sample analyzer

CN116256528BActive Publication Date: 2026-09-25ZYBIO INC
View PDF 1 Cites 0 Cited by

Patent Information

Application Number
CN202310035505.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-01-10
Publication Date
2026-09-25
Estimated Expiration
2043-01-10

AI Technical Summary

Technical Problem

[0004]本发明的主要目的是提供一种样本分析仪,旨在解决现有分析仪中为提高加液效率而增加多个注射器导致成本过高的问题

Benefits of technology

[0020]本发明技术方案中,第一驱动组件、第二驱动组件均采用注射器组件,正压组件作为正压源提供正压动力,采用正压源和注射器并用的供液方案,在定量精度要求高的场景下使用恒流源的注射器提供试剂,在定量精度要求低的清洗环节使用恒压源的正压组件提供试剂,即正压组件为样本分析仪提供清洗液动力源,总之,正压源和注射器两种动力源配合使用,在完成不同的动作,例如清洗、推样本液等动作,通过液路设计,可以对注射器和正压组件进行分配,实现两个动作的并行,而不必等待或增加新的注射器或动力源。本发明的样本分析仪无需多个注射器,可以节约注射器资源,加液效率高,从而在整体设计上降低了成本,提高检测速度,缩短测量周期。

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN116256528B_ABST
    Figure CN116256528B_ABST
Patent Text Reader

Abstract

The application discloses a sample analyzer, which comprises a liquid storage mechanism, a detection mechanism and a dispensing mechanism. The liquid storage mechanism comprises a first reaction pool and a liquid storage tank which are communicated with each other. The detection mechanism comprises a first detection assembly which is communicated with the first reaction pool and detects a to-be-tested liquid in the first reaction pool. The dispensing mechanism comprises a positive pressure assembly, a first driving assembly, a sampling assembly, a second driving assembly, a switching assembly and a waste discharge driving member. The positive pressure assembly is communicated with the liquid storage tank and drives diluent liquid in the liquid storage tank into the first reaction pool. The first driving assembly drives the sampling assembly to take a sample into the first reaction pool. The second driving assembly cooperates with the switching assembly to drive the to-be-tested liquid in the first reaction pool to the first detection assembly, and drives the diluent liquid in the liquid storage tank to the first detection assembly. The first detection assembly and the first reaction pool are both communicated with the waste discharge driving member. The sample analyzer of the application does not need multiple syringes, has high liquid adding efficiency and low cost.
Need to check novelty before this filing date? Find Prior Art

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a sample analyzer. Background Technology

[0002] In existing analyzers, whether chemical methods are used for WBC / BASO / DIFF detection or impedance methods are used for RBC / PLT detection, samples must be added to the reaction cell for optical detection. After optical detection, the waste liquid outlet usually needs to be connected to the reaction cell or negative pressure chamber. The liquid path system typically uses a syringe to inject cleaning reagent into the reaction cell for cleaning. Moreover, within a test cycle, the syringe needs a backflow time before the reagent is used, resulting in low liquid addition efficiency. In existing technologies, multiple syringes are often used to improve liquid addition efficiency, but this leads to excessive costs.

[0003] In view of the above-mentioned shortcomings, it is necessary to provide a new sample analyzer. Summary of the Invention

[0004] The main objective of this invention is to provide a sample analyzer that addresses the problem of excessively high costs associated with adding multiple syringes to improve liquid dispensing efficiency in existing analyzers.

