Gas reaction chamber

Abstract

The application provides a gas reaction chamber, which can change the relative position of a reaction part in a fluid, so as to improve the reaction degree of a gas colorimetric reaction, and further improve the detection signal strength. The gas reaction chamber has a gas inlet, a gas outlet and a reaction chamber. The reaction chamber is used for accommodating a test film. The test film comprises a base surface and a plurality of protruding structures. The plurality of protruding structures protrude from the base surface. A reaction part for reacting with a gas is arranged on the top surface of the plurality of protruding structures. The gas enters the reaction chamber through the gas inlet and flows to the gas outlet along the side of the base surface provided with the plurality of protruding structures.

Description

Technical Field

[0001] This invention relates to the field of detection technology, and in particular to a novel and unique gas reaction chamber. Background Technology

[0002] Among the many types of reactions, solid-phase reactions and liquid-phase reactions are very pronounced due to the high concentration of reactants. However, in chemical reactions involving gases, such as gas-phase reactions and gas-solid interface reactions, the degree of reaction is generally lower due to various reasons, including the need for adsorption before reaction and the low concentration of gas molecules during diffusion. This is exemplified by gas-solid interface reactions.

[0003] Applications of gaseous reactions include the health and environmental fields. For example, for some serious diseases such as cancer, early detection is extremely difficult, and detection methods are very limited. By the time it is discovered, it may already be in an advanced stage, resulting in a very low survival rate. In recent years, methods for rapid screening of early diseases, such as VOC colorimetry, have been proposed and have gradually become a research hotspot. Detecting characteristic gases exhaled by humans using colorimetry is an effective means of screening for early diseases.

[0004] However, for a gas with very low viscosity, when it comes into contact with an object and there is relative motion at high Reynolds numbers, the thin fluid layer near the object's surface experiences reduced velocity due to viscous shear stress. The fluid adhering tightly to the object's surface has a relative velocity of zero. From the object's surface upwards, the velocities of each layer gradually increase until they equal the free flow velocity. This thin layer of decelerating fluid rising from the object's surface is called the boundary layer.

[0005] For commonly designed reactants, trace levels of gas are unlikely to cross the boundary layer and react with the reactants. Improving the reactivity at the gas-solid interface is an effective way to enhance the accuracy of colorimetric disease detection. Currently, there is no single effective method to solve this problem. Most methods for increasing the intensity of gas reactions have limitations, such as enriching characteristic molecules in the gas before the reaction, increasing the reaction time, or designing the reaction based on the reactant's structure. However, these methods all have certain drawbacks, such as high cost, complex and uncontrollable processes, and low repeatability of experimental data. Summary of the Invention

[0006] The problem the invention aims to solve

[0007] As described above, the presence of viscous resistance in the gas results in a thicker boundary layer, which reduces the intensity of the gas-solid interface reaction. In view of this, the present invention provides a gas reaction chamber that addresses the aforementioned difficulties, increases the reactivity of trace gas molecules in the gas colorimetric reaction chamber, and thereby enhances the intensity of the detection signal.

[0008] Solution for solving the problem

[0009] Through dedicated research, the inventors of this application designed a reaction chamber with a raised structure based on the characteristics of gas-solid interface reactions. This alters the relative positions of the reactants (reaction section) in the fluid, thereby improving the sensitivity of gas colorimetric reactions.

[0010] According to one technical solution of the present invention, a gas reaction chamber is provided, which has an inlet, an outlet, and a reaction chamber. The reaction chamber is used to house a test membrane. The test membrane includes a base surface and a plurality of protruding structures. The plurality of protruding structures protrude from the base surface, and a reaction part for reacting with gas is provided on the top surface of the plurality of protruding structures. The gas enters the reaction chamber through the inlet and flows along the side of the base surface with the plurality of protruding structures to the outlet.

[0011] Preferably, the total area of ​​the top surfaces of the plurality of protruding structures accounts for 1% to 30% of the area of ​​the base surface exposed to the reaction chamber.

[0012] Preferably, the distance between the two protruding structures furthest apart in the gas flow direction is taken as the length, and the distance between the two protruding structures furthest apart in a direction orthogonal to the gas flow direction is taken as the width. The area obtained by multiplying the length by the width is regarded as a specific area. The sum of the areas of the top surfaces of the plurality of protruding structures accounts for 1% to 30% of the area of ​​the specific region. The area of ​​the specific region satisfies the following condition: specific area ≤ area of ​​the specific region ≤ 1.25 × specific area.

[0013] Preferably, the gas reaction chamber further has a window for detecting the test membrane via the window.

[0014] Preferably, the plurality of protrusions are arranged at intervals in the gas flow direction.

[0015] Preferably, the materials of the reaction portions provided on at least two of the protruding structures are different from each other.

[0016] Preferably, the area of ​​the top surface of each of the protruding structures is greater than or equal to 0.01 mm². 2 And less than or equal to 0.05mm 2 And / or, the distance between adjacent protrusions is greater than or equal to 0.3 mm and less than or equal to 2.5 mm, and / or, the height of the protrusion is greater than 0 mm and less than or equal to 1 mm.

[0017] Preferably, the gas reaction chamber further comprises a base, the reaction chamber being formed by combining the base and the window portion, and the test membrane being sealed between the base and the window portion.

