Left atrial appendage occlusion device

Abstract

The application provides a left auricle occlusion device, which comprises an occlusion piece, an anchor connected with the occlusion piece, the anchor being larger than the size of the blind cavity opening of the left auricle, a fixing piece connected to the side of the occlusion piece away from the anchor and defining the occlusion piece in the blind cavity of the left auricle together with the anchor, the occlusion piece being a mesh structure, and a flow resistance film wrapped outside the anchor. The application aims at solving the problem of unreliable connection between the existing occlusion device and the left auricle.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a left atrial appendage occlusion device. Background Technology

[0002] Existing occluders typically insert an occlusal umbrella into the opening of the left atrial appendage (LAA) to completely seal it. An occlusal disc is designed behind the umbrella to support the LA wall, thus securing the umbrella in place. Since the occluder primarily acts as a bridge within the LA, allowing endothelial tissue to grow along its contour, the occluder is no longer needed once the endothelial tissue has fully developed.

[0003] Currently, biodegradable left atrial appendage occluders have been designed in the field of medical device technology, but research has mainly focused on their materials and manufacturing processes. While some structural designs have been proposed, the poor shape memory of biodegradable materials means that the occluder cannot self-expand to its predetermined shape after being pushed out of the sheath. This affects the anchoring insertion, resulting in a lack of reliable connection between the occluder and the left atrial appendage, making it prone to detachment and failing to effectively occlude the left atrial appendage. Furthermore, this poses certain safety hazards and affects surgical efficacy. Moreover, occluders used for atrial / ventricular septal defects or other conditions may also present similar problems.

[0004] To compensate for the shortcomings of biodegradable materials, those skilled in the art have attempted to make the occluder into a balloon shape and inflate it by injecting liquid, but the occluder is relatively soft and has poor adhesion to the wall. Summary of the Invention

[0005] In view of this, the purpose of the present invention is to provide a left atrial appendage occlusion device, which aims to solve the problem of unreliable connection between existing occluders and the left atrial appendage.

[0006] This invention provides a left atrial appendage occlusion device, comprising:

[0007] Sealing components;

[0008] An anchor, connected to the occlusion member, wherein the anchor is larger than the size of the blind cavity opening of the left atrial appendage;

[0009] A fixing member is connected to the side of the occluder opposite to the anchor, and together with the anchor, defines the occluder within the blind cavity of the left atrial appendage;

[0010] The sealing component has a mesh structure;

[0011] A flow-blocking membrane is applied to the outside of the anchor.

[0012] In one embodiment, a connector is also included, one end of which is connected to the fixing member, and the other end is used to connect to the sealing member.

[0013] In one embodiment, at least the sealing element is made of a first biodegradable material.

[0014] In one embodiment, the first degradable material includes one or more of amorphous polylactic acid, L-polylactic acid, D-polylactic acid, polydioxanone, polycaprolactone, or polylactic acid-glycolic acid copolymer.

[0015] In one embodiment, the sealing member has a through channel for inserting the connector, and the connector is interference-fitted with the through channel.

[0016] In one embodiment, the connector has a first connecting portion on its outer side and a second connecting portion on its inner side, and the connector and the through channel are detachably connected through the first connecting portion and the second connecting portion.

[0017] In one embodiment, the anchor has a delivery channel communicating with the through channel; the flow-blocking membrane has a movable portion corresponding to the delivery channel, the movable portion being used to expose or cover the delivery channel.

[0018] In one embodiment, the flow-blocking membrane is made of a second biodegradable material; the structure of the flow-blocking membrane is one of spunlace nonwoven fabric, spunbond nonwoven fabric, thermally bonded nonwoven fabric, wet-laid nonwoven fabric, or electrospun fiber membrane.

[0019] In one embodiment, the fixing member has a covering cavity on the side facing the occlusion member for covering the left atrial appendage.