[0005] To achieve the above objectives, the sample analyzer proposed in this invention includes:

[0006] The liquid storage mechanism includes a first reaction tank and a liquid storage tank for containing diluent, wherein the first reaction tank and the liquid storage tank are connected by a pipeline;

[0007] The testing mechanism includes a first testing component connected to the first reaction tank via a buffer pipe, the first testing component being used to test the test liquid in the first reaction tank;

[0008] The distribution mechanism includes a positive pressure component, a first driving component, a sampling component, a second driving component, a switching component, and a waste discharge driving component. The positive pressure component is connected to the storage tank and is used to drive the diluent in the storage tank to the first reaction pool. The first driving component is used to drive the sampling component to collect the sample into the first reaction pool. The second driving component cooperates with the switching component to drive the test liquid in the first reaction pool to the first detection component. The second driving component is also used to drive the diluent in the storage tank to the first detection component. The outlet of the first detection component and the waste discharge port of the first reaction pool are both connected to the waste discharge driving component. The waste discharge driving component is used to drive the waste liquid in the first detection component to be discharged from the outlet and to drive the waste liquid in the first reaction pool to be discharged from the waste discharge port.

[0009] Preferably, the positive pressure assembly includes a positive pressure tank and a gas driving component, wherein the positive pressure tank is connected to the liquid storage tank and the gas driving component is connected to the positive pressure tank.

[0010] Preferably, the dispensing mechanism further includes an atmospheric pressure component, and the liquid outlet of the first detection component is connected to the waste discharge drive component through the atmospheric pressure component.

[0011] Preferably, the switching component includes a switching element disposed on a pipe between the first reaction tank and the first detection component, and the second driving component includes a second driving element and a third driving element. The switching element is used to connect the buffer pipe and the first reaction tank when it is in a connected state, or to disconnect the buffer pipe and the first reaction tank when it is in a disconnected state. The second driving element and the third driving element are used to jointly drive the test liquid in the first reaction tank into the buffer pipe when the switching element is in a connected state, and to jointly drive the test liquid in the buffer pipe into the first detection component when the switching element is in a disconnected state. The second driving element is also used to drive the diluent in the storage tank into the first detection component.

[0012] Preferably, both the second and third driving components are syringes, and the second driving assembly is a dual-syringe assembly.

[0013] Preferably, the first detection component is an optical detection module, used to perform DIFF detection and BASO detection on the test liquid in the first detection component.

[0014] Preferably, the first driving component includes a fourth driving element, which is used to drive the sampling component to take the sample into the first reaction cell.

[0015] Preferably, the liquid storage mechanism further includes a second reaction tank, which is connected to the liquid storage tank via a pipeline. The first driving component further includes a first driving member, which is used to drive the diluent in the liquid storage tank into the second reaction tank. The positive pressure component is also used to drive the diluent in the liquid storage tank into the second reaction tank. The detection mechanism further includes a second detection component connected to the second reaction tank via a pipeline, which is used to detect the test liquid in the second reaction tank. The distribution mechanism further includes a negative pressure component connected to the outlet of the second detection component.

[0016] Preferably, both the first driving element and the fourth driving element are syringes.

[0017] Preferably, the second detection component is an impedance detection module, used to perform RBC detection on the test liquid in the second reaction cell.

[0018] Preferably, the waste outlets of the first reaction tank and the second reaction tank are both connected to the positive pressure component. The positive pressure component is also used to inject gas into the first reaction tank through the waste outlet of the first reaction tank, and to inject gas into the second reaction tank through the waste outlet of the second reaction tank.

[0019] Preferably, the sample analyzer further includes a reagent quantification mechanism for adding reagents and samples to the first reaction chamber and the second reaction chamber.

[0020] In this invention, both the first and second driving components employ syringe assemblies, while the positive pressure component acts as a positive pressure source, providing positive pressure power. A liquid supply scheme combining the positive pressure source and syringe is used. In scenarios requiring high quantitative accuracy, a constant current source syringe provides the reagent; in cleaning stages where quantitative accuracy is less critical, a constant pressure source positive pressure component provides the reagent. In other words, the positive pressure component provides the cleaning fluid power source for the sample analyzer. In short, the positive pressure source and syringe work together to perform different actions, such as cleaning and pushing sample liquid. Through the fluid path design, the syringe and positive pressure component can be allocated to achieve parallel operation of the two actions without waiting for or adding new syringes or power sources. This invention's sample analyzer eliminates the need for multiple syringes, saving syringe resources and increasing liquid supply efficiency. This results in reduced overall cost, increased detection speed, and a shorter measurement cycle. Attached Figure Description

[0021] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0022] Figure 1 This is a schematic diagram of the sample analyzer in one embodiment of the present invention.

