Optical systems and their operating methods

Abstract

This invention discloses an optical system and its operation method. The optical system includes a light source device, a gaze module, and a fundus detection device. The light source device includes a light source module, a light intensity modulation module, and a lens module. The light source module emits therapeutic light to the eye. The light intensity modulation module modulates the intensity of the therapeutic light. The lens module controls the depth of the therapeutic light. The gaze module allows the eye to focus and fixate on the fundus. The fundus detection device integrates the light source device and is used to detect the fundus to obtain a fundus image.

Description

Technical Field

[0001] This invention relates to optical systems, and more particularly to an optical system for use in the eye and a method of operation thereof. Background Technology

[0002] Low-intensity laser therapy is a method for treating eye diseases such as macular degeneration, primary open-angle glaucoma, or retinitis pigmentosa. By irradiating the eye with a handheld or fixed low-intensity infrared laser (670nm or 780nm, below 10mW), the blood vessels in the eye can be dilated, improving blood circulation in the retina and choroidal tissues, thereby reducing the symptoms of hypoxia and ischemia in the eye tissues caused by glaucoma, macular degeneration, and retinal diseases.

[0003] Furthermore, low-intensity laser illumination can reduce the production of fluid in the eye and enhance fluid drainage efficiency, thereby lowering intraocular pressure and reducing glaucoma symptoms. In addition, mitochondrial dysfunction is considered a major pathological mechanism of glaucoma. Some papers have indicated that irradiating eye cells with low-intensity lasers can stimulate mitochondria to synthesize adenosine triphosphate (ATP), thereby increasing mitochondrial function and improving glaucoma symptoms.

[0004] However, the natural tremors of the eye significantly increase the difficulty of pinpointing specific locations, meaning traditional light therapy can only roughly illuminate a large area of ​​the fundus, unable to scan or target detailed areas for focused treatment. Furthermore, the effectiveness of light therapy still requires imaging the affected area with other instruments, which is time-consuming and inconvenient.

[0005] Therefore, the aforementioned problems encountered by existing technologies still urgently need to be addressed. Summary of the Invention

[0006] In view of this, the present invention proposes an optical system and its operation method related to the treatment of eye diseases. It can integrate phototherapy devices that employ photodynamic therapy and low-level laser therapy with fundus detection optical paths (fundus camera, optical coherence tomography) to achieve targeted irradiation of specific areas or precise locations, control of light dose, and acquisition of fundus images and structural data after phototherapy, thereby tracking the treatment effect and effectively solving the above-mentioned problems encountered by the prior art.

[0007] According to a specific embodiment of the present invention, an optical system is provided. In this embodiment, the optical system includes a light source device, a gaze module, and a fundus detection device. The light source device includes a light source module, a light intensity modulation module, and a lens module. The light source module is used to emit therapeutic light to the eye. The light intensity modulation module is used to modulate the intensity of the therapeutic light. The lens module is used to control the depth of the therapeutic light. The gaze module is used for eye fixation to fix the fundus of the eye. The fundus detection device integrates the light source device and is used to detect the fundus to obtain a fundus image.

[0008] In one embodiment, when the light source module includes only a single light source, the single light source needs to be paired with a light scanning module to modulate the therapeutic light to irradiate a specific location and range of the eye.

[0009] In one embodiment, when the light source module includes multiple light sources arranged in an array, the multiple light sources can operate independently and provide light therapy only at a rough location and range.

[0010] In one embodiment, the fundus detection device is a fundus camera or an optical coherence tomography scanner.

[0011] In one embodiment, the optical system further includes a switch module coupled to a light source device. The switch module selectively turns on the light source device based on whether a specific area of ​​the eye is scanned by the light scanning module, so as to track the specific position of the eye and capture its image, avoiding the influence of natural eye movement.

[0012] In one embodiment, the optical system further includes an illumination position control optical path and an illumination range control lens to lock a specific area of ​​the eye to be illuminated and to capture its image, avoiding the influence of natural eye movement.

[0013] In one embodiment, the optical system further includes a feedback control module for the analysis module and the light scanning module to correct and synchronize the coordinates of the optical coherence tomography scanner and the coordinates of the light scanning module.

[0014] In one embodiment, the light intensity modulation module modulates the luminous intensity of the light source module according to the thickness of each retinal layer in the eye as determined by the optical coherence tomography scanner, so as to precisely control the light therapy dose.