[0020] The left atrial appendage occlusion device provided by this invention comprises an occlusion element, an anchor, and a fixing element arranged in a mesh structure, possessing self-expansion and strong support. Made of biodegradable materials, the device not only achieves its biodegradability but also improves its adherence to the wall and self-expansion effect. Simultaneously, it guides the endothelial tissue to cover the device surface. After endothelialization, the left atrial appendage occlusion device gradually degrades and disappears to avoid long-term complications. A barrier membrane is placed on the side of the anchor near the left atrial wall to prevent blood from flowing into the delivery channel. Furthermore, the fixing element and anchor are located at opposite ends of the occlusion element, forming an "I"-shaped left atrial appendage occlusion device. The anchor is secured at the opening of the blind cavity of the left atrial appendage and connected to the left atrial wall, restricting the movement of the occlusion element towards the blind end; the fixing element compresses the left atrial appendage between the fixing element and the occlusion element, improving the relative stability of the occlusion element and the left atrial appendage and preventing the left atrial appendage occlusion device from dislodging. The flow-blocking membrane is placed on the outside of the anchor, or the side of the anchor near the occluder may not have a flow-blocking membrane, to prevent blood from entering the left atrial appendage through the mesh gaps of the anchor. Attached Figure Description

[0021] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0022] Figure 1 This is a schematic diagram of the left atrial appendage occlusion device in the first embodiment of the present invention.

[0023] Figure 2 for Figure 1 A schematic diagram of the connection between the fixing component and the sealing component.

[0024] Figure 3 This is a schematic diagram of the left atrial appendage occlusion device in the second embodiment of the present invention.

[0025] Figure 4 This is a schematic diagram of the left atrial appendage occlusion device in the third embodiment of the present invention.

[0026] Explanation of reference numerals in the attached drawings: 10, sealing component; 20, anchor; 30, fixing component; 31, elastic rod; 40, connector; 41, connecting rod; 50, flow-blocking membrane. Detailed Implementation

[0027] The specific embodiments of the present invention will now be described in detail with reference to the accompanying drawings. Obviously, the described embodiments are merely some, not all, of the embodiments of the present invention. Based on the description of the present invention, all other embodiments obtained by those skilled in the art without inventive effort are within the scope of protection of the present invention.

[0028] In the description of this invention, unless otherwise explicitly specified and limited, the terms "set," "install," "connect," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection; they can refer to a direct connection or an indirect connection through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms according to the specific circumstances.

[0029] The terms “upper,” “lower,” “left,” “right,” “front,” “back,” “top,” “bottom,” “inner,” and “outer,” etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship commonly used when the product of the invention is in use. They are only for the convenience of description and simplification, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the present invention.

[0030] The terms “first,” “second,” “third,” etc., are used merely to distinguish elements with similar properties, not to indicate or imply relative importance or a specific order.

[0031] The terms “include,” “comprising,” or any other variation thereof are intended to cover non-exclusive inclusion, which includes not only the elements listed but also other elements not expressly listed.

[0032] First Embodiment

[0033] One embodiment of the present invention provides a left atrial appendage occlusion device, comprising:

[0034] Occlusion component 10 is used to block the blind cavity of the left atrial appendage;

[0035] Anchor 20 is connected to the sealing member 10, and the anchor 20 is larger than the size of the blind cavity opening of the left atrial appendage;

[0036] The fixing member 30 is connected to the side of the occlusion member 10 away from the anchor 20, and together with the anchor 20, it defines the occlusion member 10 in the blind cavity of the left atrial appendage.

[0037] The sealing component 10 has a mesh structure;

[0038] A flow-blocking membrane 50 is wrapped around the outside of the anchor 20.

[0039] Connector 40, one end of which is connected to fixing member 30, and the other end is used to connect to sealing member 10.

[0040] Specifically, the anchor 20 and the fixing member 30 are respectively located at the blind cavity opening of the left atrial appendage and the outer side of the left atrial appendage, and are connected to both ends of the occlusion member 10, so that the occlusion member 10 can stably seal the blind cavity of the left atrial appendage. The occlusion member 10 is preferably cylindrical, and the diameter of the occlusion member 10 is larger than the diameter of the blind cavity of the left atrial appendage, so that after the occlusion member 10 is released from the sheath and expands, it can seal the blind cavity of the left atrial appendage and support the left atrial appendage tissue, thereby improving its adherence to the wall, enhancing the effect of fixing the left atrial appendage, and ensuring better stability, thus ensuring the initial stability of the relative fixation between the occlusion member 10 and the left atrial appendage.