[0018] Preferably, one of the base and the window has a groove, and the other of the base and the window has a boss, which is embedded in the groove to seal the test membrane between the base and the window.

[0019] Preferably, the protruding structure is circular when viewed from above, or the protruding structure is elliptical when viewed from above, with the major axis of the ellipse parallel to the direction of gas flow, or the protruding structure is polygonal when viewed from above, with one edge of the protruding structure facing the direction of gas flow.

[0020] The effects of the invention

[0021] The gas reaction chamber of this invention, based on its unique structure, can effectively suppress the hindering effect of the boundary layer, enhance the diffusion of molecules in the gas phase to the sample surface, improve the reaction degree of trace gas molecules in the gas colorimetric reaction chamber, and thus improve the detection signal intensity. Attached Figure Description

[0022] Figure 1 This is a perspective view of the gas reaction chamber of the present invention.

[0023] Figure 2 This is an exploded view of the gas reaction chamber of the present invention.

[0024] Figure 3 This is a longitudinal sectional view of the gas reaction chamber of the present invention.

[0025] Figure 4 yes Figure 3 A sectional view of view AA in the middle.

[0026] Figure 5 yes Figure 4 An enlarged view of part B in the image.

[0027] Figure 6 This is a schematic diagram of the microstructure of the test membrane.

[0028] Figure 7 This is a magnified schematic diagram of the microstructure of the test membrane.

[0029] Figure 8 This is a velocity contour plot showing the speed when using an existing test membrane (without protrusions).

[0030] Figure 9This graph shows the relationship between speed and reaction chamber height when using an existing test membrane (without protrusions).

[0031] Figure 10 This is a velocity contour plot showing the speed when using the test membrane (with a raised structure) of this application.

[0032] Figure 11 This is a graph showing the relationship between speed and reaction chamber height when using the test membrane (with raised structure) of this application.

[0033] Figure 12 It is a schematic diagram showing a certain density of raised structures set in a specific area.

[0034] Figure 13 It means Figure 12 Velocity contour plot under structural conditions.

[0035] Figure 14 This is a schematic diagram illustrating the setting of a higher density of raised structures in a specific area.

[0036] Figure 15 It means Figure 14 Velocity contour plot under structural conditions.

[0037] Figure 16 This represents a comparison of the reaction strength of a protruding structure and the reaction strength of a planar structure under finite element simulation analysis.

[0038] Explanation of reference numerals in the attached figures

[0039] 100. Gas reaction chamber; 1. Inlet; 2. Filter cartridge; 3. Base; 4. Window; 5. Test membrane; 6. Outlet; 11. Annular boss; 21. Annular groove; 22. Annular boss; 31. Limiting groove; 32. Groove; 33. Snapped part; 34. Placement platform; 42. Boss; 43. Snapped part; 44. Inlet opening; 51. Base surface; 52. Protruding structure; 53. Reaction section. Detailed Implementation

[0040] The technical solutions of the present invention are described below with reference to the accompanying drawings. The present invention is not limited to the technical solutions described below. Those skilled in the art can make any combination, modification, addition, or deletion while satisfying the spirit of the present invention.

[0041] Figure 1 This is a perspective view of the gas reaction chamber of this application. Figure 1 As shown, the gas reaction chamber 100 of this application has an inlet 1, a filter cartridge 2, a base 3, a window 4, a test membrane 5, and an outlet 6. Figure 2 The image shows an exploded view of the gas reaction chamber 100. (See image for details.) Figure 2As shown, the base 3 and window 4 house the test membrane 5 within them. Specifically, a placement platform 34 is formed on the base 3. The test membrane 5 is placed on the placement platform 34, and the window 4 is securely attached to the base 3 by snapping it into the snapped portion 33 of the base 3. Figure 2 As shown, the window portion 4 has an air inlet 44, through which gas can enter the reaction chamber formed by the base 3 and the window portion 4. The window portion 4 also has an air outlet (not shown), through which gas can enter the air outlet 6 from the reaction chamber. Figure 3 The diagram shows a longitudinal sectional view of the gas reaction chamber 100, that is, a view taken along the gas flow direction. An annular boss 11 is formed at the left end of the inlet 1, and an annular groove 21 is formed at the right end of the filter cartridge 2. The inlet 1 is sealed to the filter cartridge 2 by inserting the annular boss 11 of the inlet 1 into the annular groove 21 of the filter cartridge 2.

[0042] An annular boss 22 is formed at the left end of the filter cartridge 2. For example... Figure 2 and Figure 3 As shown, at the right end of the window portion 4, specifically at the position opposite to the annular boss 22, a semi-annular groove of the window portion 4 is formed. At the right end of the base 3, specifically at the position opposite to the annular boss 22, a semi-annular groove of the base 3 is formed. After the base 3 and the window portion 4 are fastened together, the semi-annular groove of the window portion 4 and the semi-annular groove of the base 3 together form an annular groove (similar to the structure of annular groove 21). Thus, after the base 3 and the window portion 4 are fastened together, by inserting the annular boss 22 at the left end of the filter cartridge 2 into the jointly formed annular groove, the base 3 and the window portion 4 can be sealed and fitted into the filter cartridge 2 as a whole.