[0015] In one embodiment, the lens module controls the convergence and divergence of the therapeutic light according to the thickness of each retinal layer of the eye as determined by the optical coherence tomography scanner, so as to precisely control the depth of light therapy.

[0016] According to another specific embodiment of the present invention, there is an optical system operation method. In this embodiment, the optical system operation method includes the following steps: (a) setting a gaze module for eye fixation to fix the fundus of the eye; (b) emitting therapeutic light to the eye; (c) modulating the intensity of the therapeutic light and controlling the depth of the therapeutic light; and (d) probing the fundus to obtain a fundus image.

[0017] In one embodiment, step (b) involves emitting therapeutic light from a single light source, which is then paired with a light scanning module to modulate the therapeutic light to a specific location and area of ​​the eye.

[0018] In one embodiment, step (b) involves emitting therapeutic light from a plurality of light sources arranged in an array, wherein the plurality of light sources can operate independently and provide light therapy only at a rough location and range.

[0019] In one embodiment, step (d) is performed by a fundus camera or an optical coherence tomography scanner.

[0020] In one embodiment, the optical system operation method further includes: selectively turning on a single light source based on whether a specific area of ​​the eye is scanned by the light scanning module, so as to track the specific position of the eye and capture its image, avoiding the influence of natural eye movement.

[0021] In one embodiment, the optical system operation method further includes: setting an illumination position control optical path and an illumination range control lens to lock a specific area of ​​the eye to be illuminated and capture its image, avoiding the influence of natural eye movement.

[0022] In one embodiment, the optical system operation method further includes: setting a feedback control module for the analysis module and the light scanning module to correct and synchronize the coordinates of the optical coherence tomography scanner and the coordinates of the light scanning module.

[0023] In one embodiment, the optical system operation method further includes: modulating the intensity of the therapeutic light according to the thickness of each retinal layer of the eye as determined by the optical coherence tomography scanner, so as to precisely control the light therapy dose.

[0024] In one embodiment, the optical system operation method further includes: controlling the convergence and divergence of the therapeutic light according to the thickness of each retinal layer of the eye as determined by the optical coherence tomography scanner, so as to precisely control the depth of light therapy.

[0025] Compared to existing technologies, the optical system and its operation method proposed in this invention can scan local areas of the fundus, avoid the influence of natural eye movement to lock onto local locations, concentrate low-intensity light sources on specific areas and depths, and use optical coherence tomography to analyze the thickness of the target retinal tissue layer to adjust the appropriate light dose. Furthermore, photographs of the eye area are taken before and after treatment to track the treatment effect. This effectively solves the problems of traditional phototherapy instruments, which can only roughly irradiate the entire eye, cannot concentrate treatment on local areas or lock onto delicate areas, cannot control the light dose according to tissue thickness, and cannot directly observe the treatment effect after treatment. Therefore, it can achieve five-dimensional (three-dimensional space, time, and light dose) phototherapy effects and can provide different wavelengths of light therapy for different retinal layers.

[0026] The advantages and spirit of the present invention can be further understood through the following detailed embodiments and accompanying drawings. Attached Figure Description

[0027] The accompanying drawings of this invention are described below:

[0028] Figure 1 This is a schematic diagram of an optical system according to an embodiment of the present invention.

[0029] Figure 2 This is a timing diagram showing how the brightness of the light source is rapidly switched within the same treatment cycle to achieve both therapeutic and imaging illumination effects when the therapeutic light and illumination light share the same light source.

[0030] Figure 3 This is a flowchart of an optical system operation method according to another embodiment of the present invention.

[0031] Figure 4 This is a schematic diagram of the light path of the phototherapy light source, the gaze module, the optical path coupling module, and the eye being tested.

[0032] Figure 5 This diagram illustrates how the therapeutic light source and optical path coupling module can be manually / automatically adjusted via mechanical linkage when combined with a wearable device.

[0033] Figure 6 This is a schematic diagram of an optical system according to another embodiment of the present invention.

[0034] Figure 7 This is a flowchart of an optical system operation method according to another embodiment of the present invention.

[0035] Figure 8 This is a schematic diagram of the optical path when the detection light source and the phototherapy light source share the same scanning module.

[0036] Figure 9A This is a schematic diagram of the optical path when the detection light source and the phototherapy light source do not share the same scanning module.

[0037] Figure 9B This is a schematic diagram of the optical path required for positional correction of the probe light scanning module and the therapeutic light scanning module using a photosensitive module.