[0041] In this embodiment, the anchor 20 can be in various shapes, such as plate, disc, or sphere, preferably disc-shaped, with arc-shaped edges to avoid sharp edges scraping against the heart tissue. The cross-sectional area of ​​the anchor 20 is larger than the opening area of ​​the left atrial appendage blind cavity and larger than the cross-sectional area of ​​the occlusion member 10, so that the anchor 20 is confined to the left atrial wall and cannot enter the left atrial appendage blind cavity, thus preventing the occlusion member 10 from sliding into the blind end of the left atrial appendage blind cavity.

[0042] In this embodiment, the fixing member 30 has a mesh structure, which can be woven, laser-cut, or thermally melted. A biodegradable film is applied to the interior and / or exterior of the fixing member 30 to prevent blood from entering the left atrial appendage. The mesh structure increases the elasticity of the material. When the mesh density is insufficient, blood can easily flow into the left atrial appendage, causing occlusion failure. Wrapping the portion of the left atrial appendage occlusion device placed in the left atrium with a flow-blocking membrane 50 gives it the elastic properties of a mesh structure and prevents blood from flowing into the left atrial appendage through the mesh gaps, while simultaneously guiding the endothelial tissue to cover the device surface, promoting endothelialization.

[0043] Furthermore, the flow-blocking membrane 50 completely covers the side of the anchor 20 away from the sealing member 10, and the number of layers of the flow-blocking membrane is 3-5.

[0044] In this embodiment, the flow-blocking membrane 50 is made of a second biodegradable material, which may be any one or more of polydioxanone, polycaprolactone, polyglycolic acid, amorphous polylactic acid, L-polylactic acid, and D-polylactic acid; the structure of the flow-blocking membrane 50 is one of spunlace nonwoven fabric, spunbond nonwoven fabric, thermally bonded nonwoven fabric, wet-laid nonwoven fabric, or electrospun fiber membrane.

[0045] In this embodiment, the fixing member 30 has a covering cavity for covering the left atrial appendage on the side facing the sealing member 10.

[0046] Specifically, by bending the periphery of the fixing member 30 toward the occlusion member 10, a covering cavity for covering the blind end of the left atrial appendage is defined on the inner side of the fixing member 30, so that the occlusion member 10 is sealed within the blind cavity of the left atrial appendage. After the fixing member 30 covers the left atrial appendage from the outside of the blind cavity, it can clamp the left atrial appendage between the occlusion member 10 and the fixing member 30, preventing the movement of the left atrial appendage from causing instability or detachment of the structural connection within the left atrial appendage occlusion device. This strengthens the connection stability between the left atrial appendage occlusion device and the left atrial appendage, preventing the left atrial appendage occlusion device from detaching. Furthermore, the curved portion of the fixing member 30 transitions smoothly with the unbent portion, which helps to accelerate the endothelialization process on the surface of the left atrial appendage occlusion device.

[0047] In this embodiment, the left atrial appendage is punctured into the pericardial cavity through a puncture device. The fixation member 30 is released into the pericardial cavity through a delivery system, and the body of the left atrial appendage is squeezed between the fixation structure 2 and the occlusion structure 1. Compared with the prior art of directly occluding the left atrial appendage or having internal barbs hooking the inner wall of the left atrial appendage, the left atrial appendage occlusion device in this embodiment has a more stable puncture depth, lower requirements on the shape of the left atrial appendage, better fixation effect, is less likely to fall off, and improves stability.

[0048] Current occluder structures are made of metal mesh, and barbs are required on the outer surface of the occluder. Occluders used in percutaneous interventional occlusion procedures are mostly made of nickel-titanium alloy, and many are double-riveted. However, continuous pressure from nickel-titanium alloys can cause delayed atrioventricular block, and there are several potential complications such as long-term metal ion allergies and device-related thrombosis.

[0049] Furthermore, once the left atrial appendage orifice is completely endothelialized, the left atrial appendage occluder loses its function and there is no need for it to remain in the body. In addition, patients who have received implanted metal occluders may be unable to undergo atrial fibrillation ablation, mitral valve repair, or left atrial appendage interventional procedures later on. An ideal occluder should act as a bridge, guiding the patient's own endothelial tissue to cover the device surface, completing self-repair, and then gradually disappearing to avoid long-term complications. Addressing the shortcomings of current biodegradable left atrial appendage occluders, such as poor self-expansion, unsatisfactory intended effects, impaired anchoring, easy dislodgement, poor postoperative results, and poor stability, the left atrial appendage occluder device provided in this embodiment has the following improvements.

