the support frame. The isolation seat is placed on the temperature control block seat, and the temperature control block is located on the isolation seat.

6. The automated integrated processing device for centrifuge tubes according to claim 5, characterized in that, The temperature control mechanism further includes a first guide mechanism, which includes two guide posts and two first sliders. The two first sliders are respectively sleeved on the guide posts on both sides. The two ends of the first bracket are respectively fixedly connected to the first sliders on both sides. The first sliders slide up and down along the guide posts.

7. The automated integrated processing device for centrifuge tubes according to claim 1, characterized in that, The support includes two spaced-apart left and right supports. The magnetic bead adsorption mechanism also includes a second guide mechanism, which includes two vertical guide rails. The two vertical guide rails are respectively fixedly installed on the left and right supports. A second slider is fixedly connected to both ends of the second bracket. The second sliders at both ends are slidably connected to the vertical guide rails on both sides. The second drive mechanism is fixedly installed on the left or right support. The output end of the second drive mechanism is connected to the second bracket.

8. The automated integrated processing device for centrifuge tubes according to claim 7, characterized in that, The second drive mechanism includes a drive motor, a lead screw, and a transmission nut. The output end of the drive motor is connected to the lead screw, the lead screw is parallel to the guide rail, the transmission nut is sleeved on the lead screw, and one end of the transmission nut is connected to a slider on one side.

9. The automated integrated processing device for centrifuge tubes according to claim 1, characterized in that, The temperature control mechanism further includes a first photoelectric switch, and the magnetic bead adsorption mechanism further includes a second photoelectric switch. The first photoelectric switch and the second photoelectric switch are respectively used to limit the lifting height of the temperature control block and the magnet. The first photoelectric switch and the second photoelectric switch are respectively fixedly installed on the base and the support.

10. The automated integrated processing device for centrifuge tubes according to claim 1, characterized in that, The temperature control mechanism also includes a temperature detection mechanism, which is fixedly installed on the base of the temperature control block to detect the temperature of the temperature control block and feed the detection result back to the controller. The controller controls the temperature of the temperature control block according to the detected temperature.

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