A laboratory animal pain detection device

Abstract

The utility model provides a laboratory animal pain sensation detection device relates to biological experiment technical field, apply to the detection experiment of animal pain sensation, to accurate detection animal appears the tensile force size of pain sensation, including base, experiment table, bandaging subassembly and loading subassembly, experiment table is located above base and is fixedly connected with base, the bandaging subassembly includes four leg clamps, two leg clamps are located one end of experiment table, and the other two leg clamps are located the other end of experiment table, and the other end of experiment table has a line reel, and the line reel is wound with a pull line, and one end of the pull line is fixedly connected with the leg clamp of the other end of experiment table, and the other end of the pull line is fixed with loading bucket, loading subassembly includes the weight storage bucket of fixed base, the individual loading unit in the bottom of weight storage bucket, the spherical weight is placed in weight storage bucket, and the individual loading unit obtains the weight from weight storage bucket one by one and adds to loading bucket in. The utility model can accurately detect animal pain sensation.

Description

Technical Field

[0001] This invention relates to the field of biological experimental technology, specifically to a pain detection device for laboratory animals. Background Technology

[0002] Pain is an unpleasant sensory and emotional experience caused by actual or potential tissue damage. Under normal physiological conditions, pain is an essential protective mechanism that alerts the body to noxious stimuli. However, under pathological conditions, such as cancer, inflammation, and nerve damage, abnormal and persistent pain not only severely interferes with people's quality of life but can also lead to various mental illnesses such as depression, irritability, and anxiety, earning it the nickname "the cancer that doesn't kill." In research, abnormal pain is generally classified into two types: "hyperalgaeticism" and "algae hypersensitivity." Hyperalgaeticism refers to a stronger pain response to noxious stimuli, such as mechanical, cold, and hot stimuli. Algae hypersensitivity refers to a pain response to stimuli below the noxious threshold. Due to ethical constraints and practical difficulties, it is difficult to conduct pain pathology research on humans; instead, rodents are used. Therefore, there is an urgent need for a laboratory animal pain detection device to detect pain in animals. Summary of the Invention

[0003] The purpose of this invention is to provide a laboratory animal pain detection device for use in experiments on animal pain detection, so as to accurately detect the magnitude of the pulling force that causes pain in animals.

[0004] The technical solution adopted by this invention to solve its technical problem is as follows: a laboratory animal pain detection device, comprising a base, an experimental table, a binding assembly, and a loading assembly. The experimental table is located above the base and is fixedly connected to the base. The binding assembly includes four leg clamps, two of which are located at one end of the experimental table and the other two at the other end. The other end of the experimental table has a reel with a pull line wound on it. One end of the pull line is fixedly connected to the leg clamps at the other end of the experimental table, and the other end of the pull line is fixed to a loading bucket. The loading assembly includes a weight storage bucket fixed on the base and individual loading units located at the bottom of the weight storage bucket. Spherical weights are placed in the weight storage bucket, and the individual loading units retrieve weights one by one from the weight storage bucket and add them to the loading bucket.

[0005] Furthermore, one end of the experimental platform has two uprights, and there is a connecting strap between the uprights and the leg clamp. One end of the connecting strap has a loop that fits onto the upright, and the other end of the connecting strap is fixed to the leg clamp.

[0006] Furthermore, the leg clamp includes two semi-circular clamping plates, the side walls of the clamping plates have handles, the two handles of the leg clamp are hinged together, and a torsion spring is provided between the two handles.

[0007] Furthermore, the column and the experimental table are provided with a leg clamp spacing adjustment mechanism. The leg clamp spacing adjustment mechanism includes a first screw nut fixed to the bottom of the column and a first screw that cooperates with the first screw nut. The first screw is rotatably connected to the experimental table, and a first adjustment knob located on the outside of the experimental table is fixed at one end of the first screw.

[0008] Furthermore, a thread reel adjustment mechanism is provided between the thread reel and the experimental platform. This mechanism includes a second lead screw slidably connected to the experimental platform, a second lead screw engaging with the second lead screw, a worm gear fixed to the second lead screw, and a worm meshing with the worm gear. One end of the worm gear is fixed to a second adjustment knob located outside the experimental platform. The thread reel is rotatably connected to the second lead screw nut. Furthermore, the top of the loading bucket has a lid, which is threadedly connected to the loading bucket and fixedly connected to the other end of the pull line.

[0009] Furthermore, an inclined tube is fixed to the side wall of the loading barrel, the lower end of the inclined tube is fixedly connected to the outer wall of the loading barrel, the upper end of the inclined tube has a receiving hopper, and the lower end of the inclined tube communicates with the inner cavity of the loading barrel.