[0050] In this embodiment, in the structure of the left atrial appendage occlusion device described above, at least the occlusion element 10 is made of a first biodegradable material.

[0051] Specifically, the purpose of implanting a biodegradable left atrial appendage occlusion device into the human body is to guide endothelial tissue to grow along its surface, so that the defect in the left atrial appendage can be repaired by its own tissue. Once the repair is complete, the left atrial appendage occlusion device made of the first biodegradable material can be degraded by the body, thereby avoiding long-term complications and other safety hazards caused by metal remaining in the body.

[0052] Furthermore, the entire structure of the left atrial appendage occlusion device is made of the first biodegradable material.

[0053] In this embodiment, the first biodegradable material includes one or more of amorphous polylactic acid, L-polylactic acid, D-polylactic acid, polydioxanone, polycaprolactone, or polylactic acid-glycolic acid copolymer.

[0054] Specifically, the aforementioned materials have excellent biocompatibility and can be completely absorbed by the human body, thus avoiding the long-term effects of implanted foreign objects on the human body.

[0055] In this embodiment, the sealing member 10 has a through channel for inserting the connector 40. The connector 40 is interference-fitted with the through channel to ensure the watertightness between the connector 40 and the through channel, thus preventing blood leakage.

[0056] Specifically, there is at least one connector 40, and the number of through channels on the sealing member 10 corresponds to the number of connectors 40. Preferably, in this embodiment, there is one connector 40, and one through channel is provided on the sealing member 10. The through channel is arranged along the central axis of the sealing member 10. The end of the connector 40 that is not inserted into the through channel is fixed to the middle of the fixing member 30 from the encapsulation cavity, so that the sealing member 10, the fixing member 30 and the connector 40 are relatively balanced in force after being fixed to each other.

[0057] In this embodiment, the connector 40 has a first connecting portion on its outer side and a second connecting portion on its inner side of the through channel. The connector 40 and the through channel are detachably connected through the first connecting portion and the second connecting portion.

[0058] Specifically, the connector 40 and the sealing member 10 are detachably connected, allowing for adaptive adjustment of the fixed position and improving treatment effectiveness.

[0059] In other embodiments, the second connecting part may also be provided at a part of the sealing member 10 where no through channel is provided, such as the outer surface of the sealing member 10. The connecting member 40 is detachably connected to the outer surface of the sealing member 10 by means of snap-fit, clamping or welding through the first connecting part and the second connecting part.

[0060] In this embodiment, the first connecting portion includes a connecting protrusion, and the second connecting portion includes a connecting groove that mates with the connecting protrusion.

[0061] Specifically, the surgeon can sense when the connecting protrusion and the connecting groove are properly engaged, which helps the surgeon control the progress of the operation.

[0062] In other embodiments, the first connecting part and the second connecting part may also be threaded or bonded.

[0063] In this embodiment, the anchor 20 has a delivery channel for inserting the left atrial appendage occlusion device into the human body. When the through channel is set along the central axis of the occlusion member 10, the delivery channel is connected to the through channel.

[0064] Specifically, the delivery channel is equipped with a sheath connection point for connecting the sheath tube, through which the left atrial appendage occlusion device is inserted into the body. The sheath tube and the sheath connection point can be detachably connected by threads. The delivery channel is connected to the through channel, allowing the delivery sheath tube to pass through the delivery channel and the through channel to deliver the fixation member 30 into the pericardial cavity.

[0065] In this embodiment, the flow-blocking membrane 50 has a movable portion corresponding to the delivery channel. The movable portion is used to expose or cover the delivery channel, such that the movable portion can be lifted at the opening of the delivery channel to expose the sheath connection point, or to cover the opening of the delivery channel to prevent blood from entering the left atrial appendage and causing adverse effects.

[0066] In this embodiment, the left atrial appendage occlusion device is elastic and self-expanding, so that the left atrial appendage occlusion device can be retracted into the sheath during implantation and can return to its expanded state after being released by the sheath.

[0067] In this embodiment, the end of the left atrial appendage occlusion device that is closer to the surgeon after implantation is defined as the proximal end, and the end that is away from the surgeon is defined as the distal end.