[0023] Explanation of icon numbers:

[0024]

[0025]

[0026] The realization of the objective, functional features and advantages of the present invention will be further explained in conjunction with the embodiments and with reference to the accompanying drawings. Detailed Implementation

[0027] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0028] It should be noted that all directional indications (such as up, down, left, right, front, back, etc.) in the embodiments of the present invention are only used to explain the relative positional relationship and movement of each component in a certain specific posture (as shown in the figure). If the specific posture changes, the directional indication will also change accordingly.

[0029] Furthermore, in this invention, descriptions involving "first," "second," etc., are for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this invention, "a plurality of" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0030] In this invention, unless otherwise explicitly specified and limited, the terms "connection," "fixed," etc., should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral part; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be the internal communication of two components or the interaction between two components, unless otherwise explicitly limited. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0031] Furthermore, the technical solutions of the various embodiments of the present invention can be combined with each other, but only if they are based on the ability of those skilled in the art to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be considered that such combination of technical solutions does not exist and is not within the scope of protection claimed by the present invention.

[0032] This invention proposes a sample analyzer that aims to solve the problem of excessive costs caused by adding multiple syringes to improve liquid dispensing efficiency in existing analyzers.

[0033] Please refer to Figure 1 The sample analyzer includes a liquid storage mechanism, a detection mechanism, and a dispensing mechanism. The liquid storage mechanism includes a first reaction pool 11 and a storage tank 13 for containing diluent. The first reaction pool 11 and the storage tank 13 are connected by a pipeline. The detection mechanism includes a first detection component 21 connected to the first reaction pool 11 via a buffer pipeline. The first detection component 21 is used to detect the test liquid in the first reaction pool 11. The dispensing mechanism includes a positive pressure component 31, a first drive component 32, a sampling component 33, a second drive component 34, a switching component 35, and a waste discharge drive component 36. The positive pressure component 31 is connected to the storage tank 13 and is used to drive the diluent in the storage tank 13 into the first reaction pool 11. The first drive component... 32 is used to drive the sampling component 33 to collect the sample into the first reaction pool 11. The second driving component 34 cooperates with the switching component 35 to drive the test liquid in the first reaction pool 11 into the first detection component 21. The second driving component 34 is also used to drive the diluent in the storage tank 13 into the first detection component 21. The outlet of the first detection component 21 and the waste outlet of the first reaction pool 11 are both connected to the waste discharge driving component 36. The waste discharge driving component 36 is used to drive the waste liquid in the first detection component 21 to be discharged from the outlet and to drive the waste liquid in the first reaction pool 11 to be discharged from the waste outlet.

[0034] In the sample analyzer of this invention, both the first driving component 32 and the second driving component 34 are syringe assemblies. The positive pressure component 31 serves as a positive pressure source, providing positive pressure power. A liquid supply scheme combining the positive pressure source and the syringe is employed. In scenarios requiring high quantitative accuracy, the syringe with a constant current source provides the reagent; in the cleaning stage where quantitative accuracy requirements are low, the positive pressure component 31 with a constant pressure source provides the reagent. In other words, the positive pressure component 31 provides the cleaning fluid power source for the sample analyzer. In short, the positive pressure source and the syringe work together to complete different actions, such as cleaning and pushing sample liquid. Through the liquid path design, the syringe and the positive pressure component 31 can be allocated to achieve parallel operation of the two actions without waiting for or adding new syringes or power sources. The sample analyzer of this invention eliminates the need for multiple syringes, saving syringe resources and increasing liquid supply efficiency. This reduces overall design costs, increases detection speed, and shortens the measurement cycle.