[0043] A desiccant can be placed in the filter cartridge 2 as needed, or a material that can filter the substance can be placed accordingly, depending on what needs to be filtered.

[0044] In addition, such as Figure 2 and Figure 3 As shown, a semi-annular groove is also formed at the left end of the base 3 and the window 4, which has the same structure as the semi-annular groove at the right end. After the base 3 and the window 4 are fastened together, the semi-annular groove at the left end of the base 3 and the semi-annular groove at the left end of the window 4 together form an annular groove, which can be sealed and fitted with the annular boss formed at the right end of the air outlet 6.

[0045] like Figure 3As shown, a limiting groove 31 is formed at the bottom of the gas reaction chamber 100. Using this limiting groove 31, when the gas reaction chamber 100 after gas collection is completed is placed on the detection instrument, the gas reaction chamber 100 can be limited to ensure that the spectral detection device can be aligned with the test membrane 5 when performing detection.

[0046] Figure 4 yes Figure 3 View AA in the figure. As described above, the base 3 and the window 4 can be fastened together, and a reaction chamber is formed inside the fastened base 3 and the window 4, which can house the test membrane 5. Figure 4 As shown, in the width direction of base 3 ( Figure 4 A placement platform 34 is located in the middle of the base 3 (in the left-right direction). The placement platform 34 has straight-line extending grooves 32 at both ends in the width direction. The test membrane 5 is placed on the placement platform 34. In the width direction of the base 3 (in the left-right direction), a placement platform 34 is provided. Figure 4 In the left-right direction, the length of the test membrane 5 is greater than the distance between the two grooves 32. Therefore, when the test membrane 5 is placed on the placement stage 34, the portion of the test membrane 5 corresponding to the groove 32 can be placed into the two grooves 32.

[0047] A through-hole is provided approximately at the center of the window portion 4, and a viewing window 41 is disposed approximately at the center of the window portion 4 to block the through-hole. The viewing window 41 is formed of a transparent material and is used to detect the reaction surface of the test membrane 5 through the viewing window 41. When the window portion 4 is projected onto the plane where the test membrane 5 is located, the viewing window 41 at least covers a portion of the test membrane 5. More preferably, the viewing window 41 is completely opposite to the test membrane 5, and when the window portion 4 is projected onto the plane where the test membrane 5 is located, the test membrane 5 completely includes the projection of the viewing window 41 or the projection of the viewing window 41 completely includes the test membrane 5 (i.e., the viewing window 41 completely covers the test membrane 5). More preferably, when the window portion 4 is projected onto the plane where the test membrane 5 is located, the test membrane 5 is completely included within the projection of the viewing window 41. Thus, the test membrane 5 can be detected well.

[0048] Similarly, Figure 4 As shown, when viewed from a cross-sectional view of the gas reaction chamber 100 along a direction orthogonal to the gas flow direction, the width of the window portion 4 ( Figure 4 The two ends of the window 4 (in the left and right directions) are combined with the base 3. The viewing window 41 of the window 4 is mounted between the upper parts of the two ends in the width direction of the window 4, thus forming a space between the two ends in the width direction of the window 4. When the base 3 and the window 4 can be fastened together, as Figure 4 As shown, the space surrounded by the two ends of the window portion 4 in the width direction, the viewing window 41, and the placement platform 34 serves as a reaction chamber for storing the test membrane 5.

[0049] At both ends of the window portion 4 in the width direction, specifically at positions corresponding to the grooves 32 of the base 3, there are protrusions 42 extending in a straight line. For example... Figure 5 As shown, the groove 32 is a curved recess, and the boss 42 is a curved protrusion. That is, the cross-sectional shapes of the groove 32 and the boss 42 are curved, and the mating surfaces of the boss 42 and the groove 32 are curved. The curved mating surfaces increase the contact area and improve the sealing strength. By embedding the linearly extending boss 42 into the linearly extending groove 32, the edge of the test membrane 5 is clamped, and the test membrane 5 is sealed between the groove 32 and the boss 42. Furthermore, in Figure 2 and Figure 4 The diagram only shows a structure that seals the edges of two sides of the test membrane 5. In reality, a sealing structure with bosses and grooves could be provided around the entire circumference of the test membrane 5. Moreover, as long as a seal can be achieved, the grooves 32 and bosses 42 do not have to be straight lines, but have other shapes. Alternatively, the test membrane 5 can be sealed using other structures instead of a groove and boss fitting structure. That is, for the reaction chamber and the test membrane 5 housed in the reaction chamber, it is sealed so that it is only connected to the gas flow path inside the inlet 1 (filter cartridge 2) and the gas flow path inside the outlet 6, and no gas enters or exits in other parts (e.g., the part between the base 3 and the window 4, the part between the entire base 3 and the window 4 and the filter cartridge 2, the part between the entire base 3 and the window 4 and the outlet 6, etc.).

[0050] Furthermore, the engagement between the groove 32 and the boss 42 not only seals the test membrane 5 but also facilitates the connection between the base 3 and the window 4. While the groove 32 and the boss 42 are engaged, the snap-fit ​​portion 43 of the window 4 (see reference)... Figure 3 ) and the latched part 33 of the base 3 (refer to Figure 2 , Figure 3 This achieves a snap-fit ​​connection. Thus, the base 3 and the window portion 4 are reliably snapped together as a single unit.