[0010] Furthermore, the bottom of the weight storage barrel has an outer shell, the inner side of the outer shell has a receiving plate, the top of the outer shell has a side hole, the side wall of the receiving plate has a receiving groove, and the bottom of the outer shell has a discharge pipe. When the receiving groove is connected to the side hole, the weights in the weight storage barrel enter the receiving groove; when the receiving groove is connected to the discharge pipe, the weights in the receiving groove enter the discharge pipe, and the discharge pipe is located directly above the receiving hopper.

[0011] Furthermore, the bottom of the weight storage container is open, and the inner side of the weight storage container has multiple independent storage chambers. Weights are placed in the storage chambers. A tray is slidably installed on the bottom of the weight storage container. The bottom of the storage chamber has a retrieval plate with a bowl-shaped structure. The retrieval plate is rotatably connected to the weight storage container. The side wall of the retrieval plate has a release knob located outside the weight storage container.

[0012] Furthermore, the side wall of the weight storage tank has a side plate, the bottom of which is slidably connected to the top of the tray.

[0013] The beneficial effects of this invention are:

[0014] (1) In this invention, an animal is placed on an experimental table, and the animal's legs are bound by a leg clamp. A loading bucket fixedly connected to one side of the leg clamp is used to apply a pulling force to the animal. Weights are gradually added to the loading bucket to increase the pulling force on the animal, thereby obtaining accurate experimental data.

[0015] (2) The present invention achieves a gradual increase in load by acquiring and adding weights with unit weight one by one, which makes it easier to obtain accurate experimental data;

[0016] (3) The weights per unit weight are spherical solids, which are easy to put into the loading bucket; and the spherical weights are easy to count. Attached Figure Description

[0017] Figure 1 This is a front view of the present invention;

[0018] Figure 2 This is a top view of the experimental platform;

[0019] Figure 3 Top view of the connecting strap and leg clamp;

[0020] Figure 4 This is a side view of the leg clamp;

[0021] Figure 5 This is a schematic diagram of the leg clamp spacing adjustment mechanism and the thread wheel adjustment mechanism on the experimental platform;

[0022] Figure 6 This is a front view of the reel and the reel adjustment mechanism;

[0023] Figure 7 This is a front view of the column and leg clamp spacing adjustment mechanism;

[0024] Figure 8 This is a top view of the column and leg clamp spacing adjustment mechanism;

[0025] Figure 9 This is a cross-sectional view of the tension adjustment component in Embodiment 1;

[0026] Figure 10 This is a front view of the weight storage container in Example 2;

[0027] Figure 11 This is a front view of the acquisition disk in Example 2;

[0028] Figure 12 for Figure 10 A sectional view;

[0029] In the diagram: 1. Base, 11. First support rod, 12. Second support rod, 2. Experimental table, 21. Column, 22. Top cap, 23. Wire wheel, 24. Slide groove, 25. Mounting groove, 3. Connecting belt, 31. Clamping plate, 32. Handle, 33. Ear plate, 34. Ring, 35. Pull wire, 4. First lead screw, 41. First lead nut, 42. First adjustment knob, 5. Second lead nut, 51. Second lead screw, 52. Bearing, 53. Worm gear, 54. Worm, 55. Second adjustment knob, 6. Weight storage bucket, 61. Outer shell, 62. Side hole, 63. Retrieval plate, 64. Retrieval groove, 65. Discharge pipe, 66. Side plate, 67. Support plate, 68. Partition plate, 7. Weight, 8. Loading bucket, 81. Bucket lid, 82. Inclined tube, 83. Receiving hopper, 9. Release knob. Detailed Implementation

[0030] like Figures 1 to 12 As shown, the present invention includes a base 1, an experimental platform 2, a binding assembly, and a loading assembly. The present invention will be described in detail below with reference to the accompanying drawings.

[0031] like Figures 1 to 12 As shown, a laboratory animal pain detection device includes a base 1, an experimental platform 2, a binding assembly, and a loading assembly. The experimental platform 2 is located above and fixedly connected to the base 1. The top of the base 1 has a first support rod 11, which is located between the experimental platform 2 and the base 1 to achieve a fixed connection between the experimental platform 2 and the base 1. The binding assembly includes four leg clamps, two of which are located at one end of the experimental platform 2 and the other two at the other end. The other end of the experimental platform 2 has a reel 23 with a pull line 35 wound on it. One end of the pull line 35 is fixedly connected to the leg clamps at the other end of the experimental platform 2, and the other end of the pull line 35 is fixed to a loading bucket 8. The loading assembly includes a weight storage bucket 6 fixed to the base 1 and individual loading units located at the bottom of the weight storage bucket 6. Spherical weights 7 are placed in the weight storage bucket 6, and the weights 7 have a unit weight, such as 1g. The individual loading units retrieve weights 7 one by one from the weight storage bucket 6 and add them to the loading bucket 8. In use, experimental animals such as mice are placed on the experimental table and held in place by clamps on their four legs. The mice are then pulled under the influence of the loading bucket 8. Weights are retrieved from the weight storage bucket 6 one by one and added to the loading bucket 8, gradually increasing the load on the mouse. The magnitude of the load applied to the mouse is determined based on the number of weights in the loading bucket 8 and the weight of the loading bucket 8, thus revealing the load magnitude under different pain levels in the mouse.