[0038] Figure 10 This is a schematic diagram showing the range of light spots scanned on the photosensitive module by the detection light and the therapeutic light.

[0039] Figure 11 This is a flowchart illustrating the optical system operation method for correcting the light scanning module of the probe light / therapeutic light in another embodiment of the present invention.

[0040] Figure 12 This is a schematic diagram of a phototherapy light source, including the light source, a light intensity modulation module, and a lens module.

[0041] Explanation of key component symbols:

[0042] 1…Optical System

[0043] 10…Lighting Module

[0044] 12…Gaze Module

[0045] 14…Imaging Module

[0046] 16…Light Therapy Light Source

[0047] 18… Optical path coupling module

[0048] L1…Illumination light

[0049] L2…Healing Light

[0050] RL…reflected light

[0051] E…tested eye

[0052] T…treatment cycle

[0053] LEN…lens

[0054] 6…Optical System

[0055] 60…Detection light source

[0056] 61…Reference Optical Path Modulation Module

[0057] 62…Gaze Module

[0058] 63… switch

[0059] 64…Analysis System

[0060] 65…Using a lens to change the illumination range

[0061] 66…Light Therapy Light Source

[0062] 67…Therapeutic Light Beam Scanning Module

[0063] 68… Optical path coupling module

[0064] 69…Detector light beam scanning module

[0065] 660…light source

[0066] 662…Light Intensity Modulation Module

[0067] 664… Lens Module

[0068] Steps S10~S18…

[0069] S70~S79…Steps

[0070] S110~S118…Steps Detailed Implementation

[0071] Reference will now be made in detail to exemplary embodiments of the invention, examples of which are illustrated in the accompanying drawings. Elements / components referred to by the same or similar reference numerals in the drawings and embodiments are used to represent the same or similar parts.

[0072] This invention proposes an optical system and its operation method related to the treatment of eye diseases. It can integrate phototherapy devices that employ photodynamic therapy and low-level laser therapy with fundus detection optical paths (fundus camera, optical coherence tomography) to achieve targeted irradiation of specific areas or precise locations, control of light dose, and acquisition of fundus images and structural data after phototherapy, thereby tracking the treatment effect and effectively solving the problems encountered by existing technologies.

[0073] According to a specific embodiment of the present invention, an optical system is provided. In this embodiment, the optical system includes a light source device, a gaze module, and a fundus detection device. The light source device includes a light source module, a light intensity modulation module, and a lens module. The light source module is used to emit therapeutic light to the eye. The light intensity modulation module is used to modulate the intensity of the therapeutic light. The lens module is used to control the depth of the therapeutic light. The gaze module is used for eye fixation to fix the fundus of the eye. The fundus detection device integrates the light source device and is used to detect the fundus to obtain a fundus image.

[0074] In practice, the fundus detection device can be a fundus camera or an optical coherence tomography (OCT) scanner, but is not limited to these. The light intensity modulation module can adjust the luminous intensity of the light source module according to the thickness of each retinal layer in the eye as determined by the OCT scanner, to precisely control the phototherapy dose, but is not limited to these. The lens module can control the convergence and divergence of the treatment light according to the thickness of each retinal layer in the eye as determined by the OCT scanner, to precisely control the phototherapy depth, but is not limited to these.

[0075] In practice, a light source module may include only a single light source or multiple light sources arranged in an array, but is not limited to this. When the light source module includes only a single light source, the single light source needs to be used in conjunction with a light scanning module to modulate the therapeutic light to illuminate a specific location and area of ​​the fundus of the eye. When the light source module includes multiple light sources arranged in an array, the multiple light sources can operate independently and only provide light therapy to a coarse location and area.

[0076] In another embodiment, the optical system may further include a switching module. The switching module is coupled to the light source device. The switching module can selectively turn on the light source device based on whether a specific area of ​​the eye is scanned by the light scanning module, in order to track a specific position of the eye and capture its image, avoiding the influence of natural eye movement, but is not limited thereto.

[0077] In another embodiment, the optical system may further include an illumination position control optical path and an illumination range control lens to lock a specific area of ​​the eye to be illuminated and to capture its image, avoiding the influence of natural eye movement, but is not limited thereto.

[0078] In another embodiment, the optical system may further include a feedback control module for the analysis module and the light scanning module to correct and synchronize the coordinates of the optical coherence tomography scanner and the coordinates of the light scanning module, but is not limited thereto.