[0068] Specifically, the sealing component 10 and the anchor 20 are mesh structures, and the sealing component 10 and the anchor 20 are connected to form a sealing structure. The elastic modulus can be adjusted by gradually decreasing the mesh density of the sealing structure from the near end to the far end, or by setting the anchor 20 as a single-layer mesh structure and the sealing component 10 as a double-layer mesh structure. The anchor 20 has a low elastic modulus, that is, it has high rigidity. Under the condition of maintaining the wall adhesion and self-expansion of the sealing component 10, the anchoring effect at the near end of the sealing structure is improved.

[0069] The method for intervening in the human body using the left atrial appendage occlusion device in this embodiment includes the following steps:

[0070] Step 1: The catheter and guidewire are routinely inserted into the right atrium via the femoral vein. After puncturing the interatrial septum, the guidewire is left in the left atrium. The sheath and the left atrial appendage occlusion device are connected through the sheath connection point. The skin dilator is inserted into the sheath and together they are inserted into the left atrium along the guidewire. The skin dilator is withdrawn and a pigtail catheter is inserted through the sheath. The direction of the catheter is adjusted and the pigtail catheter is inserted into the left atrial appendage. The sheath is then inserted into the left atrial appendage along the pigtail catheter, so that the occlusion device 10 completely seals the blind cavity of the left atrial appendage and the anchor 20 is secured to the left atrial wall.

[0071] Step 2: Aspirate residual blood from the left atrial appendage via a pigtail catheter, withdraw the pigtail catheter, and insert a left atrial appendage occlusion device delivery sheath along the sheath. The sheath contains a skin dilator. Insert a puncture guidewire along the delivery sheath and use high-frequency electrical energy to penetrate the left atrial appendage and enter the pericardial cavity. Push the left atrial appendage occlusion device delivery sheath through the left atrial appendage into the pericardial cavity along the guidewire. After exchanging the left atrial guidewire into the pericardial cavity, withdraw the skin dilator and guidewire, leaving the left atrial appendage occlusion device delivery sheath in the pericardial cavity.

[0072] Step 3: After connecting the fixing member 30 to the fixing member connecting steel cable, push the left atrial appendage occlusion device along the delivery sheath, release the fixing member 30 in the pericardial cavity, retract the delivery sheath, squeeze the body of the left atrial appendage between the fixing member 30 and the occlusion member 10, fix the push rod and sheath in place, continue to retract the delivery sheath, release the connecting member 40 inside the sheath, and connect it with the inner wall of the through channel. Rotate the steel cable to release the fixing member 30, remove the fixing member connecting steel cable and the delivery sheath of the left atrial appendage occlusion device, disconnect the connection between the sheath and the occlusion structure, completely release the left atrial appendage occlusion device, and withdraw the sheath.

[0073] The left atrial appendage occlusion device provided by this invention, by setting the occlusion element 10, anchor 20, and fixing element 30 of the left atrial appendage occlusion device into a mesh structure, possesses self-expansion and strong support. For example, the left atrial appendage occlusion device made of biodegradable materials can not only obtain its biodegradability but also improve its wall adhesion and self-expansion effect. Setting the left atrial appendage occlusion device into a mesh structure also requires preventing blood from flowing into the left atrial appendage occlusion device from its end near the left atrial wall, for example, by setting a barrier membrane on the side of the anchor near the left atrial wall. In addition, the fixing element 30 and anchor 20 are located at opposite ends of the occlusion element 10 to form an "I"-shaped left atrial appendage occlusion device. Anchor 20 is secured at the opening of the blind cavity of the left atrial appendage and connected to the left atrial wall, restricting the movement of the occlusion device 10 towards the blind end. Fixing member 30 presses the left atrial appendage between fixing member 30 and occlusion device 10, improving the relative stability of the occlusion device and the left atrial appendage and preventing the left atrial appendage occlusion device from dislodging. A flow-blocking membrane 50 covers the outside of anchor 20, or the side of anchor 20 closest to occlusion device 10 may not have a flow-blocking membrane 50, preventing blood from entering the left atrial appendage through the mesh gaps of anchor 20.

[0074] Second Embodiment

[0075] Please refer to Figure 3 Another embodiment of the present invention provides a left atrial appendage occlusion device, which differs from the first embodiment in that the connecting member 40 includes multiple connecting rods 41, which are arranged in a ring and connected sequentially to form a column. The fixing member 30 includes multiple elastic rods 31, one end of which is connected to one end of the connecting rod 41, and the other end extends outward radially, with the connecting rod 41 and the elastic rod 31 forming an angle of 90°-150°. The elastic rod 31 is slender and has an arc shape, either entirely or at its end away from the connecting member 40, to form a covering cavity.

