Heterocyclic derivatives, processes for their preparation and their medical use
By designing heterocyclic derivatives of general formula (I) to target the KRas G12D enzyme, a drug composition was prepared, which solved the shortcomings of existing technologies in the treatment of KRas G12D mutant cancers and achieved effective inhibition and treatment of a variety of cancers.
CN116323625BActive Publication Date: 2026-06-26ZHEJIANG HISUN PHARMA CO LTD +1
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- ZHEJIANG HISUN PHARMA CO LTD
- Filing Date
- 2022-08-23
- Publication Date
- 2026-06-26
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Figure CN116323625B_ABST
Abstract
The present application relates to heterocyclic derivatives, processes for their preparation and their use in medicine. In particular, the present application relates to a heterocyclic derivative of general formula (I), processes for their preparation and pharmaceutically acceptable salts thereof, and their use as therapeutic agents, in particular as KRas G12D inhibitors, wherein the definitions of the substituents in general formula (I) are the same as those in the specification
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