[0032] like Figure 1 , Figure 2 , Figure 5 and Figure 6 As shown, one end of the experimental platform 2 has two uprights 21, and there is a connecting strap 3 between the uprights 21 and the leg clamps, as shown. Figure 3As shown, one end of the connecting strap 3 has a loop 34 that fits onto the column 21, and the other end of the connecting strap 3 is fixed to the leg clamp. Figure 4 As shown, the leg clamp includes two semi-circular clamping plates 31. The side walls of the clamping plates 31 have handles 32, and the two handles 32 of the leg clamp are hinged together. A torsion spring is located between the two handles 32. Under the action of the torsion spring, the two clamping plates 31 form a complete circle to clamp the animal's leg.

[0033] like Figure 5 , Figure 7 and Figure 9 As shown, a leg clamp spacing adjustment mechanism is provided between the column 21 and the experimental table 2. The mechanism includes a first nut 41 fixed to the bottom of the column 21 and a first screw 4 cooperating with the first nut 41. The first screw 4 is rotatably connected to the experimental table 2, and a first adjustment knob 42 located on the outside of the experimental table 2 is fixed to one end of the first screw 4. The two ends of the first screw 4 have external threads with different directions of rotation. When the first screw 4 rotates, the two first nuts 41 move in opposite directions, thereby adjusting the spacing between the two columns 21. The top of the column 21 has a cap 22 to prevent the connecting strap 3 from slipping off the column 21. Figure 2 As shown, the top of one end of the experimental platform 2 has a groove 24, and the column 21 passes through the groove 24 and is slidably connected to the groove 24.

[0034] like Figure 1 , Figure 5 As shown, a thread reel adjustment mechanism is provided between the thread reel 23 and the experimental platform 2. The thread reel adjustment mechanism includes a second lead screw 5 that is slidably connected to the experimental platform 2, a second lead screw 51 that cooperates with the second lead screw 5, a worm gear 53 fixed on the second lead screw 51, and a worm 54 that meshes with the worm gear 53. One end of the worm 54 is fixed with a second adjustment knob 55 located on the outside of the experimental platform 2. The thread reel 23 is rotatably connected to the second lead screw 5. Figure 5 As shown, the other end of the experimental platform 2 has a mounting groove 25, the thread wheel adjustment mechanism is located in the mounting groove 25, the mounting groove 25 has a bearing 52, and the two ends of the second lead screw 51 are fixed in the inner ring of the bearing 52.

[0035] like Figure 9As shown, the top of the loading barrel 8 has a lid 81, which is threadedly connected to the loading barrel 8 and fixedly connected to the other end of the pull line 35. The lid 81 facilitates the emptying of the weights from the loading barrel 8. An inclined tube 82 is fixed to the side wall of the loading barrel 8. The lower end of the inclined tube 82 is fixedly connected to the outer wall of the loading barrel 8, and the upper end of the inclined tube 82 has a receiving hopper 83. The lower end of the inclined tube 82 communicates with the inner cavity of the loading barrel 8. The bottom of the weight storage barrel 6 has a shell 61. Inside the shell 61 is a receiving plate 63. The top of the shell 61 has a side hole 62. The side wall of the receiving plate 63 has a receiving groove 64. The bottom of the shell 61 has a discharge pipe 65. When the receiving groove 64 communicates with the side hole 62, the weights in the weight storage barrel 6 enter the receiving groove 64. When the receiving groove 64 communicates with the discharge pipe 65, the weights in the receiving groove 64 enter the discharge pipe 65, which is located directly above the receiving hopper 83. Acquisition slots 64 are evenly distributed circumferentially on the outer wall of the acquisition disk 63. A counter can also be installed inside the casing to detect the rotation angle of the acquisition disk 63. The acquisition disk 63 rotates 90 degrees each time, and one weight enters the loading bucket 8 with each rotation. This achieves the acquisition of weights of unit weight one by one and the addition of each weight to the loading bucket 8. A second support rod 12 is provided between the weight storage bucket 6 and the base 1 to achieve a fixed connection between the weight storage bucket 6 and the base 1.

