Self-driven stable detection microfluidic biochip and application thereof

Abstract

The present application relates to the technical field of microfluidic chip, in particular to a self-driven stable detection microfluidic biochip and application thereof, which comprises a hydrophilic substrate, a hydrophobic microfluidic channel and a packaging sheet. Energy gradient is generated by the hydrophobic microchannel or structural design to realize self-transport of droplets, and micro-valve and micro-pump structures are not needed. The energy gradient is constructed in the following way: the width of the hydrophobic microfluidic channel and / or the spacing between two adjacent hydrophobic microfluidic channels is gradually reduced to construct a wettability gradient surface; or a charge gradient is formed by the silicon dioxide nanoparticles on the hydrophilic substrate in a larger area under the impact of droplets to control the directional movement of the droplets. The specific concave structure of the two side walls of the hydrophobic microfluidic channel improves the stability of droplet transport, reduces the interference in the transport process and improves the transport efficiency of droplets.

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