一种细胞内自组装血管靶向光敏剂及其制备方法和应用
The intracellular self-assembled vascular-targeting photosensitizer prepared by bioorthogonal reaction solves the problems of drug resistance and lack of targeting in the clinical application of angiogenesis inhibitors and photodynamic therapy, and achieves high yield and selective targeting of tumor cells.
CN116271024BActive Publication Date: 2026-07-17XI AN JIAOTONG UNIV
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- XI AN JIAOTONG UNIV
- Filing Date
- 2023-02-17
- Publication Date
- 2026-07-17
Smart Images
Figure CN116271024B_ABST
Abstract
本发明公开了一种细胞内自组装血管靶向光敏剂及其制备方法和应用，光敏剂通过以下步骤制备：将索拉菲尼经水解得到带有活性反应基团羧基的化合物，然后与炔基胺经酰胺缩合反应，得到带有炔基的血管靶向分子；或将BD7与炔基酸经酰胺缩合反应，得到带有炔基的血管靶向分子；将带有炔基的血管靶向分子与带有叠氮基团的苯并吩噻嗪类光敏剂，进行生物正交反应，得到细胞内自组装血管靶向光敏剂。本发明构建的细胞内自组装形成血管靶向光敏剂的制备方法简单，易于实现，并且收率较高。并且能够用于制备治疗癌症的药物中，尤其用于制备以VEGFR2为靶点的抗肿瘤药物中。
Need to check novelty before this filing date? Find Prior Art