[0051] like Figure 3 As shown, by attaching the air inlet 1 to the right end of the filter cartridge 2, attaching the snap-fit ​​base 3 and window 4 as a whole to the left end of the filter cartridge 2, and attaching the air outlet 6 to the left end of the snap-fit ​​base 3 and window 4, a gas reaction chamber 100 is assembled.

[0052] When the user uses the gas reaction chamber 100, air is blown through the air inlet 1. Figure 3In this process, the gas flows from right to left, meaning the gas enters the filter cartridge 2 through the rectifier plate of the inlet 1. After unwanted components are filtered out in the filter cartridge 2, the gas enters the reaction chamber formed by the base 3 and the window 4 through the inlet opening 44 of the window 4. In the reaction chamber, it reacts with the test membrane 5 to complete the gas collection. The gas that has passed through the test membrane 5 is discharged from the reaction chamber through the outlet opening (not shown) of the window 4 and enters the outlet 6.

[0053] The test membrane 5 is stored in the reaction chamber, and, as Figure 3 As shown by the dashed arrow, a gas flow path is formed inside the reaction chamber, connecting the inlet 1 (filter cartridge 2) and the outlet 6. Figure 3 As shown, the gas entering the reaction chamber does not pass through the test membrane 5, but rather travels along the reaction surface of the test membrane 5, enters the outlet 6, and is then discharged. The reaction surface of the test membrane 5 is the side of the test membrane 5 closest to the window portion 4, that is, Figure 3 The upper side of the test membrane 5 is located in the window 4, which allows for convenient inspection of the reaction surface of the test membrane 5 through the viewing window 41 of the window portion 4.

[0054] The following is a detailed description of test membrane 5.

[0055] exist Figure 6 The microstructure of the test membrane 5 is shown, specifically the microstructure of the side of the test membrane 5 that can be detected through the viewing window 41 of the window portion 4 (i.e., the reaction surface). Figure 6 and Figure 7 As shown, the test membrane 5 of this application has a base surface 51 and a plurality of protruding structures 52 protruding from the base surface 51. In the reaction chamber, gas entering the reaction chamber passes through the test membrane 5 in a direction parallel to the base surface 51. The gas contacts the base surface 51 and generates relative motion. The protruding structures 52 are circular when viewed from above, and a reaction section 53 for reacting with the gas is provided on the top surface of the plurality of protruding structures 52.

[0056] Multiple protrusions 52 are arranged in the direction of gas flow. As an example of the direction of gas flow, it can be the length direction of the test membrane 5. In the direction intersecting the direction of gas flow, there are multiple columns composed of protrusions 52. Here, "column" refers to a column formed by multiple protrusions 52 arranged in the direction of gas flow. As the direction intersecting the direction of gas flow, it can be the width direction of the test membrane 5. That is, in the width direction of the test membrane 5, there are multiple columns, each column being composed of protrusions 52.

[0057] There is no particular limitation on the number of protrusions 52, and they can be appropriately selected according to the components in the gas to be detected. The protrusions 52 can be formed in one row or multiple rows on the base surface 51. In the case of multiple rows, the number of protrusions 52 constituting each row can be exactly the same, or some rows can have the same number of protrusions 52 while the remaining rows have different numbers of protrusions 52, or they can be completely different between the rows.

[0058] When the gas to be detected contains only one component, for example, to detect component A in the gas, it can be collected using either a single row of raised structures 52 or multiple rows of raised structures 52.

[0059] When the gas to be detected contains only multiple components, such as component A, component B, ..., component N, a series of protruding structures 52 can be used to collect multiple components. For example, component A can be collected using the upstream protruding structures 52 in one series, component B can be collected using the downstream protruding structures 52 in another series, and component C can be collected using the upstream protruding structures 52 in another series, and so on, thus completing the collection of components A through N. Alternatively, one entire series can be used to collect component A, another entire series can be used to collect component B, and so on, thus completing the collection of components A through N. Of course, a single protruding structure 52 can also be used to detect only one component.

[0060] To detect different gas components, multiple different reaction sections corresponding to multiple different gas components are prepared. For each different reaction section, the materials constituting the reaction section are different; that is, the types of reaction sections are different. For example, when at least two components are detected, the material of the reaction section 53 provided on at least one protrusion 52 is different from the material of the reaction section 53 provided on at least another protrusion 52. That is, when at least two components are detected, the multiple reaction sections 53 provided on the multiple protrusions 52 include at least two types of reaction sections. In short, the number of types of the multiple reaction sections 53 provided on the multiple protrusions 52 is greater than or equal to the number of gas components to be detected.

[0061] Furthermore, in the case of a raised structure 52 with multiple columns, the raised structure 52 of one column can be aligned with the raised structures 52 of adjacent columns. Alternatively, as... Figure 6 and Figure 7 As shown, the protrusions 52 of one column are staggered from the protrusions 52 of the adjacent columns.

[0062] Preferably, during the fabrication of the gas reaction chamber of this application, the multiple protruding structures 52 unique to this application are numbered, and the numbering is recorded. This allows the testing personnel to clearly identify which protruding structures 52, based on different numbers, are used to collect different gas components. During testing, the testing personnel use a spectrometer to detect the specified gas components by examining the numbered protruding structures 52 (specifically, the reaction portions 53 on the protruding structures 52) through the viewing window 41 of the window portion 4.

