A method for self-assembly of osteochondral organoids and applications thereof
By employing a self-assembly method of cartilage microcarriers and bone microcarriers, and utilizing hyaluronic acid and hydroxyapatite to promote stem cell differentiation, the problem of self-repair after articular cartilage injury has been solved, achieving integrated bone and cartilage regeneration. This method is simple, economical, and highly effective in inducing differentiation.
CN116240166BActive Publication Date: 2026-06-12PEOPLES HOSPITAL PEKING UNIV
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- PEOPLES HOSPITAL PEKING UNIV
- Filing Date
- 2023-02-07
- Publication Date
- 2026-06-12
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Figure CN116240166B_ABST
Abstract
The present application relates to the field of biological materials, in particular to a kind of osteochondral organ self-assembly method and application.The present application provides a strategy based on personalized modification of ordinary microcarrier, using the characteristics of hyaluronic acid to induce stem cell chondrogenic differentiation, and the characteristics of hydroxyapatite to induce stem cell osteogenic differentiation, to prepare microcarrier with stronger chondrogenic and osteogenic differentiation induction capacity.Cartilage microcarrier and bone microcarrier have good biocompatibility, can promote cell proliferation and adhesion, compared with ordinary microcarrier, bidirectional self-assembly microcarrier has stronger chondrogenic and osteogenic differentiation induction capacity, and the microcarrier obtained by the present application will play an important role and broad application prospect in the field of bone and cartilage injury repair.
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