[0079] Figure 1 This is a schematic diagram of an optical system according to an embodiment of the present invention. Figure 1As shown, the optical system 1 includes an illumination module 10, a gaze module 12, an imaging module 14, a phototherapy light source 16, and an optical path coupling module 18. The illumination module 10, gaze module 12, and phototherapy light source 16 are each coupled to the optical path coupling module 18. The optical path coupling module 18 is coupled to the imaging module 14. The gaze module 12 is used for fixation by the tested eye E to fix the orientation of the fundus of the tested eye E. The phototherapy light source 16 provides a therapeutic light L2 to the optical path coupling module 18, and the optical path coupling module 18 directs the therapeutic light L2 to the fundus of the tested eye E for phototherapy. The illumination module 10 provides an illumination light L1 to the optical path coupling module 18, and the optical path coupling module 18 directs the illumination light L1 to the fundus of the tested eye E to illuminate the fundus of the tested eye E. The reflected light RL of the fundus illumination light L1 of the tested eye E is transmitted to the imaging module 14 via the optical path coupling module 18, so that the imaging module 14 can capture the fundus image of the tested eye E.

[0080] like Figure 2 As shown, assuming that the illumination light L1 and the treatment light L2 are provided by the same light source (e.g., infrared light), the light source can be quickly switched to provide illumination light L1 with higher light source brightness or treatment light L2 with lower light source brightness at different working times within the same treatment cycle T, so as to provide illumination light L1 and treatment light L2 respectively at different working times, thus achieving the effects of both treatment and imaging illumination.

[0081] Figure 3 This is a flowchart illustrating an optical system operation method according to another embodiment of the present invention. Figure 3 As shown, the operation method of the optical system may include the following steps:

[0082] Step S10: The tested eye E fixates on the gazing module 12 to fix the orientation of the fundus of the tested eye E;

[0083] Step S12: The light therapy light source 16 emits therapeutic light L2 to the tested eye E;

[0084] Step S14: Turn off the light therapy light source 16;

[0085] Step S16: Turn on the illumination module 10 to emit illumination light L1 to illuminate the fundus of the tested eye E; and

[0086] Step S18: Imaging module 14 acquires fundus images of the tested eye E.

[0087] For example, when the light source of the gazing module 12 is lit, the subject's tested eye E focuses on the light source of the gazing module 12 to fix the orientation of the fundus of the tested eye E. Next, one or more light sources in the phototherapy light source 16 are turned on, and one or more lenses or mirrors in the optical path coupling module 18 are moved to adjust the range and position of the therapeutic light L2 emitted by the phototherapy light source 16 projected onto the fundus of the tested eye E. After the phototherapy treatment is completed, before taking a fundus image, if the imaging module 14 does not contain a filter for the wavelength used by the phototherapy light source 16, the phototherapy light source 16 is turned off. Then, the illumination module 10 is turned on to emit illumination light L1 to illuminate the fundus of the tested eye E, and the imaging module 14 takes a fundus image of the tested eye E.

[0088] Figure 4 This is a schematic diagram of the optical path of the phototherapy light source 16, the gaze module 12, the optical path coupling module 18, and the tested eye E.

[0089] like Figure 4 As shown, the gazing module 12 includes a light source 120 and a lens LEN that can move up and down. The phototherapy light source 16 includes a light source 160 and a lens LEN that can move left and right, for the tested eye E to gaze at, so as to fix the orientation of the fundus of the tested eye E. The therapeutic light L2 emitted by the light source 160 is refracted by the lens LEN and then directed to the tested eye E through the optical path coupling module 18 to perform phototherapy.

[0090] It should be noted that, Figure 4 A common optical path design for fundus cameras: The therapeutic light L2 emitted from the point light source 160 of the phototherapy light source 16 is converged onto the pupillary plane of the tested eye E through the optical path coupling module 18, and then diffused to the fundus of the tested eye E. The optical path coupling module 18 can be composed of multiple lenses, lens arrays, and mirrors to achieve individual control over the range and position of the phototherapy light source 16 illuminating the fundus. The optical path between the phototherapy light source 16, the optical path coupling module 18, and the tested eye E is not limited to this. The light sources 120 of the gaze module 12 are respectively set in different positions, which can allow the tested eye E to gaze and adjust the angle of the tested eye E by illuminating the light sources 120 in different positions.