[0035] Please refer to the specific details. Figure 1 As shown, V01 to V19 are all switching components in the switching assembly 35. Before the test begins, blood samples are collected and dispensed. The reagents soaking in the first reaction tank 11 after the previous test are removed by the waste discharge drive 36 (waste liquid pump module in the figure) and the switching component V13. The measurement process is started. The sampling needle is driven by the first drive assembly 32 to draw up the sample, move the sampling needle and dispense the sample into the first reaction tank 11. The quantitative hemolysin is dispensed into the first reaction tank 11 by the hemolysin dispensing device.

[0036] After sample dispensing, switching between V04 and V07 uses the positive pressure generated by the positive pressure component 31 to push the diluent to clean the inner wall of the sample needle, achieving atmospheric pressure cleaning. If necessary, for example, after sample dispensing and when the remaining sample needle contains whole blood, high-pressure cleaning can be achieved using the first drive element 322 of the first drive component 32. After sample and reagent addition, switching between V18 allows the PC positive pressure source (Bubble-1) to push gas into the first reaction chamber 11, completing bubble mixing in the first reaction chamber 11 and thus completing sample preparation.

[0037] It should be noted that the sample needle inner wall cleaning is equipped with two power sources: regular cleaning can be achieved through the positive pressure component 31, and high-pressure cleaning can be achieved through the first drive component 32 and the positive pressure component 31. Furthermore, the storage tank 13 is constantly under positive pressure, which effectively prevents the release of dissolved gases from the diluent, eliminating the need for separate filtration of the DIL entering the optical system.

[0038] In one embodiment, the positive pressure component 31 includes a positive pressure tank 311 and a gas drive component 312. The positive pressure tank 311 is connected to the liquid storage tank 13, and the gas drive component 312 is also connected to the positive pressure tank 311. The liquid inlet of the liquid storage tank 13 is connected to the instrument's liquid pump power source, and the air inlet is normally connected to the positive pressure tank 311. The liquid outlet is connected to the cleaning component or syringe via a switching component. The air inlet of the positive pressure tank 311 is connected to the air pump via a switching component to establish positive pressure. The air outlet of the positive pressure tank 311 is connected to the atmospheric pressure tank via the liquid storage tank 13 and a throttling component to achieve pressure release and regulation. A positive pressure source is established in the sample analyzer. The positive pressure build-up process involves turning on the air pumps LP and V01. The pressure monitoring component ensures that the pressure value in the gas chamber reaches a value slightly higher than a preset value. If the pressure exceeds the range, V17 switches to release the pressure to reach the preset value. Moreover, the positive pressure source air pump has low flow requirements and low cost.

[0039] Furthermore, the distribution mechanism includes an atmospheric pressure component 37, and the outlet of the first detection component 21 is connected to the waste discharge drive component 36 via the atmospheric pressure component 37. An atmospheric pressure chamber is introduced as a temporary storage device for collecting optical detection waste liquid. The outlet of the optical detection waste liquid is connected to the atmospheric pressure tank NC, not to the reaction tank. The start-up time of the first reaction tank 11 does not need to wait for the optical detection to end; the start-up time is entirely determined by the reaction conditions. This allows for iterative preparation of the sample liquid for the next sample test in advance, simplifying the design and saving overall process time. Moreover, since the outlet of the optical detection module is connected to the atmospheric pressure tank, there is no need to consider the influence of other resources or actions. The stable outlet pressure is beneficial to the stability of the optical sheath flow, improving the accuracy of the detection results.