[0063] In addition, Figure 6 and Figure 7 The diagram shows the protruding structure 52 formed in a cylindrical shape, that is, in top view, the protruding structure 52 appears circular. However, the shape of the protruding structure is not limited to this; the protruding structure can also be formed into an ellipse in top view, with the major axis of the ellipse parallel to the gas flow direction on the base surface 51. Furthermore, the protruding structure can also be formed into a triangle in top view, with the gas flow direction perpendicular to the base of the triangle on the base surface 51. The base of the triangle mentioned above refers to the side of the triangle located downstream of the gas flow direction.

[0064] In this application Figure 6 and Figure 7 In the structure of the test membrane 5 shown, the original state of the airflow field is not changed by setting tiny protrusions 52 on the substrate surface 51. These tiny protrusions can lift the reaction surface, allowing it to pass over a thicker fluid boundary layer, making it easier for reactant molecules in the gas phase to diffuse to the surface of the reaction section 53, thus improving responsiveness. Furthermore, the shape of the protrusions when viewed from above is not limited to the three shapes exemplified above. As long as it does not adversely affect the diversion of gas flow, it can be set in any shape on the substrate surface. For example, the protrusions can also be polygonal when viewed from above, with one edge of the polygonal protrusion facing the gas flow direction, that is, the edge that first contacts the gas is not the edge perpendicular to the gas flow direction.

[0065] The area of ​​the top surface of the protruding structure is, for example, 0.01 mm². 2 ~0.05mm 2 For example, the area of ​​the top surface of the protruding structure is 0.01 mm². 2 0.015mm 2 0.02mm 2 0.026mm 2 0.03mm 2 0.034mm 2 0.04mm 2 0.043mm 2 0.05mm 2The area of ​​the top surface of the protruding structure can be arbitrarily selected within the range of the above values, for example, it can be 0.02 mm. 2 ~0.05mm 2 It can be selected arbitrarily between 0.01mm. 2 ~0.04mm 2 The area can be chosen arbitrarily between these values, but preferably, the area of ​​the top surface of the protruding structure is 0.01–0.04 mm². 2 More preferably, the area of ​​the top surface of the protruding structure is 0.01–0.03 mm². 2 The height of the protruding structure is, for example, greater than 0 mm and less than or equal to 1 mm. For instance, the height of the protruding structure can be 0.01 mm, 0.05 mm, 0.1 mm, 0.2 mm, 0.3 mm, 0.4 mm, 0.5 mm, 0.6 mm, 0.7 mm, 0.8 mm, 0.9 mm, or 1 mm. The height of the protruding structure can be arbitrarily selected within the range of the above values, for example, arbitrarily selected between 0.05 mm and 1 mm, or arbitrarily selected between 0.1 mm and 0.9 mm. Preferably, the height of the protruding structure is 0.4 mm to 1 mm; more preferably, the height of the protruding structure is 0.6 mm to 0.9 mm; and even more preferably, the height of the protruding structure is 0.8 mm to 0.9 mm. The distance between adjacent protruding structures is, for example, between 0.3 mm and 2.5 mm. For example, the distance between adjacent protrusions is 0.3mm, 0.4mm, 0.5mm, 0.6mm, 0.7mm, 0.8mm, 0.9mm, 1.0mm, 1.1mm, 1.2mm, 1.3mm, 1.4mm, 1.5mm, 1.6mm, 1.7mm, 1.8mm, 1.9mm, 2.0mm, 2.1mm, 2.2mm, 2.3mm, 2.4mm, or 2.5mm. The distance between adjacent protrusions can be arbitrarily selected within the range of the above values. For example, it can be arbitrarily selected between 0.5mm and 2.0mm, or between 0.8mm and 2.5mm. Preferably, the height of the protrusion is 0.8mm to 2.0mm, more preferably, the height of the protrusion is 1.0mm to 1.8mm, and even more preferably, the height of the protrusion is 1.0mm to 1.5mm.

[0066] Regarding the fabrication method of the protruding structure 52, for example, such a protruding structure can be achieved by 3D printing. After forming the protruding structure 52, a reaction part 53 is set on the top surface of the protruding structure 52 by imprinting. In addition, the fabrication method of the protruding structure 52 is not limited to 3D printing; for example, the protruding structure 52 can also be fabricated by micro-nano fabrication technology.

[0067] The following describes the effect of the test membrane 5 of this application.

[0068] The test membrane 5, acting as a component that reacts with the gas, comes into contact with the gas entering the reaction chamber through the inlet 1. In existing technologies, a reaction section for reacting with the gas is formed on a planar membrane component. Because existing test membranes are merely planar components, the presence of a boundary layer makes it relatively difficult for reactant molecules in the gas phase to diffuse to the reaction surface and react. Figure 8 The velocity contour plot shows the cross-section of the reaction chamber, with a height of, for example, 1.5 mm, and no protruding structures at the top or bottom. Because the fluid in close contact with the object surface will adhere to it, therefore, as... Figure 8 As shown on the left, the closer to the upper and lower walls (i.e., the closer to the object surface), the closer the fluid velocity is to 0. The closer to the middle part, the greater the fluid velocity (closer to the original velocity of the gas, for example, 1.6 m / s).

