A method for preparing 4-quinolone derivatives

CN116120227BActive Publication Date: 2025-02-28THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI
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Patent Information

Application Number
CN202211498942.8
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-11-28
Publication Date
2025-02-28
Estimated Expiration
2042-11-28

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Abstract

The invention discloses a method for preparing a 4-quinolone derivative: 2-aminoacetophenone, aldehyde, alcohol, PPA and DMF are added to a container, and the reaction is refluxed for 3 hours; after the reaction is completed, the 4-quinolone derivative is separated and purified. The preparation method of the invention is proposed for the first time, and the one-pot preparation method is simple to operate, the raw materials are simple and easy to obtain, no metal catalyst is required, and the yield is high, which provides a new method for the preparation of 4-quinolone derivatives.
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