[0040] In another embodiment, the switching component 35 includes a switching element 351 disposed on a pipe between the first reaction tank 11 and the first detection component 21, and the second driving component 34 includes a second driving element 341 and a third driving element 342. The switching element 351 is used to connect the buffer pipe and the first reaction tank 11 when it is in a connected state, or to disconnect the buffer pipe and the first reaction tank 11 when it is in a disconnected state. The second driving element 341 and the third driving element 342 are used to jointly drive the test liquid in the first reaction tank 11 into the buffer pipe when the switching element 351 is in a connected state, and to jointly drive the test liquid in the buffer pipe into the first detection component 21 when the switching element 351 is in a disconnected state. The second driving element 341 is also used to drive the diluent in the storage tank 13 into the first detection component 21. In the optical detection sample preparation and detection process, switching V08 and the on / off switch 351, through the simultaneous operation of the second drive component 341 and the third drive component 342 of the second drive assembly 34, transfer the prepared sample solution, which has been thoroughly mixed, from the first reaction cell 11 to the pipeline between the on / off switch 351, the flow chamber of the first detection assembly 21, and the third drive component 342, thus completing the sample preparation for optical detection. Then, the on / off switch 351 is closed, and V11 is switched. The second drive component 341 pushes the diluent to form a sheath fluid, and the third drive component 342 pushes the sample solution through the sample needle into the flow chamber of the first detection assembly 21. The sheath fluid encapsulates the sample solution and flows through the optical detection device of the first detection assembly 21 for detection. During this process, switching V10 collects the waste liquid generated during detection into the atmospheric pressure tank NC. This step actually involves the DIFF and BASO sample solutions being prepared separately in two reaction cells and then sequentially transferred to the optical detection position. In this system, valve V16 is connected to the storage tank 13 at one end and to V08 at the other. V08 is connected to the first reaction tank 11. Opening V16 and V08 allows the liquid in the storage tank 13 to be pushed into the first reaction tank 11 under positive pressure. During DIFF detection, switching between V16 and V08, and using the positive pressure generated by the positive pressure component 31 to drive the diluent, allows for pre-cleaning of the reaction tank without waiting for the second drive component 341 to complete the sample detection process, thus achieving parallel processing and increased speed. After DIFF optical detection is completed, switching between V16 and the on / off switch 351 allows the positive pressure generated by the positive pressure component 31 to drive the diluent, cooperating with the second drive component 341 to clean the optical detection device and pipelines. The on / off switch 351 can be a pressure-cutoff valve.

[0041] Both the second driving component 341 and the third driving component 342 are syringes, and the second driving assembly 34 is a dual-syringe assembly. The syringes can not only propel samples and reagents, but also measure samples and reagents more accurately.

[0042] Furthermore, to achieve multiple functions, the first detection component 21 is an optical detection module used to perform DIFF and BASO detection on the test liquid within the first detection component 21. Quantitative operations such as the transfer of the test liquid are completed by the second drive unit 341 and the third drive unit 342. The detections that the first detection component 21 can perform on the test liquid include, but are not limited to, DIFF and BASO detection. In the prior art, since the outlet end of the optical detection needs to be connected to a waste liquid tank or reaction tank, the pressure of the negative pressure chamber used for impedance detection is unstable during the pressure build-up process, which affects the optical detection. Therefore, not connecting the outlet end of the first detection component 21 to the negative pressure chamber can effectively avoid this problem. This application connects the optical detection waste liquid outlet to the atmospheric pressure component 37, i.e., the atmospheric pressure chamber NC, so that the optical detection waste liquid outlet is not connected to the negative pressure chamber. Therefore, the pressure build-up time of the negative pressure chamber does not need to consider the optical outlet state, making the pressure build-up time flexible and simplifying the design.

[0043] In addition, in the above embodiments, the first driving component 32 includes a fourth driving element 321, which is used to drive the sampling component 33 to collect the sample into the first reaction cell 11. The measurement process is initiated by controlling the fourth driving element 321 to drive the sampling needle to draw the sample, move the sampling needle and dispense the sample into the first reaction cell 11, and dispense a quantitative amount of hemolysin into the first reaction cell 11 through the hemolysin dispensing device.