[0076] Furthermore, the first connecting part can be located on the outside of the connecting rod 41.

[0077] Third Embodiment

[0078] Please refer to Figure 4 Another embodiment of the present invention provides a left atrial appendage occlusion device, which differs from the first embodiment in that the anchor 20, the fixing member 30, and the occlusion member 10 are integrally formed and cannot be disassembled. In this embodiment, the occlusion member 10 may not have a through channel, and the connecting member 40 is located between the occlusion member 10 and the fixing member 30 (or the connecting member 40 is not provided); to puncture the left atrial appendage and clamp the left atrial appendage between the occlusion member 10 and the fixing member 30.

[0079] The method for intervening in the human body using the left atrial appendage occlusion device in this embodiment includes the following steps:

[0080] Step 1: The catheter and guidewire are routinely inserted into the right atrium via the femoral vein. The skin dilator is inserted into the sheath. After puncturing the interatrial septum, the catheter and guidewire are inserted together into the left atrium along the guidewire. High-frequency electrical energy is used to penetrate the left atrial appendage and enter the pericardial cavity. The left atrial appendage occlusion device delivery sheath is pushed along the guidewire through the left atrial appendage into the pericardial cavity. After positioning, the skin dilator and guidewire are withdrawn, and the left atrial appendage occlusion device delivery sheath is left in the pericardial cavity.

[0081] Step 2: After the left atrial appendage occlusion device is connected to the steel cable, push the left atrial appendage occlusion device along the delivery sheath, release the fixing member 30 in the pericardial cavity, retract the delivery sheath, squeeze the body of the left atrial appendage, fix the push rod and sheath in place, continue to retract the delivery sheath, release the occlusion member 10 on the right side of the proximal end of the left atrial appendage, release the anchor member 20 on the left side of the proximal end of the left atrial appendage, disconnect the connection between the sheath and the occlusion structure, completely release the occlusion device, and withdraw the sheath.

[0082] The above are merely specific embodiments of the present invention, but the scope of protection of the present invention is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in the present invention should be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the appended claims.

Claims

1. A left atrial appendage occlusion device, characterized in that, include: Sealing component (10); An anchor (20) is connected to the occluder (10). The anchor (20) is larger than the size of the blind cavity opening of the left atrial appendage. The anchor (20) is locked at the opening of the blind cavity of the left atrial appendage and connected to the left atrial wall, restricting the movement of the occluder (10) to the blind end. A fixing member (30) is connected to the side of the occluder (10) away from the anchor (20) and together with the anchor (20) defines the occluder (10) within the blind cavity of the left atrial appendage; The sealing component (10) has a mesh structure; A flow-blocking membrane (50) is wrapped around the outside of the anchor (20); At least the sealing element (10) is made of a first biodegradable material; It also includes a connector (40), one end of which is connected to the fixing member (30), and the other end is used to connect to the sealing member (10); The sealing member (10) has a through channel for inserting the connector (40), and the connector (40) is interference-fitted with the through channel; The connector (40) has a first connecting part on its outer side and a second connecting part on its inner side. The connector (40) and the through channel are detachably connected through the first connecting part and the second connecting part.

2. The left atrial appendage occlusion device as described in claim 1, characterized in that, The first biodegradable material includes one or more of amorphous polylactic acid, L-polylactic acid, D-polylactic acid, polydioxanone, polycaprolactone, or polylactic acid-glycolic acid copolymer.

3. The left atrial appendage occlusion device as described in claim 1, characterized in that, The anchor (20) has a conveying channel that communicates with the through channel, and the flow-blocking membrane (50) has a movable part corresponding to the conveying channel, which is used to expose or cover the conveying channel.

4. The left atrial appendage occlusion device as described in claim 1, characterized in that, The flow-blocking membrane (50) is made of a second biodegradable material; the structure of the flow-blocking membrane (50) is one of spunlace nonwoven fabric, spunbond nonwoven fabric, thermally bonded nonwoven fabric, wet-laid nonwoven fabric or electrospun fiber membrane.

5. The left atrial appendage occlusion device as described in claim 1, characterized in that, The fixing member (30) has a covering cavity for covering the left atrial appendage on the side facing the sealing member (10).

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