二氟代环状磷酸酯化合物及其制备方法和应用
The preparation of difluorocyclic phosphates via cyclization, esterification, halogenation, and fluorohalogen exchange reactions solves the problems of poor reaction selectivity and low yield in existing technologies, achieving efficient and safe synthesis of difluorocyclic phosphates and laying the foundation for industrial production.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANGHAI ROLECHEM CO LTD
- Filing Date
- 2023-03-14
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies for preparing difluorophosphates suffer from poor reaction selectivity, low yields, and the use of highly toxic fluorinating agents such as HgF2 and fluorophosgene that are difficult to use in large quantities. Furthermore, there is a lack of methods for synthesizing difluorophosphates containing strained ring structures.
Using diols and phosphorus trichloride as starting materials, novel difluorocyclic phosphate compounds were prepared through cyclization, esterification, halogenation, and fluorine-halogen exchange reactions, avoiding the use of highly toxic fluorinating reagents and improving reaction safety and selectivity.
The synthesis of difluorocyclic phosphate compounds with high yield (85%) and high purity (99.8%) was achieved, providing feasibility for industrial production and avoiding the use of highly toxic fluorinating agents.
Smart Images
Figure CN116284140B_ABST