[0069] like Figure 8 As shown, at the lower wall surface, the relative velocity between the gas and the wall approaches 0. As the gas rises from the lower wall, the velocity gradually increases to its original value of 1.6 m / s (refer to...). Figure 8 (The portion shown in the dashed box) rises from the region with a velocity of 1.6 m / s towards the upper wall, where the velocity gradually decreases, approaching zero at the upper wall. Finite element simulation analysis of the gas velocity passing through the existing test membrane yields... Figure 9 The results are shown. The distance between the position where the velocity is 0 and the position where the velocity reaches its maximum (which can be regarded as the thickness of the boundary layer) is 0.65 mm. This distance significantly hinders the diffusion of molecules from the gas phase to the reaction surface. Therefore, in the prior art, the boundary layer generally results in a lower degree of reaction at the gas-solid interface.

[0070] In this application, by forming a protruding structure 52 on the substrate surface, the relative position of the substrate surface in the boundary layer is improved without affecting the original fluid flow field, thereby effectively reducing the boundary layer thickness, making it easier for gas molecules to diffuse, and thus improving the response loudness.

[0071] Figure 10 This represents the velocity contour plot of the reaction chamber cross-section when using a test membrane with a raised structure. For example... Figure 10 As shown, when such protruding microstructures exist, although a boundary layer of a certain thickness also exists at the reaction interface (refer to...), Figure 10 (The part shown in the dashed box on the left) means that the boundary layer thickness remains almost unchanged, but the boundary layer thickness at the protruding structure is much thinner than that at the planar structure (see reference). Figure 10The distance between the position where the velocity is 0 and the position where the velocity reaches its maximum (which can be considered as the thickness of the boundary layer at the protruding structure) shown in the dashed box on the right side of the image is 0.14 mm. Figure 11 As shown, this special structure effectively suppresses the hindering effect of the boundary layer and enhances the diffusion of molecules from the gas phase to the sample surface, thereby effectively improving the reaction intensity.

[0072] The following explains the density of the protrusion structure 52.

[0073] The density of the protrusion structure 52 refers to the area A of a defined specific region, such as a 2mm × 2mm region, where the area A is 4mm². 2 In this specific region, protruding structures 52 are uniformly arranged, and the total area of ​​the top surface of the protruding structures 52 in the specific region is relative to the area A (4mm) of the specific region. 2 The proportion of ).

[0074] In this application, the specific region can be any region set by those skilled in the art according to actual needs. For example, based on factors such as the size of the reaction chamber and the types and quantities of components in the gas to be detected, an appropriate number of protrusions 52 can be set at appropriate locations. As mentioned above, a specific region of 2mm × 2mm can be set, but the specific region is obviously not limited to this size. The length can be set in the range of 1 to 50mm, and the width can be set in the range of 1 to 50mm, that is, within 1mm... 2 ~2500mm 2 Within a certain area, an appropriate number of protruding structures 52 are set. It should be noted that setting an appropriate number of protruding structures 52 in a specific area means that the protruding structures 52 are evenly set at a certain density throughout the entire area of ​​the specific area, that is, the protruding structures 52 are distributed throughout the entire specific area, rather than "setting multiple protruding structures 52 in a concentrated part of the specific area, but hardly setting any protruding structures 52 in other parts of the specific area". The "evenly set" mentioned above can be a strictly uniform setting (that is, for all protruding structures 52, the distance between adjacent protruding structures 52 is equal), but it can also be a roughly uniform setting, that is, for a part of the protruding structures 52, the distance between adjacent protruding structures 52 is not equal, or for all the protruding structures 52, the distance between adjacent protruding structures 52 is not equal, as long as they are set throughout the entire specific area.

[0075] Furthermore, the specific region can be an area approximately equivalent to the following specific area: The area obtained by multiplying the distance between the two furthest protrusions 52 in the gas flow direction (length) and the distance between the two furthest protrusions 52 in a direction orthogonal to the gas flow direction (width) is considered a specific area. The area of ​​the specific region is approximately equivalent to the specific area. Here, "approximately equivalent" means that the specific area obtained by multiplying the length and width is 80% or more, preferably 90% or more, more preferably 95% or more, particularly preferably 98% or more, and of course, it can also be 100%, that is, the area of ​​the specific region is completely equal to the specific area. In this case, the specific region is the area with the distance between the two furthest protrusions 52 in the gas flow direction as its length and the distance between the two furthest protrusions 52 in a direction orthogonal to the gas flow direction as its width. In other words, the area of ​​the specific region satisfies the following condition: specific area ≤ area of ​​specific region ≤ 1.25 × specific area.

[0076] In this application, a specific area may also be understood as "the area of ​​the base surface 51 exposed to the reaction chamber".

[0077] exist Figure 10 In the structure, the density of the protruding structure 52 in a specific region of the reaction chamber is approximately 1%, such as... Figure 10 and Figure 11 As shown, Figure 10 The structure shown can increase the height of the reaction section without affecting the thickness of the boundary layer, thereby increasing the degree of reaction.