[0091] like Figure 5 As shown, when the optical system of the present invention is combined with a wearable device, the phototherapy light source 16 and the optical path coupling module 18 can be manually / automatically adjusted through mechanical linkage, or the therapeutic light L2 emitted by the phototherapy light source 16 can be projected onto the fundus area of ​​the tested eye E using DLP technology.

[0092] Figure 6 This is a schematic diagram of an optical system according to another embodiment of the present invention. Figure 6As shown, the optical system 6 includes a light source 60, a reference light path modulation module 61, a gaze module 62, an analysis system 64, a phototherapy light source 66, an optical path coupling module 68, and a light scanning module 69. The light source 60, reference light path modulation module 61, gaze module 62, analysis system 64, phototherapy light source 66, and light scanning module 69 are all coupled to the optical path coupling module 68. The analysis system 64 is coupled to the phototherapy light source 66, the optical path coupling module 68, and the light scanning module 69. The light scanning module 69 is positioned between the optical path coupling module 68 and the eye being tested, E.

[0093] Light source 60 provides the light L required for optical coherence tomography. After entering the optical path coupling module 68, light L is split into probe light LD and reference light LR. Probe light LD enters the light scanning module 69 and is guided to a specific location on the tested eye E, then reflected back to the optical path coupling module 68. Reference light LR enters the reference light path length modulation module 61 to adjust the optical path before being reflected back to the optical path coupling module 68. The reflected probe light LD' and the reflected reference light LR' interfere through the analysis system 64, resolving the fundus structure at a specific location on the tested eye E.

[0094] The gaze module 62 provides the target for the tested eye E to gaze at. It can be composed of an LCD panel or multiple LEDs. By adjusting the position of the gaze point, the gaze angle of the tested eye E is changed, facilitating the illumination of the probe light LD and the therapeutic light L2 on the selected area of ​​the tested eye E. The analysis system 64 records and analyzes the currently scanned area and the area to be scanned. When the selected area is about to be scanned, the light therapy light source 66 is turned on. When leaving the selected area, the light therapy light source 66 is turned off.

[0095] Furthermore, the analysis system 64 can control the light scanning module 69 to lock the scanning area. The probe light LD and the therapeutic light L2 can share the light scanning module 69 or not. If they share the light scanning module 69, the phototherapy light source 66 needs to be turned off / on whenever the scanning position leaves / enters the selected area. If they do not share the light scanning module 69, the probe light LD scans the fundus of the tested eye E to confirm fundus movement and track the selected area, while the phototherapy light source 66 can continuously irradiate the selected area using an independent light scanning module 69. This independent light scanning module 69 can be fitted with a lens to adjust the irradiation range of the phototherapy light source 66.

[0096] Figure 7 This is a flowchart illustrating an optical system operation method according to another embodiment of the present invention. Figure 7 As shown, the operation method of the optical system may include the following steps:

[0097] Step S70: The tested eye E fixates on the gazing module 62 to fix the orientation of the fundus of the tested eye E;

[0098] Step S71: The light source 60 is split into a reference light LR and a probe light LD via the optical path coupling module 68. The reference light LR enters the reference light optical path modulation module 61 to adjust the optical path and is then reflected back to the optical path coupling module 68. The probe light LD enters the fundus of the tested eye E and is reflected back to the optical path coupling module 68. The reflected probe light LD' and the reflected reference light LR' interfere through the analysis system 64, and the interference is captured and analyzed.

[0099] Step S72: The light scanning module 69 modulates the position of the detection light LD;

[0100] Step S73: Determine whether the scanning analysis of a specific area of ​​the fundus has been completed;

[0101] Step S74: If the judgment result of step S73 is yes, extract or match specific region features in the analysis system 64 to lock the phototherapy area;

[0102] If the result of step S73 is negative, then return to step S71.

[0103] Step S75: Determine if it matches a phototherapy area;

[0104] Step S76: If the judgment result of step S75 is yes, turn on the light therapy light source;

[0105] Step S77: If the judgment result of step S75 is negative, turn off the light therapy light source;

[0106] Step S78: Determine whether the phototherapy has been completed;

[0107] Step S79: If the judgment result of step S78 is yes, turn off the light source and the light therapy light source; and

[0108] If the result of step S78 is negative, then return to step S71.