[0044] In one embodiment, the liquid storage mechanism further includes a second reaction tank 12, which is connected to the liquid storage tank 13 via a pipeline. The first driving component 32 further includes a first driving member 322, which is used to drive the diluent in the liquid storage tank 13 into the second reaction tank 12. The positive pressure component 31 is also used to drive the diluent in the liquid storage tank 13 into the second reaction tank 12. The detection mechanism further includes a second detection component 22 connected to the second reaction tank 12 via a pipeline, which is used to detect the test liquid in the second reaction tank 12. The distribution mechanism further includes a negative pressure component 38 connected to the outlet of the second detection component 22. The impedance detection sample preparation and detection process is as follows: The sampling needle is driven by the fourth driving element 321 in the first driving assembly 32 to draw up the sample. The sampling needle is moved and the sample is dispensed into the second reaction chamber 12. A quantitative hemolytic agent is dispensed into the second reaction chamber 12 through the hemolytic agent quantitative device. A quantitative diluent is dispensed into the second reaction chamber 12 through the first driving element 322 of the first driving assembly 32. After the sample and reagents are added, by switching V19, gas can be pushed into the second reaction chamber 12 using a PC positive pressure source (Bubble-2) to complete the mixing of bubbles in the second reaction chamber 12, thus completing sample preparation. During the preparation process, pressure is built up in the negative pressure chamber by a liquid pump. After sample preparation is completed in the reaction chamber of the impedance detection module, impedance detection is completed by the shutdown pressure of the negative pressure chamber.

[0045] The negative pressure component 38 includes a negative pressure tank, which is directly pressurized by a liquid pump and connected to the second reaction cell 12 used in the impedance channel of the second detection component 22, providing negative pressure for the counting process. A negative pressure source is established in the sample analyzer; the negative pressure build-up process involves turning on the waste liquid pump component and VO3, and the pressure monitoring component ensures the gas chamber pressure reaches a preset value. The negative pressure chamber pressurization or impedance counting stage and the optical detection stage can be arbitrarily arranged without mutual constraints. Furthermore, before impedance detection, the waste discharge drive component 36 (attached)... Figure 1 The waste liquid pump discharge module and V14 discharge the reagents soaked in the second reaction tank 12 after the last test.

[0046] Furthermore, both the first driving component 322 and the fourth driving component 321 are syringes. The syringes can not only propel samples and reagents, but also measure samples and reagents more accurately.

[0047] In addition, the second detection component 22 is an impedance detection module used to perform RBC detection on the test solution in the second reaction cell 12. The second reaction cell 12 is used to prepare the test sample solution for RBC detection. After the sample solution is prepared, it passes through the second detection component 22, and the detection is achieved by providing negative pressure through the negative pressure chamber.

[0048] Furthermore, the waste outlets of the first reaction tank 11 and the second reaction tank 12 are both connected to the positive pressure component 31. The positive pressure component 31 is also used to inject gas into the first reaction tank 11 through the waste outlet of the first reaction tank 11, and to inject gas into the second reaction tank 12 through the waste outlet of the second reaction tank 12. The cleaning of the first reaction tank 11 and the second reaction tank 12 is achieved by the positive pressure component 31 driving the liquid in the storage tank 13 to the first reaction tank 11 and the second reaction tank 12. The mixing of samples and reagents is achieved by providing positive pressure and generating bubbles in the positive pressure chamber. That is, the positive pressure component 31 is the source of bubble mixing. Thus, the positive pressure component 31 can be used to clean the first reaction tank 11 and the second reaction tank 12, and to generate bubbles and mix the samples in the first reaction tank 11 and the second reaction tank 12, making full use of the positive pressure component 31 and improving resource utilization.

[0049] In addition, the sample analyzer also includes a reagent dispensing mechanism, which is used to add reagents and samples to the first reaction chamber 11 and the second reaction chamber 12. The reagent dispensing mechanism includes a syringe, a sample needle, and a valve, used for sample aspiration and dispensing, reagent addition, etc.

[0050] The above description is merely a preferred embodiment of the present invention and does not limit the patent scope of the present invention. Any equivalent structural transformations made using the contents of the present invention's specification and drawings under the inventive concept of the present invention, or direct / indirect applications in other related technical fields, are included within the patent protection scope of the present invention.