[0036] like Figure 10 , Figure 12 As shown, the bottom of the weight storage container 6 is open. The inside of the weight storage container 6 has multiple partitions 68, which divide the inner cavity of the weight storage container 6 into multiple independent storage chambers. Weights 7 are placed in the storage chambers. A tray 67 is slidably installed on the bottom of the weight storage container 6. A retrieval plate 63 is located at the bottom of each storage chamber. Figure 11 As shown, the acquisition pan 63 has a bowl-shaped structure and is rotatably connected to the weight storage tank 6. The side wall of the acquisition pan 63 has a release knob 9 located outside the weight storage tank 6. A side plate 66 is fixed to the lower side wall of the weight storage tank 6, and the bottom of the side plate 66 is slidably connected to the top of the support plate 67. Four storage chambers are arranged along the same straight line. By sliding the support plate 67, the bottom of the corresponding storage chamber is hollowed out, facilitating the removal of weights from that chamber. For example, when the support plate 67 moves to hollow out the bottom of the foremost storage chamber, flipping the acquisition pan 63 so that its opening faces downwards causes the weights in the foremost storage chamber to fall into the receiving hopper 83. Rotating the release knob 9 drives the acquisition pan 63 to rotate. When the opening of the acquisition pan 63 faces upwards, the weights enter the acquisition pan 63. When the acquisition pan 63 rotates to face downwards, the weights in the acquisition pan 63 fall into the receiving hopper 83 and then into the loading tank 8, thus achieving loading.

[0037] The beneficial effects of this invention are as follows: This invention places the animal on an experimental table, binds the animal's legs with leg clamps, applies tension to the animal through a loading bucket fixedly connected to one side of the leg clamp, and increases the tension on the animal by gradually adding weights into the loading bucket, thereby obtaining accurate experimental data; This invention achieves a gradual increase in load by acquiring and adding weights of unit weight one by one, which facilitates obtaining accurate experimental data; The weights of unit weight are spherical solids, which are easy to enter into the loading bucket; and the spherical weights are easy to count.

Claims

1. A laboratory animal pain detection device, characterized in that, The device includes a base, an experimental platform, a binding assembly, and a loading assembly. The experimental platform is located above and fixedly connected to the base. The binding assembly includes four leg clamps, two of which are located at one end of the experimental platform and the other two at the other end. The other end of the experimental platform has a reel with a pull line wound on it. One end of the pull line is fixedly connected to the leg clamps at the other end of the experimental platform, and the other end of the pull line is fixed to a loading bucket. The loading assembly includes a weight storage bucket fixed to the base and individual loading units located at the bottom of the weight storage bucket. The weight storage bucket contains multiple spherical weights with a unit weight. The individual loading units retrieve weights one by one from the weight storage bucket and add them to the loading bucket. Each individual loading unit includes a retrieval plate. An inclined tube is fixed to the side wall of the loading barrel. The upper end of the inclined tube has a receiving hopper, and the lower end of the inclined tube is connected to the inner cavity of the loading barrel. The weight storage tank has a shell at the bottom, the acquisition plate is located inside the shell, the top of the shell has a side hole, the side wall of the acquisition plate has an acquisition groove, and the bottom of the shell has a discharge pipe. When the acquisition groove is rotated to communicate with the side hole, the weights in the weight storage tank enter the acquisition groove. When the acquisition groove is connected to the discharge pipe, the weights in the acquisition groove enter the discharge pipe one by one. The discharge pipe is located directly above the receiving hopper.

2. The laboratory animal pain detection device according to claim 1, characterized in that, The experimental platform has two uprights at one end, and a connecting strap between the uprights and the leg clamps. One end of the connecting strap has a loop that fits onto the uprights, and the other end of the connecting strap is fixed to the leg clamps.

3. The laboratory animal pain detection device according to claim 2, characterized in that, The leg clamp includes two semi-circular clamping plates, the side walls of which have handles. The two handles of the leg clamp are hinged together, and a torsion spring is located between the two handles.

4. The laboratory animal pain detection device according to claim 2, characterized in that, The column and the experimental table are provided with a leg clamp spacing adjustment mechanism. The leg clamp spacing adjustment mechanism includes a first screw nut fixed to the bottom of the column and a first screw that cooperates with the first screw nut. The first screw is rotatably connected to the experimental table, and a first adjustment knob located on the outside of the experimental table is fixed at one end of the first screw.

5. The laboratory animal pain detection device according to claim 4, characterized in that, A thread wheel adjustment mechanism is provided between the thread wheel and the experimental table. The thread wheel adjustment mechanism includes a second nut that is slidably connected to the experimental table, a second screw that cooperates with the second nut, a worm wheel fixed on the second screw, and a worm that meshes with the worm wheel. One end of the worm is fixed with a second adjustment knob located on the outside of the experimental table. The thread wheel is rotatably connected to the second nut.

6. The laboratory animal pain detection device according to claim 1, characterized in that, The top of the loading bucket has a bucket lid, which is threadedly connected to the loading bucket and fixedly connected to the other end of the pull line.

Images