[0078] Furthermore, the number of protrusions 52 set in a specific area can be increased (i.e., the density of protrusions 52 can be increased), such as... Figure 12 As shown, the density of the protrusions is 7% at this time. Figure 13 In, it means to Figure 12 The velocity contour plot was obtained by simulating the reaction chamber under the structure shown, as follows. Figure 13 As shown, the velocity at the upper and lower walls approaches 0, and as the distance from the upper and lower walls to the middle section increases, the velocity gradually returns to its original magnitude (e.g., 4.1 m / s). Furthermore, Figure 13 The dashed box on the left represents the boundary layer at planar structures on the base surface, while the single-dotted box on the right represents the boundary layer at protruding structures. According to... Figure 13 As shown in the velocity cloud diagram, the thickness of the boundary layer at the protruding structure hardly changes. Therefore, the height of the reaction part in the boundary layer can be increased by means of the protruding structure. As a result, the boundary layer thickness of the sample on the protruding structure is much smaller than that on the planar substrate, which is very beneficial to the diffusion and mass transfer of gas molecules.

[0079] On the other hand, when the number of protrusions 52 set in a specific area is further increased (i.e., the density of protrusions 52 is increased), such as Figure 14 As shown, the density of the protrusions is 30% at this time. Figure 15 In, it means to Figure 14 The velocity contour plot was obtained by simulating the reaction chamber under the structure shown, as follows. Figure 15 As shown, the velocity at the upper and lower walls approaches 0. As the distance from the upper and lower walls moves towards the middle section, the velocity gradually increases to 3.8 m / s (but does not return to the maximum velocity of 5.4 m / s). Furthermore, the dashed box on the left represents the boundary layer at the planar structure of the base surface, and the single-dot dashed box on the right represents the boundary layer at the protruding structure. According to... Figure 15 As shown in the velocity cloud diagram, the boundary layer at the protruding structure begins to increase, making it more difficult for the gas to cross the boundary layer and react with the reaction section.

[0080] Therefore, in this application, the density of the protrusion structure 52 is between 1% and 30%, for example, the density of the protrusion structure 52 is 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, or 30%. The density of the protrusion structure 52 can be arbitrarily selected within the range of the above values, for example, it can be arbitrarily selected between 1% and 10%, or arbitrarily selected between 5% and 15%. Preferably, the density of the protrusion structure 52 is 2% to 15%, more preferably, the density of the protrusion structure 52 is 5% to 10%. Even more preferably, the density of the protrusion structure 52 is 7% to 9%.

[0081] The difference in response intensity between the protruding structure and the planar structure in this application was verified using finite element simulation. On the same sample card with protruding structures, 17 points with protruding structures were randomly selected, and the response intensity of the protruding structures and the surrounding planar structures were statistically analyzed. Figure 16 The reaction intensities of the protruding structure and the planar structure are shown respectively, according to Figure 16 The comparison shows that, for all 17 protruding structures and their surrounding planar structures, the surrounding planar structures at all sites exhibited lower response intensities. Figure 16 The reaction intensity of the planar structures surrounding sites 1, 6, and 12 is so low that it is almost not shown in the figure. In contrast, higher reaction intensity is shown at all 17 sites of the protruding structures, indicating that the special protruding structures of this application significantly enhance the intensity of the gas-solid interface reaction.

[0082] other

[0083] In the connection between the various components mentioned above, for example, the air inlet 1 and the filter cartridge 2 are connected by an interlocking method, but a threaded connection method can also be used. Regarding the sealing structure of the test membrane 5 achieved by the base 3 and the window portion 4, the above description uses an interlocking connection structure, that is, the boss 42 is embedded in the groove 32, but other connection structures can also be used between the base 3 and the window portion 4. For example, a recess that can accommodate the entire test membrane 5 can be formed in either the base 3 or the window portion 4, and a pressing part that can press the edge of the test membrane 5 can be formed in the other of the base 3 and the window portion 4. The test membrane 5 is sealed and accommodated inside by the base 3 and the window portion 4 being snapped together.

[0084] Alternatively, the groove 32 and the boss 42 may not be formed in a curved shape, but rather in other shapes. Furthermore, such as Figure 4 As shown, for the left and right edges of the test membrane 5 in the figure, there is only one groove 32 and one boss 42 on the left and right edges respectively. However, it is also possible to form two or more grooves 32 and the same number of bosses 42 for at least one edge of the test membrane 5. Thus, for at least one edge of the test membrane 5, with one groove 32 and one boss 42 as a pair, two or more pairs of grooves 32 and bosses 42 are formed, sandwiching at least one edge of the test membrane between two or more pairs of grooves 32 and bosses 42, thereby further improving the sealing effect. In addition, in the above structure, a groove 32 is formed in the base 3 and a boss 42 is formed in the window portion 4, but it is also possible to reverse this, with a boss formed in the base 3 and a groove formed in the window portion 4.

[0085] In the above description, the structures mentioned as "the viewing window 41 at least covers a portion of the test membrane 5" and "the test membrane 5 is completely contained within the projection of the viewing window 41" refer to the area of ​​the test membrane 5 that substantially functions to react with the gas, specifically the area where the raised structure 52 is formed. For areas such as the edges of the test membrane 5, there are no special structural limitations as long as they do not affect the inspector's ability to inspect the test membrane 5 through the viewing window 41.