Claims

1. A sample analyzer, characterized in that, include: storage solution The apparatus includes a first reaction tank and a storage tank for containing a diluent, the first reaction tank and the storage tank being connected by a pipeline; The testing mechanism includes a first testing component connected to the first reaction tank via a buffer pipe, the first testing component being used to test the test liquid in the first reaction tank; The distribution mechanism includes a positive pressure component, a first driving component, a sampling component, a second driving component, a switching component, and a waste discharge driving component. The positive pressure component is connected to the storage tank and is used to drive the diluent in the storage tank to the first reaction pool. The first driving component is used to drive the sampling component to collect the sample into the first reaction pool. The second driving component cooperates with the switching component to drive the test liquid in the first reaction pool to the first detection component. The second driving component is also used to drive the diluent in the storage tank to the first detection component. The outlet of the first detection component and the waste discharge port of the first reaction pool are both connected to the waste discharge driving component. The waste discharge driving component is used to drive the waste liquid in the first detection component to be discharged from the outlet and to drive the waste liquid in the first reaction pool to be discharged from the waste discharge port. The distribution mechanism also includes an atmospheric pressure component, and the liquid outlet of the first detection component is connected to the waste discharge drive component through the atmospheric pressure component; The switching component includes a switching element disposed on a pipe between the first reaction tank and the first detection component. The second driving component includes a second driving element and a third driving element. The switching element is used to connect the buffer pipe and the first reaction tank when it is in a connected state, or to disconnect the buffer pipe and the first reaction tank when it is in a disconnected state. The second driving element and the third driving element are used to jointly drive the test liquid in the first reaction tank into the buffer pipe when the switching element is in a connected state, and to jointly drive the test liquid in the buffer pipe into the first detection component when the switching element is in a disconnected state. The second driving element is also used to drive the diluent in the storage tank into the first detection component. The positive pressure component drives the diluent to clean the first reaction chamber, the second driving component pushes the diluent to form a sheath fluid, and the third driving component pushes the sample fluid into the flow chamber of the first detection component through the sample needle, all of which can be performed simultaneously.

2. The sample analyzer as described in claim 1, characterized in that, The positive pressure assembly includes a positive pressure tank and a gas driving component. The positive pressure tank is connected to the liquid storage tank, and the gas driving component is connected to the positive pressure tank.

3. The sample analyzer as described in claim 1, characterized in that, Both the second and third driving components are syringes, and the second driving assembly is a dual-syringe assembly.

4. The sample analyzer as described in any one of claims 1 to 3, characterized in that, The first detection component is an optical detection module, used to perform DIFF detection and BASO detection on the test liquid in the first detection component.

5. The sample analyzer as described in any one of claims 1 to 3, characterized in that, The first driving component includes a fourth driving element, which is used to drive the sampling component to take the sample into the first reaction cell.

6. The sample analyzer as described in claim 5, characterized in that, The liquid storage mechanism further includes a second reaction tank, which is connected to the liquid storage tank via a pipeline. The first driving component further includes a first driving member, which is used to drive the diluent in the liquid storage tank into the second reaction tank. The positive pressure component is also used to drive the diluent in the liquid storage tank into the second reaction tank. The detection mechanism further includes a second detection component connected to the second reaction tank via a pipeline, which is used to detect the test liquid in the second reaction tank. The distribution mechanism further includes a negative pressure component connected to the outlet of the second detection component.

7. The sample analyzer as described in claim 6, characterized in that, Both the first and fourth driving components are syringes.

8. The sample analyzer as described in claim 6, characterized in that, The second detection component is an impedance detection module, used to perform RBC detection on the test liquid in the second reaction cell.

9. The sample analyzer as described in claim 6, characterized in that, The waste outlets of the first reaction tank and the second reaction tank are both connected to the positive pressure component. The positive pressure component is also used to inject gas into the first reaction tank through the waste outlet of the first reaction tank, and to inject gas into the second reaction tank through the waste outlet of the second reaction tank.

10. The sample analyzer as described in claim 6, characterized in that, The sample analyzer also includes a reagent quantification mechanism, which is used to add reagents and samples to the first reaction chamber and the second reaction chamber.

Citation Information

Patent Citations

  • Cell analyzer and detection method thereof

    CN114112806A