[0109] For example, when the light source of the gaze module 62 is lit, the subject's tested eye E focuses on the light source of the gaze module 62 to fix the orientation of the fundus of the tested eye E. Next, optical coherence tomography (OCT) is performed on the fundus and its features are analyzed. The analysis system 64 selects the area to be locked, continuously detecting the direction of movement in that area and changing the scanning position of the light scanning module 69 to lock the area. When the scanning position leaves / enters the selected area, the light therapy light source needs to be turned off / on. Furthermore, since OCT can obtain a map of the blood vessel distribution in the fundus, it can be used to identify individual retinal characteristics. During the scanning process, the analysis system can retrieve the subject's historical scan records from the database, track historical treatment sites and treatment effects, and analyze whether any new features (potentially new symptoms) appear.

[0110] Figure 8This is a schematic diagram of the optical path when the detection light source 60 and the phototherapy light source 66 share the same detection light beam scanning module 69. For example... Figure 8 As shown, a switch 63 is added to the optical path of the optical coherence tomography scan. When the system scans a local area of ​​the tested eye E, the phototherapy light source 66 is turned on; when it leaves the local area of ​​the tested eye E, the phototherapy light source 66 is turned off. This allows for the treatment and improvement of diseases in the local area of ​​the tested eye E while scanning that area.

[0111] Figure 9A This is a schematic diagram of the optical path when the detection light source 60 and the phototherapy light source 66 do not share the scanning module 69. For example... Figure 9A As shown, a therapeutic light beam scanning module 67 is added to the optical path of the optical coherence tomography scan to achieve the effect of scanning a local area of ​​the tested eye E with the probe light beam scanning module 69 and treating another local area of ​​the tested eye E with the therapeutic light beam scanning module 67.

[0112] Figure 9B A schematic diagram of the optical path required for position correction of the probe light scanning module 69 and the therapeutic light scanning module 67 using the photosensitive module 68. Figure 10 This is a schematic diagram showing the range of light spots scanned on the photosensitive module 68 by the probe light and the therapeutic light, which can be used to correct the positions of the probe light scanning module 69 and the therapeutic light scanning module 67.

[0113] In practical applications, before using the test eye E, the control position range of the probe light scanning module 69 and the treatment light scanning module 67 must be calibrated so that the probe light and the treatment light can scan different areas within the test eye E respectively.

[0114] For example, the calibration method may include the following steps: using a photosensitive module 68 to detect the probe light and the therapeutic light; moving the probe light using a probe light scanning module 69, leaving a series of light spots within the field of view of the photosensitive module 68, thus determining the coordinates of the movement range of the probe light scanning module 69. Then, moving the therapeutic light using a therapeutic light scanning module 67, leaving another series of light spots within the field of view of the photosensitive module 68, thus determining the coordinates of the movement range of the therapeutic light scanning module 67. Finally, aligning these two sets of coordinates completes the calibration.

[0115] Figure 11 This is a flowchart illustrating the optical system operation method for correcting the light scanning module of the probe light / therapeutic light in another embodiment of the present invention. Figure 11 As shown, the operation method of the optical system may include the following steps:

[0116] Step S110: Install the photosensitive module 68, which can detect probe light and therapeutic light, in the optical path to prepare for calibration;

[0117] Step S112: Move the probe light using the probe light scanning module 69 to scan a series of light spots sequentially on the photosensitive module 68, and record the coordinates of the probe light scanning range;

[0118] Step S114: Move the therapeutic light using the therapeutic light beam scanning module 67, scan a series of light spots sequentially on the photosensitive module 68, and record the coordinates of the therapeutic light scanning range;

[0119] Step S116: Record the coordinates of the probe light scanning range and the treatment light scanning range, and align them to complete the calibration; and

[0120] Step S118: The treatment light scanning module 67 can move independently of the probe light scanning module 69 to treat a specific location within the field of vision of the tested eye E.

[0121] It should be noted that, in order to enable the therapeutic light to move independently of the probe light during treatment, the photosensitive module 68 needs to first measure the coordinates of the movement range of the probe light scanning module 69, and then measure the coordinates of the movement range of the therapeutic light scanning module 67. Finally, these two sets of coordinates are aligned to complete the calibration. Thus, the calibrated therapeutic light scanning module 67 can move independently of the probe light scanning module 69 to treat diseases at specific locations within the visual field of the tested eye E.

[0122] like Figure 12 As shown, in one embodiment, the phototherapy light source 66 may include a light source 660, a light intensity modulation module 662, and a lens module 664. The light source 660 may be a single light source or a light source array. The light intensity modulation module 662 may change the intensity of the therapeutic light entering the lens module 664 by means of liquid crystal or adjusting the polarization of the light source. The lens module 664 may adjust the contraction and divergence of the therapeutic light, providing another degree of freedom to control the irradiation range of the fundus of the tested eye E.

