用于难溶性药物的缓释组合物及其用途、含有缓释组合物的药物组合物
By using hydroxyethyl cellulose compositions of different molecular weights to regulate the release of poorly soluble drugs, the problems of complexity and high cost in the preparation of osmotic pump tablets have been solved, achieving zero-order release and stable dissolution under different pH conditions, and reducing production costs.
CN116212035BActive Publication Date: 2026-07-17GUANGZHOU HUIYUAN PHARM TECH CO LTD
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- GUANGZHOU HUIYUAN PHARM TECH CO LTD
- Filing Date
- 2023-03-06
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing osmotic pump tablets have complex manufacturing processes, high costs, and poor reproducibility, making it difficult to achieve zero-order release of poorly soluble drugs in environments with varying pH values.
Method used
By employing a sustained-release composition composed of hydroxyethyl cellulose with different average molecular weights, the release behavior of poorly soluble drugs is regulated through a dissolution mechanism, and combined with traditional formulation processes, zero-order release is achieved.
Benefits of technology
It achieves zero-order release within the pH range of 1.0 to 6.8, with a stable dissolution rate, reducing production costs and making it suitable for large-scale production.
✦ Generated by Eureka AI based on patent content.
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Figure CN116212035B_ABST
Abstract
本申请公开了一种用于难溶性药物的缓释组合物及其用途、含有缓释组合物的药物组合物，涉及药物制剂技术领域；本申请采用与渗透泵片不同的释药机制，通过两种平均分子量不同的羟乙基纤维素对难溶性药物的释放行为进行调节，共同联用时可以得到零级线性释放的溶蚀机理的缓释骨架。该缓释骨架用于难溶性药物时，能制备出不受pH(1.0～6.8)影响且具有零级释放行为，溶出速率稳定的药物制剂，从而稳定发挥药效。且制剂制备工艺简单，生产成本较低，适合大规模生产的的药物组合物。
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