[0086] The test membrane 5 can collect substances from the gas passing through the gas flow path by physical and / or chemical means, thereby collecting the gas. Specifically, the test membrane 5 can test multiple substances or components in the gas through physical adsorption, chemical adsorption, chemical reaction, or other methods. For example, the test membrane 5 is configured to chemically or physically adsorb a specific substance in the gas. When the adsorption of the specific substance is detected through the window 4 (described later), the specific substance contained in the gas can be collected. Alternatively, the test membrane 5 contains a substance that can chemically react with a specific substance in the gas. When a chemical reaction is detected through the window 4 (described later), the specific substance contained in the gas can be collected.

[0087] The aforementioned test membrane 5 can be a test strip for measuring diabetes, a test strip for measuring Helicobacter pylori, etc.

[0088] Optionally, the color of the reaction section of the test membrane 5 changes after it interacts with the corresponding reactants in the gas.

[0089] The materials used in the reaction section include one or more of the following: quantum dot materials, chemical dyes, and fluorescent luminescent materials.

[0090] The quantum dot materials may include group II-VI CdS, CdSe, CdTe, ZnS, ZnSe, PbS, PbSe, group III-V InP, GaP, GaN, AlN, and core-shell structured materials CdS / ZnS, CdSe / CdS, CdSe / ZnS, CdSe / CdS / ZnS, CdTe / CdS, CdTe / CdS / ZnS, ZnSe / ZnS, InP / ZnSe, InP / ZnS, InP / ZnSe / ZnS, InP / GaP / ZnS, carbon quantum dots, perovskite quantum dots, and noble metal (e.g., Au, Ag) quantum dots.

[0091] Chemical dyes can be acid-base indicator dyes, Lewis acid-base dyes, redox dyes, and π-π conjugated dyes.

[0092] Specifically, the chemical dyes and fluorescent materials can be one or more of the following: thymol blue, methyl yellow, methyl orange, bromophenol blue, bromocresol green, methyl red, bromocresol purple, bromomethylphenol blue, neutral red, phenol red, phenolphthalein, thymolphthalein, hexanal (DNPH), dinitrophenylhydrazine, copper tetraphenylporphyrin (CuTPP), iron porphyrin (FeTPP), zinc porphyrin (ZnTPP), tetraphenylporphyrin (H2TPP), methyl red, bromophenol red, bromothymol green, porphyrin, metalloporphyrin dyes, bromoxylenol blue, 4-nitrophenylhydrazine, Rechardt's Dye, Malachite Green Chloride, hydrazine-containing fluorescent molecules, and porphyrin manganese.

Claims

1. A gas reaction chamber, characterized in that, The gas reaction chamber has an inlet, an outlet, and a reaction chamber, the reaction chamber being used to house the test membrane. The test membrane includes: Base surface; and Multiple protruding structures protrude from the base surface, and a reaction section for reacting with gas is provided on the top surface of each protruding structure. The distance between adjacent protruding structures is greater than or equal to 0.3 mm and less than or equal to 2.5 mm. The gas enters the reaction chamber through the inlet. The gas does not pass through the test membrane, but flows parallel to the substrate surface along the side of the test membrane with the plurality of protruding structures, towards the outlet. The length is defined as the distance between the two farthest protrusions in the gas flow direction, and the width is defined as the distance between the two farthest protrusions in a direction orthogonal to the gas flow direction. The area obtained by multiplying the length by the width is considered as a specific area. The total area of ​​the top surfaces of the multiple protruding structures accounts for 1% to 30% of the area of ​​the specific region. The area of ​​the specific region satisfies the following condition: The area of ​​a specific region is less than or equal to 1.25 × the area of ​​the specific region.

2. The gas reaction chamber according to claim 1, characterized in that, The total area of ​​the top surfaces of the plurality of protruding structures accounts for 1% to 30% of the area of ​​the base surface exposed to the reaction chamber.

3. The gas reaction chamber according to claim 1, characterized in that, The gas reaction chamber also has a window for detecting the test membrane via the window.

4. The gas reaction chamber according to claim 1, characterized in that, The plurality of protruding structures are arranged at intervals in the gas flow direction.

5. The gas reaction chamber according to any one of claims 1 to 4, characterized in that, The reaction portions provided on at least two of the protruding structures are made of different materials.

6. The gas reaction chamber according to claim 1, characterized in that, An area of the top surface of each of the protruding structures is greater than or equal to 0.01 mm 2 and less than or equal to 0.05 mm 2 and / or, The height of the protruding structure is greater than 0 mm and less than or equal to 1 mm.

7. The gas reaction chamber according to claim 3, characterized in that, The gas reaction chamber also has a base, and the reaction chamber is formed by combining the base and the window portion. The test membrane is sealed between the base and the window.

8. The gas reaction chamber according to claim 7, characterized in that, One of the base and the window portion has a groove. The other of the base and the window portion has a boss. The protrusion is embedded in the groove to seal the test membrane between the base and the window.

9. The gas reaction chamber according to claim 1, characterized in that, The protruding structure appears circular when viewed from above, or... The protruding structure appears elliptical when viewed from above, with the major axis of the ellipse parallel to the direction of gas flow, or... The protruding structure appears as a polygon when viewed from above, and one edge of the protruding structure is positioned to face the direction of gas flow.

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