[0123] Compared to existing technologies, the optical system and its operation method proposed in this invention can scan local areas of the fundus, avoid the influence of natural eye movement to lock onto local locations, concentrate low-intensity light sources on specific areas and depths, and use optical coherence tomography to analyze the thickness of the target retinal tissue layer to adjust the appropriate light dose. Furthermore, photographs of the eye area are taken before and after treatment to track the treatment effect. This effectively solves the problems of traditional phototherapy instruments, which can only roughly irradiate the entire eye, cannot concentrate treatment on local areas or lock onto delicate areas, cannot control the light dose according to tissue thickness, and cannot directly observe the treatment effect after treatment. Therefore, it can achieve five-dimensional (three-dimensional space, time, and light dose) phototherapy effects and can provide different wavelengths of light therapy for different retinal layers.

Claims

1. An optical system characterized by comprising: It includes a light source device, a staring module, and a fundus detection device, wherein The light source device includes a light source module, a light intensity modulation module, and a lens module. The light source module is used to emit a therapeutic light to one eye, the light intensity modulation module is used to modulate the intensity of the therapeutic light, and the lens module is used to control the depth of the therapeutic light. A gaze module is used to fix the fundus of the eye by allowing the eye to gaze at it. as well as A fundus detection device, integrating the light source device, is used to detect the fundus of the eye to obtain a fundus image; When the light source module includes only a single light source, the single light source needs to be paired with a light scanning module to modulate the treatment light to illuminate a specific position and range of the eye. The fundus detection device is a fundus camera or an optical coherence tomography scanner. The optical system also includes: A switch module is coupled to the light source device. The switch module selectively turns on the light source device based on whether a specific area of ​​the eye is scanned by the light scanning module, so as to track the specific position of the eye and capture its image, avoiding the influence of the natural movement of the eye. An illumination position control optical path and an illumination range control lens are used to lock a specific area of ​​the eye to be illuminated and its image captured, avoiding the influence of natural eye movement; and An analysis module and a feedback control module for the optical coherence tomography scanner are provided to correct and synchronize the coordinates of the optical coherence tomography scanner and the optical scanning module.

2. The optical system of claim 1, wherein, The light intensity modulation module modulates the light intensity of the light source module according to the thickness of each retinal layer in the eye as determined by the optical coherence tomography scanner, so as to precisely control the light therapy dose.

3. The optical system of claim 1, wherein, The lens module controls the convergence and divergence of the therapeutic light according to the thickness of each retinal layer in the eye as determined by the optical coherence tomography scanner, so as to precisely control the depth of light therapy.

4. An optical system operation method characterized by comprising: Includes the following steps: (a) A gaze module is provided for one eye to gaze at in order to fix the fundus of that eye; (b) Emit a therapeutic light to the eye; (c) Modulate the intensity of the therapeutic light and control the depth of the therapeutic light; and (d) To examine the fundus and obtain an image of the fundus; Among them, step (b) is to emit the treatment light from a single light source and the single light source needs to be paired with a light scanning module to modulate the treatment light to illuminate a specific position and range of the eye, and step (d) is to be performed by a fundus camera or an optical coherence tomography scanner. The operation method of this optical system also includes: The single light source is selectively turned on based on whether a specific area of ​​the eye is scanned by the light scanning module, in order to track the specific position of the eye and capture its image, avoiding the influence of the natural movement of the eye. A beam path for controlling the illumination position and a lens for controlling the illumination range are set up to lock a specific area of ​​the eye to be illuminated and capture its image, avoiding the influence of the natural movement of the eye. An analysis module and a feedback control module for the optical scanning module are configured to correct and synchronize the coordinates of the optical coherence tomography scanner and the coordinates of the optical scanning module.

5. The method of claim 4, wherein the optical system is a microscope. Also includes: The intensity of the therapeutic light is modulated according to the thickness of each retinal layer in the eye as determined by the optical coherence tomography scanner, so as to precisely control the light therapy dose.

6. The method of claim 4, wherein the optical system is a microscope. Also includes: The convergence and divergence of the therapeutic light are controlled according to the thickness of each retinal layer in the eye as determined by the optical coherence tomography scanner, so as to precisely control the depth of light therapy.

Images